7,631
Views
60
CrossRef citations to date
0
Altmetric
Research Article

Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers

, , , , , , & show all
Pages 1041-1046 | Received 12 Aug 2016, Accepted 25 Jan 2017, Published online: 09 Feb 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Sze Wa Chan, Brian Tomlinson, Paul Chan & Christopher Wai Kei Lam. (2021) The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharmaceutical Biology 59:1, pages 1159-1169.
Read now

Articles from other publishers (59)

Hongjie Shao, Ye Li, Changhui Wu, Ruoyun Chen & Jie Kang. (2024) Triterpenes from antler-shaped fruiting body of Ganoderma lucidum and their hepatoprotective activities. Phytochemistry 224, pages 114148.
Crossref
Ludovica Gaiaschi, Fabrizio De Luca, Elisa Roda, Beatrice Ferrari, Claudio Casali, Chiara Rita Inguscio, Federica Gola, Enrico Pelloni, Elena Savino, Mauro Ravera, Paola Rossi & Maria Grazia Bottone. (2024) A Phyto-mycotherapeutic Supplement, Namely Ganostile, as Effective Adjuvant in Brain Cancer Management: An In Vitro Study Using U251 Human Glioblastoma Cell Line. International Journal of Molecular Sciences 25:11, pages 6204.
Crossref
Geir Bjørklund, Natália Cruz-Martins, Bey Hing Goh, Olha Mykhailenko, Roman Lysiuk, Mariia ShanaidaLarysa Lenchyk, Taras Upyr, Marius Emil Rusu, Antonina Pryshlyak, Volodymyr Shanaida & Salvatore Chirumbolo. (2024) Medicinal Plant-derived Phytochemicals in Detoxification. Current Pharmaceutical Design 30:13, pages 988-1015.
Crossref
Jing Zhang, Wen Wang, Xinge Cui, Pengling Zhu, Siyu Li, Shujie Yuan, Daiyin Peng & Can Peng. (2024) Ganoderma lucidum ethanol extracts ameliorate hepatic fibrosis and promote the communication between metabolites and gut microbiota g_Ruminococcus through the NF-κB and TGF-β1/Smads pathways. Journal of Ethnopharmacology 322, pages 117656.
Crossref
Xiaomei Sun, Jing Wang, Mengtao Cheng, Yitong Qi & Chunchao Han. (2024) Strategies to Increase the Production of Triterpene Acids in Ligzhi or Reishi Medicinal Mushroom (Ganoderma lucidum, Agaricomycetes): A Review. International Journal of Medicinal Mushrooms 26:5, pages 25-41.
Crossref
Lijuan Xia, Ruimin Sun, Liyan Zhang, Jinrong Li, Chengda Zhang, Qian Yang, Lili Zhang, Siming Zhang, Hanbo Wang, Hanying Lyu, Wanqiang Lyu, Zhenhao Li & Lijiang Zhang. (2023) A 26-week repeated dose toxicity evaluation of sporoderm-removed Ganoderma lucidum spores in rats. Food and Chemical Toxicology 182, pages 114175.
Crossref
Dongmei Liu, Wentong Diao, Xueyan Sun, Junqin Zong, Xiwu Qi & Chengyuan Liang. (2023) Application of Miscanthus substrates in the cultivation of Ganoderma lingzhi. Archives of Microbiology 205:12.
Crossref
Purna Nandi, Sudeep Mitra, Dr. Mousumi Mitra, Dr. Mrinal Kanti Paira & Dr. Dilip Kumar Nandi. (2023) Effect of Ganoderma lucidum on physiological indices and gut microflora: A review. Measurement: Food 12, pages 100116.
Crossref
Xuefei Li, Frederick Leo Sossah, Yonglan Tuo, Jiajun Hu, Qian Wei, Shiyu Li, Na Rong, Michael Wiafe-Kwagyan, Changtian Li, Bo Zhang, Xiao Li & Yu Li. (2023) Characterization and fungicide sensitivity of Trichoderma species causing green mold of Ganoderma sichuanense in China. Frontiers in Microbiology 14.
Crossref
Yuchen Liu, Dongsheng Tan, Hong Cui & Jihua Wang. (2023) Ganoderic acid C2 exerts the pharmacological effects against cyclophosphamide-induced immunosuppression: a study involving molecular docking and experimental validation. Scientific Reports 13:1.
Crossref
Yiming Cao, Xiaoxue Fang, Mingyang Sun, Yegang Zhang, Mengyao Shan, Xintian Lan, Difu Zhu & Haoming Luo. (2023) Preventive and therapeutic effects of natural products and herbal extracts on nonalcoholic fatty liver disease / nonalcoholic steatohepatitis . Phytotherapy Research 37:9, pages 3867-3897.
