703
Views
71
CrossRef citations to date
0
Altmetric
Review

Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration

, , , , , & show all
Pages 197-212 | Received 25 Jul 2016, Accepted 08 Nov 2016, Published online: 28 Nov 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Zenghua Zhou, Xin Hu, Fangran Yan, Yanhua Zhou, Ruilin He, Xiaolong Ye & Zongbin Jiang. (2022) Observation on the effect of platelet-rich plasma combined with drugs in the treatment of herpes zoster neuralgia. International Journal of Neuroscience 0:0, pages 1-7.
Read now
E Anitua, B de la Sen-Corcuera, G Orive, RM Sánchez-Ávila, P Heredia, F Muruzabal & J Merayo-Lloves. (2022) Progress in the use of plasma rich in growth factors in ophthalmology: from ocular surface to ocular fundus. Expert Opinion on Biological Therapy 22:1, pages 31-45.
Read now
Christopher F. Brewer, Alexander Smith & Ben H. Miranda. (2021) The use of platelet-rich products for skin graft donor site healing: a systematic review and meta-analysis. Journal of Plastic Surgery and Hand Surgery 55:3, pages 133-140.
Read now
Paula Oneto & Julia Etulain. (2021) PRP in wound healing applications. Platelets 32:2, pages 189-199.
Read now
S Padilla, G Orive & E Anitua. (2017) Shedding light on biosafety of platelet rich plasma. Expert Opinion on Biological Therapy 17:8, pages 1047-1048.
Read now
Eleftherios Spartalis, Antonios Athanasiou, Michael Spartalis, Demetrios Moris, Alexandros Papalampros & Nikolaos Nikiteas. (2017) Platelet-rich plasma and peripheral nerve regeneration: a potential contraindication to its use after tumor excision. Expert Opinion on Biological Therapy 17:8, pages 1045-1046.
Read now

Articles from other publishers (65)

Prasad Patil, Mamtha Jadhav, Tarun Kumar Suvvari & Vimal Thomas. (2024) Therapeutic uses of platelet-rich plasma (PRP) in sport injuries – A narrative review. Journal of Orthopaedic Reports 3:2, pages 100287.
Crossref
Eduardo Anitua, Mar Zalduendo, María Troya, Roberto Tierno & Mohammad H. Alkhraisat. (2023) Cellular composition modifies the biological properties and stability of platelet rich plasma membranes for tissue engineering. Journal of Biomedical Materials Research Part A 111:11, pages 1710-1721.
Crossref
Ivo Lambrichts, Esther Wolfs, Annelies Bronckaers, Pascal Gervois & Tim Vangansewinkel. (2023) The Effect of Leukocyte- and Platelet-Rich Fibrin on Central and Peripheral Nervous System Neurons—Implications for Biomaterial Applicability. International Journal of Molecular Sciences 24:18, pages 14314.
Crossref
Homid Fahandezh-Saddi Díaz, Antonio Ríos Luna, Manuel Villanueva Martínez, María Elena Cantero Yubero, Roberto Prado, Sabino Padilla & Eduardo Anitua. (2023) Surgical Treatment of Saphenous Nerve Injury Assisted by Plasma Rich in Growth Factors (PRGF): Lessons from a Case Report. Clinics and Practice 13:5, pages 1090-1099.
Crossref
Michael C Bejarano & Daniel A Clearfield. (2023) Platelet Releasate Injection as a Novel Treatment for Ulnar Neuritis at the Elbow: A Case Report. Cureus.
Crossref
José Correa, Henry Cortés, Lucia Correa & Rita López. 2023. Epidural Administration - New Perspectives and Uses. Epidural Administration - New Perspectives and Uses.
Nan Gao, Lizhao Yan, Fangxing Ai, Jiamin Kang, Lixia Wang & Yuxiong Weng. (2023) Comparison of the Short-Term Clinical Effectiveness of 5% Dextrose Water, Platelet-rich Plasma and Corticosteroid Injections for Carpal Tunnel Syndrome: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials. Archives of Physical Medicine and Rehabilitation 104:5, pages 799-811.
