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Pharmaceutical Biology Volume 55, 2017 - Issue 1
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Research Article

Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression

Manoela Viar Fogaçaa Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil;
,
Priscila de Matos Cândido-Bacania Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil; Correspondence[email protected]
,
Lucas Milanez Benicioa Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil;
,
Lara Martinelli Zapataa Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil;
,
Priscilla de Freitas Cardosoa Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil;
,
Marcelo Tempesta de Oliveiraa Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil;
,
Tamara Regina Calvob Araraquara Institute of Chemistry, São Paulo State University, Araraquara, Brazil;
,
Eliana Aparecida Varandac Araraquara Faculty of Pharmaceutical Sciences, Department of Biological Sciences, São Paulo State University, Araraquara, Brazil;
,
Wagner Vilegasb Araraquara Institute of Chemistry, São Paulo State University, Araraquara, Brazil; ;d Experimental Campus of the Paulista Coast, São Paulo State University, São Vicente, Brazil
&
Ilce Mara de Syllos Cólusa Department of General Biology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil;
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Pages 2005-2014 | Received 15 Feb 2016, Accepted 06 Jul 2017, Published online: 25 Jul 2017

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Gerciane Silva de Oliveira, Amanda Maria de Souza Nascimento, Anna Beatriz Santana Luz, Ana Júlia Felipe Camelo Aguiar, Mayara Santa Rosa Lima, Lídia Leonize Rodrigues Matias, Isabel Rodríguez Amado, Thais Souza Passos, Karla Suzane Florentino da Silva Chaves Damasceno, Norberto de Kássio Vieira Monteiro, Susana Margarida Gomes Moreira, Lorenzo Pastrana & Ana Heloneida de Araújo Morais. (2023) Prospecting in silico antibacterial activity of a peptide from trypsin inhibitor isolated from tamarind seed. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 67-83.
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Articles from other publishers (9)

Jean Fotie, Caitlyn M. Matherne, Jasmine B. Mather, Jordan E. Wroblewski, Khaitlynn Johnson, Lara G. Boudreaux & Alba A. Perez. (2023) The Fundamental Role of Oxime and Oxime Ether Moieties in Improving the Physicochemical and Anticancer Properties of Structurally Diverse Scaffolds. International Journal of Molecular Sciences 24:23, pages 16854.
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Lin Yang, Xinyun Li, Wei Huang, Xiangshu Rao & Yu Lai. (2022) Pharmacological properties of indirubin and its derivatives. Biomedicine & Pharmacotherapy 151, pages 113112.
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Iffah Syazana Rusli, Norazlinaliza Salim, Nur Hana Faujan, Nur Kartinee Kassim & Mohd Basyaruddin Abd Rahman. (2022) Phytochemical investigation and cytotoxicity study of Indigofera zollingeriana crude extract. Materials Today: Proceedings 60, pages 1074-1081.
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Hezhen Wang, Zhiyuan Wang, Chunyong Wei, Jing Wang, Yingshu Xu, Guohui Bai, Qizheng Yao, Lei Zhang & Yongzheng Chen. (2021) Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship. European Journal of Medicinal Chemistry 223, pages 113652.
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Christophe Wiart. 2021. Medicinal Plants in Asia and Pacific for Parasitic Infections. Medicinal Plants in Asia and Pacific for Parasitic Infections 121 232 .
Alexei Medvedev, Arthur Kopylov, Olga Buneeva, Leonid Kurbatov, Olga Tikhonova, Alexis Ivanov & Victor Zgoda. (2020) A Neuroprotective Dose of Isatin Causes Multilevel Changes Involving the Brain Proteome: Prospects for Further Research. International Journal of Molecular Sciences 21:11, pages 4187.
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Elise Gerometta, Isabelle Grondin, Jacqueline Smadja, Michel Frederich & Anne Gauvin-Bialecki. (2020) A review of traditional uses, phytochemistry and pharmacology of the genus Indigofera. Journal of Ethnopharmacology 253, pages 112608.
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Alpana K. Gupta, Sonam Tulsyan, Mausumi Bharadwaj & Ravi Mehrotra. (2019) Systematic Review on Cytotoxic and Anticancer Potential of N-Substituted Isatins as Novel Class of Compounds Useful in Multidrug-Resistant Cancer Therapy: In Silico and In Vitro Analysis. Topics in Current Chemistry 377:3.
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Alexei Medvedev, Olga Buneeva, Oksana Gnedenko, Pavel Ershov & Alexis Ivanov. (2018) Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications. BioFactors 44:2, pages 95-108.
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