Citations (113)
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Philipp F. Lange, Oliver Schilling & Pitter F. Huesgen. (2023) Positional proteomics: is the technology ready to study clinical cohorts?. Expert Review of Proteomics 0:0, pages 1-10.
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Simone Andrea Rørdam Preil, Anne-Sofie Faarvang Thorsen, Anne Lindegaard Christiansen, Mikael Kjær Poulsen, Morten Asser Karsdal, Diana Julie Leeming & Lars Melholt Rasmussen. (2017) Is cardiovascular disease in patients with diabetes associated with serum levels of MMP-2, LOX, and the elastin degradation products ELM and ELM-2?. Scandinavian Journal of Clinical and Laboratory Investigation 77:7, pages 493-497.
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Federica Genovese & Morten Asser Karsdal. (2016) Protein degradation fragments as diagnostic and prognostic biomarkers of connective tissue diseases: understanding the extracellular matrix message and implication for current and future serological biomarkers. Expert Review of Proteomics 13:2, pages 213-225.
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K. Henriksen, C. Christiansen & M. A. Karsdal. (2015) Role of biochemical markers in the management of osteoporosis. Climacteric 18:sup2, pages 10-18.
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Gary W Caldwell. (2015) In silico tools used for compound selection during target-based drug discovery and development. Expert Opinion on Drug Discovery 10:8, pages 901-923.
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Morten A. Karsdal, Anne Christine Bay-Jensen, Diana Julie Leeming, Kim Henriksen & Claus Christiansen. (2013) Quantification of “end products” of tissue destruction in inflammation may reflect convergence of cytokine and signaling pathways – implications for modern clinical chemistry. Biomarkers 18:5, pages 375-378.
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Efstathios Vassiliadis, Sanne S. Veidal, Henrik Simonsen, Dorthe V. Larsen, Ben Vainer, Xiaoliang Chen, Qinlong Zheng, Morten A. Karsdal & Diana J. Leeming. (2011) Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis. Biomarkers 16:5, pages 426-433.
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Erik B Dam, Inger Byrjalsen, Lars Arendt-Nielsen, Claus Christiansen & Morten A Karsdal. (2011) Relationships Between Knee Pain and Osteoarthritis Biomarkers Based on Systemic Fluids and Magnetic Resonance Imaging. Journal of Musculoskeletal Pain 19:3, pages 144-153.
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D. J. Leeming, A. C. Bay-Jensen, E. Vassiliadis, M. R. Larsen, K. Henriksen & M. A. Karsdal. (2011) Post-translational modifications of the extracellular matrix are key events in cancer progression: Opportunities for biochemical marker development. Biomarkers 16:3, pages 193-205.
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K. Henriksen, K. M. Bohren, A. C. Bay-Jensen & M. A. Karsdal. (2010) Should biochemical markers of bone turnover be considered standard practice for safety pharmacology?. Biomarkers 15:3, pages 195-204.
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Articles from other publishers (103)
Ambrish Singh & Benny Antony. 2024. Cartilage Tissue and Knee Joint Biomechanics. Cartilage Tissue and Knee Joint Biomechanics
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Hans Carl Hasselbalch, Peter Junker, Vibe Skov, Lasse Kjær, Trine A. Knudsen, Morten Kranker Larsen, Morten Orebo Holmström, Mads Hald Andersen, Christina Jensen, Morten A. Karsdal & Nicholas Willumsen. (2023) Revisiting Circulating Extracellular Matrix Fragments as Disease Markers in Myelofibrosis and Related Neoplasms. Cancers 15:17, pages 4323.
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Xueqiang Chen, Juntao Xu, Houjian Zhang & Lixin Yu. (2023) A nomogram for predicting osteoarthritis based on serum biomarkers of bone turnover in middle age: A cross-sectional study of PTH and β-CTx. Medicine 102:20, pages e33833.
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Signe Holm Nielsen, Shu Sun, Anne C. Bay-Jensen, Morten Karsdal, Inge Juul Sørensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Gorm Thamsborg, Ole Rintek Madsen, Jakob Møller, Mikkel Østergaard & Susanne Juhl Pedersen. (2022) Levels of extracellular matrix metabolites are associated with changes in Ankylosing Spondylitis Disease Activity Score and MRI inflammation scores in patients with axial spondyloarthritis during TNF inhibitor therapy. Arthritis Research & Therapy 24:1.
