2,611
Views
59
CrossRef citations to date
0
Altmetric
Research Article

Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

, , &
Pages 1442-1449 | Received 11 May 2016, Accepted 27 Feb 2017, Published online: 22 Mar 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Gopalsamy Rajiv Gandhi, Varghese Edwin Hillary, Poovathumkal James Antony, Linda L. D. Zhong, Devarajan Yogesh, Neenthamadathil Mohandas Krishnakumar, Stanislaus Antony Ceasar & Ren-You Gan. (2024) A systematic review on anti-diabetic plant essential oil compounds: Dietary sources, effects, molecular mechanisms, and safety. Critical Reviews in Food Science and Nutrition 64:19, pages 6526-6545.
Read now
Emmanuel Ejiofor, Sunday Oyedemi, Chima Egedigwe-Ekeleme, Chiemeziem Obike, Chinedu Aguwamba, Paul Nweje-Anyalowu, Maureen Ejiofor & Oluchi Okwuonu. (2023) Essential oil components with antidiabetic and anti-obesity properties: a review of mechanisms of action and toxicity. Journal of Essential Oil Research 35:4, pages 335-371.
Read now
José Fernando Rinaldi de Alvarenga, Brunna Genaro, Bruna Lamesa Costa, Eduardo Purgatto, Claudine Manach & Jarlei Fiamoncini. (2023) Monoterpenes: current knowledge on food source, metabolism, and health effects. Critical Reviews in Food Science and Nutrition 63:10, pages 1352-1389.
Read now
Hanaa H Ahmed, Hadeer A Aglan, Hanan H Beherei, Mostafa Mabrouk & Nadia S Mahmoud. (2022) The Promising Role of hypoxia-resistant insulin-producing Cells in Ameliorating Diabetes Mellitus In Vivo. Future Science OA 8:7.
Read now
Sachin Sharma, Karan Wadhwa, Manjusha Choudhary & Vikas Budhwar. (2022) Ethnopharmacological perspectives of glucokinase activators in the treatment of diabetes mellitus. Natural Product Research 36:11, pages 2962-2976.
Read now
Maria Helena Pereira de Lira, Francisco Patricio de Andrade Júnior, Gustavo Fernandes Queiroga Moraes, Girlene da Silva Macena, Fillipe de Oliveira Pereira & Igara Oliveira Lima. (2020) Antimicrobial activity of geraniol: an integrative review. Journal of Essential Oil Research 32:3, pages 187-197.
Read now

Articles from other publishers (52)

Asmaa Elebishehy, Mohamed M. Ahmed, Badr Aldahmash, Mostafa Abdelgaber Mohamed, Aya A. Shetaia, Shaden A.M. Khalifa, Mabrouk Attia Abd Eldaim, Hesham R. El-Seedi & Nermeen Yosri. (2024) Cymbopogon schoenanthus (L) extract ameliorates high fat diet-induced obesity and dyslipidemia via reducing expression of lipogenic and thermogenic proteins. Fitoterapia 175, pages 105897.
Crossref
Ye Eun Yoon, Young Jae Jung & Sung-Joon Lee. (2024) The Anticancer Activities of Natural Terpenoids That Inhibit Both Melanoma and Non-Melanoma Skin Cancers. International Journal of Molecular Sciences 25:8, pages 4423.
Crossref
Casper S. Poulsen, Dan Hesse, Gabriel R. Fernandes, Tue H. Hansen, Timo Kern, Allan Linneberg, Lore Van Espen, Torben Jørgensen, Trine Nielsen, Amra C. Alibegovic, Jelle Matthijnssens, Oluf Pedersen, Henrik Vestergaard, Torben Hansen & Mette K. Andersen. (2024) Characterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults. Scientific Reports 14:1.
Crossref
Raffaella Cancello. 2024. Whole-Body Cryostimulation. Whole-Body Cryostimulation 93 108 .
