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Inhibition of Bruton´s tyrosine kinase as a novel therapeutic approach in multiple sclerosis

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Pages 1143-1150 | Received 30 Apr 2020, Accepted 06 Aug 2020, Published online: 19 Aug 2020

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Alamgir Khan, Komal Zia, Salman Ali Khan, Asaad Khalid, Ashraf N. Abdalla, Marium Bibi & Zaheer Ul-Haq. (2023) Identification of IL-2 inducible tyrosine kinase inhibitors by quantum mechanics and ligand based virtual screening approaches. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-11.
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Darius Saberi, Anastasia Geladaris, Sarah Dybowski & Martin S. Weber. (2023) Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis. Expert Opinion on Therapeutic Targets 27:4-5, pages 347-359.
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Anna Wolska-Washer & Tadeusz Robak. (2022) Acalabrutinib: a bruton tyrosine kinase inhibitor for the treatment of chronic lymphocytic leukemia. Expert Review of Hematology 15:3, pages 183-194.
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Dejan Jakimovski, Stefan Bittner, Robert Zivadinov, Sarah A Morrow, Ralph HB Benedict, Frauke Zipp & Bianca Weinstock-Guttman. (2023) Multiple sclerosis. The Lancet.
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Julia Krämer, Amit Bar-Or, Timothy J. Turner & Heinz Wiendl. (2023) Bruton tyrosine kinase inhibitors for multiple sclerosis. Nature Reviews Neurology 19:5, pages 289-304.
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Panagiotis Kanatas, Ioannis Stouras, Leonidas Stefanis & Panos Stathopoulos. (2022) B-Cell-Directed Therapies: A New Era in Multiple Sclerosis Treatment. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 50:3, pages 355-364.
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Sarah Dybowski, Sebastian Torke & Martin S. Weber. (2023) Targeting B Cells and Microglia in Multiple Sclerosis With Bruton Tyrosine Kinase Inhibitors. JAMA Neurology 80:4, pages 404.
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Ganesha Liyanage & Fabienne Brilot. (2022) Targeting B cell dysregulation with emerging therapies in autoimmune demyelinating disorders. Current Opinion in Neurobiology 77, pages 102643.
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Neeta Garg, Elizabeth Jordan Padron, Kottil W. Rammohan & Courtney Frances Goodman. (2022) Bruton’s Tyrosine Kinase Inhibitors: The Next Frontier of B-Cell-Targeted Therapies for Cancer, Autoimmune Disorders, and Multiple Sclerosis. Journal of Clinical Medicine 11:20, pages 6139.
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Pablo Villoslada & Sara Llufriu. (2022) Preventing Neurodegeneration in Multiple Sclerosis Is Required From the Earliest Stages of the Disease. Neurology 99:15, pages 641-642.
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Anastasia Geladaris, Sebastian Torke & Martin S. Weber. (2022) Bruton’s Tyrosine Kinase Inhibitors in Multiple Sclerosis: Pioneering the Path Towards Treatment of Progression?. CNS Drugs 36:10, pages 1019-1030.
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Zeya Yan, Feng Gu, Zilan Wang, Jiahao Meng, Xinyu Tao, Qiling Dai, Wei Wang, Meirong Liu & Zhong Wang. (2022) Safety and efficacy of tyrosine kinase inhibitors for the treatment of multiple sclerosis: A systematic review and meta-analysis from randomized controlled trials. Frontiers in Neurology 13.
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Özgür Yaldizli & Tobias Derfuss. (2022) All Bruton’s tyrosine kinase inhibitors have similar efficacy and risks: Commentary. Multiple Sclerosis Journal 28:10, pages 1502-1503.
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Fioravante Capone, Angela Albanese, Giorgia Quadri, Vincenzo Di Lazzaro, Emma Falato, Antonio Cortese, Laura De Giglio & Elisabetta Ferraro. (2022) Disease-Modifying Drugs and Breastfeeding in Multiple Sclerosis: A Narrative Literature Review. Frontiers in Neurology 13.
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A.N. Boyko. (2022) Tyrosine kinases: a target of epigenetic influences and a new direction in the treatment of multiple sclerosis. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 122:7, pages 27.
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Garth E. Ringheim, Matthew Wampole & Kinsi Oberoi. (2021) Bruton’s Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures. Frontiers in Immunology 12.
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Martin S. WeberJacqueline A. NicholasMichael R. Yeaman. (2021) Balancing Potential Benefits and Risks of Bruton Tyrosine Kinase Inhibitor Therapies in Multiple Sclerosis During the COVID-19 Pandemic. Neurology Neuroimmunology & Neuroinflammation 8:6.
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Kenji Kufukihara. (2021) Anti‐B cell therapies in multiple sclerosis. Clinical and Experimental Neuroimmunology 12:4, pages 228-237.
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Sining Zhu, Jaeyong Jung, Eton Victor, Johann Arceo, Samantha Gokhale & Ping Xie. (2021) Clinical Trials of the BTK Inhibitors Ibrutinib and Acalabrutinib in Human Diseases Beyond B Cell Malignancies. Frontiers in Oncology 11.
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Chiara Brullo, Carla Villa, Bruno Tasso, Eleonora Russo & Andrea Spallarossa. (2021) Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective. International Journal of Molecular Sciences 22:14, pages 7641.
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Jiamin Zheng, Jun Wu, Xiao Ding, Hong C. Shen & Ge Zou. (2021) Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 38, pages 127862.
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Tobias Brummer, Tobias Ruck, Sven G. Meuth, Frauke Zipp & Stefan Bittner. (2021) Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders. Therapeutic Advances in Neurological Disorders 14, pages 175628642110355.
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