Crossref
Rinchen Yangzom & Phurpa Wangchuk. 2023. Phytochemistry and Nutritional Composition of Significant Wild Medicinal and Edible Mushrooms. Phytochemistry and Nutritional Composition of Significant Wild Medicinal and Edible Mushrooms 221 241 .
Ting Ye, Yang Ge, Xiaoying Jiang, Hang Song, Can Peng & Bin Liu. (2023) A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer. Chinese Medicine 18:1.
Crossref
Henan Zhang, Jingsong Zhang, Yanfang Liu & Chuanhong Tang. (2023) Recent Advances in the Preparation, Structure, and Biological Activities of β-Glucan from Ganoderma Species: A Review. Foods 12:15, pages 2975.
Crossref
Maryam Naseri, Kamyar Movagharnejad & Sara Nanvakenari. (2023) Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer. Scientific Reports 13:1.
Crossref
Cheng-Shih Chen, Edmund Cheung So & Sheng-Nan Wu. (2023) Modulating Hyperpolarization-Activated Cation Currents through Small Molecule Perturbations: Magnitude and Gating Control. Biomedicines 11:8, pages 2177.
Crossref
Katarzyna Sułkowska-Ziaja, Monika Balik, Andrzej Szczepkowski, Monika Trepa, Gokhan Zengin, Katarzyna Kała & Bożena Muszyńska. (2023) A Review of Chemical Composition and Bioactivity Studies of the Most Promising Species of Ganoderma spp.. Diversity 15:8, pages 882.
Crossref
Jing Xie, Dongmei Lin, Jing Li, Tonghui Zhou, Shuqian Lin & Zhanxi Lin. (2023) Effects of Ganoderma lucidum polysaccharide peptide ameliorating cyclophosphamide-induced immune dysfunctions based on metabolomics analysis. Frontiers in Nutrition 10.
Crossref
Zhijie Tan, Qiaoyi Zhang, Rou Zhao, Ting Huang, Yun Tian & Yuanshan Lin. (2023) A Comparative Study on the Effects of Different Sources of Carboxymethyl Poria Polysaccharides on the Repair of DSS-Induced Colitis in Mice. International Journal of Molecular Sciences 24:10, pages 9034.
Crossref
Débora Elisa Antunes de Mendonça, Mariane Aparecida Franco de Godoy, Naiara Cristina Lucredi, Jurandir Fernando Comar, Igor Vivian Almeida & Veronica Elisa Pimenta Vicentini. (2023) Toxicogenic effects of the mushroom Ganoderma lucidum on human liver and kidney tumor cells and peripheral blood lymphocytes. Journal of Ethnopharmacology 307, pages 116226.
Crossref
Md Faruque Ahmad, Fakhruddin Ali Ahmad, Md. Zeyaullah, Abdulrahman A. Alsayegh, Syed Esam Mahmood, Abdullah M. AlShahrani, Mohammad Suhail Khan, Eman Shama, Alshaimaa Hamouda, Ehab Y. Elbendary & Kandil Abdel Hai Ali Attia. (2023) Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action. Nutrients 15:8, pages 1874.
Crossref
Ruobing Liu, Jing Gan, Mengdi Du, Xiao Kong, Chunxia Xu, Yue Lü, Shengliang Cao, Ting Meng, Bo Wang & Tianying Yu. (2023) Preparation and Characterization of Multilayer pH-Responsive Hydrogel Loaded Ganoderma lucidum Peptides. Foods 12:7, pages 1481.
Crossref
Chaojie Chen, Jiajun Chen, Ying Wang, Liu Fang, Cuiling Guo, Tingting Sang, He Peng, Qian Zhao, Shengjia Chen, Xiaojian Lin & Xingya Wang. (2023) Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling. Phytomedicine 110, pages 154626.
Crossref
Yong-Nan Liu, Feng-Yuan Wu, Ren-Yuan Tian, Yi-Xin Shi, Zi-Qi Xu, Ji-Ye Liu, Jia Huang, Fei-Fei Xue, Bi-Yang Liu & Gao-Qiang Liu. (2023) The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi. Communications Biology 6:1.
Crossref
Yajuan Chen, Qinlu Lin, Jianqiang Wang, Jianfei Mu & Ying Liang. (2023) Proteins, polysaccharides and their derivatives as macromolecular antioxidant supplements: A review of in vitro screening methods and strategies. International Journal of Biological Macromolecules 224, pages 958-971.
Crossref
Christopher Hobbs. 2023. Biochemical Engineering and Biotechnology of Medicinal Mushrooms. Biochemical Engineering and Biotechnology of Medicinal Mushrooms 285 356 .
