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Expert Opinion on Investigational Drugs Volume 30, 2021 - Issue 9
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Drug Evaluation

Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas

Susan Dababoua Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, ItalyView further author information
,
Simone Garzona Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, ItalyORCID Iconhttps://orcid.org/0000-0002-5840-699XView further author information
ORCID Icon,
Antonio Simone Laganàb Department of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, Varese (VA), ItalyORCID Iconhttps://orcid.org/0000-0003-1543-2802View further author information
ORCID Icon,
Simone Ferreroc Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (Dinogmi), University of Genova, Italy;d Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genova, ItalyView further author information
,
Giulio Evangelistic Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (Dinogmi), University of Genova, Italy;d Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genova, ItalyORCID Iconhttps://orcid.org/0000-0001-8075-7916View further author information
ORCID Icon,
Marco Noventae Department of Women and Children’s Health, Clinic of Gynecology and Obstetrics, University of Padua, Padua, ItalyView further author information
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Maurizio Nicola D’Alteriof Department of Surgical Sciences, Section of Obstetrics & Gynecology, University of Cagliari, Monserrato, ItalyView further author information
,
Stefano Palombag Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, ItalyView further author information
,
Stefano Uccellaa Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, ItalyView further author information
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Massimo Franchia Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, ItalyORCID Iconhttps://orcid.org/0000-0001-6156-158XView further author information
ORCID Icon &
Fabio Barrac Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (Dinogmi), University of Genova, Italy;d Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genova, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4117-6603View further author information
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Pages 903-911 | Received 11 May 2021, Accepted 16 Jul 2021, Published online: 04 Aug 2021

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Gabriel Hartner, Heinrich Husslein, Lorenz Kuessel, Manuela Gstoettner, Denise Tiringer, René Wenzl & Alexandra Perricos. (2023) The latest advances in the pharmacological management of endometriosis. Expert Opinion on Pharmacotherapy 24:1, pages 121-133.
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Sara Clemenza, Silvia Vannuccini, Agostino Ruotolo, Tommaso Capezzuoli & Felice Petraglia. (2022) Advances in targeting estrogen synthesis and receptors in patients with endometriosis. Expert Opinion on Investigational Drugs 31:11, pages 1227-1238.
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Laura Buggio, Dhouha Dridi, Giussy Barbara, Camilla E.M. Merli, Giulia Emily Cetera & Paolo Vercellini. (2022) Novel pharmacological therapies for the treatment of endometriosis. Expert Review of Clinical Pharmacology 15:9, pages 1039-1052.
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Kaoru Kobayashi, Motohiro Tezuka, Yasuyuki Toyoda, Takao Kurooka, Emiko Oota, Yasuaki Tamai, Yoshikazu Abe, Sumiyoshi Kiguchi & Takuro Endo. (2022) Non-clinical studies indicating lack of interactions between iron/calcium ions and linzagolix, an orally available GnRH antagonist. Xenobiotica 52:5, pages 488-497.
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Mohamed Ali, Hsin-Yuan Chen, Yi-Fen Chiang, Osama A Badary, Shih-Min Hsia & Ayman Al-Hendy. (2022) An evaluation of relugolix/estradiol/norethindrone acetate for the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women. Expert Opinion on Pharmacotherapy 23:4, pages 421-429.
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Lingli Xin, Yinghao Ma, Mei Ye, Ling Chen, Fuzhou Liu & Qingxiang Hou. (2023) Efficacy and safety of oral gonadotropin-releasing hormone antagonists in moderate-to-severe endometriosis-associated pain: a systematic review and network meta-analysis. Archives of Gynecology and Obstetrics 308:4, pages 1047-1056.
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Daniel Ernesto Carvallo Ruiz, Elizabeth Natalia Martínez-Núñez & José Núñez-Troconis. (2022) Gynecological uses of GnRH antagonists: review article. Obstetrics & Gynecology International Journal 13:4, pages 226-238.
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Antonio Simone Laganà, Amerigo Vitagliano, Vito Chiantera & Ettore Cicinelli. (2022) Diagnosis and Treatment of Endometriosis and Endometriosis-Associated Infertility: Novel Approaches to an Old Problem. Journal of Clinical Medicine 11:13, pages 3914.
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Zhenyue Qin, Zhiyong Dong, Junling Liu, Ahong Zhong, Mingyue Bao, Huihui Wang, Hongxia Yu, Shoufeng Zhang, Wendi Zhang, Li Shen, Jie Wu & Jiming Chen. (2022) A Preliminary Study on the Effects of Black Cohosh Preparations on Bone Metabolism of Rat Models With GnRH-a-Induced Peri-Menopausal Symptoms. Frontiers in Endocrinology 13.
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Shan Chih Lee, Ying-Hsiang Chou, Disline Manli Tantoh, Shu-Yi Hsu, Oswald Ndi Nfor, Yeu Sheng Tyan & Yung-Po Liaw. (2022) Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet. BMC Women's Health 22:1.
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Xiaotong Peng, Yanqun Mo, Junliang Liu, Huining Liu & Shuo Wang. (2022) Identification and Validation of miRNA-TF-mRNA Regulatory Networks in Uterine Fibroids. Frontiers in Bioengineering and Biotechnology 10.
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Chiho Miyagawa, Kosuke Murakami, Takako Tobiume, Takafumi Nonogaki & Noriomi Matsumura. (2021) Characterization of patients that can continue conservative treatment for adenomyosis. BMC Women's Health 21:1.
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