Shushmita Chand, Alok Shiomurti Tripathi, Tabinda Hasan, Kavitha Ganesh, Mary Anne W. Cordero, Mohammad Yasir, Magdi E. A. Zaki, Pankaj Tripathi, Lucy Mohapatra & Rahul Kumar Maurya. (2023) Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase. Nutrition & Diabetes 13:1.
Crossref
Leonardo da Rocha Sousa, Nildomar Ribeiro Viana, Angélica Gomes Coêlho, Celma de Oliveira Barbosa, Débora Santos Lula Barros, Maria do Carmo de Carvalho e Martins, Ricardo Martins Ramos & Daniel Dias Rufino Arcanjo. (2023) Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review. Advances in Pharmacological and Pharmaceutical Sciences 2023, pages 1-21.
Crossref
Tolulope A. Oyedeji, Holiness SA. Olasore, Abimbola K. Oluwole-Banjo, Josiah A. Isong, Blessing O. David, Comfort Ekpere, Omofolarin O. Ilesanmi, Daniella G. Madu & Clementina Matthew. (2023) Geraniol ameliorates testicular damage in diabetic rats via inhibition of redox parameters and mitochondrial-mediated apoptosis. Pharmacological Research - Modern Chinese Medicine 8, pages 100268.
Crossref
R. Mata, L. Flores-Bocanegra, B. Ovalle-Magallanes & M. Figueroa. (2023) Natural products from plants targeting key enzymes for the future development of antidiabetic agents. Natural Product Reports 40:7, pages 1198-1249.
Crossref
Rebai Ben Ammar. (2023) Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings. Molecules 28:9, pages 3669.
Crossref
Seren Danış, Senanur Can, Fatma Yıldız, Işıl Tan Yılmaz, Mediha Canbek & Ayşe Özmen Yaylacı. (2023) The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats. Brazilian Journal of Pharmaceutical Sciences 59.
Crossref
Sergey Kuranov, Mariya Marenina, Dmitriy Ivankin, Mikhail Blokhin, Sergey Borisov, Tatyana Khomenko, Olga Luzina, Mikhail Khvostov, Konstantin Volcho, Tatyana Tolstikova & Nariman Salakhutdinov. (2022) The Study of Hypoglycemic Activity of 7-Terpenylcoumarins. Molecules 27:24, pages 8663.
Crossref
Esmaeel Ghasemi-Gojani, Igor Kovalchuk & Olga Kovalchuk. (2022) Cannabinoids and terpenes for diabetes mellitus and its complications: from mechanisms to new therapies. Trends in Endocrinology & Metabolism 33:12, pages 828-849.
Crossref
Xiaolin Feng, Kexin Feng, Qinhua Zheng, Weijian Tan, Wenting Zhong, Caiyu Liao, Yuntong Liu, Shangjian Li & Wenzhong Hu. (2022) Preparation and characterization of geraniol nanoemulsions and its antibacterial activity. Frontiers in Microbiology 13.
Crossref
Eman Fawzy El Azab & Shaymaa Abdulmalek. (2022) Amelioration of Age-Related Multiple Neuronal Impairments and Inflammation in High-Fat Diet-Fed Rats: The Prospective Multitargets of Geraniol. Oxidative Medicine and Cellular Longevity 2022, pages 1-38.
Crossref
Inah Gu, Luke Howard & Sun-Ok Lee. (2022) Volatiles in Berries: Biosynthesis, Composition, Bioavailability, and Health Benefits. Applied Sciences 12:20, pages 10238.
Crossref
Bruno N. Paulino, Gloria N.S. Silva, Fábio F. Araújo, Iramaia A. Néri-Numa, Gláucia M. Pastore, Juliano L. Bicas & Gustavo Molina. (2022) Beyond natural aromas: The bioactive and technological potential of monoterpenes. Trends in Food Science & Technology 128, pages 188-201.
