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Biomarkers Volume 22, 2017 - Issue 5
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Research Article

MGMT hypomethylation is associated with DNA damage in workers exposed to low-dose benzene

Jie LiGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Xinjie ZhangGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Zhini HeGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
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Qing SunGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
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Fei QinGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
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Zhenlie HuangGuangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, China; View further author information
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Xiao ZhangKey Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China; View further author information
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Xin SunKey Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China; View further author information
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Linhua LiuDepartment of Toxicology, School of Public Health, Guangdong Medical University, Guangzhou, ChinaView further author information
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Liping ChenGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
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Chen GaoGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Shan WangGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
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Fangping WangGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Daochuan LiGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Xiaowen ZengGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Qifei DengGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Qing WangGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Bo ZhangGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; View further author information
,
Huanwen TangDepartment of Toxicology, School of Public Health, Guangdong Medical University, Guangzhou, ChinaView further author information
,
Wen ChenGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; Correspondence[email protected]
View further author information
&
Yongmei XiaoGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China; Correspondence[email protected]
View further author information
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Pages 470-475 | Received 21 Jul 2016, Accepted 07 Dec 2016, Published online: 12 Jan 2017

Citations (13)

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Rachael V. Phillips, Linqing Wei, Andres Cardenas, Alan E. Hubbard, Cliona M. McHale, Roel Vermeulen, Hu Wei, Martyn T. Smith, Luoping Zhang, Qing Lan & Nathaniel Rothman. (2022) Epigenome-wide association studies of occupational exposure to benzene and formaldehyde. Epigenetics 17:13, pages 2259-2277.
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Articles from other publishers (12)

Octavio Jiménez-Garza, Manosij Ghosh, Timothy M. Barrow & Lode Godderis. (2023) Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents. Frontiers in Public Health 11.
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Evita Rostoka, Ilze Salna, Alise Dekante, Leonora Pahirko, Vitalijs Borisovs, Laura Celma, Jānis Valeinis, Nikolajs Sjakste & Jelizaveta Sokolovska. (2021) DNA damage in leukocytes and serum nitrite concentration are negatively associated in type 1 diabetes. Mutagenesis 36:3, pages 213-222.
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Rachel L. Miller & Jessica Oh. 2021. Medical Epigenetics. Medical Epigenetics 51 79 .
Yanhua Zhou, Kun Wang, Boshen Wang, Yuepu Pu & Juan Zhang. (2020) Occupational benzene exposure and the risk of genetic damage: a systematic review and meta-analysis. BMC Public Health 20:1.
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Chi-Jung Chung, Hui-Tsung Hsu, Chao-Hsiang Chang, Sheng-Wei Li, Chiu-Shong Liu, Mu-Chi Chung, Guo-Wei Wu, Wei-Ting Jung, Yen-Jung Kuo & Hui-Ling Lee. (2020) Relationships among cigarette smoking, urinary biomarkers, and urothelial carcinoma risk: a case-control study. Environmental Science and Pollution Research 27:34, pages 43177-43185.
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A. Robert Schnatter, Martijn Rooseboom, Neslihan Aygun Kocabas, Colin M. North, Abigail Dalzell, Johannes Twisk, Frank Faulhammer, Erik Rushton, Peter J. Boogaard, Viktorija Ostapenkaite & Stephen D. Williams. (2020) Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools. Toxicology Letters 334, pages 117-144.
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Felicia Fei-Lei Chung & Zdenko Herceg. (2020) The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome. Environmental Health Perspectives 128:1.
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Jingchao Ren, Jun-peng Cui, Mengkai Luo, Huan Liu, Pengfei Hao, Xiao Wang & Guang-hui Zhang. (2019) The prevalence and persistence of aberrant promoter DNA methylation in benzene-exposed Chinese workers. PLOS ONE 14:8, pages e0220500.
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Liping Chen, Ping Guo, Haiyan Zhang, Wenxue Li, Chen Gao, Zhenlie Huang, Junling Fan, Yuling Zhang, Xue Li, Xiaoling Liu, Fangping Wang, Shan Wang, Qingye Li, Zhini He, Huiyao Li, Shen Chen, Xiaonen Wu, Lizhu Ye, Qiong Li, Huanwen Tang, Qing Wang, Guanghui Dong, Yongmei Xiao, Wen Chen & Daochuan Li. (2019) Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1. Journal of Biological Chemistry 294:7, pages 2486-2499.
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Huiyao Li, Daochuan Li, Zhini He, Junling Fan, Qingye Li, Xiaoling Liu, Ping Guo, Haiyan Zhang, Shen Chen, Qiong Li, Rui Zhang, Xiumei Xing, Xiaowen Zeng, Aihua Zhang, Huanwen Tang, Guanghui Dong, Qing Wang, Yongmei Xiao, Liping Chen & Wen Chen. (2018) The effects of Nrf2 knockout on regulation of benzene-induced mouse hematotoxicity. Toxicology and Applied Pharmacology 358, pages 56-67.
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Elisa Sauer, Bruna Gauer, Sabrina Nascimento, Jessica Nardi, Gabriela Göethel, Bárbara Costa, Douglas Correia, Ursula Matte, Mariele Charão, Marcelo Arbo, Albert Duschl, Angela Moro & Solange Cristina Garcia. (2018) The role of B7 costimulation in benzene immunotoxicity and its potential association with cancer risk. Environmental Research 166, pages 91-99.
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Jie Li, Xiumei Xing, Xinjie Zhang, Boxuan Liang, Zhini He, Chen Gao, Shan Wang, Fangping Wang, Haiyan Zhang, Shan Zeng, Junling Fan, Liping Chen, Zhengbao Zhang, Bo Zhang, Caixia Liu, Qing Wang, Weiwei Lin, Guanghui Dong, Huanwen Tang, Wen Chen, Yongmei Xiao & Daochuan Li. (2018) Enhanced H3K4me3 modifications are involved in the transactivation of DNA damage responsive genes in workers exposed to low-level benzene. Environmental Pollution 234, pages 127-135.
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