1,188
Views
54
CrossRef citations to date
0
Altmetric
Review

Non-viral nucleic acid delivery methods

, , , &
Pages 105-118 | Received 20 May 2016, Accepted 12 Oct 2016, Published online: 09 Nov 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Masumi Ueda, Jun-Ichiro Jo, Jian-Qing Gao & Yasuhiko Tabata. (2019) Effect of lipopolysaccharide addition on the gene transfection of spermine-introduced pullulan-plasmid DNA complexes for human mesenchymal stem cells. Journal of Biomaterials Science, Polymer Edition 30:16, pages 1542-1558.
Read now

Articles from other publishers (53)

Saba Zanganeh, Mohammad Doroudian, Zohreh R. Nowzari, Pourya Nasirmoghadas, Javid Sadri Nahand, Shima Sepehrpour & Mohsen Moghoofei. (2023) Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo. Advanced Therapeutics 6:10.
Crossref
Longfei Deng, Ping Liang & Hongjuan Cui. (2023) Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?. Genes & Diseases 10:5, pages 1937-1955.
Crossref
Xuan Wang, Ying Wan, Xian-En Zhang, Chengchen Xu & Feng Li. (2023) Progress in mRNA delivery systems based on virus-like particles. Chinese Science Bulletin.
Crossref
Krishna Yadav, Kantrol Kumar Sahu, Sucheta, S. Princely Ebenezer Gnanakani, Pavani Sure, R. Vijayalakshmi, V.D. Sundar, Versha Sharma, Ruchita Antil, Megha Jha, Sunita Minz, Anindya Bagchi & Madhulika Pradhan. (2023) Biomedical applications of nanomaterials in the advancement of nucleic acid therapy: Mechanistic challenges, delivery strategies, and therapeutic applications. International Journal of Biological Macromolecules 241, pages 124582.
Crossref
Devrim Demir-Dora & Feride Öner. (2023) Development and evaluation of polyethylenimine polyplexes as non-viral vectors for delivery of plasmid DNA encoding shRNA against STAT3 activity into triple negative breast cancer cells. Journal of Drug Delivery Science and Technology 82, pages 104113.
Crossref
Seunghee Oh, Min Seong Jang, Kyung Jin Jung, Ji-Seok Han, Hyojin Lee, Areum Gil, Bohyun Jeon, Christine C. Roberts, Joel N. Maslow, Yong-Bum Kim & Kang-Hyun Han. (2023) Preclinical safety assessment of the suction-assisted intradermal injection of the SARS-CoV-2 DNA vaccine candidate pGO-1002 in white rabbit. Archives of Toxicology 97:4, pages 1177-1189.
Crossref
Zhiwei Jiang, Yi Xu, Mengdie Fu, Danji Zhu, Na Li & Guoli Yang. (2023) Genetically modified cell spheroids for tissue engineering and regenerative medicine. Journal of Controlled Release 354, pages 588-605.
Crossref
Androulla N. Miliotou, Parthena F. Foltopoulou, Alexandra Ingendoh-Tsakmakidis, Asterios S. Tsiftsoglou, Ioannis S. Vizirianakis, Ioannis S. Pappas & Lefkothea C. Papadopoulou. (2023) Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency. Pharmaceutics 15:1, pages 286.
Crossref
Christopher V. Nagelli, Christopher H. Evans & Rodolfo E. De la Vega. 2023. Electromechanobiology of Cartilage and Osteoarthritis. Electromechanobiology of Cartilage and Osteoarthritis 95 105 .
Ananya Pattnaik, Swarnaparabha Pany, A. S. Sanket, Sudiptee Das, Sanghamitra Pati & Sangram K. Samal. 2022. Targeted Drug Delivery. Targeted Drug Delivery 221 246 .
Elnaz Shaabani, Maryam Sharifiaghdam, Reza Faridi-Majidi, Stefaan C. De Smedt, Kevin Braeckmans & Juan C. Fraire. (2022) Gene therapy to enhance angiogenesis in chronic wounds. Molecular Therapy - Nucleic Acids 29, pages 871-899.
