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Research Article

A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis

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Pages 201-206 | Published online: 10 Jul 2009

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Saeed Asadzadeh Bayqara, Mohammadreza Aghazadeh Yamchelu, Sheyda Abdolahzadeyadegari, Mona Farhadi, Shabnam Nadjafi, Javad fahanik Babaei & Nasrin Hosseini. (2022) The effects of a chalcone derivative on memory, hippocampal corticosterone and BDNF levels in adult rats. International Journal of Neuroscience 0:0, pages 1-10.
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Peter Deng, Johnathon D. Anderson, Abigail S. Yu, Geralyn Annett, Kyle D. Fink & Jan A. Nolta. (2016) Engineered BDNF producing cells as a potential treatment for neurologic disease. Expert Opinion on Biological Therapy 16:8, pages 1025-1033.
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Namita A Goyal & Tahseen Mozaffar. (2014) Experimental trials in amyotrophic lateral sclerosis: a review of recently completed, ongoing and planned trials using existing and novel drugs. Expert Opinion on Investigational Drugs 23:11, pages 1541-1551.
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Philip Van Damme & Wim Robberecht. (2014) Developments in treatments for amyotrophic lateral sclerosis via intracerebroventricular or intrathecal delivery. Expert Opinion on Investigational Drugs 23:7, pages 955-963.
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Thomas A. Lanz, Susan E. Bove, Catherine D. Pilsmaker, Abigail Mariga, Elena M. Drummond, Gregory W. Cadelina, Wendy O. Adamowicz, Brentt J. Swetter, Sharon Carmel, Jo Ann Dumin & Robin J. Kleiman. (2012) Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma. Biomarkers 17:6, pages 524-531.
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D. Poston, R. Raghavan & G. T. Gillies. (2011) Catheter delivery systems for infusions into the cortex. Journal of Medical Engineering & Technology 35:5, pages 246-253.
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Magdalena Kuzma-Kozakiewicz & Hubert Kwiecinski. (2011) New therapeutic targets for amyotrophic lateral sclerosis. Expert Opinion on Therapeutic Targets 15:2, pages 127-143.
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Toru Yasuda & Hideki Mochizuki. (2010) Use of growth factors for the treatment of Parkinson’s disease. Expert Review of Neurotherapeutics 10:6, pages 915-924.
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Stefano Zoccolella, Andrea Santamato & Paolo Lamberti. (2009) Current and emerging treatments for amyotrophic lateral sclerosis. Neuropsychiatric Disease and Treatment 5, pages 577-595.
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Ceryl A. Harwood, Christopher J. McDermott & Pamela J. Shaw. (2009) Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence. Amyotrophic Lateral Sclerosis 10:4, pages 191-204.
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J. Simon Lunn, Michael P. Hefferan, Martin Marsala & Eva L. Feldman. (2009) Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery. Growth Factors 27:3, pages 133-140.
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Vassilis E Koliatsos, Leyan Xu & Jun Yan. (2008) Human stem cell grafts as therapies for motor neuron disease. Expert Opinion on Biological Therapy 8:2, pages 137-141.
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Isao Nagano, Mito Shiote, Tetsuro Murakami, Hiroshi Kamada, Yoshiyuki Hamakawa, Etsuro Matsubara, Masataka Yokoyama, Kiyoshi Morita, Mikio Shoji & Koji Abe. (2005) Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis. Neurological Research 27:7, pages 768-772.
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Marcus Beck, Peter Flachenecker, Tim Magnus, Ralf Giess, Karlheinz Reiners, Klaus V. Toyka & Markus Naumann. (2005) Autonomic dysfunction in ALS: A preliminary study on the effects of intrathecal BDNF. Amyotrophic Lateral Sclerosis 6:2, pages 100-103.
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Michael D Weiss, Patrick Weydt & Gregory T Carter. (2004) Current pharmacological management of amyotropic lateral sclerosis and a role for rational polypharmacy. Expert Opinion on Pharmacotherapy 5:4, pages 735-746.
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Claude Brodski, Daniela M Vogt Weisenhorn & Georg Dechant. (2002) Therapy of neurodegenerative diseases using neurotrophic factors: cell biological perspective. Expert Review of Neurotherapeutics 2:3, pages 417-426.
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