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The Aging Male Volume 7, 2004 - Issue 2
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Original Article

Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency

AR Genazzani Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
,
S Inglese Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
,
I Lombardi Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
,
M Pieri Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
,
F Bernardi Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
,
AD Genazzani Department of Gynecology and Obstetrics, University of Modena, Modena, Italy
,
L Rovati Rotta Research Laboratory, Monza, Italy
&
M Luisi Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
 show all
Pages 133-143 | Received 08 Jul 2003, Accepted 11 Feb 2004, Published online: 18 Sep 2010

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Ariel Weissman, Eran Horowitz, Amir Ravhon, Abraham Golan & David Levran. (2011) Dehydroepiandrosterone supplementation increases baseline follicular phase progesterone levels. Gynecological Endocrinology 27:12, pages 1014-1017.
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J. P. Scarth. (2006) Modulation of the growth hormone–insulin-like growth factor (GH–IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: An emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review. Xenobiotica 36:2-3, pages 119-218.
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Andrea R. Genazzani, Nicola Pluchino, Silvia Begliuomini, Massimo Stomati, Francesca Bernardi, Matteo Pieri, Elena Casarosa, Marco Palumbo, Alessandro D. Genazzani & Michele Luisi. (2006) Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women. Gynecological Endocrinology 22:11, pages 627-635.
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Surabhi Mishra & Radha Chaube. (2022) Impact of ovariectomy and estradiol-17β (E2) replacement on the brain steroid levels of the Indian stinging catfish Heteropneustes fossilis. Aquaculture and Fisheries 7:5, pages 474-483.
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Alexander Römmler. 2022. Präventionsmedizin und Anti-Aging-Medizin. Präventionsmedizin und Anti-Aging-Medizin 141 166 .
Conor Bentley, Claire Potter, Kamal Makram Yakoub, Kristian Brock, Victoria Homer, Emma Toman, Angela E Taylor, Fozia Shaheen, Lorna C Gilligan, Amrita Athwal, Darren Barton, Ronald Carrera, Katie Young, Amisha Desai, Kirsty McGee, Christos Ermogenous, Gurneet Sur, Carolyn A Greig, Jon Hazeldine, Wiebke Arlt, Janet M Lord & Mark A Foster. (2021) A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT. BMJ Open 11:7, pages e040823.
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Tongtong Wang, Xin Ye, Wei Bian, Zhichi Chen, Juanjuan Du, Mengyi Li, Peng Zhou, Huairui Cui, Yu-Qiang Ding, Shuangshuang Qi, Min Liao & Chenyou Sun. (2020) Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage. Frontiers in Cellular Neuroscience 13.
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Conor Bentley, Jon Hazeldine, Carolyn Greig, Janet Lord & Mark Foster. (2019) Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient. Burns & Trauma 7.
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K. Collomp, N. Gravisse, N. Vibarel-Rebot, M. Asselin, M.-C. Do, O. Gagey, C. Le-Tiec, S. Dufay, C. Buisson & M. Audran. (2018) Neuroendocrine and inflammatory responses to DHEA administration in young healthy women. Pharmacology Biochemistry and Behavior 175, pages 19-23.
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Jason R. Kovac, Michael Pan, Shawn Arent & Larry I. Lipshultz. (2016) Dietary Adjuncts for Improving Testosterone Levels in Hypogonadal Males. American Journal of Men's Health 10:6, pages NP109-NP117.
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Meixiang Zhang, Wenbin Niu, Yu Wang, Jiawei Xu, Xiao Bao, Linlin Wang, Linqing Du & Yingpu Sun. (2016) Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics 33:8, pages 981-991.
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Jason M. Franasiak, Semara Thomas, Susan Ng, Maria Fano, Andrew Ruiz, Richard T. ScottJrJr & Eric J. Forman. (2016) Dehydroepiandrosterone (DHEA) supplementation results in supraphysiologic DHEA-S serum levels and progesterone assay interference that may impact clinical management in IVF. Journal of Assisted Reproduction and Genetics 33:3, pages 387-391.
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Marie M. Onakomaiya & Leslie P. Henderson. (2016) Mad men, women and steroid cocktails: a review of the impact of sex and other factors on anabolic androgenic steroids effects on affective behaviors. Psychopharmacology 233:4, pages 549-569.
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Jennifer C. Naylor, Jason D. Kilts, Jennifer L. Strauss, Steven T. Szabo, Charlotte E. Dunn, H. Ryan Wagner, Robert M. Hamer, Lawrence J. Shampine, Joseph R. Zanga & Christine E. Marx. (2016) An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans. Journal of Rehabilitation Research and Development 53:4, pages 499-510.
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Susanne Strauss, Tine Greve, Erik Ernst, Matthiaos Fraidakis, Jurgis Gedis Grudzinskas & Claus Yding Andersen. (2014) Administration of DHEA augments progesterone production in a woman with low ovarian reserve being transplanted with cryopreserved ovarian tissue. Journal of Assisted Reproduction and Genetics 31:6, pages 645-649.
