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Expert Opinion on Investigational Drugs Volume 29, 2020 - Issue 2: NASH and NAFLD: Emerging drugs, therapeutic targets and translational and clinical challenges
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Review

Multi-drug approaches to NASH: what’s in the development pipeline?

Michael P JohnstonDepartment of Hepatology, University Hospital Southampton NHS Foundation Trust, Southampton, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4704-8349View further author information
ORCID Icon,
Janisha PatelDepartment of Hepatology, University Hospital Southampton NHS Foundation Trust, Southampton, UKView further author information
&
Christopher D ByrneHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK;National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, UKView further author information
Pages 143-150 | Received 11 Jul 2019, Accepted 13 Sep 2019, Published online: 23 Sep 2019

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Chongyang Ma, Kai Yan, Zisong Wang, Qiuyun Zhang, Lianyin Gao, Tian Xu, Jiayang Sai, Fafeng Cheng & Yuqiong Du. (2021) The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis. Bioengineered 12:1, pages 2187-2202.
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Fouzia Gul, Nousheen Parvaiz & Syed Sikander Azam. (2023) Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations. PLOS ONE 18:3, pages e0283743.
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Huicun Zhang, Xiang Gao, Pengmin Chen & Hongbing Wang. (2022) Protective Effects of Tiaoganquzhi Decoction in Treating inflammatory Injury of Nonalcoholic Fatty liver Disease by Promoting CGI-58 and Inhibiting Expression of NLRP3 Inflammasome. Frontiers in Pharmacology 13.
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Takeshi Okanoue, Michiie Sakamoto, Kenichi Harada, Masaya Inagaki, Naoko Totsuka, Gaia Hashimoto & Hiromitsu Kumada. (2021) Efficacy and safety of apararenone (MT‐3995) in patients with nonalcoholic steatohepatitis: A randomized controlled study. Hepatology Research 51:9, pages 943-956.
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Giovanni Targher, Kathleen E. Corey, Christopher D. Byrne & Michael Roden. (2021) The complex link between NAFLD and type 2 diabetes mellitus — mechanisms and treatments. Nature Reviews Gastroenterology & Hepatology 18:9, pages 599-612.
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Michael P. Johnston, Janisha Patel & Christopher D. Byrne. (2021) Update on cardiovascular risk in nonalcoholic fatty liver disease. Current Opinion in Cardiology 36:4, pages 478-486.
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Sarah Altajar & Gyorgy Baffy. (2020) Skeletal Muscle Dysfunction in the Development and Progression of Nonalcoholic Fatty Liver Disease. Journal of Clinical and Translational Hepatology 8:4, pages 1-10.
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Mithun Sharma, Madhumita Premkumar, Anand V Kulkarni, Pramod Kumar, D Nageshwar Reddy & Nagaraja Padaki Rao. (2020) Drugs for Non-alcoholic Steatohepatitis (NASH): Quest for the Holy Grail. Journal of Clinical and Translational Hepatology 000:000, pages 1-11.
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Giovanni Targher. (2020) What’s Past Is Prologue: History of Nonalcoholic Fatty Liver Disease. Metabolites 10:10, pages 397.
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Nicolas Lanthier. (2020) Les nouveaux traitements de la stéatohépatite non-alcoolique. Nutrition Clinique et Métabolisme 34:3, pages 216-222.
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Chrysoula Boutari, Eirini Bouzoni, Aditya Joshi, Konstantinos Stefanakis, Olivia M. Farr & Christos S. Mantzoros. (2020) Metabolism updates: new directions, techniques, and exciting research that is broadening the horizons. Metabolism 102, pages 154009.
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