Crossref
Anupama Kumari, Simanti Pal, Betsy Reshma G, Franklin Pulikkottil Mohny, Nidhi Gupta, Chirag Miglani, Bijay Pattnaik, Asish Pal & Munia Ganguli. (2022) Surface-Engineered Mucus Penetrating Nucleic Acid Delivery Systems with Cell Penetrating Peptides for the Lungs. Molecular Pharmaceutics 19:5, pages 1309-1324.
Crossref
Huixiao Yuan, Xin Huang, Qingqing Li, Cici Luo, Chenyu Lin, Shuxian Zhang, Yaguang Zhang, Zhilin Yan, Ning Du, Zhongmin Liu, Hua Jiang & Bingdi Chen. (2022) SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression. Biomedicine & Pharmacotherapy 147, pages 112672.
Crossref
Mathias Mangion, Marc-André Robert, Igor Slivac, Rénald Gilbert & Bruno Gaillet. (2021) Production and Use of Gesicles for Nucleic Acid Delivery. Molecular Biotechnology 64:3, pages 278-292.
Crossref
Niloufar Tavakoli Dastjerd, Ali Valibeik, Sobhan Rahimi Monfared, Golnaz Goodarzi, Mostafa Moradi Sarabi, Faezeh Hajabdollahi, Mahmood Maniati, Jamal Amri & Sadra Samavarchi Tehrani. (2021) Gene therapy: A promising approach for breast cancer treatment. Cell Biochemistry and Function 40:1, pages 28-48.
Crossref
Dengning Xia, Rui JinGaurav Byagathvalli, Huan YuLing YeChao-Yi Lu, M. Saad Bhamla, Chinglai YangMark R. Prausnitz. (2021) An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination. Proceedings of the National Academy of Sciences 118:45.
Crossref
Emran O. Lallow, Nandita C. JhumurIjaz AhmedSagar B. Kudchodkar, Christine C. Roberts, Moonsup Jeong, Juliet M. Melnik, Sarah H. ParkKar Muthumani, Jerry W. ShanJeffrey D. Zahn, David I. Shreiber, Jonathan P. Singer, Young K. ParkJoel N. Maslow & Hao Lin. (2021) Novel suction-based in vivo cutaneous DNA transfection platform. Science Advances 7:45.
Crossref
Sara Mancinelli, Andrea Turcato, Annamaria Kisslinger, Antonella Bongiovanni, Valeria Zazzu, Antonella Lanati & Giovanna Lucia Liguori. (2021) Design of transfections: Implementation of design of experiments for cell transfection fine tuning. Biotechnology and Bioengineering 118:11, pages 4488-4502.
Crossref
Maria L. Ibba, Giuseppe Ciccone, Carla L. Esposito, Silvia Catuogno & Paloma H. Giangrande. (2021) Advances in mRNA non-viral delivery approaches. Advanced Drug Delivery Reviews 177, pages 113930.
Crossref
Maryam Zohri, Ehsan Arefian, Hamid Akbari Javar, Taraneh Gazori, Seyed Hamid Aghaee-Bakhtiari, Mojtaba Taheri, Yousef Fatahi, Amir Azadi, Mohammad Reza Khoshayand & Mohammad Hossein Ghahremani. (2021) Potential of chitosan/alginate nanoparticles as a non-viral vector for gene delivery: Formulation and optimization using D-optimal design. Materials Science and Engineering: C 128, pages 112262.
Crossref
Livia Naszályi Nagy, Evert Dhaene, Matthias Van Zele, Judith Mihály, Szilvia Klébert, Zoltán Varga, Katalin E. Kövér, Klaartje De Buysser, Isabel Van Driessche, José C. Martins & Krisztina Fehér. (2021) Silica@zirconia Core@shell Nanoparticles for Nucleic Acid Building Block Sorption. Nanomaterials 11:9, pages 2166.
Crossref
Christopher H. Evans, Steve C. Ghivizzani & Paul D. Robbins. (2021) Orthopaedic Gene Therapy. JBJS Reviews 9:8.
