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Expert Opinion on Pharmacotherapy Volume 20, 2019 - Issue 7
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Drug Evaluation

ETC-1002 (Bempedoic acid) for the management of hyperlipidemia: from preclinical studies to phase 3 trials

M. RuscicaDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, ItalyCorrespondence[email protected]
[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0195-7061View further author information
ORCID Icon,
M. BanachDepartment of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland;Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, PolandCorrespondence[email protected]
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A. SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranORCID Iconhttps://orcid.org/0000-0002-8656-1444View further author information
ORCID Icon,
A. CorsiniDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy;Multimedica IRCCS, Milan, ItalyORCID Iconhttps://orcid.org/0000-0002-9912-9482View further author information
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C. R. SirtoriDyslipidemia Center, A.S.S.T. Grande Ospedale Metropolitano Niguarda, Milan, ItalyView further author information
Pages 791-803 | Received 19 Nov 2018, Accepted 12 Feb 2019, Published online: 27 Feb 2019

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Arrigo F.G. Cicero, Federica Fogacci & Ivan Cincione. (2021) Evaluating pharmacokinetics of bempedoic acid in the treatment of hypercholesterolemia. Expert Opinion on Drug Metabolism & Toxicology 17:9, pages 1031-1038.
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Brian Tomlinson, Paul Chan, Yuzhen Zhang, Zhongmin Liu & Christopher Wai Kei Lam. (2020) Pharmacokinetics of current and emerging treatments for hypercholesterolemia. Expert Opinion on Drug Metabolism & Toxicology 16:5, pages 371-385.
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Niki Katsiki, Dimitri P Mikhailidis & Maciej Banach. (2019) Lipid-lowering agents for concurrent cardiovascular and chronic kidney disease. Expert Opinion on Pharmacotherapy 20:16, pages 2007-2017.
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Massimiliano Ruscica, Zeljko Reiner & Cesare R. Sirtori. (2019) Can we further optimize statin therapy to increase tolerability?. Expert Opinion on Drug Discovery 14:9, pages 843-847.
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Articles from other publishers (28)