Crossref
Connie Labate, Andrea Panunzio, Francesco De Carlo, Federico Zacheo, Sara De Matteis, Maria Cristina Barba, Umberto Carbonara, Floriana Luigina Rizzo, Silvana Leo, Saverio Forte, Pasquale Ditonno, Alessandro Tafuri & Vincenzo Pagliarulo. (2023) Current Knowledge on Radiation-Therapy-Induced Erectile Dysfunction in Prostate-Cancer Patients: A Narrative Review. Uro 3:2, pages 104-116.
Crossref
Christian A. Foy, William F. Micheo & Damien P. Kuffler. (2023) Inducing Ulnar Nerve Function while Eliminating Claw Hand and Reducing Chronic Neuropathic Pain. Plastic and Reconstructive Surgery - Global Open 11:4, pages e4927.
Crossref
Xiao Cui, Guiqiu Shan, Sha Yuan & Biao Cheng. 2023. Platelet-Rich Plasma in Tissue Repair and Regeneration. Platelet-Rich Plasma in Tissue Repair and Regeneration 13 29 .
Yaqiong Zhu, Nan Peng, Jing Wang, Zhuang Jin, Lianhua Zhu, Yu Wang, Siming Chen, Yongqiang Hu, Tieyuan Zhang, Qing Song, Fang Xie, Lin Yan, Yingying Li, Jing Xiao, Xinyang Li, Bo Jiang, Jiang Peng, Yuexiang Wang & Yukun Luo. (2022) Peripheral nerve defects repaired with autogenous vein grafts filled with platelet-rich plasma and active nerve microtissues and evaluated by novel multimodal ultrasound techniques. Biomaterials Research 26:1.
Crossref
Michael Bies, Zachary Ashmore, Wenchun Qu & Christine Hunt. (2022) Injectable Biologics for Neuropathic Pain: A Systematic Review. Pain Medicine 23:10, pages 1733-1749.
Crossref
Eduardo Anitua, María de la Fuente, María Troya, Mar Zalduendo & Mohammad Hamdan Alkhraisat. (2022) Autologous Platelet Rich Plasma (PRGF) Preserves Genomic Stability of Gingival Fibroblasts and Alveolar Osteoblasts after Long-Term Cell Culture. Dentistry Journal 10:9, pages 173.
Crossref
Ping-Jui Lee, Yuan-Hong Jiang & Hann-Chorng Kuo. (2022) Therapeutic Efficacy and Mid-Term Durability of Urethral Sphincter Platelet-Rich Plasma Injections to Treat Postprostatectomy Stress Urinary Incontinence. Biomedicines 10:9, pages 2235.
Crossref
Víctor Galán, Iñaki Iñigo-Dendariarena, Iñigo Galán, Roberto Prado, Sabino Padilla & Eduardo Anitua. (2022) The Effectiveness of Plasma Rich in Growth Factors (PRGF) in the Treatment of Nerve Compression Syndromes of the Upper Extremity: A Retrospective Observational Clinical Study. Journal of Clinical Medicine 11:16, pages 4789.
Crossref
Jiaojiao Liu, Zhaoxue Liu, Yuan Tang, Alvaro Munoz, Yingchun Zhang & Xuhong Li. (2022) Treatment with platelet-rich plasma attenuates proprioceptor abnormalities in a rat model of postpartum stress urinary incontinence. International Urogynecology Journal 33:8, pages 2159-2167.
Crossref
Sung-Min Rhee, Yun Hee Kim, Joo Hyun Park, Hyeon Jang Jeong, Jikhyon Han, Saewha Jeon & Joo Han Oh. (2022) Allogeneic Dermal Fibroblasts Improve Tendon-to-Bone Healing in a Rabbit Model of Chronic Rotator Cuff Tear Compared With Platelet-Rich Plasma. Arthroscopy: The Journal of Arthroscopic & Related Surgery 38:7, pages 2118-2128.
