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Aging, Neuropsychology, and Cognition
A Journal on Normal and Dysfunctional Development
Volume 13, 2006 - Issue 3-4
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Original Articles

The Relation of White Matter Hyperintensities to Cognitive Performance in the Normal Old: Education Matters

Robert D. Nebes University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USACorrespondence[email protected]
,
Carolyn C. Meltzer University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
,
Ellen M. Whyte University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
,
Joelle M. Scanlon University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
,
Edythe M. Halligan University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
,
Judith A. Saxton University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
,
Patricia R. Houck University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
,
Fernando E. Boada University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
&
Steven T. DeKosky University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
 show all
Pages 326-340 | Published online: 01 Feb 2007

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Marion Mortamais, Sylvaine Artero & Karen Ritchie. (2013) Cerebral white matter hyperintensities in the prediction of cognitive decline and incident dementia. International Review of Psychiatry 25:6, pages 686-698.
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Helen M. Genova, John DeLuca, Nancy Chiaravalloti & Glenn Wylie. (2013) The relationship between executive functioning, processing speed, and white matter integrity in multiple sclerosis. Journal of Clinical and Experimental Neuropsychology 35:6, pages 631-641.
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Colleen M. Parks, Charles DeCarli, Larry L. Jacoby & Andrew P. Yonelinas. (2010) Aging Effects on Recollection and Familiarity: The Role of White Matter Hyperintensities. Aging, Neuropsychology, and Cognition 17:4, pages 422-438.
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Articles from other publishers (31)

Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell & Tamsyn E. Van Rheenen. (2024) To what extent does white matter map to cognition in bipolar disorder? A systematic review of the evidence. Progress in Neuro-Psychopharmacology and Biological Psychiatry 128, pages 110868.
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Romella Durrani, Amanpreet Badhwar, Jaspreet Bhangu, Aravind Ganesh, Sandra E. Black, Philip A. Barber, Richard Frayne, Thalia S. Field, Vladimir Hachinski, Demetrios Sahlas, Lauren M. Mai, Mukul Sharma, Richard H. Swartz & Eric E. Smith. (2022) Vascular Brain Lesions, Cognitive Reserve, and Their Association with Cognitive Profile in Persons with Early-Stage Cognitive Decline. Journal of Alzheimer's Disease Reports 6:1, pages 607-616.
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Isabel Hotz, Pascal Frédéric Deschwanden, Susan Mérillat, Franziskus Liem, Spyridon Kollias & Lutz Jäncke. (2021) Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study. NeuroImage: Clinical 32, pages 102884.
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Anja Soldan, Corinne Pettigrew, Yuxin Zhu, Mei‐Cheng Wang, Rebecca F. Gottesman, Charles DeCarli & Marilyn Albert. (2020) Cognitive reserve and midlife vascular risk: Cognitive and clinical outcomes. Annals of Clinical and Translational Neurology 7:8, pages 1307-1317.
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Chemin Lin, Chih-Mao Huang, Yang-Teng Fan, Ho-Ling Liu, Yao-Liang Chen, Howard J. Aizenstein, Tatia Mei-Chun Lee & Shwu-Hua Lee. (2020) Cognitive Reserve Moderates Effects of White Matter Hyperintensity on Depressive Symptoms and Cognitive Function in Late-Life Depression. Frontiers in Psychiatry 11.
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Laura B. Zahodne, Elizabeth Rose Mayeda, Timothy J. Hohman, Evan Fletcher, Annie M. Racine, Brandon Gavett, Jennifer J. Manly, Nicole Schupf, Richard Mayeux, Adam M. Brickman & Dan Mungas. (2019) The role of education in a vascular pathway to episodic memory: brain maintenance or cognitive reserve?. Neurobiology of Aging 84, pages 109-118.
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Alexandra Basilakos, Brielle C. Stark, Lisa Johnson, Chris Rorden, Grigori Yourganov, Leonardo Bonilha & Julius Fridriksson. (2019) Leukoaraiosis Is Associated With a Decline in Language Abilities in Chronic Aphasia. Neurorehabilitation and Neural Repair 33:9, pages 718-729.
