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Free Radical Research Volume 39, 2005 - Issue 12
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Original

Hispidulin: Antioxidant properties and effect on mitochondrial energy metabolism†

Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Anderson Franco da Cruz Lima Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Anderson Franco da Cruz Lima Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Brás Heleno de Oliveira Universidade Federal do Paraná, Departamento de Química, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Anderson Franco da Cruz Lima Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Brás Heleno de Oliveira Universidade Federal do Paraná, Departamento de Química, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Maria Benigna Martinelli de Oliveira Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Anderson Franco da Cruz Lima Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Brás Heleno de Oliveira Universidade Federal do Paraná, Departamento de Química, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Maria Benigna Martinelli de Oliveira Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Eva Gunilla Skare Carnieri Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Anderson Franco da Cruz Lima Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Brás Heleno de Oliveira Universidade Federal do Paraná, Departamento de Química, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Maria Benigna Martinelli de Oliveira Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Eva Gunilla Skare Carnieri Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Sílvia M.S.C. Cadena Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Anderson Franco da Cruz Lima Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Brás Heleno de Oliveira Universidade Federal do Paraná, Departamento de Química, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Maria Benigna Martinelli de Oliveira Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Eva Gunilla Skare Carnieri Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Sílvia M.S.C. Cadena Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Maria Eliane Merlin Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, BrazilCorrespondence[email protected]
,
Priscila Dabaghi-Barbosa Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Andreia Mariante Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Anderson Franco da Cruz Lima Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Brás Heleno de Oliveira Universidade Federal do Paraná, Departamento de Química, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Maria Benigna Martinelli de Oliveira Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Eva Gunilla Skare Carnieri Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
,
Sílvia M.S.C. Cadena Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, Brazil
&
Maria Eliane Merlin Rocha Universidade Federal do Paraná, Departamento de Bioquímica, CP 19046, Curitiba, PR, CEP 81531-590, BrazilCorrespondence[email protected]
 show all
Pages 1305-1315 | Received 07 Mar 2005, Published online: 07 Jul 2009

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Kacper Kut, Grzegorz Bartosz, Mirosław Soszyński & Izabela Sadowska-Bartosz. (2022) Antioxidant properties of hispidulin. Natural Product Research 36:24, pages 6401-6404.
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Articles from other publishers (27)