Jia Meng, Ang Ma, Shun Zhang, Dongmei Lin, Shuqian Lin, Min Li, Hong Zhou & Baoxue Yang. (2022) Ganoderma Lucidum Polysaccharide Peptide attenuates post myocardial infarction fibrosis via down-regulating TGF-β1/SMAD and relieving oxidative stress. Pharmacological Research - Modern Chinese Medicine 4, pages 100152.
Crossref
Ping Huang, Fei-Jun Luo, You-Chu Ma, Si-Xian Wang, Jia Huang, Dan-Dan Qin, Fei-Fei Xue, Bi-Yang Liu, Qiang Wu, Xiao-Ling Wang & Gao-Qiang Liu. (2022) Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia of Ganoderma lingzhi . Food & Function 13:17, pages 9032-9048.
Crossref
Xin Zhang, Wentao Lv, Yongping Fu, Yu Li, Jinhe Wang, Dongjie Chen, Xuerong Han & Zhenhao Li. (2022) Hepatoprotective Activity of Ethanol Extract of Rice Solid-State Fermentation of Ganoderma tsugae against CCl4-Induced Acute Liver Injury in Mice. Molecules 27:16, pages 5347.
Crossref
Yulia Kirdeeva, Olga Fedorova, Alexandra Daks, Nikolai Barlev & Oleg Shuvalov. (2022) How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?. Pharmaceuticals 15:7, pages 868.
Crossref
Man Wang & Fei Yu. (2022) Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma. Frontiers in Pharmacology 13.
Crossref
Fu-Ying Qin, Dai-Wei Wang, Te Xu, Bi-Shan Zhang & Yong-Xian Cheng. (2022) Meroterpenoids containing benzopyran or benzofuran motif from Ganoderma cochlear. Phytochemistry 199, pages 113184.
Crossref
H. M. Akshay Kumar, Mehulee Sarkar, K. Darshan, Thungri Ghoshal, B. S. Kavya, Bishnu Maya Bashayl, A. J. K. Asaiya & Nanitha Berry. 2022. Fungal diversity, ecology and control management. Fungal diversity, ecology and control management 255 291 .
Stephanie M. Boas, Kathlene L. Joyce & Rita M. Cowell. (2021) The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention. Antioxidants 11:1, pages 8.
Crossref
Shasha Zhang, Fangyi Long, Hong Lin, Xi Wang, Gang Jiang & Ting Wang. (2021) Regulatory roles of phytochemicals on circular RNAs in cancer and other chronic diseases. Pharmacological Research 174, pages 105936.
Crossref
Shuang Zhao, Chengbo Rong, Yi Gao, Linfeng Wu, Xiaoheng Luo, Shuang Song, Yu Liu, Jack Ho Wong, Hexiang Wang, Litao Yi & Tzibun Ng. (2021) Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor. Applied Microbiology and Biotechnology 105:23, pages 8675-8688.
Crossref
Rizwan Ahmad, Muhammad Riaz, Aslam Khan, Ahmed Aljamea, Mohammad Algheryafi, Deya Sewaket & Aljawharah Alqathama. (2021) Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties . Phytotherapy Research 35:11, pages 6030-6062.
Crossref
Hui‐Fang Chiu, Hsiao‐Ju Lee, Yi‐Chun Han, Kamesh Venkatakrishnan, Oksana Golovinskaia & Chin‐Kun Wang. (2021) Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo‐controlled, double‐blind, cross‐over clinical trial . Journal of Food Biochemistry 45:4.
Crossref
Qing Du, Yuxin Cao & Chang Liu. 2021. The Lingzhi Mushroom Genome. The Lingzhi Mushroom Genome 1 25 .
Anqi Wang, Changhao Xiao, Jianxian Zheng, Chuansong Ye, Zhen Dai, Qinghai Wu, Jinguang Liu, Padraig Strappe & Zhongkai Zhou. (2020) Terpenoids of Ganoderma lucidum reverse cognitive impairment through attenuating neurodegeneration via suppression of PI3K/AKT/mTOR expression in vivo model. Journal of Functional Foods 73, pages 104142.
Crossref
Changqin Li, Yiping Cui, Jie Lu, Cunyu Liu, Sitan Chen, Changyang Ma, Zhenhua Liu, Jinmei Wang & Wenyi Kang. (2020) Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum. Molecules 25:6, pages 1309.
Crossref
Henrik E. Poulsen, Allan Weimann, Trine Henriksen, Laura Kofoed Kjær, Emil List Larsen, Elin Rebecka Carlsson, Cramer K. Christensen, Ivan Brandslund & Mogens Fenger. (2019) Oxidatively generated modifications to nucleic acids in vivo: Measurement in urine and plasma. Free Radical Biology and Medicine 145, pages 336-341.
