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Biomarkers Volume 14, 2009 - Issue 1
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Research Article

Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis

Chihiro FujimakiDepartment of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, JapanCorrespondence[email protected]
,
Hideki HayashiDepartment of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan
,
Seiji TsuboiDepartment of Rheumatology, Shizuoka Kousei Hospital, Aoi-ku, Shizuoka, Japan
,
Taiji MatsuyamaDepartment of Pharmacy, Shizuoka Kousei Hospital, Aoi-ku, Shizuoka, Japan
,
Kazuhiro KosugeDepartment of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan
,
Hiroshi YamadaDepartment of Drug Evaluation & Informatics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan
,
Kazuyuki InoueDepartment of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan
&
Kunihiko ItohDepartment of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan
 show all
Pages 49-54 | Received 31 Jul 2008, Accepted 21 Dec 2008, Published online: 01 Feb 2009

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Heng Li, Huimin Lu, Wei Tang & Jianping Zuo. (2017) Targeting methionine cycle as a potential therapeutic strategy for immune disorders. Expert Opinion on Therapeutic Targets 21:9, pages 861-877.
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Massimo Fusconi, Antonio Chistolini, Armando de Virgilio, Antonio Greco, Fulvio Massaro, Rosaria Turchetta, Anna Teresa Benincasa, Mario Tombolini & Marco de Vincentiis. (2012) Sudden sensorineural hearing loss: A vascular cause? Analysis of prothrombotic risk factors in head and neck. International Journal of Audiology 51:11, pages 800-805.
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Articles from other publishers (15)

Goitybell Martínez, Yaima Zuñiga, Jonas Bybjerg, Ole Mors & Beatriz Marcheco. (2023) Single Nucleotide Polymorphisms of MTHFR (rs1051266) and SLC19A1 (rs1801133) Associated to Genomic Ancestry in Cuban Healthy Population. Current Pharmacogenomics and Personalized Medicine 20:2, pages 106-115.
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Aikaterini Arida, Adrianos Nezos, Ioanna Papadaki, Petros P. Sfikakis & Clio P. Mavragani. (2022) Osteoprotegerin and MTHFR gene variations in rheumatoid arthritis: association with disease susceptibility and markers of subclinical atherosclerosis. Scientific Reports 12:1.
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A. Álvarez-Cienfuegos, L. Cantero-Nieto, J.A. García-Gomez, J.L. Callejas-Rubio, M.A. González-Gay & N. Ortego-Centeno. (2020) Association Between Homocysteine Serum Level and Bone Mineral Density in Patients With Rheumatoid Arthritis. Journal of Clinical Densitometry 23:4, pages 561-567.
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Zahra Bagheri-Hosseinabadi, Danyal Imani, Hassan Yousefi & Mitra Abbasifard. (2020) MTHFR gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis based on 16 studies. Clinical Rheumatology 39:8, pages 2267-2279.
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Souhir Chaabane, Meriam Messedi, Rim Akrout, Mariem Ben Hamad, Mouna Turki, Sameh Marzouk, Leila Keskes, Zouheir Bahloul, Ahmed Rebai, Fatma Ayedi & Abdellatif Maalej. (2018) Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients. Inflammation Research 67:8, pages 703-710.
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Yi Yuan, Wenjing Shao & Yuying Li. (2017) Associations between C677T and A1298C polymorphisms of MTHFR and susceptibility to rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology International 37:4, pages 557-569.
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Han Cen, Hua Huang, Li-Na Zhang, Li-Ya Liu, Li Zhou, Xia-Fei Xin & Ren-Jie Zhuo. (2016) Associations of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with genetic susceptibility to rheumatoid arthritis: a meta-analysis. Clinical Rheumatology 36:2, pages 287-297.
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Souhir Chaabane, Sameh Marzouk, Rim Akrout, Mariem Ben Hamad, Yosser Achour, Ahmed Rebai, Leila Keskes, Hela Fourati, Zouhir Bahloul & Abdellatif Maalej. (2015) Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway. European Journal of Drug Metabolism and Pharmacokinetics 41:4, pages 385-393.
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Michel Neidhart. 2016. DNA Methylation and Complex Human Disease. DNA Methylation and Complex Human Disease 381 393 .
Mickael Essouma & Jean Jacques N. Noubiap. (2015) Therapeutic potential of folic acid supplementation for cardiovascular disease prevention through homocysteine lowering and blockade in rheumatoid arthritis patients. Biomarker Research 3:1.
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Pınar Borman, Özgur Taşbaş, Halil Karabulut, Ajlan Tukun & Rezan Yorgancıoğlu. (2015) Thymidylate synthase genetic polymorphism and plasma total homocysteine level in a group of Turkish patients with rheumatoid arthritis: relationship with disease activity and methotrexate toxicity. Revista Brasileira de Reumatologia (English Edition) 55:6, pages 485-492.
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Pınar Borman, Özgur Taşbaş, Halil Karabulut, Ajlan Tukun & Rezan Yorgancıoğlu. (2015) Polimorfismo do gene timidilato sintase e nível plasmático total de homocisteína em um grupo de pacientes turcos com artrite reumatoide: relação com a atividade da doença e toxicidade ao metotrexato. Revista Brasileira de Reumatologia 55:6, pages 485-492.
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Á. O'Connor. (2014) An overview of the role of diet in the treatment of rheumatoid arthritis. Nutrition Bulletin 39:1, pages 74-88.
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C L Raison & A H Miller. (2012) The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D). Molecular Psychiatry 18:1, pages 15-37.
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Iztok Holc, Radovan Hojs, Nada Čikeš, Aleš Ambrožič, Saša Čučnik, Tanja Kveder, Blaž Rozman & Artur Pahor. (2011) Antiphospholipid antibodies and atherosclerosis: Insights from Rheumatoid arthritis – A five-year follow-up study. Immunobiology 216:12, pages 1331-1337.
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