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Research Article

Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis

Pages 319-327 | Published online: 10 Jul 2009

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Jeff Agar & Heather Durham. (2003) Relevance of oxidative injury in the pathogenesis of motor neuron diseases. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 4:4, pages 232-242.
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Articles from other publishers (20)

Shivani Batra, Shagufta Jahan, Anam Ashraf, Bandar Alharby, Talha Jawaid, Asimul Islam & Imtaiyaz Hassan. (2023) A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases. International Journal of Biological Macromolecules 230, pages 123259.
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Valle Palomo, Vanesa Nozal, Elisa Rojas‐Prats, Carmen Gil & Ana Martinez. (2020) Protein kinase inhibitors for amyotrophic lateral sclerosis therapy. British Journal of Pharmacology 178:6, pages 1316-1335.
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Binukumar BK, Susan Skuntz, Michaela Prochazkova, Sashi Kesavapany, Niranjana D Amin, Varsha Shukla, Philip Grant, Ashok B Kulkarni & Harish C Pant. (2019) Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model. Human Molecular Genetics 28:19, pages 3175-3187.
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Amir Zeb, Donghwan Kim, Sayed Alam, Minky Son, Raj Kumar, Shailima Rampogu, Saravanan Parameswaran, Rahul Shelake, Rabia Rana, Shraddha Parate, Jae-Yean Kim & Keun Lee. (2019) Computational Simulations Identify Pyrrolidine-2,3-Dione Derivatives as Novel Inhibitors of Cdk5/p25 Complex to Attenuate Alzheimer’s Pathology. Journal of Clinical Medicine 8:5, pages 746.
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Rui Zhang, Cui Liu, Yaqing Ji, Lei Teng & Yunliang Guo. (2018) Neuregulin-1β Plays a Neuroprotective Role by Inhibiting the Cdk5 Signaling Pathway after Cerebral Ischemia-Reperfusion Injury in Rats. Journal of Molecular Neuroscience 66:2, pages 261-272.
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Giovanna Morello & Sebastiano Cavallaro. (2015) Transcriptional analysis reveals distinct subtypes in amyotrophic lateral sclerosis: implications for personalized therapy. Future Medicinal Chemistry 7:10, pages 1335-1359.
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Bhavin Parekh. (2015) A(a)LS: Ammonia-induced amyotrophic lateral sclerosis. F1000Research 4, pages 119.
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Xiaofeng Liu, Jie Zhou, Morad Dirhem Naji Abid, Huanhuan Yan, Hao Huang, Limin Wan, Zuohua Feng & Juan Chen. (2014) Berberine Attenuates Axonal Transport Impairment and Axonopathy Induced by Calyculin A in N2a Cells. PLoS ONE 9:4, pages e93974.
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B. K. Binukumar, Varsha Shukla, Niranjana D. Amin, Preethi Reddy, Suzanne Skuntz, Philip Grant & Harish C. Pant. (2013) Topographic regulation of neuronal intermediate filaments by phosphorylation, role of peptidyl-prolyl isomerase 1: significance in neurodegeneration. Histochemistry and Cell Biology 140:1, pages 23-32.
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Yu-Fang Xiong, Qing Chen, Juan Chen, Jie Zhou & Hong-Xing Wang. (2011) Melatonin reduces the impairment of axonal transport and axonopathy induced by calyculin A. Journal of Pineal Research 50:3, pages 319-327.
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Qiang Li, Xianghua Liu, Mingjun Zhang, Guangming Ye, Qian Qiao, Yichen Ling, Yanhua Wu, Yuanyuan Zhang & Long Yu. (2009) Characterization of a novel human CDK5 splicing variant that inhibits Wnt/β-catenin signaling. Molecular Biology Reports 37:5, pages 2415-2421.
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Jie Zhou, Hongxing Wang, Youmei Feng & Juan Chen. (2010) Increased expression of cdk5/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins. Life Sciences 86:13-14, pages 532-537.
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Wencheng Yang, Cheryl Leystra-Lantz & Michael J. Strong. (2008) Upregulation of GSK3β expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci). Brain Research 1196, pages 131-139.
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Timothy G. Lesnick, Eric J. Sorenson, J. Eric Ahlskog, John R. Henley, Lina Shehadeh, Spiridon Papapetropoulos & Demetrius M. Maraganore. (2008) Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway. PLoS ONE 3:1, pages e1449.
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Sashi Kesavapany, Ya-Li Zheng, Niranjana Amin & Harish C. Pant. (2007) Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5. Biotechnology Journal 2:8, pages 978-987.
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Jesusa L. Rosales & Ki-Young Lee. (2006) Extraneuronal roles of cyclin-dependent kinase 5. BioEssays 28:10, pages 1023-1034.
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Paola Strocchi, Annalisa Pession & Barbara Dozza. (2003) Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells. Journal of Cellular Biochemistry 88:4, pages 758-765.
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Marie Knockaert, Paul Greengard & Laurent Meijer. (2002) Pharmacological inhibitors of cyclin-dependent kinases. Trends in Pharmacological Sciences 23:9, pages 417-425.
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Tone Sandal, Camilla Stapnes, Hans Kleivdal, Lars Hedin & Stein Ove Døskeland. (2002) A Novel, Extraneuronal Role for Cyclin-dependent Protein Kinase 5 (CDK5). Journal of Biological Chemistry 277:23, pages 20783-20793.
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Nikolaus Seiler, Benoit Duranton, Francis Raul, Zhi Hong, Craig E. Cameron, Jie Hong Hu, Charles Krieger, James O. Schenk, Laszlo Prokai, David F. Horrobin, Suprabhat Ray, Reema Rastogi & Atul KumarJie Hong Hu & Charles Krieger. 2002. Progress in Drug Research. Progress in Drug Research 71 109 .

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