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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 126, 2020 - Issue 4
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Original Articles

Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats

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Pages 300-307 | Received 26 Jul 2018, Accepted 25 Sep 2018, Published online: 08 Nov 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Sachinthi S. Amarasiri, Anoja P. Attanayake, Lakmini K. B. Mudduwa & Kamani A. P. W. Jayatilaka. (2023) Asparagus falcatus L. (Asparagaceae) leaf extracts attenuate doxorubicin-induced renal toxicity via antioxidant, anti-inflammatory, and anti-apoptotic pathways. Drug and Chemical Toxicology 46:4, pages 677-691.
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Manuel Adrian Picos-Salas, Luis Ángel Cabanillas-Bojórquez, Cristina Alicia Elizalde-Romero, Nayely Leyva-López, Luis Aurelio Montoya-Inzunza, J. Basilio Heredia & Erick P. Gutiérrez-Grijalva. (2022) Naringenin as a Natural Agent Against Oxidative Stress and Inflammation, and Its Bioavailability. Food Reviews International 0:0, pages 1-39.
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Carolina Sousa, Denise Duarte, Beatriz Silva-Lima & Mafalda Videira. (2022) Repurposing Natural Dietary Flavonoids in the Modulation of Cancer Tumorigenesis: Decrypting the Molecular Targets of Naringenin, Hesperetin and Myricetin. Nutrition and Cancer 74:4, pages 1188-1202.
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Azam Hosseinzadeh, Mehdi Goudarzi, Iman Fatemi, Mohammad Javad Khodayar, Saeed Mehrzadi, Hamid Reza Khalili & Mohammad Ali Karimi. (2020) Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation. Biotechnic & Histochemistry 95:7, pages 532-539.
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Muhammad Umar Ijaz, Kaynat Alvi, Hammad Ahmad Khan, Muhammad Imran, Tayyaba Afsar, Ali Almajwal, Houda Amor & Suhail Razak. (2023) Gossypetin mitigates doxorubicin-induced nephrotoxicity: A histopathological and biochemical evaluation. Journal of King Saud University - Science 35:7, pages 102830.
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Sepideh Mirzaei, Mohammad Hossein Gholami, Amirhossein Zabolian, Hossein Saleki, Morteza Bagherian, Seyed Mohammadreza Torabi, Seyed Omid Sharifzadeh, Kiavash Hushmandi, Kaila R. Fives, Haroon Khan, Milad Ashrafizadeh, Ali Zarrabi & Anupam Bishayee. (2023) Resveratrol Augments Doxorubicin and Cisplatin Chemotherapy: A Novel Therapeutic Strategy. Current Molecular Pharmacology 16:3, pages 280-306.
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Nouf K. Alaqeel & Mohammed T. Al-Hariri. (2023) Naringenin ameliorates Cyclophosphamide-induced nephrotoxicity in experimental model. Saudi Journal of Biological Sciences 30:6, pages 103674.
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Ru Wang, Mengnan Zeng, Beibei Zhang, Qinqin Zhang, Shuangshuang Xie, Yingbo Hu, Ruyi Fan, Mengya Wang, Xiao Yu, Yuhan Zhang, Xiaoke Zheng & Weisheng Feng. (2023) Epimedium sagittatum Maxim ameliorates adriamycin‐induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathway. Immunity, Inflammation and Disease 11:6.
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Ankita Rajput, Palvi Sharma, Davinder Singh, Sharabjit Singh, Prabhjot Kaur, Shivani Attri, Pallvi Mohana, Harneetpal Kaur, Farhana Rashid, Astha Bhatia, Joachim Jankowski, Vanita Arora, Hardeep Singh Tuli & Saroj Arora. (2023) Role of polyphenolic compounds and their nanoformulations: a comprehensive review on cross-talk between chronic kidney and cardiovascular diseases. Naunyn-Schmiedeberg's Archives of Pharmacology 396:5, pages 901-924.
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Haizhao Liu, Min Cao, Yutong Jin, Beitian Jia, Liming Wang, Mengxue Dong, Lu Han, Joseph Abankwah, Jianwei Liu, Tao Zhou, Baogui Chen, Yiyang Wang & Yuhong Bian. (2023) Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones. Frontiers in Endocrinology 14.
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Ahmed Elfadadny, Rokaia F. Ragab, Rania Hamada, Soad K. Al Jaouni, Junjiang Fu, Shaker A. Mousa & Ali H. El-Far. (2023) Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety. Toxicology and Applied Pharmacology 461, pages 116405.
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Rodrigo Castañeda, Armando Cáceres, Sully M. Cruz, J. Agustín Aceituno, E. Sebastián Marroquín, Ana C. Barrios Sosa, Wendy K. Strangman & R. Thomas Williamson. (2023) Nephroprotective plant species used in traditional Mayan Medicine for renal-associated diseases. Journal of Ethnopharmacology 301, pages 115755.
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Zhao Fang, Wen Wei & Xuejun Jiang. (2023) Monotropein attenuates doxorubicin-induced oxidative stress, inflammation, and arrhythmia via the AKT signal pathway. Biochemical and Biophysical Research Communications 638, pages 14-22.
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İlter İLHAN, Halil AŞCI, Mehmer Abdulkadir SEVÜK, Orhan Berk İMECİ, Adem MİLLETSEVER & Okan SANCER. (2022) DOKSORUBİSİN İLE OLUŞTURULAN BÖBREK HASARINDA LERKANİDİPİNİN ANTİOKSİDAN VE ANTİAPOPTOTİK ETKİLERİNİN BCL-2/BAX/SİT C/ CAS-3 YOLAĞI ÜZERİNDEN ARAŞTIRILMASIINVESTIGATION OF ANTIOXIDANT AND ANTIAPOPTOTIC EFFECTS OF LERCANIDIPINE IN DOXORUBICIN-INDUCED KIDNEY DAMAGE VIA BCL-2/BAX/SIT C/CAS-3 SIGNALING PATHWAY. SDÜ Tıp Fakültesi Dergisi 29:4, pages 671-679.