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N. P. Goncharov, G. V. Katsiya, A. A. Dzhokua, V. S. Barkaya, Z. V. Kulava & Z. Ya. Mikvabiya. (2014) Effect of neurosteroid dehydroepiandrosterone on the higher nervous activity of old non-human primates. Human Physiology 40:2, pages 149-155.
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Alexander Römmler & Josefine Römmler-Zehrer. (2013) Die Rolle des Schlüsselhormons DHEA. gynäkologie + geburtshilfe 18:7, pages 34-41.
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C.C. ZouboulisE. Makrantonaki. (2012) Hormonal Therapy of Intrinsic Aging. Rejuvenation Research 15:3, pages 302-312.
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Abdulmaged M. Traish, H. Paco Kang, Farid Saad & Andre T. Guay. (2011) Dehydroepiandrosterone (DHEA)—A Precursor Steroid or an Active Hormone in Human Physiology (CME). The Journal of Sexual Medicine 8:11, pages 2960-2982.
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Damian G. Zuloaga, Jessica E. Poort, Cynthia L. Jordan & S. Marc Breedlove. (2011) Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress. Hormones and Behavior 60:4, pages 380-388.
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Alessandro Genazzani & Chiara Lanzoni. 2011. DHEA in Human Health and Aging. DHEA in Human Health and Aging 9 34 .
Jason D. Kilts, Larry A. Tupler, Francis J. Keefe, Victoria M. Payne, Robert M. Hamer, Jennifer C. Naylor, Rohana P. Calnaido, Rajendra A. Morey, Jennifer L. Strauss, Gillian Parke, Mark W. Massing, Nagy A. Youssef, Lawrence J. Shampine & Christine E. Marx. (2010) Neurosteroids and Self-Reported Pain in Veterans Who Served in the U.S. Military after September 11, 2001. Pain Medicine 11:10, pages 1469-1476.
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E. Makrantonaki & C.C. Zouboulis. (2010) DermatoendokrinologieDermatoendocrinology. Der Hautarzt 61:6, pages 505-510.
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Fernand Labrie. 2010. Neuroendocrinology - Pathological Situations and Diseases. Neuroendocrinology - Pathological Situations and Diseases 97 148 .
Rebecca Z. Sokol. 2010. Infertility in the Male. Infertility in the Male 199 214 .
Ioannis Charalampopoulos, Eumorphia Remboutsika, Andrew N. Margioris & Achille Gravanis. (2008) Neurosteroids as modulators of neurogenesis and neuronal survival. Trends in Endocrinology & Metabolism 19:8, pages 300-307.
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Nicola Pluchino, Filippo Ninni, Massimo Stomati, Letizia Freschi, Elena Casarosa, Valeria Valentino, Stefano Luisi, Alessandro D. Genazzani, Elena Potì & Andrea R. Genazzani. (2008) One-year therapy with 10mg/day DHEA alone or in combination with HRT in postmenopausal women: Effects on hormonal milieu. Maturitas 59:4, pages 293-303.
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Klaus Fritz. 2008. Hautalterung. Hautalterung 37 57 .
Michael S. Ritsner. 2008. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders 337 368 .
Mauro Di Pasquale. 2007. Amino Acids and Proteins for the Athlete. Amino Acids and Proteins for the Athlete 335 396 .
Ronald Tamler & Jeffrey I. Mechanick. (2007) Dietary Supplements and Nutraceuticals in the Management of Andrologic Disorders. Endocrinology and Metabolism Clinics of North America 36:2, pages 533-552.
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Alessandro D Genazzani, Chiara Lanzoni & Andrea R Genazzani. (2007) Might DHEA be Considered a Beneficial Replacement Therapy in the Elderly?. Drugs & Aging 24:3, pages 173-185.
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J. Herbert. 2007. Encyclopedia of Stress. Encyclopedia of Stress 788 791 .
Ronald Tamler & Jeffrey I Mechanick. (2006) Dietary supplements and nutraceuticals in the management of endocrine disorders. Current Opinion in Endocrinology and Diabetes 13:5, pages 425-430.
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Matthew T. Haren, Moon Jong Kim, Syed H. Tariq, Gary A. Wittert & John E. Morley. (2006) Andropause: A Quality-of-Life Issue in Older Males. Medical Clinics of North America 90:5, pages 1005-1023.
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Cheng-Cheng Hsiao. (2006) Difference in pre- and post-treatment plasma DHEA levels were significantly and positively correlated with difference in pre- and post-treatment Hamilton depression scores following successful therapy for major depression. Psychoneuroendocrinology 31:7, pages 839-846.
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Yoshiji Miwa, Taisei Kaneda & Osamu Yokoyama. (2006) Correlation Between the Aging Males’ Symptoms Scale and Sex Steroids, Gonadotropins, Dehydroepiandrosterone Sulfate, and Growth Hormone Levels in Ambulatory Men. The Journal of Sexual Medicine 3:4, pages 723-726.
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Kevin Short. 2006. Scientific Evidence for Musculoskeletal, Bariatric, and Sports Nutrition. Scientific Evidence for Musculoskeletal, Bariatric, and Sports Nutrition 305 335 .
Christos C. Zouboulis & Evgenia Makrantonaki. 2006. Skin Aging. Skin Aging 55 64 .

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