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Biomarkers Volume 24, 2019 - Issue 1
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Original Articles

Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren’s Syndrome

Srikanth R. JangaDepartment of Ophthalmology, USC Keck School of Medicine, Roski Eye Institute, Los Angeles, CA, USA; ORCID Iconhttps://orcid.org/0000-0001-7377-7871View further author information
ORCID Icon,
Mihir ShahDepartment of Ophthalmology, USC Keck School of Medicine, Roski Eye Institute, Los Angeles, CA, USA; View further author information
,
Yaping JuDepartment of Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, Los Angeles, CA, USAORCID Iconhttps://orcid.org/0000-0003-1953-585XView further author information
ORCID Icon,
Zhen MengDepartment of Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, Los Angeles, CA, USAORCID Iconhttps://orcid.org/0000-0003-0131-4135View further author information
ORCID Icon,
Maria C. EdmanDepartment of Ophthalmology, USC Keck School of Medicine, Roski Eye Institute, Los Angeles, CA, USA; ORCID Iconhttps://orcid.org/0000-0001-7399-4358View further author information
ORCID Icon &
Sarah F. Hamm-AlvarezDepartment of Ophthalmology, USC Keck School of Medicine, Roski Eye Institute, Los Angeles, CA, USA; ;Department of Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, Los Angeles, CA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8195-5703View further author information
ORCID Icon
Pages 91-102 | Received 02 Apr 2018, Accepted 12 Aug 2018, Published online: 12 Sep 2018

Citations (17)

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Matej Vizovišek, Eva Vidak, Urban Javoršek, Georgy Mikhaylov, Andreja Bratovš & Boris Turk. (2020) Cysteine cathepsins as therapeutic targets in inflammatory diseases. Expert Opinion on Therapeutic Targets 24:6, pages 573-588.
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Articles from other publishers (16)

Shruti Singh Kakan, Xiaoyang Li, Maria C. Edman, Curtis T. Okamoto, Brooke E. Hjelm & Sarah F. Hamm-Alvarez. (2023) The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis. Investigative Opthalmology & Visual Science 64:4, pages 1.
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Emanuela Senjor, Janko Kos & Milica Perišić Nanut. (2023) Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders. Biomedicines 11:2, pages 476.
Crossref
Peter Smyth, Jutharat Sasiwachirangkul, Rich Williams & Christopher J. Scott. (2022) Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential. Molecular Aspects of Medicine 88, pages 101106.
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Shruti Singh Kakan, Maria C. Edman, Alexander Yao, Curtis T. Okamoto, Annie Nguyen, Brooke E. Hjelm & Sarah F. Hamm-Alvarez. (2022) Tear miRNAs Identified in a Murine Model of Sjögren’s Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism. Frontiers in Immunology 13.
Crossref
Zhiyuan Yu, Jinmiao Li, Gowthaman Govindarajan, Sarah F. Hamm-Alvarez, Jehan Alam, De-Quan Li & Cintia S. de Paiva. (2022) Cathepsin S is a novel target for age-related dry eye. Experimental Eye Research 214, pages 108895.
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Runzhong Fu, Srikanth Janga, Maria C. Edman & Sarah F. Hamm-Alvarez. (2021) Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway. Experimental Eye Research 211, pages 108760.
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Claudio Vitali, Antonina Minniti, Francesca Pignataro, Wanda Maglione & Nicoletta Del Papa. (2021) Management of Sjögren's Syndrome: Present Issues and Future Perspectives. Frontiers in Medicine 8.
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Yaping Ju, Maria C. Edman, Hao Guo, Srikanth Reddy Janga, Santosh Peddi, Stan G. Louie, Jason A. Junge, J. Andrew MacKay & Sarah F. Hamm-Alvarez. (2020) Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren’s Syndrome. Biomacromolecules 22:3, pages 1102-1114.
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Runzhong Fu, Maria C. Edman & Sarah F. Hamm-Alvarez. (2021) Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells. International Journal of Molecular Sciences 22:4, pages 1630.
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Bin Wang, Shiju Chen, Qing Zheng, Yan Li, Xinwei Zhang, Jingxiu Xuan, Yuan Liu & Guixiu Shi. (2021) Early diagnosis and treatment for Sjögren's syndrome: current challenges, redefined disease stages and future prospects. Journal of Autoimmunity 117, pages 102590.
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Runzhong Fu, Wannita Klinngam, Martin Heur, Maria C. Edman & Sarah F. Hamm-Alvarez. (2020) Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease. Eye & Contact Lens: Science & Clinical Practice 46:2, pages S70-S83.
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Runzhong Fu, Hao Guo, Srikanth Janga, Minchang Choi, Wannita Klinngam, Maria C. Edman & Sarah F. Hamm-Alvarez. (2020) Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren’s syndrome murine model. Scientific Reports 10:1.
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Patrick Hargreaves, Douglas Daoudlarian, Michel Theron, Fabrice A. Kolb, Marianne Manchester Young, Bernhard Reis, Andre Tiaden, Bettina Bannert, Diego Kyburz & Tobias Manigold. (2019) Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome. Arthritis Research & Therapy 21:1.
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Shengyang Huang & Yu Cao. (2019) Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis. Experimental and Therapeutic Medicine.
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Wannita Klinngam, Srikanth R. Janga, Changrim Lee, Yaping Ju, Frances Yarber, Mihir Shah, Hao Guo, Dandan Wang, J. Andrew MacKay, Maria C. Edman & Sarah F. Hamm-Alvarez. (2019) Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren’s Syndrome. Scientific Reports 9:1.
Crossref
Changrim Lee, Hao Guo, Wannita Klinngam, Srikanth R. Janga, Frances Yarber, Santosh Peddi, Maria C. Edman, Nishant Tiwari, Siyu Liu, Stan G. Louie, Sarah F. Hamm-Alvarez & J. Andrew MacKay. (2019) Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease. Molecular Pharmaceutics 16:7, pages 3024-3039.
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