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Review article

Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trial

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Pages 84-98 | Received 28 Nov 2003, Accepted 02 Mar 2004, Published online: 10 Jul 2009

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Andrea Kübler. 2009. The Neurology of Consciousness. The Neurology of Consciousness 217 233 .
Adam Czaplinski, Albert A. Yen, Ericka P. Simpson & Stanley H. Appel. (2006) Predictability of disease progression in amyotrophic lateral sclerosis. Muscle & Nerve 34:6, pages 702-708.
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S. G. Mueller, N. Schuff & M. W. Weiner. (2006) Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS. NMR in Biomedicine 19:6, pages 655-668.
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V. Danel-Brunaud. (2006) Évaluation du handicap et de la qualité de vie dans la sclérose latérale amyotrophique. Revue Neurologique 162, pages 200-204.
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Niranjanan Nirmalananthan & Linda Greensmith. (2005) Amyotrophic lateral sclerosis: recent advances and future therapies. Current Opinion in Neurology 18:6, pages 712-719.
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Matthew C Kiernan. (2005) Riluzole: a glimmer of hope in the treatment of motor neurone disease. Medical Journal of Australia 182:7, pages 319-320.
Crossref
Jennica MC Winhammar, Dominic B Rowe, Robert D Henderson & Matthew C Kiernan. (2005) Assessment of disease progression in motor neuron disease. The Lancet Neurology 4:4, pages 229-238.
Crossref
Andrea Kübler & Nicola Neumann. 2005. The Boundaries of Consciousness: Neurobiology and Neuropathology. The Boundaries of Consciousness: Neurobiology and Neuropathology 513 525 .

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