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Modern Rheumatology Volume 29, 2019 - Issue 6
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Original Articles: Rheumatoid Arthritis

Peptidyl arginine deiminase inhibition suppresses arthritis via decreased protein citrullination in joints and serum with the downregulation of interleukin-6

Hoshimi KawaguchiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Isao MatsumotoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Correspondence[email protected]
View further author information
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Atsumu OsadaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Izumi KurataDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Hiroshi EbeDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Yuki TanakaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
,
Asuka InoueDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Naoto UmedaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Yuya KondoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Hiroto TsuboiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
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Akihito IshigamiMolecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanView further author information
&
Takayuki SumidaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; View further author information
 show all
Pages 964-969 | Received 27 Jul 2018, Accepted 25 Sep 2018, Published online: 08 Jan 2019

Citations (15)

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Ylke Bruggeman, Fernanda M.C. Sodré, Mijke Buitinga, Chantal Mathieu, Lut Overbergh & Maria J.L. Kracht. (2021) Targeting citrullination in autoimmunity: insights learned from preclinical mouse models. Expert Opinion on Therapeutic Targets 25:4, pages 269-281.
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Laura Martinez-Prat, Boaz Palterer, Gianfranco Vitiello, Paola Parronchi, William H. Robinson & Michael Mahler. (2019) Autoantibodies to protein-arginine deiminase (PAD) 4 in rheumatoid arthritis: immunological and clinical significance, and potential for precision medicine. Expert Review of Clinical Immunology 15:10, pages 1073-1087.
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Articles from other publishers (13)

Jianxin Du, Ning Wang, Hui Sun, Linlin Zheng & Xiangqin Qi. (2022) Cl-amidine attenuates lipopolysaccharide-induced inflammation in human gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways. Human Cell 36:1, pages 223-233.
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Gianluigi Pironti, Stefano Gastaldello, Dilson E. Rassier, Johanna T. Lanner, Mattias Carlström, Lars H. Lund, Håkan Westerblad, Takashi Yamada & Daniel C. Andersson. (2022) Citrullination is linked to reduced Ca 2+ sensitivity in hearts of a murine model of rheumatoid arthritis . Acta Physiologica 236:3.
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Ang Hu, Haohong Zou, Bin Chen & Jianing Zhong. (2022) Posttranslational modifications in diabetes: Mechanisms and functions. Reviews in Endocrine and Metabolic Disorders 23:5, pages 1011-1033.
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Drinalda Cela, Sebastian Lorenz Knackstedt, Sarah Groves, Christopher M Rice, Jamie Tae Wook Kwon, Benjamin Mordmüller & Borko Amulic. (2022) PAD4 controls chemoattractant production and neutrophil trafficking in malaria. Journal of Leukocyte Biology 111:6, pages 1235-1242.
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Miranda M. Standiford, Ethan M. Grund & Charles L. Howe. (2021) Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination. Journal of Neuroinflammation 18:1.
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Ayako Ohyama, Atsumu Osada, Hoshimi Kawaguchi, Izumi Kurata, Taihei Nishiyama, Tamaki Iwai, Akihito Ishigami, Yuya Kondo, Hiroto Tsuboi, Takayuki Sumida & Isao Matsumoto. (2021) Specific Increase in Joint Neutrophil Extracellular Traps and Its Relation to Interleukin 6 in Autoimmune Arthritis. International Journal of Molecular Sciences 22:14, pages 7633.
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Mei-Ling Yang, Fernanda M. C. Sodré, Mark J. Mamula & Lut Overbergh. (2021) Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pathology. Frontiers in Immunology 12.
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Shuang Ling & Jin-Wen Xu. (2021) NETosis as a Pathogenic Factor for Heart Failure. Oxidative Medicine and Cellular Longevity 2021, pages 1-24.
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Fernanda M.C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga & Lut Overbergh. (2021) Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice. Diabetes 70:2, pages 516-528.
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Wenpeng Song, Jing Ye, Nanfang Pan, Chunyu Tan & Martin Herrmann. (2021) Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder. Frontiers in Immunology 11.
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Hendrik J Nel, Vivianne Malmström, David C Wraith & Ranjeny Thomas. (2020) Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy. The Lancet Rheumatology 2:11, pages e712-e723.
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Esther Fousert, René Toes & Jyaysi Desai. (2020) Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses. Cells 9:4, pages 915.
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Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang & Ming-Chi Lu. (2019) Increased peptidylarginine deiminases expression during the macrophage differentiation and participated inflammatory responses. Arthritis Research & Therapy 21:1.
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