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Viktor Domislovic, Joachim Høg Mortensen, Majken Lindholm, Morten Asser Kaarsdal, Marko Brinar, Ana Barisic, Tina Manon-Jensen & Zeljko Krznaric. (2022) Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis. Journal of Clinical Medicine 11:19, pages 5907.
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Pablo Muriel. 2022. Hepatic Fibrosis. Hepatic Fibrosis
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Patryk J. Drobinski, Anne C. Bay-Jensen, Morten A. Karsdal, Samra Sardar & Anne S. Siebuhr. (2021) Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study. Arthritis Research & Therapy 23:1.
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Solveig Skovlund Groen, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Christian S. Thudium, Morten A. Karsdal, Simon Francis Thomsen, Sven Lindemann, Daniela Werkmann, Joseph Blair, Line Mærsk Staunstrup, Patrik Önnerfjord, Lars Arendt-Nielsen & Signe Holm Nielsen. (2021) A serological type II collagen neoepitope biomarker reflects cartilage breakdown in patients with osteoarthritis. Osteoarthritis and Cartilage Open 3:4, pages 100207.
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Lei Feng, Jinming Li & Rui Zhang. (2021) Current research status of blood biomarkers in Alzheimer’s disease: Diagnosis and prognosis. Ageing Research Reviews 72, pages 101492.
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M.A. Karsdal, F. Genovese, D.G.K. Rasmussen, A.C. Bay-Jensen, J.H. Mortensen, S. Holm Nielsen, N. Willumsen, C. Jensen, T. Manon-Jensen, L. Jennings, A.L. Reese-Petersen, K. Henriksen, J.M. Sand, C. Bager & D.J. Leeming. (2021) Considerations for understanding protein measurements: Identification of formation, degradation and more pathological relevant epitopes. Clinical Biochemistry 97, pages 11-24.
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Jennifer C. Erhart‐Hledik, Gordhan B. Mahtani, Jessica L. Asay, Eleonora Migliore, Michelle M. Nguyen, Thomas P. Andriacchi & Constance R. Chu. (2020) Changes in knee adduction moment wearing a variable‐stiffness shoe correlate with changes in pain and mechanically stimulated cartilage oligomeric matrix levels. Journal of Orthopaedic Research 39:3, pages 619-627.
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Marcus Fager Ferrari, Eva Zetterberg, Maria Rossing, Tina Manon‐Jensen, Martin Pehrsson, Morten A. Karsdal, Jens Lykkesfeldt & Eva Leinoe. (2020) Collagen remodelling and plasma ascorbic acid levels in patients suspected of inherited bleeding disorders harbouring germline variants in collagen‐related genes. Haemophilia 27:1.
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Morten Asser Karsdal, Virginia Byers Kraus, Diane Shevell, Anne Christine Bay-Jensen, Jörn Schattenberg, R. Rambabu Surabattula & Detlef Schuppan. (2021) Profiling and targeting connective tissue remodeling in autoimmunity - A novel paradigm for diagnosing and treating chronic diseases. Autoimmunity Reviews 20:1, pages 102706.
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Wenyu Wei, Dongfang Li, Xiangdong Cai, Zhao Liu, Zhongtian Bai & Jianxi Xiao. (2020) Highly specific recognition of denatured collagen by fluorescent peptide probes with the repetitive Gly-Pro-Pro and Gly-Hyp-Hyp sequences. Journal of Materials Chemistry B 8:44, pages 10093-10100.
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Morten A. Karsdal, Samuel J. Daniels, Signe Holm Nielsen, Cecilie Bager, Daniel G.K. Rasmussen, Rohit Loomba, Rambabu Surabattula, Ida Falk Villesen, Yi Luo, Diane Shevell, Natasja S. Gudmann, Mette J. Nielsen, Jacob George, Rose Christian, Diana J. Leeming & Detlef Schuppan. (2020) Collagen biology and non‐invasive biomarkers of liver fibrosis. Liver International 40:4, pages 736-750.
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April Hartley, Lavinia Paternoster, David M. Evans, William D. Fraser, Jonathan Tang, Debbie A. Lawlor, Jon H. Tobias & Celia L. Gregson. (2019) Metabolomics analysis in adults with high bone mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population. Clinical Endocrinology 92:1, pages 29-37.