Gul-e-Saba Chaudhry, Zeenia, Javad Sharifi-Rad & Daniela Calina. (2023) Hispidulin: a promising anticancer agent and mechanistic breakthrough for targeted cancer therapy. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Adriane Dâmares de Sousa Jorge Batalha, Damy Caroline de Melo Souza, Rosmery Duran Ubiera, Francisco Celio Maia Chaves, Wuelton Marcelo Monteiro, Felipe Moura Araújo da Silva, Hector Henrique Ferreira Koolen, Antônio Luiz Boechat & Marco Aurélio Sartim. (2022) Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action. Biomolecules 12:9, pages 1208.
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Dinesh Kumar Patel. (2022) Protective Role of Eupafolin against Tumor, Inflammation, Melanogenesis, Viral Disease and Renal Injury: Pharmacological and Analytical Aspects through Scientific Data Analysis. Current Chinese Science 2:2, pages 143-151.
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Shaimaa R. Ahmed, Ahmed R. Hamed, Mohammed I. Ali, Mohamed S. Sedeek, Narek Abelyan & Mohammad M. Al-Sanea. (2022) Cancer Chemopreventive Potential and Chemical Profiling of Euphorbia abyssinica Endowed with Docking Studies . ACS Omega 7:4, pages 3596-3604.
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Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Seung Hyun Kim, Dong-Wook Kim & Ki Sung Kang. (2021) Combined Anti-Adipogenic Effects of Hispidulin and p-Synephrine on 3T3-L1 Adipocytes. Biomolecules 11:12, pages 1764.
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Ece Sevgi, Aydan Dag, Çağla Kızılarslan-Hançer, Sezen Atasoy, Belma Zengin Kurt & Öznur Aksakal. (2021) Evaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine. Journal of Ethnopharmacology 276, pages 114211.
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Kaili Liu, Fei Zhao, Jingjing Yan, Zhengchao Xia, Dandan Jiang & Peizhi Ma. (2020) Hispidulin: A promising flavonoid with diverse anti-cancer properties. Life Sciences 259, pages 118395.
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Anna Kicinska & Wieslawa Jarmuszkiewicz. (2020) Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?. Molecules 25:13, pages 3060.
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Stephane Janaina de Moura Escobar, Martin Simone, Nathan Martin, Ciro Alberto de Oliveira Ribeiro, Glaucia Regina Martinez, Sheila Maria Brochado Winnischofer, Paul Kenneth Witting & Maria Eliane Merlin Rocha. (2019) Cytotoxic effects of 4′-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicology in Vitro 61, pages 104640.
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Huiyao Lu, Jiayin Guo & Chaoxiang Xu. (2019) Cardioprotective Efficacy of Hispidulin on Isoproterenol-induced Heart Failure in Wistar Rats. International Journal of Pharmacology 15:7, pages 816-822.
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Seul Gi Lee, Jin Soo Kim, Kyoungjin Min, Taeg Kyu Kwon & Ju-Ock Nam. (2018) Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway. Chemico-Biological Interactions 293, pages 89-93.
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Dahae Lee, Chang-Eop Kim, Sa-Yoon Park, Kem Kim, Nguyen Hiep, Dongho Lee, Hyuk-Jai Jang, Jae Lee & Ki Kang. (2018) Protective Effect of Artemisia argyi and Its Flavonoid Constituents against Contrast-Induced Cytotoxicity by Iodixanol in LLC-PK1 Cells. International Journal of Molecular Sciences 19:5, pages 1387.
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Lubin Huang, Kejing Huang & Hong Ning. (2018) Hispidulin prevents sevoflurane— Induced memory dysfunction in aged rats. Biomedicine & Pharmacotherapy 97, pages 412-422.
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Kanika Patel & Dinesh Kumar Patel. (2017) Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. Journal of Traditional and Complementary Medicine 7:3, pages 360-366.
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Hsin-Ching Sung, Chan-Jung Liang, Chiang-Wen Lee, Feng-Lin Yen, Chien-Yu Hsiao, Shu-Huei Wang, Ya-Fen Jiang-Shieh, Jaw-Shiun Tsai & Yuh-Lien Chen. (2015) The protective effect of eupafolin against TNF-α-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. Journal of Ethnopharmacology 170, pages 136-147.
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Tzu Yu Lin, Cheng Wei Lu, Su Jane Wang & Shu Kuei Huang. (2015) Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. European Journal of Pharmacology 755, pages 6-15.
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Cristian Sandoval-Acuña, Jorge Ferreira & Hernán Speisky. (2014) Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions. Archives of Biochemistry and Biophysics 559, pages 75-90.
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Hui Gao, Hui Wang & Jianjun Peng. (2013) Hispidulin Induces Apoptosis Through Mitochondrial Dysfunction and Inhibition of P13k/Akt Signalling Pathway in HepG2 Cancer Cells. Cell Biochemistry and Biophysics 69:1, pages 27-34.
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Manoj Nepal, Hwa Jung Choi, Bo-Yun Choi, Moon-Shik Yang, Jung-Il Chae, Liang Li & Yunjo Soh. (2013) Hispidulin attenuates bone resorption and osteoclastogenesis via the RANKL-induced NF-κB and NFATc1 pathways. European Journal of Pharmacology 715:1-3, pages 96-104.
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Jian Qiu, Xiaofeng Xue, Fudong Chen, Chonghui Li, Nuer Bolat, Xiaojun Wang, Yuzhen Baima, Qiao Zhao, Dexiu Zhao & Fengshan Ma. (2010) Quality evaluation of snow lotus (Saussurea): quantitative chemical analysis and antioxidant activity assessment. Plant Cell Reports 29:12, pages 1325-1337.
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Glaucio Valdameri, Tatiana Herrerias, Eva Gunilla Skare Carnieri, Silvia Maria Suter Correia Cadena, Glaucia Regina Martinez & Maria Eliane Merlin Rocha. (2010) Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain. Chemico-Biological Interactions 188:1, pages 52-58.
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Kyung‐Sook Chung, Jung‐Hye Choi, Nam‐In Back, Myung‐Sook Choi, Eun‐Kyung Kang, Hae‐Gon Chung, Tae‐Sook Jeong & Kyung‐Tae Lee. (2010) Eupafolin, a flavonoid isolated from Artemisia princeps , induced apoptosis in human cervical adenocarcinoma HeLa cells . Molecular Nutrition & Food Research 54:9, pages 1318-1328.
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Tatiana Herrerias, Brás H. de Oliveira, Maria A.B. Gomes, Maria B.M. de Oliveira, Eva G.S. Carnieri, Sílvia M.S.C. Cadena, Glaucia R. Martinez & Maria E.M. Rocha. (2008) Eupafolin: Effect on mitochondrial energetic metabolism. Bioorganic & Medicinal Chemistry 16:2, pages 854-861.
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Rojsanga Piyanuch, Mugdha Sukhthankar, Gritsanapan Wandee & Seung Joon Baek. (2007) Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. Cancer Letters 258:2, pages 230-240.
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