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Pharmaceutical Biology Volume 59, 2021 - Issue 1
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Research Article

In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model

Aline de Sousa Barbosa Freitas Pereiraa Post-Graduation Program in Oral Science, Department of Dentistry, UFRN, Natal, BrazilView further author information
,
Maria Laura de Souza Limaa Post-Graduation Program in Oral Science, Department of Dentistry, UFRN, Natal, BrazilView further author information
,
Arnobio Antonio da Silva-Juniorb Postgraduate Program in Pharmaceutical Science, Federal University of Rio Grande do Norte, Natal, BrazilView further author information
,
Emanuell dos Santos Silvab Postgraduate Program in Pharmaceutical Science, Federal University of Rio Grande do Norte, Natal, BrazilORCID Iconhttps://orcid.org/0000-0002-9849-4496View further author information
ORCID Icon,
Raimundo Fernandes de Araújo Júniorc Post-Graduation program in Functional and Structural Biology/Post-graduation program Health Science/Department of Morphology, UFRN, Natal, BrazilORCID Iconhttps://orcid.org/0000-0003-2349-2354View further author information
ORCID Icon,
Agnes Andrade Martinsd Department of Dentistry, UFRN, Natal, BrazilView further author information
,
Jovelina Samara Ferreira Alvese Drug Quality Control Laboratory (LCQMed), Department of Pharmacy, UFRN, Natal, BrazilView further author information
,
Artur de Santana Oliveirae Drug Quality Control Laboratory (LCQMed), Department of Pharmacy, UFRN, Natal, BrazilView further author information
,
Leandro De Santis Ferreirae Drug Quality Control Laboratory (LCQMed), Department of Pharmacy, UFRN, Natal, BrazilORCID Iconhttps://orcid.org/0000-0002-8408-5886View further author information
ORCID Icon,
Emily Cintia Tossi de Araújo Costaf Institute of Chemistry, UFRN, Natal, BrazilView further author information
,
Gerlane Coelho Bernardo Guerrag Post-Graduation Program in Biochemistry and Molecular Biology/Post-Graduation Program in Pharmaceutical Science, Department of Biophysics and Pharmacology, UFRN, Natal, BrazilView further author information
,
Caroline Addison Carvalho Xavier de Medeirosh Post-Graduation Program in Biochemistry and Molecular Biology/Post-Graduation Program in RENORBIO, Department of Biophysics and Pharmacology, UFRN, Natal, BrazilView further author information
,
Gerly A. C. Britoi Postgraduate Program in Pharmacology, Postgraduate Program in Morphology, Department of Morphology, UFC, Fortaleza, BrazilView further author information
,
Renata Ferreira de Carvalho Leitaoj Postgraduate Program in Morphology, Department of Morphology, UFC, Fortaleza, BrazilView further author information
&
Aurigena Antunes de Araújok Post-Graduation Program Oral Science/Post-Graduation Program in Pharmaceutical Science, Department of Biophysics and Pharmacology, UFRN, Natal, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9264-4695View further author information
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Pages 1574-1582 | Received 02 Jul 2021, Accepted 29 Oct 2021, Published online: 22 Nov 2021

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Amina Alam Kotha, Shihab Uddin Ahmad, Irin Dewan, Mohiuddin Ahmed Bhuiyan, Fahad Imtiaz Rahman, Isa Naina Mohamed & Md Selim Reza. (2023) Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design. Drug Design, Development and Therapy 17, pages 3661-3684.
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Articles from other publishers (5)

Ubaldo de Jesús Martín-Camacho, Noé Rodríguez-Barajas, Jorge Alberto Sánchez-Burgos & Alejandro Pérez-Larios. (2023) Weibull β value for the discernment of drug release mechanism of PLGA particles. International Journal of Pharmaceutics 640, pages 123017.
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Leela Subhashini C. Alluri, Kristen Puckett, Chethan Sampath, David A. Mott, Kaitlyn Logan, Jazmyne Walker, Gerald Davis, Cherae Farmer-Dixon & Pandu R. Gangula. 2023. Periodontology - New Insights. Periodontology - New Insights.
Shafaat Husain Talib, Umar Quadri, Sachin Patel & Pranita Barapatre. 2023. Metformin - A Prospective Alternative for the Treatment of Chronic Diseases. Metformin - A Prospective Alternative for the Treatment of Chronic Diseases.
YUTTANA SUDJAROEN, KANITTADA THONGKAO & PIMPORN THONGMUANG. (2023) A PHYSIOCHEMICAL STUDY ON DRUG DELIVERY OF METFORMIN HCL-LOADED CS-PLGA NANOPARTICLES. International Journal of Applied Pharmaceutics, pages 66-71.
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Hongnian Wu, Dan Huang, Hong Zhou, Xueqin Sima, Zhe Wu, Yanling Sun, Long Wang, Ying Ruan, Qian Wu, Feng Wu, Tonghui She, Ying Chu, Qizhi Huang, Zhifeng Ning & Hao Zhang. (2022) Metformin: A promising drug for human cancers (Review). Oncology Letters 24:1.
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