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Povilas Kavaliauskas, Felipe Stambuk Opazo, Waldo Acevedo, Ruta Petraitiene, Birutė Grybaitė, Kazimieras Anusevičius, Vytautas Mickevičius, Sergey Belyakov & Vidmantas Petraitis. (2022) Synthesis, Biological Activity, and Molecular Modelling Studies of Naphthoquinone Derivatives as Promising Anticancer Candidates Targeting COX-2. Pharmaceuticals 15:5, pages 541.
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Guoshun Huang, Yiye Zhu, Chen Yong, Fang Tian, Li Liu, Qijing Wu, Yang Shu, Min Yao, Chenquan Tang, Xiaofang Wang, Wei Chen & Enchao Zhou. (2022) Artemisia capillaris Thunb. water extract attenuates adriamycin‐induced renal injury by regulating apoptosis through the ROS/MAPK axis . Journal of Food Biochemistry 46:2.
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Chaoling Chen, Dengpiao Xie, David A. Gewirtz & Ningjun Li. 2022. Strategies to Mitigate the Toxicity of Cancer Therapeutics. Strategies to Mitigate the Toxicity of Cancer Therapeutics 77 129 .
Hong Zhang, Mengyi Chi, Yaxian Wang, Linlin Chen, Xipeng Sun, Lili Wan, Quanjun Yang & Cheng Guo. (2021) Naringenin alleviates cisplatin induced muscle atrophy by regulating RIPK1/AMPK/NF-κB pathway. Journal of Functional Foods 86, pages 104714.
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Xiang Yu, Peng Zhang, Kai Tang, Gengyang Shen, Honglin Chen, Zhida Zhang, Wenhua Zhao, Qi Shang, Guangye Zhu, Riwei Tan, Yanchi Gan, You Zhang, De Liang, Hui Ren, Xiaobing Jiang & Bengen Zhou. (2021) Network Pharmacology Integrated with Molecular Docking Explores the Mechanisms of Naringin against Osteoporotic Fracture by Regulating Oxidative Stress. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-12.
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Karim Naraki, Ramin Rezaee & Gholamreza Karimi. (2021) A review on the protective effects of naringenin against natural and chemical toxic agents. Phytotherapy Research 35:8, pages 4075-4091.
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Hong-Wei Jiang, Yong Zhou, Pin-Yi Zhou, Tian-Yi Zhang, Jing-Yao Hu & Xue-Tao Bai. (2021) Protective Effects of Bariatric Surgery on Kidney Functions by Inhibiting Oxidative Stress Responses Through Activating PPARα in Rats With Diabetes. Frontiers in Physiology 12.
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Sepideh Mirzaei, Ali Zarrabi, Farid Hashemi, Amirhossein Zabolian, Hossein Saleki, Negar Azami, Soodeh Hamzehlou, Mahdi Vasheghani Farahani, Kiavash Hushmandi, Milad Ashrafizadeh, Haroon Khan & Alan Prem Kumar. (2021) Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery. Antioxidants 10:3, pages 349.
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Weiyang Fan, Rui Shi, Minyi Guan, Pan Chen, Hao Wu, Weiwei Su, Yonggang Wang & Peibo Li. (2021) The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells. International Journal of Molecular Sciences 22:5, pages 2292.
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Catherine C. Ikewuchi, Mercy O. IfeanachoJude C. Ikewuchi. (2021) Moderation of doxorubicin-induced nephrotoxicity in Wistar rats by aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens. Porto Biomedical Journal 6:1, pages e129.
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Elena Valeria Fuior, Cristina Ana Mocanu, Mariana Deleanu, Geanina Voicu, Maria Anghelache, Daniela Rebleanu, Maya Simionescu & Manuela Calin. (2020) Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation. Pharmaceutics 12:11, pages 1066.
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Abdulaziz S. Saeedan, Majid Ahmad Ganaie, Basit Latief Jan, Hassan Madhkali, Mohd Nazam Ansa, Najeeb U. Rehman, Summya Rashid & Muneeb U. Rehman. (2020) Brucine Prevents DMH Induced Colon Carcinogenesis in Wistar Rats. International Journal of Pharmacology 16:4, pages 319-329.
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Muneeb U. Rehman & Irfan A. Rather. (2019) Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats. Plants 9:1, pages 28.
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Daniela Maria Tanase, Evelina Maria Gosav, Smaranda Radu, Claudia Florida Costea, Manuela Ciocoiu, Alexandru Carauleanu, Cristina Mihaela Lacatusu, Minela Aida Maranduca, Mariana Floria & Ciprian Rezus. (2019) The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity. International Journal of Molecular Sciences 20:20, pages 5238.
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Othman Al- Shabanah, Lulwah Al- Ahmed, Raghad Al- Qunebet, Wejdzan Al- Yousuf, Raghad Mustafa & Salim Al- Rejaie. (2019) Losartan and/or Naringenin Ameliorates Doxorubicin Induced Cardiac, Hepatic and Renal Toxicities in Rats. International Journal of Pharmacology 15:6, pages 675-685.
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Said Said Elshama. (2021) Ameliorative Effect of Naringenin in Intoxication Cases Recovery. SSRN Electronic Journal.
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