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Expert Opinion on Investigational Drugs Volume 29, 2020 - Issue 10
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Review

Huntingtin-lowering strategies for Huntington’s disease

Roger A. Barkera Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair, and MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UKCorrespondence[email protected]
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,
Motoki Fujimakib Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK;c UK Dementia Research Institute, Cambridge, UKCorrespondence[email protected]
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,
Priya Rogersa Department of Clinical Neurosciences, John Van Geest Centre for Brain Repair, and MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UKView further author information
&
David C. Rubinszteinb Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK;c UK Dementia Research Institute, Cambridge, UKORCID Iconhttps://orcid.org/0000-0001-5002-5263View further author information
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Pages 1125-1132 | Received 03 Jun 2020, Accepted 29 Jul 2020, Published online: 14 Aug 2020

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Karolina Pierzynowska, Magdalena Podlacha, Lidia Gaffke, Estera Rintz, Karolina Wiśniewska, Zuzanna Cyske & Grzegorz Węgrzyn. (2023) Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation. Autophagy 0:0, pages 1-24.
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Articles from other publishers (17)

Heqiao Li, Wenxian Yang, Huizi Li, Xiaoyuan Bai, He Zhang, Wenhui Fan, Wenjun Liu & Lei Sun. (2023) PROTAC targeting cyclophilin A controls virus-induced cytokine storm. iScience 26:9, pages 107535.
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Yuri Mezentsev, Pavel Ershov, Evgeniy Yablokov, Leonid Kaluzhskiy, Konstantin Kupriyanov, Oksana Gnedenko & Alexis Ivanov. (2022) Protein Interactome Profiling of Stable Molecular Complexes in Biomaterial Lysate. International Journal of Molecular Sciences 23:24, pages 15697.
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Deping Li, Dongmin Yu, Yan Li & Renze Yang. (2022) A bibliometric analysis of PROTAC from 2001 to 2021. European Journal of Medicinal Chemistry 244, pages 114838.
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Khalid Saad Alharbi, Mohammad Arshad Javed Shaikh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, M Ravindra Babu, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua & Gaurav Gupta. (2022) Oligonucleotides: A novel area of interest for drug delivery in neurodegenerative diseases. Journal of Drug Delivery Science and Technology 77, pages 103849.
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Jiaming Guan, Zhijian Song, Guanghong Wei & Qin Qiao. (2022) Distinct binding interactions trigger opposite conformational modulations on pathogenic and wildtype Huntingtin exon 1 proteins. Physical Chemistry Chemical Physics 24:40, pages 24959-24974.
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Jing Jin, Nicolas Arbez, James J. Sahn, Yan Lu, Kathryn T. Linkens, Timothy R. Hodges, Anthony Tang, Robyn Wiseman, Stephen F. Martin & Christopher A. Ross. (2022) Neuroprotective Effects of σ 2 R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington’s Disease . ACS Chemical Neuroscience 13:19, pages 2852-2862.
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Andreas Neueder, Kerstin Kojer, Tanja Hering, Daniel J. Lavery, Jian Chen, Nathalie Birth, Jaqueline Hallitsch, Sonja Trautmann, Jennifer Parker, Michael Flower, Huma Sethi, Salman Haider, Jong-Min Lee, Sarah J. Tabrizi & Michael Orth. (2022) Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues. Genome Biology 23:1.
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Sara Melisa Arciniegas Ruiz & Hagit Eldar-Finkelman. (2022) Glycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward. Frontiers in Molecular Neuroscience 14.
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Haobin Li, Jinyun Dong, Maohua Cai, Zhiyuan Xu, Xiang-Dong Cheng & Jiang-Jiang Qin. (2021) Protein degradation technology: a strategic paradigm shift in drug discovery. Journal of Hematology & Oncology 14:1.
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Chaebin Kim, Ali Yousefian-Jazi, Seung-Hye Choi, Inyoung Chang, Junghee Lee & Hoon Ryu. (2021) Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease. International Journal of Molecular Sciences 22:22, pages 12499.
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Sara Picó, Alberto Parras, María Santos-Galindo, Julia Pose-Utrilla, Margarita Castro, Enrique Fraga, Ivó H. HernándezAinara Elorza, Héctor Anta, Nan WangLaura Martí-Sánchez, Eulàlia Belloc, Paula Garcia-Esparcia, Juan J. Garrido, Isidro Ferrer, Daniel Macías-García, Pablo Mir, Rafael Artuch, Belén PérezFélix HernándezPilar Navarro, José Luis López-Sendón, Teresa Iglesias, X. William YangRaúl Méndez & José J. Lucas. (2021) CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease. Science Translational Medicine 13:613.
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Stefano Puglisi-Allegra, Stefano Ruggieri & Francesco Fornai. (2021) Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders. Translational Psychiatry 11:1.
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Gabriel Vasata Furtado, Jing Yang, Di Wu, Christos I Papagiannopoulos, Hanna M Terpstra, E F Elsiena Kuiper, Sybille Krauss, Wei-Guo Zhu, Harm H Kampinga & Steven Bergink. (2021) FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation. Human Molecular Genetics 30:11, pages 996-1005.
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Tarik Seref Onur, Andrew Laitman, He Zhao, Ryan Keyho, Hyemin Kim, Jennifer Wang, Megan Mair, Huilan Wang, Lifang Li, Alma Perez, Maria de Haro, Ying-Wooi Wan, Genevera Allen, Boxun Lu, Ismael Al-Ramahi, Zhandong Liu & Juan Botas. (2021) Downregulation of glial genes involved in synaptic function mitigates Huntington's Disease pathogenesis. eLife 10.
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Dharmendra Kumar Khatri, Amey Kadbhane, Monica Patel, Shweta Nene, Srividya Atmakuri, Saurabh Srivastava & Shashi Bala Singh. (2021) Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders. Current Research in Pharmacology and Drug Discovery 2, pages 100022.
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Thomas B. Stoker, Katie E.R. Andresen & Roger A. Barker. (2020) Hydrocephalus Complicating Intrathecal Antisense Oligonucleotide Therapy for Huntington's Disease. Movement Disorders 36:1, pages 263-264.
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Magdalena Czeredys. (2020) Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease. Frontiers in Cell and Developmental Biology 8.
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