225
Views
28
CrossRef citations to date
0
Altmetric
Review

Prospects for the introduction of targeted antioxidant drugs for the prevention and treatment of diseases related to free radical pathology

&
Pages 593-603 | Received 16 Feb 2019, Accepted 09 Jun 2019, Published online: 21 Jun 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Taraneh Mousavi, Nastaran Hadizadeh, Shekoufeh Nikfar & Mohammad Abdollahi. (2020) Drug discovery strategies for modulating oxidative stress in gastrointestinal disorders. Expert Opinion on Drug Discovery 15:11, pages 1309-1341.
Read now
George J. Kontoghiorghes. (2020) How to manage iron toxicity in post-allogeneic hematopoietic stem cell transplantation?. Expert Review of Hematology 13:4, pages 299-302.
Read now

Articles from other publishers (26)

George J. Kontoghiorghes. (2023) Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs. International Journal of Molecular Sciences 24:23, pages 16749.
Crossref
George J. Kontoghiorghes. (2023) Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications. International Journal of Molecular Sciences 24:16, pages 12928.
Crossref
George J. Kontoghiorghes. (2023) The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases. Pharmaceuticals 16:7, pages 1016.
Crossref
Syed Anees Ali Jafri, Zafar Mehmood Khalid, Mohammad Rizwan Khan, Sadia Ashraf, Naushad Ahmad, Abdulnasser Mahmoud Karami, Ejaz Rafique, Mohamed Ouladsmane, Nouf Mohammad Saad Al Suliman & Summan Aslam. (2023) Evaluation of some essential traditional medicinal plants for their potential free scavenging and antioxidant properties. Journal of King Saud University - Science 35:3, pages 102562.
Crossref
George J. Kontoghiorghes. (2023) Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. International Journal of Molecular Sciences 24:5, pages 4970.
Crossref
Munazza Tamkeen Fatima, Ajaz Ahmad Bhat, Sabah Nisar, Khalid Adnan Fakhro & Ammira Sarah Al-Shabeeb Akil. (2023) The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile. Heliyon 9:1, pages e12698.
Crossref
George J. Kontoghiorghes. (2022) New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer. International Journal of Molecular Sciences 23:22, pages 13990.
Crossref
George J. Kontoghiorghes. (2022) Deferiprone: A Forty-Year-Old Multi-Targeting Drug with Possible Activity against COVID-19 and Diseases of Similar Symptomatology. International Journal of Molecular Sciences 23:12, pages 6735.
Crossref
Sammia Shahid, Sana Mansoor, Mohsin Javed, Shahid Iqbal, Umair Yousaf, Hashem O. Alsaab, Nasser S. Awwad, Hala A. Ibrahium, Rami M. Alzhrani, Mashael D. Alqahtani, Nissren Tamam, Eslam B. Elkaeed, Sabah Zaman, Muhammad Nazim Sarwar & Tauheeda Riaz. (2022) CuO-GO-Ag; Green Synthesis With Fagonia Arabica and Biomedical Potential is a Bioinspired Nano Theranostics Composite. Frontiers in Materials 9.
Crossref
Khadija El Hadri, Rémy Smith, Eric Duplus & Chahrazade El Amri. (2021) Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target. International Journal of Molecular Sciences 23:1, pages 77.
Crossref
Muhammad Arshad, Kainat Ahmed, Maryam Bashir, Naveen Kosar, Maleeha Kanwal, Maqsood Ahmed, Hidayat Ullah Khan, Shahnaz Khan, Abdul Rauf, Amir Waseem & Tariq Mahmood. (2021) Synthesis, structural properties and potent bioactivities supported by molecular docking and DFT studies of new hydrazones derived from 5-chloroisatin and 2-thiophenecarboxaldehyde. Journal of Molecular Structure 1246, pages 131204.
Crossref
Chita Ranjan Sahoo, Sudhir Kumar Paidesetty & Rabindra Nath Padhy. (2021) The recent development of thymol derivative as a promising pharmacological scaffold. Drug Development Research 82:8, pages 1079-1095.
Crossref
