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Expert Opinion on Investigational Drugs Volume 28, 2019 - Issue 9
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Review

An update of SGLT1 and SGLT2 inhibitors in early phase diabetes-type 2 clinical trials

Ernest AdeghateDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, HungaryView further author information
,
Sahar MohsinDepartment of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesView further author information
,
Faisal AdiDepartment of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesView further author information
,
Fares AhmedDepartment of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesView further author information
,
Ali YahyaDepartment of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesView further author information
,
Huba KalászDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, HungaryView further author information
,
Kornelia TekesDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryView further author information
&
Ernest A. AdeghateDepartment of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesCorrespondence[email protected]
View further author information
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Pages 811-820 | Received 22 Apr 2019, Accepted 09 Aug 2019, Published online: 22 Aug 2019

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Ernest A. Adeghate, Huba Kalász, Saeeda Al Jaberi, Jennifer Adeghate & Kornelia Tekes. (2021) Tackling type 2 diabetes-associated cardiovascular and renal comorbidities: a key challenge for drug development. Expert Opinion on Investigational Drugs 30:2, pages 85-93.
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Articles from other publishers (14)

Lei Huang, Bei Cao, Yan Geng, Xiaoli Zhou, Yuanxun Yang, Tingting Ma, Hui Lin, Zhijiang Huang, Lang Zhuo & Juan Li. (2024) A randomized double-blind phase Ib clinical trial of SY-009 in patients with type 2 diabetes mellitus. European Journal of Pharmaceutical Sciences 192, pages 106644.
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Jiamei Le, Yilong Chen, Wei Yang, Ligong Chen & Jianping Ye. (2023) Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus. Acta Pharmaceutica Sinica B.
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Haigang Cui, Xin Luo, Mingwei Chen, Jun Lu & Johnson J. Liu. (2023) Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of Type 2 Diabetes Mellitus. Current Drug Targets 24:8, pages 648-661.
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Mohamed Omer Mahgoub, Ifrah Ismail Ali, Jennifer O. Adeghate, Kornélia Tekes, Huba Kalász & Ernest A. Adeghate. (2023) An Update on the Molecular and Cellular Basis of Pharmacotherapy in Type 2 Diabetes Mellitus. International Journal of Molecular Sciences 24:11, pages 9328.
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Taiwei Zhang, Jiuchong Wang, Zhaozhao Hua, Xiaoyun Yao, Fang Zhang & Yiyuan Zhou. (2023) Effect of adjunctive prophylactic macrolides used at the caesarean section on endometritis and surgical site wound infection: A meta‐analysis. International Wound Journal.
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Gary Williamson. (2022) Effects of Polyphenols on Glucose‐Induced Metabolic Changes in Healthy Human Subjects and on Glucose Transporters. Molecular Nutrition & Food Research 66:21.
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Rosanna Maccari & Rosaria Ottanà. (2022) Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives. Journal of Medicinal Chemistry 65:16, pages 10848-10881.
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Ifrah Ismail Ali, Crystal D’Souza, Jaipaul Singh & Ernest Adeghate. (2022) Adropin’s Role in Energy Homeostasis and Metabolic Disorders. International Journal of Molecular Sciences 23:15, pages 8318.
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Ana Karen Estrada, Timoteo Delgado-Maldonado, Edgar E. Lara-Ramírez, Ana Verónica Martínez-Vázquez, Eyra Ortiz-Pérez, Alma D. Paz-González, Debasish Bandyopadhyay & Gildardo Rivera. (2022) Recent Advances in the Development of Type 2 Sodium-Glucose Cotransporter Inhibitors for the Treatment of Type 2 Diabetes Mellitus. Mini-Reviews in Medicinal Chemistry 22:4, pages 586-599.
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Lina T. Al Kury, Aya Abdoh, Kamel Ikbariah, Bassem Sadek & Mohamed Mahgoub. (2021) In Vitro and In Vivo Antidiabetic Potential of Monoterpenoids: An Update. Molecules 27:1, pages 182.
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Manal M. Smail, Jaipaul Singh, Abla Mohammed Ismail, Emanuel Cummings, Carlin Hanoman, Sunil Rupee, Khemraj Rupee & Ernest Adeghate. 2021. Cellular and Biochemical Mechanisms of Obesity. Cellular and Biochemical Mechanisms of Obesity 105 118 .
Saeeda Al Jaberi, Athena Cohen, Zulqarnain Saeed, Shreesh Ojha, Jaipaul Singh & Ernest Adeghate. 2021. Cellular and Biochemical Mechanisms of Obesity. Cellular and Biochemical Mechanisms of Obesity 249 266 .
Edoardo Gronda, Mariell Jessup, Massimo Iacoviello, Alberto Palazzuoli & Claudio Napoli. (2020) Glucose Metabolism in the Kidney: Neurohormonal Activation and Heart Failure Development. Journal of the American Heart Association 9:23.
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Nabil Eid, Manoj B. Menon, Paul Thomes, Tao Zeng, Nuno Raimundo, Jose C. Fernandez-Checa, Lin Wang, Yuko Ito, Yoshinori Otsuki & Ernest Adeghate. (2020) Editorial: Autophagy and Related Transcription Factors in Liver and Gut Diseases. Frontiers in Pharmacology 10.
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