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Expert Opinion on Pharmacotherapy Volume 20, 2019 - Issue 5
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Review

An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma

Dhuha Al-SajeeDepartment of Medicine, McMaster University, Hamilton, ON, CanadaView further author information
,
Xuanzhi YinDepartment of Medicine, McMaster University, Hamilton, ON, CanadaView further author information
&
Gail M. GauvreauDepartment of Medicine, McMaster University, Hamilton, ON, CanadaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6187-2385View further author information
ORCID Icon
Pages 609-620 | Received 30 Jul 2018, Accepted 11 Jan 2019, Published online: 05 Feb 2019

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Read on this site (3)

Maria Gabriella Matera, Josuel Ora, Francesco Cavalli, Paola Rogliani & Mario Cazzola. (2021) New Avenues for Phosphodiesterase Inhibitors in Asthma. Journal of Experimental Pharmacology 13, pages 291-302.
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Timothy E. Albertson, Janelle V. Pugashetti, Florence Chau-Etchepare, James A. Chenoweth & Susan Murin. (2020) Pharmacotherapeutic management of asthma in the elderly patient. Expert Opinion on Pharmacotherapy 21:16, pages 1991-2010.
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Timothy E. Albertson, James A. Chenoweth, Skyler J. Pearson & Susan Murin. (2020) The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Expert Opinion on Pharmacotherapy 21:2, pages 213-231.
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Articles from other publishers (10)

Renan Fernandes do Espírito-Santo, Cássio Santana Meira, Luiza Carolina França Opretzka, Karoline Cristina Jatobá da Silva, Fênix Alexandra de Araújo, Rafael dos Santos Costa, Eudes Silva Velozo, Fabio Rocha Formiga, Darizy Flávia Silva, Milena Botelho Pereira Soares & Cristiane Flora Villarreal. (2023) Inhaled braylin regulates Th2 response and induces relaxant effects in the airway muscles in a model of ovalbumin-induced asthma. Phytomedicine Plus 3:2, pages 100435.
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Xiaowei Ji, Yao Ye, Lin Wang, Suying Liu & Xi Dong. (2023) PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA‐induced granulosa cell apoptosis in vitro. Drug Development Research 84:2, pages 226-237.
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Gang Li, Dengqin He, Xiaojia Cai, Wen Guan, Yali Zhang, Jia-Qiang Wu & Hongliang Yao. (2023) Advances in the development of phosphodiesterase-4 inhibitors. European Journal of Medicinal Chemistry 250, pages 115195.
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Jia-Xi Huang, Bo-Lin Zhu, Jiang-Ping Xu & Zhong-Zhen Zhou. (2023) Advances in the development of phosphodiesterase 7 inhibitors. European Journal of Medicinal Chemistry 250, pages 115194.
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Daniela Mokra, Romana Barosova & Juraj Mokry. (2023) Sex-Based Differences in Bronchial Asthma: What Are the Mechanisms behind Them?. Applied Sciences 13:4, pages 2694.
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Malvika Chawla, R.D. Kaushik, Mayank Kumar Malik, Vishakha Pundir, Jaspal Singh & Hafeezur Rehmaan. (2022) Development and optimization of RofA-PAMAM dendrimer complex materials for sustained drug delivery. Materials Today Communications 33, pages 104881.
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Chan Kwon Park, Tai Joon An, Ji Hye Kim, Chin Kook Rhee & Hyoung Kyu Yoon. (2022) Synergistic effect of roflumilast with dexamethasone in a neutrophilic asthma mouse model. Clinical and Experimental Pharmacology and Physiology.
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Hong Jo Kim, Jin Yong Song, Tae Il Park, Won Seok Choi, Jong Heon Kim, Oh Seong Kwon & Ji-Yun Lee. (2022) The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model. Archives of Pharmacal Research 45:1, pages 51-62.
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Jingju Hu, Jing Yang, Hua Guo, Xuesong Yao, Haiyan Qiu, Panpan Gao & Qingchun Wang. (2021) Effect of Theaflavin on Inflammatory and Remolding of Airway in the Asthma Mice. Journal of Biomaterials and Tissue Engineering 11:6, pages 1091-1098.
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Simeng Chu, Wenjuan Liu, Yujie Lu, Menglin Yan, Yingying Guo, Nianwei Chang, Min Jiang & Gang Bai. (2020) Sinigrin Enhanced Antiasthmatic Effects of Beta Adrenergic Receptors Agonists by Regulating cAMP-Mediated Pathways. Frontiers in Pharmacology 11.
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