Crossref
Liang Wei, Huiying Yang, Hui Li, Minghua Zhu, Shengcheng Mi, Qi Lu, Mengran Liu & Yuangang Zu. (2022) Comparison of chemical composition and activities of essential oils from fresh leaves of Pelargonium graveolens L′Herit. extracted by hydrodistillation and enzymatic pretreatment combined with a solvent-free microwave extraction method. Industrial Crops and Products 186, pages 115204.
Crossref
Eman Fawzy El Azab & Heba Sayed Mostafa. (2022) Geraniol ameliorates the progression of high fat‐diet/streptozotocin‐induced type 2 diabetes mellitus in rats via regulation of caspase‐3, Bcl‐2, and Bax expression. Journal of Food Biochemistry 46:7.
Crossref
Rafael Chelala Moreira, Kele A.C. Vespermann, Gustavo Molina, Juliano Lemos Bicas & Mario Roberto Marostica Junior. 2022. Biomolecules from Natural Sources. Biomolecules from Natural Sources 362 389 .
Rajeev K. Singla, Vivek Dhir, Reecha Madaan, Deepak Kumar, Simranjit Singh Bola, Monika Bansal, Suresh Kumar, Ankit Kumar Dubey, Shailja Singla & Bairong Shen. (2022) The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives. Frontiers in Pharmacology 13.
Crossref
Naoual El Menyiy, Nasreddine El Omari, Abdelaali Balahbib, Taoufiq Benali, Fatima-Ezzahrae Guaouguaou, Saoulajan Charfi & Abdelhakim Bouyahya. 2022. Herbal Biomolecules in Healthcare Applications. Herbal Biomolecules in Healthcare Applications 313 361 .
Negin Eskandari, Seifollah Bahramikia, Abdelnasser Mohammadi, Majid Taati & Saba Safari Jafarabad. (2021) Geraniol ameliorated serum lipid profile and improved antioxidant defense system in pancreas, liver and heart tissues of alloxan-induced diabetic rats. Biologia 77:1, pages 241-248.
Crossref
Biswanath Dinda, Subhajit Dinda & Mithun Chakraborty. 2022. Natural Products in Obesity and Diabetes. Natural Products in Obesity and Diabetes 277 467 .
Lina T. Al Kury, Aya Abdoh, Kamel Ikbariah, Bassem Sadek & Mohamed Mahgoub. (2021) In Vitro and In Vivo Antidiabetic Potential of Monoterpenoids: An Update. Molecules 27:1, pages 182.
Crossref
Abdelhakim Bouyahya, Nasreddine El Omari, Naoual Elmenyiy, Fatima-Ezzahrae Guaouguaou, Abdelaali Balahbib, Omar Belmehdi, Najoua Salhi, Hamada Imtara, Hanae Naceiri Mrabti, Mohamed El-Shazly & Youssef Bakri. (2021) Moroccan antidiabetic medicinal plants: Ethnobotanical studies, phytochemical bioactive compounds, preclinical investigations, toxicological validations and clinical evidences; challenges, guidance and perspectives for future management of diabetes worldwide. Trends in Food Science & Technology 115, pages 147-254.
Crossref
Monica Santin Zanatta Schindler, Jean Felipe Fossá Calisto, Katiuska Marins, Alissara Regginato, Hemilli Mezzomo, Ana Paula Zanatta, Andre Luiz Radunz, Márcio Paim Mariot, Jacir Dal Magro & Leila Zanatta. (2021) Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats. Journal of Ethnopharmacology 276, pages 114173.
Crossref
Hongwei Yang, Guanghui Liu, Hongchao Zhao, Xinhua Dong & Zhen Yang. (2021) Inhibiting the JNK/ERK signaling pathway with geraniol for attenuating the proliferation of human gastric adenocarcinoma AGS cells. Journal of Biochemical and Molecular Toxicology 35:8.
