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Pharmaceutical Biology Volume 59, 2021 - Issue 1
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Research Article

Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism

Haihua Shanga School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China;b State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, ChinaORCID Iconhttps://orcid.org/0000-0001-5726-8807View further author information
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Ze Wangb State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China;c College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaView further author information
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Hong Mab State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, ChinaView further author information
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Yinghui Sunb State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, ChinaView further author information
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Xiaoyan Cib State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, ChinaView further author information
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Yuan Gub State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China;d Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Tianjin, ChinaView further author information
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Changxiao Liua School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China;b State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, ChinaCorrespondence[email protected]
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Duanyun Sib State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China;d Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Tianjin, ChinaCorrespondence[email protected]
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Pages 198-206 | Received 05 Aug 2020, Accepted 30 Dec 2020, Published online: 17 Feb 2021

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Xin Xu, Xi-yang Sun, Ming Chang, Zhao-liang Hu, Ting-ting Cheng, Tai-jun Hang & Min Song. (2023) Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer. Pharmaceutical Biology 61:1, pages 1298-1309.
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Articles from other publishers (5)

Md. Shimul Bhuia, Raihan Chowdhury, Fatema Akter Sonia, Shrabonti Biswas, Jannatul Ferdous, Heba A. S. El‐Nashar, Mohamed El‐Shazly & Muhammad Torequl Islam. (2024) Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study. Chemistry & Biodiversity 21:2.
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Dongyun Tang, Taiwei Ye, Xiuping Chen, Jun Yang & Yan Xie. (2023) Transepithelial transport characteristics of Hydroxysafflor yellow A across cellular monolayers and the effects of the influx and efflux transporters. Food Bioscience 55, pages 103037.
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Lvying Wu, Lei Xing, Yake Zou, Zichen Wang, Yuanyuan Gou, Lei Zhang & Su Guan. (2022) UPLC-QTOF-MS Based Comparison of Rotundic Acid Metabolic Profiles in Normal and NAFLD Rats. Metabolites 13:1, pages 38.
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Haihua Shang, Yinghui Sun, Ze Wang, Ying Zhou, Huajiao Yang, Xiaoyan Ci, Tao Cui, Yuanyuan Xia, Yuan Gu, Maoliang Liao, Quansheng Li, Duanyun Si & Changxiao Liu. (2022) Intestinal absorption mechanism of rotundic acid: Involvement of P-gp and OATP2B1. Journal of Ethnopharmacology 289, pages 115006.
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Lvying Wu, Lei Xing, Yake Zou, Zichen Wang, Yuanyuan Li, Lei Zhang & Su Guan. (2022) UPLC-QTOF-MS Based Comparison of Rotundic Acid Metabolic Profiles in Normal and NAFLD Rats. SSRN Electronic Journal.
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