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Corinne Pettigrew & Anja Soldan. (2019) Defining Cognitive Reserve and Implications for Cognitive Aging. Current Neurology and Neuroscience Reports 19:1.
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Gloria Benson, Andrea Hildebrandt, Catharina Lange, Claudia Schwarz, Theresa Köbe, Werner Sommer, Agnes Flöel & Miranka Wirth. (2018) Functional connectivity in cognitive control networks mitigates the impact of white matter lesions in the elderly. Alzheimer's Research & Therapy 10:1.
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Na-Yeon Jung, Hanna Cho, Yeo Jin Kim, Hee Jin Kim, Jong Min Lee, Seongbeom Park, Sung Tae Kim, Eun-Joo Kim, Jae Seung Kim, Seung Hwan Moon, Jae-Hong Lee, Michael Ewers, Duk L Na & Sang Won Seo. (2018) The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis. Alzheimer's Research & Therapy 10:1.
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Kristine A. Wilckens, Dana L. Tudorascu, Beth E. Snitz, Julie C. Price, Howard J. Aizenstein, Oscar L. Lopez, Kirk I. Erickson, Brian J. Lopresti, Charles M. Laymon, Davneet Minhas, Chester A. Mathis, Daniel J. Buysse, William E. Klunk & Ann D. Cohen. (2018) Sleep moderates the relationship between amyloid beta and memory recall. Neurobiology of Aging 71, pages 142-148.
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Annemieke ter Telgte, Esther M. C. van Leijsen, Kim Wiegertjes, Catharina J. M. Klijn, Anil M. Tuladhar & Frank-Erik de Leeuw. (2018) Cerebral small vessel disease: from a focal to a global perspective. Nature Reviews Neurology 14:7, pages 387-398.
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Laurie M. Baker, David H. Laidlaw, Ryan Cabeen, Erbil Akbudak, Thomas E. Conturo, Stephen Correia, David F. Tate, Jodi M. Heaps-Woodruff, Matthew R. Brier, Jacob Bolzenius, Lauren E. Salminen, Elizabeth M. Lane, Amanda R. McMichael & Robert H. Paul. (2016) Cognitive reserve moderates the relationship between neuropsychological performance and white matter fiber bundle length in healthy older adults. Brain Imaging and Behavior 11:3, pages 632-639.
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Lídia Vaqué-Alcázar, Roser Sala-Llonch, Cinta Valls-Pedret, Dídac Vidal-Piñeiro, Sara Fernández-Cabello, Núria Bargalló, Emilio Ros & David Bartrés-Faz. (2016) Differential age-related gray and white matter impact mediates educational influence on elders’ cognition. Brain Imaging and Behavior 11:2, pages 318-332.
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Sara Fernández-Cabello, Cinta Valls-Pedret, Matthias Schurz, Dídac Vidal-Piñeiro, Roser Sala-Llonch, Nuria Bargallo, Emilio Ros & David Bartrés-Faz. (2016) White matter hyperintensities and cognitive reserve during a working memory task: a functional magnetic resonance imaging study in cognitively normal older adults. Neurobiology of Aging 48, pages 23-33.
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Kristin H. Hinrichs, Alex Hayek, David Kalmbach, Nicolette GabelLinas A. Bieliauskas. (2016) Cognitive reserve and executive function: Effect on judgment of health and safety. Journal of Rehabilitation Research and Development 53:6, pages 863-872.
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Caoimhe Hannigan, Robert F. Coen, Brian A. Lawlor, Ian H. Robertson & Sabina Brennan. (2015) The NEIL Memory Research Unit: psychosocial, biological, physiological and lifestyle factors associated with healthy ageing: study protocol. BMC Psychology 3:1.
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Daniela Pinter, Christian Enzinger & Franz Fazekas. (2015) Cerebral small vessel disease, cognitive reserve and cognitive dysfunction. Journal of Neurology 262:11, pages 2411-2419.
