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Pharmaceutical Biology Volume 55, 2017 - Issue 1
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Research Article

Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts

Peik Lin Teoha Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia; Correspondence[email protected]
,
Angelina Ying Fang Chenga Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia;
,
Monica Liau
,
Fui Fui Lema Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia;
,
Grace P. Kalinga Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia;
,
Fern Nie Chuab Faculty of Science & Natural Resources, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia
&
Bo Eng Cheonga Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah, Malaysia;
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Pages 394-401 | Received 21 Jun 2016, Accepted 25 Sep 2016, Published online: 08 Dec 2016

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Kummari Narendar, B. Sambasiva Rao, Satyakrishna Tirunavalli, Surender Singh Jadav, Sai Balaji Andugulapati, Vaikundamoorthy Ramalingam & K. Suresh Babu. (2023) Synthesis of novel thiazoles bearing lupeol derivatives as potent anticancer and anti-inflammatory agents. Natural Product Research 0:0, pages 1-8.
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Gideon A. Gyebi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Saheed O. Afolabi, Rotimi J. Ojo, Uju D.I. Ejike & Joseph O. Adebayo. (2022) Inhibitory potentials of phytocompounds from Ocimum gratissimum against anti-apoptotic BCL-2 proteins associated with cancer: an integrated computational study. Egyptian Journal of Basic and Applied Sciences 9:1, pages 588-608.
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Peik Lin Teoh, Monica Liau & Bo Eng Cheong. (2019) Phyla nodiflora L. Extracts Induce Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7. Nutrition and Cancer 71:4, pages 668-675.
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Kayode Ezekiel Adewole & Ahmed Adebayo Ishola. (2019) Phytosterols and triterpenes from Morinda lucida Benth (Rubiaceae) as potential inhibitors of anti-apoptotic BCL-XL, BCL-2, and MCL-1: an in-silico study. Journal of Receptors and Signal Transduction 39:1, pages 87-97.
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Articles from other publishers (18)