Azin Alizadehasl, Maryam Sadat Alavi, Shabnam Boudagh, Mohaddeseh Sadat Alavi, Somaye Mohebi, Leila Aliabadi, Mahsa Akbarian, Parisa Ahmadi, Massimo R. Mannarino & Amirhossein Sahebkar. (2023) Lipid-lowering drugs and cancer: an updated perspective. Pharmacological Reports.
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Ju Zhang, Xiangfeng Guan, Baixue Zhang, Jia Wang, Xiaodong Jin, Yunhe Zhao & Bo Li. (2023) Bempedoic Acid can Reduce Cardiovascular Events in Combination with Statins or As Monotherapy: A Systematic Review and Meta-analysis. American Journal of Cardiovascular Drugs 23:6, pages 695-708.
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Emanuel Raschi, Manuela Casula, Arrigo F.G. Cicero, Alberto Corsini, Claudio Borghi & Alberico Catapano. (2023) Beyond statins: New pharmacological targets to decrease LDL-cholesterol and cardiovascular events. Pharmacology & Therapeutics 250, pages 108507.
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V.A. Serhiyenko & A.A. Serhiyenko. (2023) Bempedoic acid: mechanism of action and therapeutic use in atherosclerotic cardiovascular diseases and diabetes. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 19:3, pages 225-234.
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Francesco Natale, Riccardo Molinari, Rosa Franzese, Noemi Mollo & Giovanni Cimmino. (2023) Bempedoic Acid and Statins in Lipid-Lowering Strategy: Which Came First, the Egg or the Chicken?. Future Pharmacology 3:2, pages 392-406.
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Erica Gianazza, Maura Brioschi, Ada Iezzi, Giuseppe Paglia & Cristina Banfi. (2023) Pharmacometabolomics for the Study of Lipid-Lowering Therapies: Opportunities and Challenges. International Journal of Molecular Sciences 24:4, pages 3291.
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Sabata Pierno & Olimpia Musumeci. (2023) Pharmacotherapy of the Lipid-Lowering Drugs: Update on Efficacy and Risk. International Journal of Molecular Sciences 24:2, pages 996.
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Massimiliano Ruscica, Cesare R. Sirtori, Stefano Carugo, Maciej Banach & Alberto Corsini. (2022) Bempedoic Acid: for Whom and When. Current Atherosclerosis Reports 24:10, pages 791-801.
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Ana Magdalena Velázquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lázaro, Jose Rodríguez-Morató, Rosa María Sánchez, Juan Carlos Laguna, Núria Roglans & Marta Alegret. (2022) KHK, PNPLA3 and PPAR as Novel Targets for the Anti-Steatotic Action of Bempedoic Acid. Biomedicines 10:7, pages 1517.
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Yi Zhou, Junyan Tao, Diego F. Calvisi & Xin Chen. (2021) Role of Lipogenesis Rewiring in Hepatocellular Carcinoma. Seminars in Liver Disease 42:01, pages 077-086.
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Maciej Banach, Paweł Burchardt, Krzysztof Chlebus, Piotr Dobrowolski, Dariusz Dudek, Krzysztof Dyrbuś, Mariusz Gąsior, Piotr Jankowski, Jacek Jóźwiak, Longina Kłosiewicz-Latoszek, Irina Kowalska, Maciej Małecki, Aleksander Prejbisz, Michał Rakowski, Jacek Rysz, Bogdan Solnica, Dariusz Sitkiewicz, Grażyna Sygitowicz, Grażyna Sypniewska, Tomasz Tomasik, Adam Windak, Dorota Zozulińska-Ziółkiewicz & Barbara Cybulska. (2021) 2021 PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on the diagnosis and therapy of lipid disorders in Poland. Diagnostyka Laboratoryjna 57:1, pages 1-99.
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William Smith, Angela Cheng-Lai & James Nawarskas. (2021) Bempedoic Acid: A New Avenue for the Treatment of Dyslipidemia. Cardiology in Review 29:5, pages 274-280.
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Andrey V. Susekov, Ludmila A. Korol & Gerald F. Watts. (2021) Bempedoic Acid in the Treatment of Patients with Dyslipidemias and Statin Intolerance. Cardiovascular Drugs and Therapy 35:4, pages 841-852.
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Chiara Schimmenti, Vincenzo Sucato, Elvira Manzone, Giulia Cancellieri, Francesca Mortillaro, Giuseppina Novo, Alfredo Ruggero Galassi & Fabio Venturella. (2020) Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia. Coronary Artery Disease 32:4, pages 340-344.
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José López-Miranda & Juan Pedro-Botet. (2021) Dianas terapéuticas en el tratamiento de las dislipemias: de las estatinas a los inhibidores de PCSK9. Necesidades no cubiertas. Clínica e Investigación en Arteriosclerosis 33, pages 46-52.
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Furio Colivicchi, Stefania Angela Di Fusco, Pietro Scicchitano, Pasquale Caldarola, Adriano Murrone, Serafina Valente, Stefano Urbinati, Loris Roncon, Vincenzo Amodeo, Nadia Aspromonte, Manlio Cipriani, Stefano Domenicucci, Giuseppina Maura Francese, Massimo Imazio, Fortunato Scotto di Uccio, Andrea Di Lenarda, Michele Massimo Gulizia & Domenico Gabrielli. (2021) Updated clinical evidence and place in therapy of bempedoic acid for hypercholesterolemia: ANMCO position paper. Journal of Cardiovascular Medicine 22:3, pages 162-171.
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Giulia Maria Camerino, Nancy Tarantino, Ileana Canfora, Michela De Bellis, Olimpia Musumeci & Sabata Pierno. (2021) Statin-Induced Myopathy: Translational Studies from Preclinical to Clinical Evidence. International Journal of Molecular Sciences 22:4, pages 2070.
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Tongxin Song, Pengli Wang, Chenyang Li, Li Jia, Qianqian Liang, Yuanlin Cao, Pengzhi Dong, Hong Shi & Miaomiao Jiang. (2021) Salidroside simultaneously reduces de novo lipogenesis and cholesterol biosynthesis to attenuate atherosclerosis in mice. Biomedicine & Pharmacotherapy 134, pages 111137.
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Akshaya Srikanth Bhagavathula, Nadya Obaid Al Matrooshi, Cain C. T. Clark & Jamal Rahmani. (2020) Bempedoic Acid and Ezetimibe for the Treatment of Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Phase II/III trials. Clinical Drug Investigation 41:1, pages 19-28.
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Li Gu, Yahui Zhu, Xi Lin, Bingjun Lu, Xinyi Zhou, Feng Zhou, Qiu Zhao, Edward V. Prochownik & Youjun Li. (2020) The IKKβ‐USP30‐ACLY Axis Controls Lipogenesis and Tumorigenesis. Hepatology 73:1, pages 160-174.
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Xing Wang, Yu Zhang, Huiwen Tan, Peng Wang, Xi Zha, Weelic Chong, Liangxue Zhou & Fang Fang. (2020) Efficacy and safety of bempedoic acid for prevention of cardiovascular events and diabetes: a systematic review and meta-analysis. Cardiovascular Diabetology 19:1.
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Cesare R Sirtori, Shizuya Yamashita, Maria Francesca Greco, Alberto Corsini, Gerald F Watts & Massimiliano Ruscica. (2019) Recent advances in synthetic pharmacotherapies for dyslipidaemias. European Journal of Preventive Cardiology 27:15, pages 1576-1596.
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Yoshiaki Sunami. (2020) NASH, Fibrosis and Hepatocellular Carcinoma: Lipid Synthesis and Glutamine/Acetate Signaling. International Journal of Molecular Sciences 21:18, pages 6799.
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Alessandro Di Minno, Roberta Lupoli, Ilenia Calcaterra, Paolo Poggio, Francesco Forte, Gaia Spadarella, Pasquale Ambrosino, Gabriella Iannuzzo & Matteo Nicola Dario Di Minno. (2020) Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta‐Analysis of Randomized Controlled Trials. Journal of the American Heart Association 9:15.
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Arrigo F. G. Cicero, Federica Fogacci, Adrian V. Hernandez & Maciej Banach. (2020) Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis. PLOS Medicine 17:7, pages e1003121.
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Xiaojun Feng, Lei Zhang, Suowen Xu & Ai-zong Shen. (2020) ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review. Progress in Lipid Research 77, pages 101006.
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Maciej Banach, Eric Bruckert, Olivier S. Descamps, Lars Ellegård, Marat Ezhov, Bernhard Föger, Zlatko Fras, Petri T. Kovanen, Gustavs Latkovskis, Winfried März, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Angela Pirillo, Andrea Poli, Željko Reiner, Günter Silbernagel, Margus Viigimaa, Michal Vrablík & Alberico L. Catapano. (2019) The role of red yeast rice (RYR) supplementation in plasma cholesterol control: A review and expert opinion. Atherosclerosis Supplements 39, pages e1-e8.
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Dongdong Wang, Yang Yang, Yingnan Lei, Nikolay T. Tzvetkov, Xingde Liu, Andy Wai Kan Yeung, Suowen Xu & Atanas G. Atanasov. (2019) Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products. Pharmacological Reviews 71:4, pages 596-670.
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