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Research Article

Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene

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Pages 236-249 | Published online: 29 Sep 2008

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Read on this site (4)

Hans-Peter Rihs, Gerhard Triebig, Philipp Werner, Sylvia Rabstein, Evelyn Heinze, Beate Pesch & Thomas Brüning. (2008) Association Between Genetic Polymorphisms in Styrene-Metabolizing Enzymes and Biomarkers in Styrene-Exposed Workers∗ . Journal of Toxicology and Environmental Health, Part A 71:13-14, pages 866-873.
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S. Fustinoni, L. Campo, P. Manini, M. Buratti, S. Waidyanatha, G. De Palma, A. Mutti, V Foa, A. Colombi & S. M. Rappaport. (2008) An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using a repeated measurements sampling design. Biomarkers 13:6, pages 560-578.
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Pavel Vodicka, Mikko Koskinen, Alessio Naccarati, Barbara Oesch-Bartlomowicz, Ludmila Vodickova, Kari Hemminki & Franz Oesch. (2006) Styrene Metabolism, Genotoxicity, and Potential Carcinogenicity. Drug Metabolism Reviews 38:4, pages 805-853.
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Articles from other publishers (25)

Ah-rum Choi, Sung-guk Im, Mi-young Lee & Se-Hoon Lee. (2019) Evaluation of the Suitability of Establishing Biological Exposure Indices of Styrene. Safety and Health at Work 10:1, pages 103-108.
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Ki-Woong Kim. (2015) Effects of Styrene-metabolizing Enzyme Polymorphisms and Lifestyle Behaviors on Blood Styrene and Urinary Metabolite Levels in Workers Chronically Exposed to Styrene. Toxicological Research 31:4, pages 355-361.
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Damiano Carbonari, Antonella Mansi, Anna Rita Proietto, Enrico Paci, Rossana Claudia Bonanni, Monica Gherardi, Maria Pia Gatto, Renata Sisto & Giovanna Tranfo. (2015) Influence of genetic polymorphisms of styrene-metabolizing enzymes on the levels of urinary biomarkers of styrene exposure. Toxicology Letters 233:2, pages 156-162.
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Penelope A. Lind, Stuart Macgregor, Andrew C. Heath, Pamela A. F. Madden, Grant W. Montgomery, Nicholas G. Martin & John B. Whitfield. (2012) Association Between In Vivo Alcohol Metabolism and Genetic Variation in Pathways that Metabolize the Carbon Skeleton of Ethanol and NADH Reoxidation in the Alcohol Challenge Twin Study . Alcoholism: Clinical and Experimental Research 36:12, pages 2074-2085.
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Mária Poláková, Zdenka Krajčovičová, Vladimír Meluš, Mária Štefkovičová & Margaréta Šulcová. (2012) Study of Urinary Concentrations of Mandelic Acid in Employees Exposed to Styrene. Central European Journal of Public Health 20:3, pages 226-232.
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Soya Sisy Sam, Vinod Thomas, Kanipakapatanam Sathyanarayana Reddy, Gopalakrishnan Surianarayanan & Adithan Chandrasekaran. (2010) Gene–gene interactions of drug metabolizing enzymes and transporter protein in the risk of upper aerodigestive tract cancers among Indians. Cancer Epidemiology 34:5, pages 626-633.
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José Rueff, João P. Teixeira, Luís Silva Santos & Jorge Francisco Gaspar. (2009) Genetic effects and biotoxicity monitoring of occupational styrene exposure. Clinica Chimica Acta 399:1-2, pages 8-23.
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J.P. Teixeira, J. Gaspar, J. Roma-Torres, S. Silva, C. Costa, J. Roach, O. Mayan, J. Rueff & P.B. Farmer. (2007) Styrene-oxide N-terminal valine haemoglobin adducts in reinforced plastic workers: Possible influence of genetic polymorphism of drug-metabolising enzymes. Toxicology 237:1-3, pages 58-64.
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Paola Manini, Giuseppe De Palma & Antonio Mutti. (2007) Exposure assessment at the workplace: Implications of biological variability. Toxicology Letters 168:3, pages 210-218.
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Paola Manini, Giuseppe De Palma, Roberta Andreoli, Diana Poli, Paola Mozzoni, Giuseppina Folesani, Antonio Mutti & Pietro Apostoli. (2006) Environmental and biological monitoring of benzene exposure in a cohort of Italian taxi drivers. Toxicology Letters 167:2, pages 142-151.