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Neel Ingemann Nissen, Morten Karsdal & Nicholas Willumsen. (2019) Post-translational modifications of vimentin reflect different pathological processes associated with non-small cell lung cancer and chronic obstructive pulmonary disease. Oncotarget 10:63, pages 6829-6841.
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Meysam Tavakoli, Konstantinos Tsekouras, Richard Day, Kenneth W. Dunn & Steve Pressé. (2019) Quantitative Kinetic Models from Intravital Microscopy: A Case Study Using Hepatic Transport. The Journal of Physical Chemistry B 123:34, pages 7302-7312.
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Matea Cedilak, Mihailo Banjanac, Daniela Belamarić, Andrea Paravić Radičević, Ivan Faraho, Krunoslav Ilić, Snježana Čužić, Ines Glojnarić, Vesna Eraković Haber & Martina Bosnar. (2019) Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis. Pulmonary Pharmacology & Therapeutics 55, pages 75-83.
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Sarah Rank Rønnow, Lasse Løcke Langholm, Jannie Marie Bülow Sand, Jeppe Thorlacius-Ussing, Diana Julie Leeming, Tina Manon-Jensen, Ruth Tal-Singer, Bruce E. Miller, Morten Asser Karsdal & Jørgen Vestbo. (2019) Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort. Scientific Reports 9:1.
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AMY K. Leblanc, Douglas H. Thamm & David M. Vail. 2019. Withrow and MacEwen's Small Animal Clinical Oncology. Withrow and MacEwen's Small Animal Clinical Oncology
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M.A. Karsdal. 2019. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin
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N. Willumsen, M.A. Karsdal & A. Kerrn-Jespersen. 2019. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin
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K. Henriksen & M.A. Karsdal. 2019. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin
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A.C. Bay-Jensen, C.F. Kjelgaard-Petersen, K.K. Petersen, L. Arendt-Nielsen, H.L. Quasnichka, A. Mobasheri, M.A. Karsdal & D.J. Leeming. (2018) Aggrecanase degradation of type III collagen is associated with clinical knee pain. Clinical Biochemistry 58, pages 37-43.
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S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming & M. A. Karsdal. (2017) Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker. BMC Pulmonary Medicine 17:1.
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M.A. Karsdal, S.H. Nielsen, D.J. Leeming, L.L. Langholm, M.J. Nielsen, T. Manon-Jensen, A. Siebuhr, N.S. Gudmann, S. Rønnow, J.M. Sand, S.J. Daniels, J.H. Mortensen & D. Schuppan. (2017) The good and the bad collagens of fibrosis – Their role in signaling and organ function. Advanced Drug Delivery Reviews 121, pages 43-56.
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Yunyun Luo, Dovile Sinkeviciute, Yi He, Morten Karsdal, Yves Henrotin, Ali Mobasheri, Patrik Önnerfjord & Anne Bay-Jensen. (2017) The minor collagens in articular cartilage. Protein & Cell 8:8, pages 560-572.
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Maja R. Radojčić, Christian S. Thudium, Kim Henriksen, Keith Tan, Rolf Karlsten, Amanda Dudley, Iain Chessell, Morten A. Karsdal, Anne-Christine Bay-Jensen, Michel D. Crema & Ali Guermazi. (2017) Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients. Pain 158:7, pages 1254-1263.
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Matthew W. Wong, Nady Braidy, Anne Poljak, Russell Pickford, Madhav Thambisetty & Perminder S. Sachdev. (2017) Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers. Alzheimer's & Dementia 13:7, pages 810-827.
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R.H.G.P. Arends, M.A. Karsdal, K.M. Verburg, C.R. West, A.C. Bay-Jensen & D.S. Keller. (2017) Identification of serological biomarker profiles associated with total joint replacement in osteoarthritis patients. Osteoarthritis and Cartilage 25:6, pages 866-877.
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Ki M. Mak & Chien Yi M. Png. 2017. Biomarkers in Liver Disease. Biomarkers in Liver Disease
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Anne C. Bay-Jensen, Adam Platt, Anne Sofie Siebuhr, Claus Christiansen, Inger Byrjalsen & Morten A. Karsdal. (2016) Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study. Arthritis Research & Therapy 18:1.
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Niels Ulrik Brandt Hansen, Morten Asser Karsdal, Sarah Brockbank, Simon Cruwys, Sarah Rønnow & Diana Julie Leeming. (2016) Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor. Respiratory Research 17:1.