Crossref
Miquel Saumell-Esnaola, Diego Delgado, Gontzal García del Caño, Maider Beitia, Joan Sallés, Imanol González-Burguera, Pello Sánchez, Maider López de Jesús, Sergio Barrondo & Mikel Sánchez. (2022) Isolation of Platelet-Derived Exosomes from Human Platelet-Rich Plasma: Biochemical and Morphological Characterization. International Journal of Molecular Sciences 23:5, pages 2861.
Crossref
Sulong Wang, Xilin Liu & Yueshu Wang. (2022) Evaluation of Platelet-Rich Plasma Therapy for Peripheral Nerve Regeneration: A Critical Review of Literature. Frontiers in Bioengineering and Biotechnology 10.
Crossref
Jinglin Wang, Danqing Huang, Hang Yu, Yi Cheng, Haozhen Ren & Yuanjin Zhao. (2022) Developing tissue engineering strategies for liver regeneration. Engineered Regeneration 3:1, pages 80-91.
Crossref
Teemu Karjalanen, Saara Raatikainen, Kati Jaatinen & Vieda Lusa. (2022) Update on Efficacy of Conservative Treatments for Carpal Tunnel Syndrome. Journal of Clinical Medicine 11:4, pages 950.
Crossref
Ching-Hsiang Chiang & Hann-Chorng Kuo. (2022) The Efficacy and Mid-term Durability of Urethral Sphincter Injections of Platelet-Rich Plasma in Treatment of Female Stress Urinary Incontinence. Frontiers in Pharmacology 13.
Crossref
Sebastian Blatt, Maximilian Krüger, Peer W. Kämmerer, Daniel G. E. Thiem, Philipp Matheis, Anne-Katrin Eisenbeiß, Jörg Wiltfang, Bilal Al-Nawas & Hendrik Naujokat. (2022) Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw. Journal of Clinical Medicine 11:3, pages 682.
Crossref
Mohammad Amir Mishan, Sahar Balagholi, Tahereh Chamani, Sepehr Feizi, Zahra-Soheila Soheili & Mozhgan Rezaei Kanavi. (2022) Comparative culture of human corneal endothelial cells following treatment with human platelet lysate/fibrin hydrogel versus Y-27632 ROCK inhibitor: in vitro and ex vivo study. International Ophthalmology 42:5, pages 1469-1479.
Crossref
Marta R. Casanova, Rui L. Reis, Albino Martins & Nuno M. Neves. (2021) Stimulation of Neurite Outgrowth Using Autologous NGF Bound at the Surface of a Fibrous Substrate. Biomolecules 12:1, pages 25.
Crossref
Sabino Padilla, Alan T. Nurden, Roberto Prado, Paquita Nurden & Eduardo Anitua. (2021) Healing through the lens of immunothrombosis: Biology-inspired, evolution-tailored, and human-engineered biomimetic therapies. Biomaterials 279, pages 121205.
Crossref
Eric Chung. (2021) A review of regenerative therapies as penile rehabilitation in men following primary prostate cancer treatment: Evidence for erectile restoration and cavernous nerve regeneration. Asian Journal of Urology.
Crossref
Bradyn J. Parker, David I. Rhodes, Carmel M. O'Brien, Andrew E. Rodda & Neil R. Cameron. (2021) Nerve guidance conduit development for primary treatment of peripheral nerve transection injuries: A commercial perspective. Acta Biomaterialia 135, pages 64-86.
Crossref
Meng Zhang, Lei Li, Heng An, Peixun Zhang & Peilai Liu. (2021) Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides. Gels 7:4, pages 152.
Crossref
Julie Gordon, Sonsiray Álvarez-Narváez & John F. Peroni. (2021) Antimicrobial Effects of Equine Platelet Lysate. Frontiers in Veterinary Science 8.
Crossref
Ping-Jui Lee, Yuan-Hong Jiang & Hann-Chorng Kuo. (2021) A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection. Scientific Reports 11:1.
