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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 125, 2019 - Issue 2
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Original Article

Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease

Amir HajighasemDepartment of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran; View further author information
,
Parvin FarzanegiDepartment of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran; Correspondence[email protected]
View further author information
&
Zohreh MazaheriDepartment of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranView further author information
Pages 142-149 | Received 12 Jan 2018, Accepted 13 Feb 2018, Published online: 20 Feb 2018

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Yifan Liu, Kaimin Wu, Yinkun Fu, Wenyan Li & Xu-Yun Zhao. (2023) Slc7a11 stimulates glutathione synthesis to preserve fatty acid metabolism in primary hepatocytes. Redox Report 28:1.
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Mariana Verdelho Machado. (2021) Aerobic Exercise in the Management of Metabolic Dysfunction Associated Fatty Liver Disease. Diabetes, Metabolic Syndrome and Obesity 14, pages 3627-3645.
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Parvin Farzanegi, Amir Dana, Zeynab Ebrahimpoor, Mahdieh Asadi & Mohammad Ali Azarbayjani. (2019) Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. European Journal of Sport Science 19:7, pages 994-1003.
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Articles from other publishers (33)

Ke Liu, Lei Chai, Taotao Zhao, Shaosan Zhang, Jixiang Wang, Yanghuan Yu, Ruiyan Niu & Zilong Sun. (2023) Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice. Biological Trace Element Research 201:12, pages 5734-5746.
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Fariba Aghaei, Alexei Wong, Mehdi Zargani, Amir Sarshin, Foad Feizolahi, Zhila Derakhshan, Mohammadreza Hashemi & Ehsan Arabzadeh. (2023) Effects of swimming exercise combined with silymarin and vitamin C supplementation on hepatic inflammation, oxidative stress, and histopathology in elderly rats with high-fat diet-induced liver damage. Nutrition 115, pages 112167.
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Shi Tang, Benson O.A. Botchway, Yong Zhang, Xichen Wang, Min Huang & Xuehong Liu. (2023) Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway. Annals of Anatomy - Anatomischer Anzeiger, pages 152180.
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Xuan He, Yubing Li, Xinyu Deng, Xiaolin Xiao & Jinhao Zeng. (2023) Integrative evidence construction for resveratrol treatment of nonalcoholic fatty liver disease: preclinical and clinical meta-analyses. Frontiers in Pharmacology 14.
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Rongxuan Li, Weiyue Xue, Huiting Wei, Qingqing Fan, Xiang Li, Ye Qiu & Di Cui. (2023) Research Progress of Pyroptosis in Fatty Liver Disease. International Journal of Molecular Sciences 24:17, pages 13065.
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Jessica Winarto, Dae-Geun Song & Cheol-Ho Pan. (2023) The Role of Fucoxanthin in Non-Alcoholic Fatty Liver Disease. International Journal of Molecular Sciences 24:9, pages 8203.
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Arefe Nemati, Zeinab Nikniaz & Ali Mota. (2023) Effects of Resveratrol Supplementation on Nonalcoholic Fatty Liver Disease Management. Topics in Clinical Nutrition 38:2, pages 144-160.
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Omid Abazari, Abolfazl Shakibaee, Alireza Shahriary, Ehsan Arabzadeh & Martin Hofmeister. (2023) Hepatoprotective effects of moderate-intensity interval training along with ginger juice in an old male rat model. Pflügers Archiv - European Journal of Physiology 475:4, pages 437-452.
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Seshagiri Rao NandulaEric S. NylenSabyasachi Sen. (2023) Novel Therapeutics in Nonalcoholic Fatty Liver Disease: A Focus on Adult Stem Cells. Metabolic Syndrome and Related Disorders 21:2, pages 71-78.
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MohammadMahdi Jaafarzadeh, Roham Mahjoob Khaligh, Zhaleh Mohsenifar, Aida Shabani, MohammadMahdi Rezvani Gilkalaei, Sara Rajabi Keleshteri & Asghar Beigi Harchegani. (2021) Protecting Effects of N-acetyl Cysteine Supplementation Against Lead and Cadmium-Induced Brain Toxicity in Rat Models. Biological Trace Element Research 200:10, pages 4395-4403.
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Zhijia Zhou, Jinghao Zhang, Liping You, Tao Wang, Kaixia Wang, Lingtai Wang, Xiaoni Kong, Yueqiu Gao & Xuehua Sun. (2022) Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine. Frontiers in Endocrinology 13.
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Doha Reda, Gehad E. Elshopakey, Hebatallah A. Mahgoub, Engy F. Risha, Anmar A. Khan, Bodour S. Rajab, Mohamed E. El-Boshy & Fatma M. Abdelhamid. (2022) Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role of Oxidative Stress, Inflammation, and Insulin Resistance. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-13.
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Ali Nouri, Parvin Farzanegi & Mohammad Ali Azarbayjani. (2022) Effects of Resveratrol Supplementation and Exercise on Apoptosis, Lipid Profile, and Expression of Farnesoid X Receptor, Liver X Receptor and Sirtuin 1 Genes in the Liver of Type 1 Diabetic Rats. Medical Laboratory Journal 16:4, pages 39-46.
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Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabrés, Cristina Bouzas, Sofía Montemayor, Catalina M. Mascaró, Miguel Casares, Isabel Llompart, José M. Gámez, Silvia Tejada, J. Alfredo Martínez, Josep A. Tur & Antoni Sureda. (2022) A Greater Improvement of Intrahepatic Fat Contents after 6 Months of Lifestyle Intervention Is Related to a Better Oxidative Stress and Inflammatory Status in Non-Alcoholic Fatty Liver Disease. Antioxidants 11:7, pages 1266.