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Hendra Wahyudi, Amanda A. Reynolds, Yang Li, Shawn C. Owen & S. Michael Yu. (2016) Targeting collagen for diagnostic imaging and therapeutic delivery. Journal of Controlled Release 240, pages 323-331.
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Ki M. Mak, Chien Yi M. Png & Danielle J. Lee. (2016) Type V Collagen in Health, Disease, and Fibrosis. The Anatomical Record 299:5, pages 613-629.
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Sunny Patel & Dylan Steen. (2015) Widening the path and window of opportunity for FDA approval of non-vitamin K oral anticoagulant specific antidotes and reversal agents. Journal of Thrombosis and Thrombolysis 41:2, pages 285-292.
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Tine Wyseure, Laurent O. Mosnier & Annette von Drygalski. (2016) Advances and challenges in hemophilic arthropathy. Seminars in Hematology 53:1, pages 10-19.
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A.C. Bay-Jensen, D. Reker, C.F. Kjelgaard-Petersen, A. Mobasheri, M.A. Karsdal, C. Ladel, Y. Henrotin & C.S. Thudium. (2016) Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria. Osteoarthritis and Cartilage 24:1, pages 9-20.
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M.A. Karsdal. 2016. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin
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A.C. Bay-Jensen, J.M.B. Sand, F. Genovese, A.S. Siebuhr, M.J. Nielsen, D.J. Leeming, T. Manon-Jensen & M.A. Karsdal. 2016. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin
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K. Henriksen & M.A. Karsdal. 2016. Biochemistry of Collagens, Laminins and Elastin. Biochemistry of Collagens, Laminins and Elastin
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Asger R. Bihlet, Morten A. Karsdal, Anne-Christine Bay-Jensen, Simon Read, Jacob Hull Kristensen, Jannie Marie B?low Sand, Diana Julie Leeming, Jeppe Ragnar Andersen, Peter Lange & J?rgen Vestbo. (2015) Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD. Chest 148:1, pages 16-23.
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Lynae J. Hanks, Orlando M. Gutiérrez, Ambika P. Ashraf & Krista Casazza. (2015) Bone Mineral Content as a Driver of Energy Expenditure in Prepubertal and Early Pubertal Boys. The Journal of Pediatrics 166:6, pages 1397-1403.
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Ki M. Mak & Chien Yi M. Png. 2016. Biomarkers in Liver Disease. Biomarkers in Liver Disease
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György Marko-Varga, Mark S. Baker, Emily S. Boja, Henry Rodriguez & Thomas E. Fehniger. (2014) Biorepository Regulatory Frameworks: Building Parallel Resources That Both Promote Scientific Investigation and Protect Human Subjects. Journal of Proteome Research 13:12, pages 5319-5324.
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Janet L. Huebner, Anne C. Bay-Jensen, Kim M. Huffman, Yi He, Diana J. Leeming, Gary E. McDaniel, Morten A. Karsdal & Virginia B. Kraus. (2014) Alpha C-Telopeptide of Type I Collagen Is Associated With Subchondral Bone Turnover and Predicts Progression of Joint Space Narrowing and Osteophytes in Osteoarthritis. Arthritis & Rheumatology 66:9, pages 2440-2449.
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Morten A. Karsdal, Anne-Christine Bay-Jensen, Kim Henriksen, Claus Christiansen, Harry K. Genant, Chris Chamberlain & Adam Platt. (2014) Rheumatoid Arthritis: A Case for Personalized Health Care?. Arthritis Care & Research 66:9, pages 1273-1280.
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M. A. Karsdal, H. Krarup, J. M. B. Sand, P. B. Christensen, J. Gerstoft, D. J. Leeming, N. Weis, O. B. Schaffalitzky de Muckadell & A. Krag. (2014) Review article: the efficacy of biomarkers in chronic fibroproliferative diseases - early diagnosis and prognosis, with liver fibrosis as an exemplar. Alimentary Pharmacology & Therapeutics 40:3, pages 233-249.
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Anne S Siebuhr, Yi He, Natasja S Gudmann, Aurelie Gram, Cecilie F Kjelgaard-Petersen, Per Qvist, Morten A Karsdal & Anne C Bay-Jensen. (2014) Biomarkers of cartilage and surrounding joint tissue. Biomarkers in Medicine 8:5, pages 713-731.