Viktor A. Timoshnikov, Lilia A. Kichigina, Olga Yu. Selyutina, Nikolay E. Polyakov & George J. Kontoghiorghes. (2021) Antioxidant Activity of Deferasirox and Its Metal Complexes in Model Systems of Oxidative Damage: Comparison with Deferiprone. Molecules 26:16, pages 5064.
Crossref
Pooja Sharma, Huu Hao Ngo, Samir Khanal, Christian Larroche, Sang-Hyoun Kim & Ashok Pandey. (2021) Efficiency of transporter genes and proteins in hyperaccumulator plants for metals tolerance in wastewater treatment: Sustainable technique for metal detoxification. Environmental Technology & Innovation 23, pages 101725.
Crossref
George J. Kontoghiorghes, Annita Kolnagou, Stella Fetta & Christina N. Kontoghiorghe. (2021) Conventional and Unconventional Approaches for Innovative Drug Treatments in COVID-19: Looking Outside of Plato’s Cave. International Journal of Molecular Sciences 22:13, pages 7208.
Crossref
Nikhilesh Joardar, Pradip Shit, Satyajit Halder, Utsab Debnath, Sudipto Saha, Anup Kumar Misra, Kuladip Jana & Santi P. Sinha Babu. (2021) Disruption of redox homeostasis with synchronized activation of apoptosis highlights the antifilarial efficacy of novel piperine derivatives: An in vitro mechanistic approach. Free Radical Biology and Medicine 169, pages 343-360.
Crossref
George Kontoghiorghes, Annita Kolnagou, Theodora Demetriou, Marina Neocleous & Christina Kontoghiorghe. (2021) New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications. International Journal of Molecular Sciences 22:11, pages 5546.
Crossref
Alexander Vaiserman, Alexander Koliada, Oleh Lushchak & Manuel J. Castillo. (2020) Repurposing drugs to fight aging: The difficult path from bench to bedside. Medicinal Research Reviews 41:3, pages 1676-1700.
Crossref
Javier Checa & Josep M. Aran. (2020) Airway Redox Homeostasis and Inflammation Gone Awry: From Molecular Pathogenesis to Emerging Therapeutics in Respiratory Pathology. International Journal of Molecular Sciences 21:23, pages 9317.
Crossref
Moustafa M.G. Fouda, Jamaan S Ajarem, Saleh N Maodaa, Ahmed A Allam, Mohamed M. Taher & M.K. Ahmed. (2020) Carboxymethyl cellulose supported green synthetic features of gold nanoparticles: Antioxidant, cell viability, and antibacterial effectiveness. Synthetic Metals 269, pages 116553.
Crossref
George J. Kontoghiorghes, Annita Kolnagou, Christina N. Kontoghiorghe, Loukia Mourouzidis, Viktor A. Timoshnikov & Nikolay E. Polyakov. (2020) Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications. Medicines 7:8, pages 45.
Crossref
George Kontoghiorghes & Christina Kontoghiorghe. (2020) Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases. Cells 9:6, pages 1456.
Crossref
Viktor A. Timoshnikov, Tatyana V. Kobzeva, Nikolay E. Polyakov & George J. Kontoghiorghes. (2020) Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone. International Journal of Molecular Sciences 21:11, pages 3967.
Crossref
George J. Kontoghiorghes. (2020) Advances on Chelation and Chelator Metal Complexes in Medicine. International Journal of Molecular Sciences 21:7, pages 2499.
Crossref
Ricardo U. Macías-Rodríguez, María Eugenia Inzaugarat, Astrid Ruiz-Margáin, Leonard J. Nelson, Christian Trautwein & Francisco Javier Cubero. (2020) Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis—A Novel Form of Non-Apoptotic Cell Death?. International Journal of Molecular Sciences 21:5, pages 1651.
Crossref
Ewa Domarecka, Magda Skarzynska, Agnieszka J Szczepek & Stavros Hatzopoulos. (2020) Use of zebrafish larvae lateral line to study protection against cisplatin-induced ototoxicity: A scoping review. International Journal of Immunopathology and Pharmacology 34, pages 205873842095955.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.