Crossref
Ana Carolina Cardoso-Teixeira, Klausen Oliveira-Abreu, Levy Gabriel de Freitas Brito, Andrelina Noronha Coelho-de-Souza & José Henrique Leal-Cardoso. 2021. Terpenes and Terpenoids - Recent Advances. Terpenes and Terpenoids - Recent Advances.
Sabiha Farooq, Sobia Rana, Amna Jabbar Siddiqui, Ayesha Iqbal & Syed Ghulam Musharraf. (2021) Association of metabolites with obesity based on two gene variants, MC4R rs17782313 and BDNF rs6265. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:7, pages 166144.
Crossref
Ping Xu, Juan Xiao & Shuixia Chi. (2021) Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT‐2/4 and AKT signaling pathway in streptozotocin‐induced diabetic rats. Journal of Biochemical and Molecular Toxicology 35:6, pages 1-12.
Crossref
Anna Drzazga, Daria Kamińska, Anna Gliszczyńska & Edyta Gendaszewska-Darmach. (2021) Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs. International Journal of Molecular Sciences 22:11, pages 5748.
Crossref
Prateek Sharma, Sukhbir Singh, Vinay Thakur, Neelam Sharma & Ajmer Singh Grewal. (2021) Novel and emerging therapeutic drug targets for management of type 2 Diabetes Mellitus. Obesity Medicine 23, pages 100329.
Crossref
Deepak Kumar Semwal, Ankit Kumar, Sonali Aswal, Ashutosh Chauhan & Ruchi Badoni Semwal. (2020) Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreatic β ‐cells and restoring their dysfunction . Phytotherapy Research 35:3, pages 1218-1229.
Crossref
Catarina Andrade, Nelson G.M. Gomes, Sutsawat Duangsrisai, Paula B. Andrade, David M. Pereira & Patrícia Valentão. (2020) Medicinal plants utilized in Thai Traditional Medicine for diabetes treatment: Ethnobotanical surveys, scientific evidence and phytochemicals. Journal of Ethnopharmacology 263, pages 113177.
Crossref
Yasmin Ahmed Mohamed El-Said, Nada Abdelmoneim Abdelhalium Sallam, Afaf Abdel-Moniem Ain-Shoka & Hekma Abdel-Tawab Abdel-Latif. (2020) Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats. Naunyn-Schmiedeberg's Archives of Pharmacology 393:12, pages 2325-2337.
Crossref
Guoxin Ji, Rong Sun, Haiyan Hu, Fengsen Xu, Xinjuan Yu, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan & Xiaoyan Chi. (2020) Vannilic acid ameliorates hyperglycemia-induced oxidative stress and inflammation in streptozotocin-induced diabetic rats. Journal of King Saud University - Science 32:7, pages 2905-2911.
Crossref
Suganya Murugesu, Vikneswari Perumal, Tavamani Balan, Sharon Fatinanthan, Alfi Khatib, Norfarahanum Juhar Arifin, Nur Syafiqah Salma Mohd Shukri, Mohammed S.M. Saleh & Lee Wing Hin. (2020) The investigation of antioxidant and antidiabetic activities of Christia vespertilionis leaves extracts. South African Journal of Botany 133, pages 227-235.
Crossref
Simona Codruta Heghes, Lorena Filip, Oliviu Vostinaru, Cristina Mogosan, Doina Miere, Cristina Adela Iuga & Mirela Moldovan. (2020) Essential Oil-Bearing Plants From Balkan Peninsula: Promising Sources for New Drug Candidates for the Prevention and Treatment of Diabetes Mellitus and Dyslipidemia. Frontiers in Pharmacology 11.
Crossref
Irrum Mushtaq, Iram Mushtaq, Zareen Akhter, Iram Murtaza, Samina Qamar, Sidra Ayub, Bushra Mirza, Tehmeena Maryum Butt, Naveed Kausar Janjua, Faiz Ullah Shah & Farasat Zaman. (2020) Engineering electroactive and biocompatible tetra(aniline)-based terpolymers with tunable intrinsic antioxidant properties in vivo. Materials Science and Engineering: C 108, pages 110456.