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Mark J. Niciu, Daniel C. Mathews, Allison C. Nugent, Dawn F. Ionescu, Maura L. Furey, Erica M. Richards, Rodrigo Machado-Vieira & Carlos A. ZarateJr.Jr.. (2014) DEVELOPING BIOMARKERS IN MOOD DISORDERS RESEARCH THROUGH THE USE OF RAPID-ACTING ANTIDEPRESSANTS. Depression and Anxiety 31:4, pages 297-307.
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Anne C. Bay-Jensen, Adam Platt, Inger Byrjalsen, Philippe Vergnoud, Claus Christiansen & Morten A. Karsdal. (2014) Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study. Seminars in Arthritis and Rheumatism 43:4, pages 470-478.
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Jacob Hull Kristensen, Morten Asser Karsdal, Federica Genovese, Simon Johnson, Birte Svensson, Susanne Jacobsen, Per Hägglund & Diana Julie Leeming. (2014) The Role of Extracellular Matrix Quality in Pulmonary Fibrosis. Respiration 88:6, pages 487-499.
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M.A. Karsdal, C. Christiansen, C. Ladel, K. Henriksen, V.B. Kraus & A.C. Bay-Jensen. (2014) Osteoarthritis – a case for personalized health care?. Osteoarthritis and Cartilage 22:1, pages 7-16.
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Kim Henriksen, Sid E. O'Bryant, Harald Hampel, John Q. Trojanowski, Thomas J. Montine, Andreas Jeromin, Kaj Blennow, Anders Lönneborg, Tony Wyss‐Coray, Holly Soares, Chantal Bazenet, Magnus Sjögren, William Hu, Simon Lovestone, Morten A. Karsdal & Michael W. Weiner. (2013) The future of blood‐based biomarkers for Alzheimer's disease. Alzheimer's & Dementia 10:1, pages 115-131.
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Federica Genovese, Natasha Barascuk, Lise Larsen, Martin Røssel Larsen, Arkadiusz Nawrocki, Yili Li, Qinlong Zheng, Jianxia Wang, Sanne Skovgård Veidal, Diana Julie Leeming & Morten Asser Karsdal. (2013) Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases. Fibrogenesis & Tissue Repair 6:1.
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Deborah L Clarke, Alan M Carruthers, Tomas Mustelin & Lynne A Murray. (2013) Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes. Fibrogenesis & Tissue Repair 6:1.
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Anders Nedergaard, Shu Sun, Morten A. Karsdal, Kim Henriksen, Michael Kjær, Yunyun Lou, Yi He, Qinlong Zheng & Charlotte Suetta. (2013) Type VI collagen turnover‐related peptides—novel serological biomarkers of muscle mass and anabolic response to loading in young men. Journal of Cachexia, Sarcopenia and Muscle 4:4, pages 267-275.
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D. J. Leeming, M. A. Karsdal, I. Byrjalsen, F. Bendtsen, J. Trebicka, M. J. Nielsen, C. Christiansen, S. Møller & A. Krag. (2013) Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension. Alimentary Pharmacology & Therapeutics 38:9, pages 1086-1096.
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Helene Skjøt-Arkil, Rikke E. Clausen, Lars M. Rasmussen, Wanchun Wang, Yaguo Wang, Qinlong Zheng, Hans Mickley, Lotte Saaby, Axel C. P. Diederichsen, Jess Lambrechtsen, Fernando J. Martinez, Cory M. Hogaboam, MeiLan Han, Martin R. Larsen, Arkadiusz Nawrocki, Ben Vainer, Dorrit Krustrup, Marina Bjørling-Poulsen, Morten A. Karsdal & Diana J. Leeming. (2013) Acute Myocardial Infarction and Pulmonary Diseases Result in Two Different Degradation Profiles of Elastin as Quantified by Two Novel ELISAs. PLoS ONE 8:6, pages e60936.
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Diana J. Leeming, Inger Byrjalsen, Wladimiro Jiménez, Claus Christiansen & Morten A. Karsdal. (2012) Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis—a serological evaluation. Liver International 33:3, pages 439-447.
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Morten A. KarsdalMette J. NielsenJannie M. SandKim HenriksenFederica GenoveseAnne-Christine Bay-JensenVictoria SmithJoanne I. AdamkewiczClaus ChristiansenDiana J. Leeming. (2013)
Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue Diseases
Possibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure
. ASSAY and Drug Development Technologies 11:2, pages 70-92.
