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Pharmaceutical Biology Volume 59, 2021 - Issue 1
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Research Article

Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation

Yueming Zhanga Department of Pharmacy, the First Hospital of Jilin University, Changchun, ChinaView further author information
,
Jian Changb Department of Pediatric Oncology, the First Hospital of Jilin University, Changchun, ChinaView further author information
,
Huan Gaoa Department of Pharmacy, the First Hospital of Jilin University, Changchun, ChinaView further author information
,
Xiaoyu Qua Department of Pharmacy, the First Hospital of Jilin University, Changchun, ChinaORCID Iconhttps://orcid.org/0000-0003-1685-6914View further author information
ORCID Icon,
Jinghui Zhaia Department of Pharmacy, the First Hospital of Jilin University, Changchun, ChinaView further author information
,
Lina Taoa Department of Pharmacy, the First Hospital of Jilin University, Changchun, ChinaView further author information
,
Jingmeng Suna Department of Pharmacy, the First Hospital of Jilin University, Changchun, ChinaView further author information
&
Yanqing Songa Department of Pharmacy, the First Hospital of Jilin University, Changchun, ChinaCorrespondence[email protected]
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Pages 1423-1429 | Received 24 Mar 2021, Accepted 26 Sep 2021, Published online: 25 Oct 2021

Citations (9)

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Ashif Iqubal, Abul Kalam Najmi, Shadab Md, Huda Mohammed Alkreathy, Javed Ali, Mansoor Ali Syed & Syed Ehtaishamul Haque. (2023) Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules. Drug Delivery 30:1.
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Articles from other publishers (8)

Junwei Wang, Guiqiao Ma, Peipei Zhang, Chaojing Ma, Jing Shao, Liping Wang & Chanjuan Ma. (2023) Mechanism of Huaiqihuang in treatment of diabetic kidney disease based on network pharmacology, molecular docking and in vitro experiment. Medicine 102:50, pages e36177.
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Huiyue Chen, Jiayu Deng, Huan Gao, Yanqing Song, Yueming Zhang, Jingmeng Sun & Jinghui Zhai. (2023) Involvement of the SIRT1-NLRP3 pathway in the inflammatory response. Cell Communication and Signaling 21:1.
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Hongrong Long & Zhongcai Wu. (2023) Immunoregulatory effects of Huaier (Trametes robiniophila Murr) and relevant clinical applications. Frontiers in Immunology 14.
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Ola S. Mohamed, Nayira A. Abdel Baky, Mohamed M. Sayed-Ahmed & Aya H. Al-Najjar. (2023) Lactoferrin alleviates cyclophosphamide induced-nephropathy through suppressing the orchestration between Wnt4/β-catenin and ERK1/2/NF-κB signaling and modulating klotho and Nrf2/HO-1 pathway. Life Sciences 319, pages 121528.
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Tuba Ozcan Metin, Ahmet Turk, Alper Yalcın & Ilkay Adanır. (2023) Anti-inflammatory and anti-apoptotic potential of beta-glucan on chemotherapy-induced nephrotoxicity in rats. Journal of Surgery and Medicine 7:1, pages 35-39.
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Qingqing Liu, Jiahua Liu, Yaya Du, Weiyan Guo, Jie Mi & Yanyan Guo. (2022) Network Pharmacology and Molecular Docking Analysis to Explore the Mechanism of Huaiqihuang-Mediated Alleviation of Henoch–Schönlein Purpura Nephritis. BioMed Research International 2022, pages 1-13.
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Lijuan Zhu, Chenxi Luo, Chaoyang Ma, Li Kong, You Huang, Wenjiang Yang, Chunlin Huang, Weiwei Jiang & Jine Yi. (2022) Inhibition of the NF-κB pathway and ERK-mediated mitochondrial apoptotic pathway takes part in the mitigative effect of betulinic acid on inflammation and oxidative stress in cyclophosphamide-triggered renal damage of mice. Ecotoxicology and Environmental Safety 246, pages 114150.
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Muluken Altaye Ayza, Kaleab Alemayehu Zewdie, Elias Fitsum Yigzaw, Solomon Gashaw Ayele, Bekalu Amare Tesfaye, Gebrehiwot Gebremedhin Tafere & Muzey Gebreyohannes Abrha. (2022) Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity. International Journal of Nephrology 2022, pages 1-12.
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