Crossref
Igor Slivac, Emilija Zdraveva, Fran Ivančić, Bojan Žunar, Tamara Holjevac Grgurić, Višnja Gaurina Srček, Ivan-Krešimir Svetec, Tamara Dolenec, Emi Govorčin Bajsić, Mirna Tominac Trcin & Budimir Mijović. (2021) Bioactivity Comparison of Electrospun PCL Mats and Liver Extracellular Matrix as Scaffolds for HepG2 Cells. Polymers 13:2, pages 279.
Crossref
Kai Ma, Chun-Liu Mi, Xiang-Xiang Cao & Tian-Yun Wang. (2021) Progress of cationic gene delivery reagents for non-viral vector. Applied Microbiology and Biotechnology 105:2, pages 525-538.
Crossref
I. A Nedorubova, T. B Bukharova, A. V Vasilyev, D. V Goldshtein & A. A Kulakov. (2020) Non-viral delivery of the BMP2 gene for bone regeneration. Genes & Cells 15:4, pages 33-39.
Crossref
M. Weissenberger, M. H. Weissenberger, F. Gilbert, J. Groll, C. H. Evans & A. F. Steinert. (2020) Reduced hypertrophy in vitro after chondrogenic differentiation of adult human mesenchymal stem cells following adenoviral SOX9 gene delivery. BMC Musculoskeletal Disorders 21:1.
Crossref
Haengseok Song & Keun-Hong Park. (2020) Regulation and function of SOX9 during cartilage development and regeneration. Seminars in Cancer Biology 67, pages 12-23.
Crossref
Erin McGraw, Radini H. Dissanayaka, John C. Vaughan, Nitish Kunte, G. Mills, Guillaume M. Laurent & L. Adriana Avila. (2020) Laser-Assisted Delivery of Molecules in Fungal Cells. ACS Applied Bio Materials 3:9, pages 6167-6176.
Crossref
Jikui Shen, Jayoung Kim, Stephany Y. Tzeng, Kun Ding, Zibran HafizDa LongJiangxia WangJordan J. Green & Peter A. Campochiaro. (2020) Suprachoroidal gene transfer with nonviral nanoparticles. Science Advances 6:27.
Crossref
Qinlin Pu, Shan Zhou, Xin Huang, Yi Yuan, Feng Du, Juan Dong, Gangyi Chen, Xin Cui & Zhuo Tang. (2020) Intracellular Selection of Theophylline-Sensitive Hammerhead Aptazyme. Molecular Therapy - Nucleic Acids 20, pages 400-408.
Crossref
Berta Capella Roca, Nga T. Lao, Martin Clynes & Padraig Doolan. (2019) Investigation and circumvention of transfection inhibition by ferric ammonium citrate in serum‐free media for Chinese hamster ovary cells. Biotechnology Progress 36:3.
Crossref
Opal L. Reddy, Bipin N. Savani, David F. Stroncek & Sandhya R. Panch. (2020) Advances in gene therapy for hematologic disease and considerations for transfusion medicine. Seminars in Hematology 57:2, pages 83-91.
Crossref
Nina Bono, Federica Ponti, Diego Mantovani & Gabriele Candiani. (2020) Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!. Pharmaceutics 12:2, pages 183.
Crossref
Itziar Gómez-Aguado, Julen Rodríguez-Castejón, Mónica Vicente-Pascual, Alicia Rodríguez-Gascón, María Ángeles Solinís & Ana del Pozo-Rodríguez. (2020) Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives. Nanomaterials 10:2, pages 364.
Crossref
Shabnam Tarvirdipour, Cora-Ann Schoenenberger, Yaakov Benenson & Cornelia G. Palivan. (2020) A self-assembling amphiphilic peptide nanoparticle for the efficient entrapment of DNA cargoes up to 100 nucleotides in length. Soft Matter 16:6, pages 1678-1691.
Crossref
Tianzhong Li, Linfeng Huang & Mengsu Yang. (2020) Lipid-based Vehicles for siRNA Delivery in Biomedical Field. Current Pharmaceutical Biotechnology 21:1, pages 3-22.
Crossref
Yaqun Jiang, Yongkang Gai, Yu Long, Qingyao Liu, Chunbao Liu, Yongxue Zhang & Xiaoli Lan. (2020) Application and Evaluation of [ 99m Tc]-Labeled Peptide Nucleic Acid Targeting MicroRNA-155 in Breast Cancer Imaging . Molecular Imaging 19, pages 153601212091612.