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Jun-ichi Furukawa, Naoki Fujitani & Yasuro Shinohara. (2013) Recent Advances in Cellular Glycomic Analyses. Biomolecules 3:4, pages 198-225.
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Anne C. Bay-Jensen, Stephanie Wichuk, Inger Byrjalsen, Diana J. Leeming, Nathalie Morency, Claus Christiansen, Morten A. Karsdal & Walter P. Maksymowych. (2013) Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis. PLoS ONE 8:1, pages e54504.
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Anne Siebuhr, Anne C Bay-Jensen, Diana J Leeming, Adam Plat, Inger Byrjalsen, Claus Christiansen, Désirée van de Heijde & Morten A Karsdal. (2013) Serological identification of fast progressors of structural damage with rheumatoid arthritis. Arthritis Research & Therapy 15:4, pages R86.
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Melissa C. Paoloni & David M. Vail. 2013. Withrow and MacEwen's Small Animal Clinical Oncology. Withrow and MacEwen's Small Animal Clinical Oncology
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Jürgen Sandow. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
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Sanne Skovgård Veidal, Mette Juul Nielsen, Diana Julie Leeming & Morten Asser Karsdal. (2012) Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model. BMC Research Notes 5:1.
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Anita V Neutzsky-Wulff, Kim V Andreassen, Sara T Hjuler, Michael Feigh, Anne-Christine Bay-Jensen, Qinlong Zheng, Kim Henriksen & Morten A Karsdal. (2012) Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: How markers of β-cell loss may assist. Journal of Translational Medicine 10:1.
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Efstathios Vassiliadis, Lars M Rasmussen, Inger Byrjalsen, Dorthe Vang Larsen, Rajiv Chaturvedi, Susanne Hosbond, Lotte Saabye, Axel CP Diederichsen, Federica Genovese, Kevin L Duffin, Qinlong Zheng, Xiaoliang Chen, Diana J Leeming, Claus Christiansen & Morten A Karsdal. (2012) Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker. Journal of Translational Medicine 10:1.
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Helene Skjøt-Arkil, Rikke E Clausen, Quoc Hai Trieu Nguyen, Yaguo Wang, Qinlong Zheng, Fernando J Martinez, Cory M Hogaboam, Meilan Han, Lloyd B Klickstein, Martin R Larsen, Arkadiusz Nawrocki, Diana J Leeming & Morten A Karsdal. (2012) Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation. BMC Pulmonary Medicine 12:1.
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Anne C. Bay-Jensen, Diana J. Leeming, Arndt Kleyer, Sanne S. Veidal, Georg Schett & Morten A. Karsdal. (2011) Ankylosing spondylitis is characterized by an increased turnover of several different metalloproteinase-derived collagen species: a cross-sectional study. Rheumatology International 32:11, pages 3565-3572.
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Morten A. Karsdal, Georg Schett, Paul Emery, Olivier Harari, Inger Byrjalsen, Andy Kenwright, Anne C. Bay-Jensen & Adam Platt. (2012) IL-6 Receptor Inhibition Positively Modulates Bone Balance in Rheumatoid Arthritis Patients with an Inadequate Response to Anti-Tumor Necrosis Factor Therapy: Biochemical Marker Analysis of Bone Metabolism in the Tocilizumab RADIATE Study (NCT00106522). Seminars in Arthritis and Rheumatism 42:2, pages 131-139.
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Diana J. Leeming, Mette J. Nielsen, Yueqin Dai, Sanne S. Veidal, Efstathios Vassiliadis, Chen Zhang, Yi He, Ben Vainer, Qinlong Zheng & Morten A. Karsdal. (2012) Enzyme-linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): A marker related to the extracellular matrix remodeling during liver fibrogenesis. Hepatology Research 42:5, pages 482-493.
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S.S. Veidal, D.V. Larsen, X. Chen, S. Sun, Q. Zheng, A.-C. Bay-Jensen, D.J. Leeming, A. Nawrocki, M.R. Larsen, G. Schett & M.A. Karsdal. (2012) MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis. Clinical Biochemistry 45:7-8, pages 541-546.
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Diana J. LeemingJannie M. SandMette J. NielsenFederica GenoveseFernando J. MartinezCory M. HogaboamMeiLan K HanLloyd B. KlicksteinMorten A. Karsdal. (2012) Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis. Biomarker Insights 7, pages BMI.S9415.