Crossref
Snehalata Prakash Kamble, Varsha Adhikrao Ghadyale, Rahul Shivaji Patil, Vivek Sudhakar Haldavnekar & Akalpita Umesh Arvindekar. (2020) Inhibition of GLUT2 transporter by geraniol from Cymbopogon martinii : a novel treatment for diabetes mellitus in streptozotocin-induced diabetic rats . Journal of Pharmacy and Pharmacology 72:2, pages 294-304.
Crossref
Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohammadinejad, Nasim Kaviyani & Shima Tavakol. (2019) Monoterpenes modulating autophagy: A review study. Basic & Clinical Pharmacology & Toxicology 126:1, pages 9-20.
Crossref
Bibi Sharmeen Jugreet & Mohamad Fawzi Mahomoodally. 2020. Plant-derived Bioactives. Plant-derived Bioactives 387 415 .
İlker Demirbolat, Cansu Ekinci, Fadime Nuhoğlu, Murat Kartal, Pelin Yıldız & Melin Özgün Geçer. (2019) Effects of Orally Consumed Rosa damascena Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats. Molecules 24:22, pages 4069.
Crossref
Georgia-Eirini Deligiannidou, Elena Philippou, Melita Vidakovic, Wim V. Berghe, Alexandros Heraclides, Nevena Grdovic, Mirjana Mihailovic & Christos Kontogiorgis. (2019) Natural Products Derived from the Mediterranean Diet with Antidiabetic Activity: from Insulin Mimetic Hypoglycemic to Nutriepigenetic Modulator Compounds. Current Pharmaceutical Design 25:15, pages 1760-1782.
Crossref
Felipe Zecchinati, Maria Manuela Barranco, Maite Rocío Arana, Guillermo Nicolás Tocchetti, Camila Juliana Domínguez, Virginia Gabriela Perdomo, María Laura Ruiz, Aldo Domingo Mottino, Fabiana García & Silvina Stella Maris Villanueva. (2019) Reversion of down-regulation of intestinal multidrug resistance-associated protein 2 in fructose-fed rats by geraniol and vitamin C: Potential role of inflammatory response and oxidative stress. The Journal of Nutritional Biochemistry 68, pages 7-15.
Crossref
Muthukumaran Jayachandran, Ziyuan Wu, Kumar Ganesan, Sumbul Khalid, S.M. Chung & Baojun Xu. (2019) Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats. Chemico-Biological Interactions 303, pages 62-69.
Crossref
Xue Yuan, Dong Dong, Zhijie Li & Baojian Wu. (2019) Rev-erbα activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice. Pharmacological Research 141, pages 310-318.
Crossref
Zhao Qin, Kun Feng, Wen-shu Wang, Wen-zhao Wang, Yun-jie Wang, Jin-lan Lu, Er-wei Li, Shu-bin Niu & Yu-guo Jiao. (2018) Comparative study on the essential oils of six Hawk tea (Litsea coreana Levl. var. lanuginosa) from China: Yields, chemical compositions and biological activities. Industrial Crops and Products 124, pages 126-135.
Crossref
Tarmo Nuutinen. (2018) Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus. European Journal of Medicinal Chemistry 157, pages 198-228.
Crossref
Lina Xu, Yue Li, Yan Dai & Jinyong Peng. (2018) Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms. Pharmacological Research 130, pages 451-465.
Crossref
Solomon Habtemariam. (2017) Antidiabetic Potential of Monoterpenes: A Case of Small Molecules Punching above Their Weight. International Journal of Molecular Sciences 19:1, pages 4.
Crossref
Kodikonda Madhuri & Prakash Ramachandra Naik. (2017) Ameliorative effect of borneol, a natural bicyclic monoterpene against hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic Wistar rats. Biomedicine & Pharmacotherapy 96, pages 336-347.
Crossref