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Research Article

In vivo protective effects of chlorogenic acid against triptolide-induced hepatotoxicity and its mechanism

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Pages 626-631 | Received 27 Jun 2018, Accepted 14 Sep 2018, Published online: 17 Dec 2018

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Elif Ayazoglu Demir, Ahmet Mentese, Ayten Livaoglu, Nihal Turkmen Alemdar, Yuksel Aliyazicioglu & Selim Demir. (2023) Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats. Drug and Chemical Toxicology 0:0, pages 1-5.
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Ayimukedisi Yalikong, Xu-Quan Li, Ping-Hong Zhou, Zhi-Peng Qi, Bing Li, Shi-Lun Cai & Yun-Shi Zhong. (2021) A Triptolide Loaded HER2-Targeted Nano-Drug Delivery System Significantly Suppressed the Proliferation of HER2-Positive and BRAF Mutant Colon Cancer. International Journal of Nanomedicine 16, pages 2323-2335.
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Articles from other publishers (16)

Haoyu Xue, Mengjuan Wei & Lili Ji. (2023) Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects. Phytomedicine 118, pages 154961.
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Zhiwei Li, Yawen Wang, Jun Liu, Dan Chen, Guilan Feng, Min Chen, Yuxi Feng, Ran Zhang & Xuebing Yan. (2023) The potential role of alfalfa polysaccharides and their sulphated derivatives in the alleviation of obesity. Food & Function 14:16, pages 7586-7602.
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Xiaohui Wu, Junming Wang, Bingyin Li, Mingzhu Gong, Can Cao, Lingling Song, Lingyu Qin, Yanmei Wang, Yueyue Zhang & Yamin Li. (2023) Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and apoptosis. Toxicology and Applied Pharmacology 467, pages 116479.
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Shiyuan Jiang, Feng Wan, Hui Lian, Zhihao Lu, Xueming Li, Dan Cao, Yangyu Jiang & Jian Li. (2023) Friend or foe? The dual role of triptolide in the liver, kidney, and heart. Biomedicine & Pharmacotherapy 161, pages 114470.
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Yeqing Hu, Qiguo Wu, Yulin Wang, Haibo Zhang, Xueying Liu, Hua Zhou & Tao Yang. (2022) The molecular pathogenesis of triptolide-induced hepatotoxicity. Frontiers in Pharmacology 13.
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Xin Yin, Xingkang He, Lingyun Wu, Danfang Yan & Senxiang Yan. (2022) Chlorogenic Acid, the Main Antioxidant in Coffee, Reduces Radiation-Induced Apoptosis and DNA Damage via NF-E2-Related Factor 2 (Nrf2) Activation in Hepatocellular Carcinoma. Oxidative Medicine and Cellular Longevity 2022, pages 1-14.
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Min Yan, Yinyin Yan, Zhenqiang Zhang, Guoqiang Wang, Wenbo Shi, Mengyuan Jiang, Junwei Zhao, Xiangxiang Wu & Huahui Zeng. (2022) The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy. Frontiers in Pharmacology 13.
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Zhiwen Cao, Bin Liu, Li Li, Peipei Lu, Lan Yan & Cheng Lu. (2022) Detoxification strategies of triptolide based on drug combinations and targeted delivery methods. Toxicology 469, pages 153134.
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Tao Yang, Yu-Lin Wang, Ya-Lei Zhang, Yu-Ting Liu, Yan-Yan Tao, Hua Zhou & Cheng-Hai Liu. (2022) The protective effect of Capparis spinosa fruit on triptolide-induced acute liver injury: A metabolomics-based systematic study. Journal of Functional Foods 90, pages 104989.
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Kyung-Ha Lee, Hwan-Kwon Do, Do-Yeon Kim & Wanil Kim. (2021) Impact of chlorogenic acid on modulation of significant genes in dermal fibroblasts and epidermal keratinocytes. Biochemical and Biophysical Research Communications 583, pages 22-28.
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Zahra Changizi, Azam Moslehi, Ali Haeri Rohani & Akram Eidi. (2020) Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl‐2, and caspase‐3 signaling pathways in BALB/c mice. Journal of Biochemical and Molecular Toxicology 35:2.
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Johanna C. Arroyave-Ospina, Zongmei Wu, Yana Geng & Han Moshage. (2021) Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy. Antioxidants 10:2, pages 174.
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Mohy E. Abdel Fattah, Hanan M. Sobhy, Areeg Reda & Heba M. A. Abdelrazek. (2020) Hepatoprotective effect of Moringa oleifera leaves aquatic extract against lead acetate–induced liver injury in male Wistar rats. Environmental Science and Pollution Research 27:34, pages 43028-43043.
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Diego dos S. Baião, Davi V. T. da Silva & Vania M. F. Paschoalin. (2020) Beetroot, A Remarkable Vegetable: Its Nitrate and Phytochemical Contents Can be Adjusted in Novel Formulations to Benefit Health and Support Cardiovascular Disease Therapies. Antioxidants 9:10, pages 960.
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