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Tianhui LiuXiaoming WangMorten A. KarsdalDiana J. LeemingFederica Genovese. (2012) Molecular Serum Markers of Liver Fibrosis. Biomarker Insights 7, pages BMI.S10009.
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Y. Wang, M. G. Sørensen, Q. Zheng, C. Zhang, M. A. Karsdal & K. Henriksen. (2012) Will Posttranslational Modifications of Brain Proteins Provide Novel Serological Markers for Dementias?. International Journal of Alzheimer's Disease 2012, pages 1-9.
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A.S. Ptolemy. 2012. Comprehensive Sampling and Sample Preparation. Comprehensive Sampling and Sample Preparation
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Sanne S Veidal, Morten A Karsdal, Arkadiusz Nawrocki, Martin R Larsen, Yueqin Dai, Qinlong Zheng, Per Hägglund, Ben Vainer, Helene Skjøt-Arkil & Diana J Leeming. (2011) Assessment of proteolytic degradation of the basement membrane: a fragment of type IV collagen as a biochemical marker for liver fibrosis. Fibrogenesis & Tissue Repair 4:1.
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K Henriksen, DJ Leeming, C Christiansen & MA Karsdal. (2011) Use of Bone Turnover Markers in Clinical Osteoporosis Assessment in Women: Current Issues and Future Options. Women's Health 7:6, pages 689-698.
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Kim Henriksen, Claus Christiansen & Morten Asser Karsdal. (2011) Serological biochemical markers of surrogate efficacy and safety as a novel approach to drug repositioning. Drug Discovery Today 16:21-22, pages 967-975.
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M.A. Karsdal, E. Delvin & C. Christiansen. (2011) Protein fingerprints — Relying on and understanding the information of serological protein measurements. Clinical Biochemistry 44:16, pages 1278-1279.
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Sanne Skovgård Veidal, Morten Asser Karsdal, Efstathios Vassiliadis, Arkadiusz Nawrocki, Martin Røssel Larsen, Quoc Hai Trieu Nguyen, Per Hägglund, Yunyun Luo, Qinlong Zheng, Ben Vainer & Diana Julie Leeming. (2011) MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay. PLoS ONE 6:9, pages e24753.
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Natasha Barascuk, Efstathios Vassiliadis, Lise Larsen, Jianxia Wang, Qinlong Zheng, Rui Xing, Yu Cao, Christine Crespo, Isabelle Lapret, Massimo Sabatini, Nicole Villeneuve, Jean-Paul Vilaine, Lars Melholt Rasmussen, Thomas C. Register & Morten A. Karsdal. (2011) Development and validation of an enzyme-linked immunosorbent assay for the quantification of a specific MMP-9 mediated degradation fragment of type III collagen—A novel biomarker of atherosclerotic plaque remodeling. Clinical Biochemistry 44:10-11, pages 900-906.
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V.B. Kraus, B. Burnett, J. Coindreau, S. Cottrell, D. Eyre, M. Gendreau, J. Gardiner, P. Garnero, J. Hardin, Y. Henrotin, D. Heineg?rd, A. Ko, L.S. Lohmander, G. Matthews, J. Menetski, R. Moskowitz, S. Persiani, A.R. Poole, J.-C. Rousseau & M. Todman. (2011) Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis and Cartilage 19:5, pages 515-542.
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M. A. Karsdal, K. Henriksen, A. C. Bay-Jensen, B. Molloy, M. Arnold, M. R. John, I. Byrjalsen, M. Azria, B. J. Riis, P. Qvist & C. Christiansen. (2011) Lessons Learned From the Development of Oral Calcitonin: The First Tablet Formulation of a Protein in Phase III Clinical Trials. The Journal of Clinical Pharmacology 51:4, pages 460-471.
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Anne-Christine Bay-Jensen, Qi Liu, Inger Byrjalsen, Yi Li, Jianxia Wang, Christian Pedersen, Diana J. Leeming, Erik B. Dam, Qinlong Zheng, Per Qvist & Morten A. Karsdal. (2011) Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis. Clinical Biochemistry 44:5-6, pages 423-429.
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N. BarascukE. VassiliadisQ. ZhengY. WangW. WangL. LarsenL.M. RasmussenM.A. Karsdal. (2011) Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice. Biomarker Insights 6, pages BMI.S7777.