Crossref
Arden G. Vanderwall & Erin D. Milligan. (2019) Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management. Frontiers in Immunology 10.
Crossref
Xiao Zhao, Juan Long, Fei Liang, Nan Liu, Yuying Sun & Yongzhi Xi. (2019) Dynamic profiles, biodistribution and integration evaluation after intramuscular/intravenous delivery of a novel therapeutic DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in vaccinated normal rodent. Journal of Nanobiotechnology 17:1.
Crossref
Timothy M. Acri, Noah Z. Laird, Sean M. Geary, Aliasger K. Salem & Kyungsup Shin. (2019) Effects of calcium concentration on nonviral gene delivery to bone marrow‐derived stem cells. Journal of Tissue Engineering and Regenerative Medicine 13:12, pages 2256-2265.
Crossref
Olga Krasheninina, Evgeny Apartsin, Elena Fuentes, Aleksandra Szulc, Maksim Ionov, Alya Venyaminova, Dzmitry Shcharbin, F. De la Mata, Maria Bryszewska & Rafael Gόmez. (2019) Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells. Pharmaceutics 11:1, pages 25.
Crossref
Brian E Hew, Ryuei Sato, Damiano Mauro, Ilko Stoytchev & Jesse B Owens. (2019) RNA-guided piggyBac transposition in human cells. Synthetic Biology 4:1.
Crossref
H. Denny Liggitt. 2019. Nanotechnology Characterization Tools for Environment, Health, and Safety. Nanotechnology Characterization Tools for Environment, Health, and Safety 65 102 .
Natasha McStay, Anthony M. Reilly, Nicholas Gathergood & Andrew Kellett. (2018) Efficient DNA Condensation by a C 3 ‐Symmetric Codeine Scaffold . ChemPlusChem.
Crossref
Gregory E Holt & Pirouz Daftarian. (2018) Non-small-cell lung cancer homing peptide-labeled dendrimers selectively transfect lung cancer cells. Immunotherapy 10:16, pages 1349-1360.
Crossref
Yulia Zhitnyuk, Peter Gee, Mandy S.Y. Lung, Noriko Sasakawa, Huaigeng Xu, Hirohide Saito & Akitsu Hotta. (2018) Efficient mRNA delivery system utilizing chimeric VSVG-L7Ae virus-like particles. Biochemical and Biophysical Research Communications 505:4, pages 1097-1102.
Crossref
M. V. Zinovyeva, A. V. Sass, A. V. Vvedensky, V. K. Potapov, L. G. Nikolaev & E. D. Sverdlov. (2019) Recombinant Histones as an Instrument for the Delivery of Nucleic Acids into Eukaryotic Cells. Molecular Genetics, Microbiology and Virology 33:3, pages 187-194.
Crossref
Bruce A. Hay, Juan Li & Ming Guo. (2018) Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation. Theriogenology 112, pages 63-74.
Crossref
Arden G. Vanderwall, Shahani Noor, Melody S. Sun, Jacob E. Sanchez, Xuexian O. Yang, Lauren L. Jantzie, Nikolaos Mellios & Erin D. Milligan. (2018) Effects of spinal non-viral interleukin-10 gene therapy formulated with d -mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues. Brain, Behavior, and Immunity 69, pages 91-112.
Crossref
Hyokyoung Kwon, Minjeong Kim, Yunmi Seo, Yae Seul Moon, Hwa Jeong Lee, Kyuri Lee & Hyukjin Lee. (2018) Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine. Biomaterials 156, pages 172-193.
Crossref
M. V. Zinovyeva, A. V. Sass, A. V. Vvedensky, V. K. Potapov, L. G. Nikolaev & E. D. Sverdlov. (2018) Recombinant histones as an instrument for delivery of nucleic acids into eukaryotic cells. Molecular Genetics Microbiology and Virology (Russian version) 36:3, pages 30.
Crossref
Michael E. Nance & Dongsheng Duan. 2018. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
C Gutiérrez-Lovera, AJ Vázquez-Ríos, J Guerra-Varela, L Sánchez & M de la Fuente. (2017) The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines. Genes 8:12, pages 349.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.