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Supat Chupradit, Dmitry Bokov, Mohammad Yassin Zamanian, Mahsa Heidari & Elham Hakimizadeh. (2022) Hepatoprotective and therapeutic effects of resveratrol: A focus on anti‐inflammatory and antioxidative activities. Fundamental & Clinical Pharmacology 36:3, pages 468-485.
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Victor Neiva Lavorato, Denise Coutinho de Miranda, Filipe Rios Drummond, Leonardo Matheus Teixeira Rezende, Maria do Carmo Gouveia Pelúzio, Marcelo Eustáquio Silva & Antônio José Natali. (2021) Combined action of açai and aerobic exercise training on the development of NAFLD induced by a high-fat diet: a preliminary exploration. Sport Sciences for Health 18:2, pages 509-515.
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Cai-Ren Wang, Hong-Wei Chen, Yan Li, Ming-Yue Zhou, Vincent Kam-Wai Wong, Zhi-Hong Jiang & Wei Zhang. (2021) Network Pharmacology Exploration Reveals Anti-Apoptosis as a Common Therapeutic Mechanism for Non-Alcoholic Fatty Liver Disease Treated with Blueberry Leaf Polyphenols. Nutrients 13:11, pages 4060.
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Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar & Hadi Habibollahi. (2021) The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular Biology Reports 48:3, pages 2533-2542.
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M. Gholami, A. B. Harchegani, S. Saeedian, M. Owrang & M. R. Parvizi. (2021) Effect of N-acetyl cysteine on oxidative stress and Bax and Bcl2 expression in the kidney tissue of rats exposed to lead. The Ukrainian Biochemical Journal 93:1, pages 59-67.
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Serkan Tursun, Hacer Fulya Gülerman, Serkal Gazyağcı, Yaşar Şahin, Özcan Erel & Salim Neşelioğlu. (2021) Investigation of Thiol/Disulfide Balance in Obese Rats with Non-Alcoholic Fatty Liver Disease. Pediatric Gastroenterology, Hepatology & Nutrition 24:5, pages 443.
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David E. Stec & Terry D. HindsJr.Jr.. (2020) Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences 21:24, pages 9493.
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Carmen P. Ortega-Santos, Layla Al-Nakkash & Corrie M. Whisner. (2020) Exercise and/or Genistein Treatment Impact Gut Microbiota and Inflammation after 12 Weeks on a High-Fat, High-Sugar Diet in C57BL/6 Mice. Nutrients 12:11, pages 3410.
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Nagamani Vunnam, Sophia Szymonski, Petra Hirsova, Gregory J. Gores, Jonathan N. Sachs & Benjamin J. Hackel. (2020) Noncompetitive Allosteric Antagonism of Death Receptor 5 by a Synthetic Affibody Ligand. Biochemistry 59:40, pages 3856-3868.
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Justyna Komorowska, Mateusz Wątroba & Dariusz Szukiewicz. (2020) Review of beneficial effects of resveratrol in neurodegenerative diseases such as Alzheimer's disease. Advances in Medical Sciences 65:2, pages 415-423.
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Yong Zou & Zhengtang Qi. (2020) Understanding the Role of Exercise in Nonalcoholic Fatty Liver Disease: ERS-Linked Molecular Pathways. Mediators of Inflammation 2020, pages 1-15.
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Stergios A. Polyzos, Jannis Kountouras & Christos S. Mantzoros. (2020) Obeticholic acid for the treatment of nonalcoholic steatohepatitis: Expectations and concerns. Metabolism 104, pages 154144.
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Ziba Keymasi, Abbas Sadeghi & Hassan Pourrazi. (2020) Effect of pilates training on hepatic fat content and liver enzymes in men with non-alcoholic fatty liver disease in Qazvin. Journal of Shahrekord University of Medical Sciences 22:1, pages 22-28.
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Abbas Sadeghi, Hassan Pourrazi & Hamid-Reza Yazdi. (2019) The Effect of Eight-Week Total Body Resistance Exercise on Liver Functional Parameters in Patients with Non-Alcoholic Fatty Liver Disease. Hormozgan Medical Journal In Press:In Press.
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Bing bing Chen, Ying Han, Xinting Pan, Jianhui Yan, Wenjuan Liu, Yangfan Li, Xu Lin, Shanghua Xu & Xian-E Peng. (2019) Association between nut intake and non-alcoholic fatty liver disease risk: a retrospective case-control study in a sample of Chinese Han adults. BMJ Open 9:9, pages e028961.
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Juan-Juan Li, Ping Zhang, Bing Fan, Xiu-Li Guo & Zhe-Shu Zheng. (2019) The efficacy of saxagliptin in T2DM patients with non-alcoholic fatty liver disease: preliminary data. Revista da Associação Médica Brasileira 65:1, pages 33-37.
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Amir Hajighasem, Parvin Farzanegi, Zohreh Mazaheri, Marjan Naghizadeh & Ghoncheh Salehi. (2018) Effects of resveratrol, exercises and their combination on Farnesoid X receptor, Liver X receptor and Sirtuin 1 gene expression and apoptosis in the liver of elderly rats with nonalcoholic fatty liver . PeerJ 6, pages e5522.
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Tatsuo Kanda, Shunichi Matsuoka, Motomi Yamazaki, Toshikatsu Shibata, Kazushige Nirei, Hiroshi Takahashi, Tomohiro Kaneko, Mariko Fujisawa, Teruhisa Higuchi, Hitomi Nakamura, Naoki Matsumoto, Hiroaki Yamagami, Masahiro Ogawa, Hiroo Imazu, Kazumichi Kuroda & Mitsuhiko Moriyama. (2018) Apoptosis and non-alcoholic fatty liver diseases. World Journal of Gastroenterology 24:25, pages 2661-2672.
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