Crossref
Emil List Larsen, Allan Weimann & Henrik Enghusen Poulsen. (2019) Interventions targeted at oxidatively generated modifications of nucleic acids focused on urine and plasma markers. Free Radical Biology and Medicine 145, pages 256-283.
Crossref
Wei-Ting Chang, Zi-Han Gao, Yi-Ching Lo & Sheng-Nan Wu. (2019) Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Ganoderma Triterpenoids, the Main Active Constitutents of Ganoderma Spores. Molecules 24:23, pages 4256.
Crossref
Shuang Zhao, Shuman Zhang, Weiwei Zhang, Yi Gao, Chengbo Rong, Hexiang Wang, Yu Liu, Jack Ho Wong & Tzibun Ng. (2019) First demonstration of protective effects of purified mushroom polysaccharide-peptides against fatty liver injury and the mechanisms involved. Scientific Reports 9:1.
Crossref
Chetan Sharma, Neha Bhardwaj, Anupam Sharma, Hardeep Singh Tuli, Priya Batra, Vikas Beniwal, Girish Kumar Gupta & Anil K. Sharma. (2019) Bioactive metabolites of Ganoderma lucidum: Factors, mechanism and broad spectrum therapeutic potential. Journal of Herbal Medicine 17-18, pages 100268.
Crossref
Ang Ren, Liang Shi, Jing Zhu, Hanshou Yu, Ailiang Jiang, Huihua Zheng & Mingwen Zhao. (2019) Shedding light on the mechanisms underlying the environmental regulation of secondary metabolite ganoderic acid in Ganoderma lucidum using physiological and genetic methods. Fungal Genetics and Biology 128, pages 43-48.
Crossref
Chengyuan Liang, Danni Tian, Yuzhi Liu, Han Li, Jialiang Zhu, Min Li, Minhang Xin & Juan Xia. (2019) Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. European Journal of Medicinal Chemistry 174, pages 130-141.
Crossref
Tianqi Li, Haoran Yu, Yangyang Song, Ruili Zhang & Ming Ge. (2019) Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers. Journal of Trace Elements in Medicine and Biology 52, pages 118-125.
Crossref
Chao Zhao, Jinlin Fan, Yuanyuan Liu, Weiling Guo, Hui Cao, Jianbo Xiao, Ying Wang & Bin Liu. (2019) Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis. Food Chemistry 271, pages 148-156.
Crossref
Zhibin Lin & Aoyi Deng. 2019. Ganoderma and Health. Ganoderma and Health 271 297 .
Xiaoqiang Geng, Dandan Zhong, Limin Su & Baoxue Yang. 2019. Ganoderma and Health. Ganoderma and Health 243 262 .
María Virginia Ozcariz-Fermoselle, Raúl Fraile-Fabero, Tomás Girbés-Juan, Oscar Arce-Cervantes, Juan Andrés Oria de Rueda-Salgueiro & Anabela Marisa Azul. (2018) Use of lignocellulosic wastes of pecan (Carya illinoinensis) in the cultivation of Ganoderma lucidum. Revista Iberoamericana de Micología 35:2, pages 103-109.
Crossref
婕宁 邱. (2018) Hepatoprotective Effects of Ganoderma lucidum on Carbon Tetrachloride-Induced Chronic Liver Disease in Rats. Hans Journal of Food and Nutrition Science 07:02, pages 101-109.
Crossref
Cheng Chen, Qiang Li, Qiangfeng Wang, Daihua Lu, Hong Zhang, Jian Wang & Rongtao Fu. (2017) Transcriptional profiling provides new insights into the role of nitric oxide in enhancing Ganoderma oregonense resistance to heat stress. Scientific Reports 7:1.
Crossref
Robert M. Levin, Li Xia, Wu Wei, Catherine Schuler, Robert E. Leggett & Alpha D.-Y. Lin. (2017) Effects of Ganoderma Lucidum shell-broken spore on oxidative stress of the rabbit urinary bladder using an in vivo model of ischemia/reperfusion. Molecular and Cellular Biochemistry 435:1-2, pages 25-35.
Crossref
Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li & Wei Li. (2017) Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway. Molecular Medicine Reports.
Crossref
Bastian Kochlik, Tilman Grune & Daniela Weber. (2017) New findings of oxidative stress biomarkers in nutritional research. Current Opinion in Clinical Nutrition & Metabolic Care 20:5, pages 349-359.
Crossref
Jia Meng, Ang Ma, Shun Zhang, Shuqian Lin, Dongmei Lin, Min Li, Hong Zhou & Baoxue Yang. (2022) Ganoderma Lucidum Polysaccharide Peptide Attenuates Post Myocardial Infarction Fibrosis Via Down-Regulating TGF-β1/Smad and Relieving Oxidative Stress. SSRN Electronic Journal.
Crossref