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Sanja KezicFlorentine Calkoen, Mira AM Wenker, John JL Jacobs & Maarten M Verberk. (2016) Genetic polymorphism of metabolic enzymes modifies the risk of chronic solvent-induced encephalopathy. Toxicology and Industrial Health 22:7, pages 281-289.
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Sara Negri, Luciano Maestri, Roberta Andreoli, Paola Manini, Antonio Mutti & Marcello Imbriani. (2006) Mercapturic acids of styrene in man: Comparability of the results obtained by LC/MS/MS and by HPLC-fluorimeter, and stability of samples under different storage conditions. Toxicology Letters 162:2-3, pages 225-233.
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Lucia Migliore, Alessio Naccarati, Fabio Coppedè, Enrico Bergamaschi, Giuseppe De Palma, Anu Voho, Paola Manini, Hilkka Järventaus, Antonio Mutti, Hannu Norppa & Ari Hirvonen. (2006) Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene. Pharmacogenetics and Genomics 16:2, pages 87-99.
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V. Haufroid & D. Lison. (2005) Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: a minireview. International Archives of Occupational and Environmental Health 78:5, pages 343-354.
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D.V. Varyvonchyk. (2005) Molecular-genetic mechanisms of cell malignant transformation and directions of application of genetic screening of the working population for prevention of occupational cancer development: systemic review. Ukrainian Journal of Occupational Health 2005:1, pages 74-84.
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Lena Ernstgard, Margareta Warholm & Gunnar Johanson. (2004) Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity. British Journal of Clinical Pharmacology 58:2, pages 190-200.
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Alison J. Shield & Barbara J.S. Sanderson. (2004) A recombinant model for assessing the role of GSTM1 in styrene-7,8-oxide toxicity and mutagenicity. Toxicology 195:1, pages 61-68.
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Lena Ernstgård, Bengt Sjögren, Margareta Warholm & Gunnar Johanson. (2003) Sex differences in the toxicokinetics of inhaled solvent vaporsin humans 1. m-Xylene. Toxicology and Applied Pharmacology 193:2, pages 147-157.
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Hannu Norppa. (2003) Genetic susceptibility, biomarker respones, and cancer. Mutation Research/Reviews in Mutation Research 544:2-3, pages 339-348.
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Paola Manini, Luca Buzio, Roberta Andreoli, Matteo Goldoni, Enrico Bergamaschi, Marek Jakubowski, Pavel Vodicka, Ari Hirvonen & Antonio Mutti. (2003) Assessment of biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers. Toxicology and Applied Pharmacology 189:3, pages 160-169.
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Blanca Laffon, Beatriz Pérez-Cadahı́a, Eduardo Pásaro & Josefina Méndez. (2003) Effect of epoxide hydrolase and glutathione S-tranferase genotypes on the induction of micronuclei and DNA damage by styrene-7,8-oxide in vitro. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 536:1-2, pages 49-59.
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Paola Manini, Roberta Andreoli, Diana Poli, Giuseppe De Palma, Antonio Mutti & Wilfried M. A. Niessen. (2002) Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat. Rapid Communications in Mass Spectrometry 16:24, pages 2239-2248.
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Vincent Haufroid, Marek Jakubowski, Beata Janasik, Danuta Ligocka, Jean-Pierre Buchet, Enrico Bergamaschi, Paola Manini, Antonio Mutti, Sergio Ghittori, Michael Arand, Nina Hangen, Franz Oesch, Ari Hirvonen & Dominique Lison. (2002) Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. Pharmacogenetics 12:9, pages 691-702.
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Paola Manini, Giuseppe De Palma, Paola Mozzoni, Roberta Andreoli, Diana Poli, Enrico Bergamaschi, Innocente Franchini & Antonio Mutti. (2002) GSTM1 polymorphism and styrene metabolism: insights from an acute accidental exposure. Toxicology Letters 134:1-3, pages 201-208.
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Stefano Bonassi & William W Au. (2002) Biomarkers in molecular epidemiology studies for health risk prediction. Mutation Research/Reviews in Mutation Research 511:1, pages 73-86.
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