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Pharmaceutical Biology Volume 59, 2021 - Issue 1
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Research Article

The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial

Zhong-Ping Goua Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Yun-Li Zhaob State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China;c Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of ChinaView further author information
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Lin-Ling Zoua Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Ying Wanga Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Shi-Qing Shua Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Xiao-Hong Zhua Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Li Zhenga Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Qi Shena Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Zhu Luoa Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Jia Miaoa Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Yong-Sheng Wanga Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaView further author information
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Xiao-Dong Luob State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China;c Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of ChinaCorrespondence[email protected]
View further author information
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Ping Fenga Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 482-491 | Received 10 Dec 2020, Accepted 16 Feb 2021, Published online: 26 Apr 2021

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