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Marion Mortamais, Florence Portet, Adam M. Brickman, Frank A. Provenzano, Jordan Muraskin, Tasnime N. Akbaraly, Claudine Berr, Jacques Touchon, Alain Bonafé, Emmanuelle le Bars, Nicolas Menjot de Champfleur, Jerome J. Maller, Chantal Meslin, Robert Sabatier, Karen Ritchie & Sylvaine Artero. (2014) Education Modulates the Impact of White Matter Lesions on the Risk of Mild Cognitive Impairment and Dementia. The American Journal of Geriatric Psychiatry 22:11, pages 1336-1345.
Crossref
Natalia Gawron & Emilia Łojek. 2014. Różne oblicza starości. Badania neuropsychologiczne. Różne oblicza starości. Badania neuropsychologiczne.
Helen M. Genova, Venkateswaran Rajagopalan, John DeLuca, Abhijit Das, Allison Binder, Aparna Arjunan, Nancy Chiaravalloti & Glenn Wylie. (2013) Examination of Cognitive Fatigue in Multiple Sclerosis using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging. PLoS ONE 8:11, pages e78811.
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Eero Vuoksimaa, Matthew S. Panizzon, Chi-Hua Chen, Lisa T. Eyler, Christine Fennema-Notestine, Mark Joseph A. Fiecas, Bruce Fischl, Carol E. Franz, Michael D. Grant, Amy J. Jak, Michael J. Lyons, Michael C. Neale, Wesley K. Thompson, Ming T. Tsuang, Hong Xian, Anders M. Dale & William S. Kremen. (2013) Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age. Neuropsychologia 51:6, pages 1124-1131.
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David Bartrés-Faz & Eider M. Arenaza-Urquijo. (2011) Structural and Functional Imaging Correlates of Cognitive and Brain Reserve Hypotheses in Healthy and Pathological Aging. Brain Topography 24:3-4, pages 340-357.
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Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima & Hiroshi Fukuda. (2010) Correlation between degree of white matter hyperintensities and global gray matter volume decline rate. Neuroradiology 53:6, pages 397-403.
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Elizabeth M. Lane, Robert H. Paul, David J. Moser, Thomas D. Fletcher & Ronald A. Cohen. (2011) Influence of Education on Subcortical Hyperintensities and Global Cognitive Status in Vascular Dementia. Journal of the International Neuropsychological Society 17:3, pages 531-536.
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Eider M. Arenaza-Urquijo, Beatriz Bosch, Roser Sala-Llonch, Cristina Solé-Padullés, Carme Junqué, Davinia Fernández-Espejo, Núria Bargalló, Lorena Rami, José Luis Molinuevo & David Bartrés-Faz. (2011) Specific Anatomic Associations Between White Matter Integrity and Cognitive Reserve in Normal and Cognitively Impaired Elders. The American Journal of Geriatric Psychiatry 19:1, pages 33-42.
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Karen M. Rodrigue & Kristen M. Kennedy. 2011. Handbook of the Psychology of Aging. Handbook of the Psychology of Aging 73 91 .
Edith V. Sullivan, Jessica Rose, Torsten Rohlfing & Adolf Pfefferbaum. (2009) Postural sway reduction in aging men and women: Relation to brain structure, cognitive status, and stabilizing factors. Neurobiology of Aging 30:5, pages 793-807.
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Brian A. Gordon, Elena I. Rykhlevskaia, Carrie R. Brumback, Yukyung Lee, Steriani Elavsky, James F. Konopack, Edward McAuley, Arthur F. Kramer, Stanley Colcombe, Gabriele Gratton & Monica Fabiani. (2008) Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education. Psychophysiology, pages ???-???.
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Marc W. Haut, Maria T. Moran, Melissa A. Lancaster, Hiroto Kuwabara, Michael W. Parsons & Aina Puce. (2007) White Matter Correlates of Cognitive Capacity Studied With Diffusion Tensor Imaging: Implications for Cognitive Reserve. Brain Imaging and Behavior 1:3-4, pages 83-92.
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