Nur Fitriyani Afiqah Binti Abu Bakar, Zhin Leng Yeo, Faisal Hussin, Priya Madhavan, Vuanghao Lim, Khairunadwa Jemon & Praseetha Prabhakaran. (2023) Synergistic effects of combined cisplatin and Clinacanthus nutans extract on triple negative breast cancer cells. Journal of Taibah University Medical Sciences 18:6, pages 1220-1236.
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Jose M. Prieto & Mohd Mukrish Mohd Hanafi. (2023) Advances in Molecular Regulation of Prostate Cancer Cells by Top Natural Products of Malaysia. Current Issues in Molecular Biology 45:2, pages 1536-1567.
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Noor Zafirah Ismail, Salwani Md Saad, Ismail Abiola Adebayo, Zaleha Md Toha, Rafedah Abas, Nur Nadhirah Mohamad Zain & Hasni Arsad. (2022) The antiproliferative and apoptotic potential of Clinacanthus nutans against human breast cancer cells through targeted apoptosis pathway. Environmental Science and Pollution Research 29:54, pages 81685-81702.
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Fui Fui Lem, Bo Eng Cheong & Peik Lin Teoh. (2022) Ruellia tuberosa Ethyl Acetate Leaf Extract Induces Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7. Scientia Pharmaceutica 90:3, pages 44.
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Sukhum Jiamton, Pattriya Chanyachailert, Yanisorn Nanchaipruek, Nuttagarn Jantanapornchai, Poramin Patthamalai, Pichaya Limphoka, Ya-Nin Nokdhes & Jiraporn Jantaravinid. (2022) Efficacy and Safety of Clinacanthus nutans Lindau Cream vs. Podophyllin for the Treatment of Adults with Condyloma Acuminata. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-6.
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Wei-Yi Ong, Deron R. Herr, Grace Y. Sun & Teng-Nan Lin. (2022) Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans. Molecules 27:11, pages 3607.
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Angelina Ying Fang Cheng, Peik Lin Teoh, Lalith Jayasinghe & Bo Eng Cheong. (2021) Volatile Profiling Aided in the Isolation of Anti-Proliferative Lupeol from the Roots of Clinacanthus nutans (Burm. f.) Lindau. Processes 9:8, pages 1383.
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Chung-Ming Lin, Hsin-Han Chen, Chi-Wen Lung & Hui-Jye Chen. (2021) Recent Advancement in Anticancer Activity of Clinacanthus nutans (Burm. f.) Lindau. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-13.
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Yun Jin Kim, Linchao Qian & Muhammad Shahzad Aslam. (2021) Bibliographic analysis of Clinacanthus nutans papers in Scopus database (2000–2019). F1000Research 10, pages 418.
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NikAina Syazana Nik Zainuddin, Hussin Muhammad, NikFakhuruddin Nik Hassan, NorHayati Othman & Yusmazura Zakaria. (2020) Clinacanthus nutans standardized fraction arrested SiHa cells at G1/S and induced apoptosis via upregulation of p53. Journal of Pharmacy And Bioallied Sciences 12:6, pages 768.
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Loh Teng-Hern Tan, Kooi Yeong Khaw, Yong Sze Ong, Tahir Mehmood Khan, Learn-Han Lee, Wai-Leng Lee & Bey-Hing Goh. 2020. Plant-derived Bioactives. Plant-derived Bioactives 461 491 .
Nik Mohd Afizan Nik Abd Rahman, M. Y. Nurliyana, M. N. F. Natasha Nur Afiqah, Mohd Azuraidi Osman, Muhajir Hamid & Mohd Azmi Mohd Lila. (2019) Antitumor and antioxidant effects of Clinacanthus nutans Lindau in 4 T1 tumor-bearing mice. BMC Complementary and Alternative Medicine 19:1.
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Yin-Yin Siew, Hui-Chuing Yew, Soek-Ying Neo, See-Voon Seow, Si-Min Lew, Shun-Wei Lim, Claire Sophie En-Shen Lim, Yi-Cheng Ng, Wei-Guang Seetoh, Azhar Ali, Chay-Hoon Tan & Hwee-Ling Koh. (2019) Evaluation of anti-proliferative activity of medicinal plants used in Asian Traditional Medicine to treat cancer. Journal of Ethnopharmacology 235, pages 75-87.
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Gabriel López‐García, Amparo Alegría, Reyes Barberá & Antonio Cilla. 2019. Nutraceuticals and Natural Product Derivatives. Nutraceuticals and Natural Product Derivatives 145 165 .
AMINA M. LAHNECHE, RATIBA BOUCHEHAM, TEVFIK OZEN, MUHAMMED ALTUN, NASSIMA BOUBEKRI, IBRAHIM DEMIRTAS, SABRINA BICHA, ALI BENTAMENE, FADILA BENAYACHE, SAMIR BENAYACHE & DJAMILA ZAMA. (2019) In vitro antioxidant, DNA-damaged protection and antiproliferative activities of ethyl acetate and n-butanol extracts of Centaurea sphaerocephalaL.. Anais da Academia Brasileira de Ciências 91:3.
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Chin Theng Ng, Lai Yen Fong, Jun Jie Tan, Nor Fadilah Rajab, Faridah Abas, Khozirah Shaari, Kok Meng Chan, Fariza Juliana & Yoke Keong Yong. (2018) Water extract of Clinacanthus nutans leaves exhibits in vitro, ex vivo and in vivo anti-angiogenic activities in endothelial cell via suppression of cell proliferation. BMC Complementary and Alternative Medicine 18:1.
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Leng Wei Khoo, Siew Audrey Kow, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham & Faridah Abas. (2018) A Comprehensive Review on Phytochemistry and Pharmacological Activities of Clinacanthus nutans (Burm.f.) Lindau . Evidence-Based Complementary and Alternative Medicine 2018, pages 1-39.
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Diana Cláudia Gouveia Alves Pinto, Ana Maria Loureiro Seca & Artur Manuel Soares Silva. 2017. Anticancer Plants: Clinical Trials and Nanotechnology. Anticancer Plants: Clinical Trials and Nanotechnology 105 151 .

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