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Efstathios VassiliadisDorthe Vang LarsenRikke Elgaard ClausenSanne Skovgård VeidalNatasha BarascukLise LarsenHenrik SimonsenToni Segovia SilvestreChristina HansenTrine OvergaardDiana Julie LeemingMorten A Karsdal. (2011) Measurement of CO3-610, a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type III, in a Rat Model of Reversible Carbon-Tetrachloride-Induced Fibrosis. Biomarker Insights 6, pages BMI.S6347.
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Morten A Karsdal, Thasia Woodworth, Kim Henriksen, Walter P Maksymowych, Harry Genant, Philippe Vergnaud, Claus Christiansen, Tanja Schubert, Per Qvist, Georg Schett, Adam Platt & Anne-Christine Bay-Jensen. (2011) Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities. Arthritis Research & Therapy 13:2, pages 215.
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Sanne Skovgård Veidal, Efstathios Vassiliadis, Anne-Christine Bay-Jensen, Gervais Tougas, Ben Vainer & Morten Asser Karsdal. (2010) Procollagen type I N-terminal propeptide (PINP) is a marker for fibrogenesis in bile duct ligation-induced fibrosis in rats. Fibrogenesis & Tissue Repair 3:1.
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MA Karsdal, I Byrjalsen, AC Bay-Jensen, K Henriksen, BJ Riis & C Christiansen. (2010) Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation. BMC Musculoskeletal Disorders 11:1.
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Mads Nielsen, Melanie Ganz, Francois Lauze, Paola C Pettersen, Marleen de Bruijne, Thomas B Clarkson, Erik B Dam, Claus Christiansen & Morten A Karsdal. (2010) Distribution, size, shape, growth potential and extent of abdominal aortic calcified deposits predict mortality in postmenopausal women. BMC Cardiovascular Disorders 10:1.
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Natasha Barascuk, Helene Skjøt-Arkil, Thomas C Register, Lise Larsen, Inger Byrjalsen, Claus Christiansen & Morten A Karsdal. (2010) Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes. BMC Cardiovascular Disorders 10:1.
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Helene Skjøt-ArkilNatasha BarascukThomas RegisterMorten A. Karsdal. (2010) Macrophage-Mediated Proteolytic Remodeling of the Extracellular Matrix in Atherosclerosis Results in Neoepitopes: A Potential New Class of Biochemical Markers. ASSAY and Drug Development Technologies 8:5, pages 542-552.
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D.J. Leeming, D.V. Larsen, C. Zhang, Y. Hi, S.S. Veidal, R.H. Nielsen, K. Henriksen, Q. Zheng, V. Barkholt, B.J. Riis, I. Byrjalsen, P. Qvist & M.A. Karsdal. (2010) Enzyme-linked immunosorbent serum assays (ELISAs) for rat and human N-terminal pro-peptide of collagen type I (PINP) — Assessment of corresponding epitopes. Clinical Biochemistry 43:15, pages 1249-1256.
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Morten Asser Karsdal, Kim Henriksen, Diana Julie Leeming, Thasia Woodworth, Efstathios Vassiliadis & Anne-Christine Bay-Jensen. (2010) Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the disease?. Clinical Biochemistry 43:10-11, pages 793-804.
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N. Barascuk, S.S. Veidal, L. Larsen, D.V. Larsen, M.R. Larsen, J. Wang, Q. Zheng, R. Xing, Y. Cao, L.M. Rasmussen & M.A. Karsdal. (2010) A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen. Clinical Biochemistry 43:10-11, pages 899-904.
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Sunali Mehta, Andrew Shelling, Anita Muthukaruppan, Annette Lasham, Cherie Blenkiron, George Laking & Cristin Print. (2010) Predictive and prognostic molecular markers for cancer medicine. Therapeutic Advances in Medical Oncology 2:2, pages 125-148.
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M.A. Karsdal, I. Byrjalsen, K. Henriksen, B.J. Riis, E.M. Lau, M. Arnold & C. Christiansen. (2010) The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study. Osteoarthritis and Cartilage 18:2, pages 150-159.
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Rajiv Mahajan & Kapil Gupta. (2010) Food and drug administration′s critical path initiative and innovations in drug development paradigm: Challenges, progress, and controversies. Journal of Pharmacy And Bioallied Sciences 2:4, pages 307.
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Morten A. Karsdal, Inger Byrjalsen, Kim Henriksen, Bente J. Riis & Claus Christiansen. (2009) Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy. European Journal of Clinical Pharmacology 66:1, pages 29-37.
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