Crossref
Diego Delgado, Ane Miren Bilbao, Maider Beitia, Ane Garate, Pello Sánchez, Imanol González-Burguera, Amaia Isasti, Maider López De Jesús, Jone Zuazo-Ibarra, Alejandro Montilla, María Domercq, Estibaliz Capetillo-Zarate, Gontzal García del Caño, Joan Sallés, Carlos Matute & Mikel Sánchez. (2021) Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age. International Journal of Molecular Sciences 22:4, pages 1725.
Crossref
宜橙 李. (2021) Research Progress of Platelet-Rich Plasma in the Treatment of Knee Joint Diseases. Advances in Clinical Medicine 11:03, pages 862-865.
Crossref
Eric Chung. (2021) Regenerative technology to restore and preserve erectile function in men following prostate cancer treatment: evidence for penile rehabilitation in the context of prostate cancer survivorship. Therapeutic Advances in Urology 13, pages 175628722110264.
Crossref
Jie FangXin WangWen JiangYaqiong ZhuYongqiang HuYanxu ZhaoXueli SongJinjuan ZhaoWenlong ZhangJiang PengYu Wang. (2020) Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries. Tissue Engineering Part B: Reviews 26:6, pages 571-585.
Crossref
Reza Salarinia, Mahmoud Hosseini, Yousef Mohamadi, Ahmad Ghorbani, Daryoush Hamidi Alamdari, Asghar Mafinezhad & Hamidreza Sadeghnia. (2020) Combined use of platelet-rich plasma and adipose tissue-derived mesenchymal stem cells shows a synergistic effect in experimental spinal cord injury. Journal of Chemical Neuroanatomy 110, pages 101870.
Crossref
Muhammad Ahmad & Mohammad Humayun Mohmand. (2020) Effect of hair restoration surgery on the scalp sensitivity. Journal of Cosmetic Dermatology 19:11, pages 2995-2999.
Crossref
Chih-Ya Chang, Liang-Cheng Chen, Yu-Ching Chou, Tsung-Ying Li, Tsung-Yen Ho & Yung-Tsan Wu. (2020) The Effectiveness of Platelet-Rich Plasma and Radial Extracorporeal Shock Wave Compared with Platelet-Rich Plasma in the Treatment of Moderate Carpal Tunnel Syndrome. Pain Medicine 21:8, pages 1668-1675.
Crossref
Ming-Che Liu, Meng-Lin Chang, Ya-Chun Wang, Wei-Hung Chen, Chien-Chih Wu & Shauh-Der Yeh. (2020) Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction. Cells 9:5, pages 1250.
Crossref
Michael Catapano, Joseph Catapano, Gregory Borschel, Seyed Mohammad Alavinia, Lawrence R. Robinson & Nimish Mittal. (2020) Effectiveness of Platelet-Rich Plasma Injections for Nonsurgical Management of Carpal Tunnel Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Archives of Physical Medicine and Rehabilitation 101:5, pages 897-906.
Crossref
Manal Hassanien, Abdelraheem Elawamy, Emad Zarief Kamel, Walaa A Khalifa, Ghada Mohamed Abolfadl, Al Shimaa Ismael Roushdy, Randa A El Zohne & Yasmine S Makarem. (2020) Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?. Pain Medicine 21:4, pages 757-765.
Crossref
Michael Catapano, Kailia Zhang, Nimish Mittal, Harpreet Sangha, Kentaro Onishi & Darren de SA. (2019) Effectiveness of Dextrose Prolotherapy for Rotator Cuff Tendinopathy: A Systematic Review. PM&R 12:3, pages 288-300.
Crossref
Carmen Trull-Ahuir, Diego Sala, Joaquín Chismol-Abad, Marian Vila-Caballer & Juan Francisco Lisón. (2020) Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial. Scientific Reports 10:1.
Crossref
Sarah Felicio Braga, Eliane Trovatti, Renata Aquino de Carvalho, Antonio José Felix de Carvalho, Mônica Rosas da Costa Iemma & André Capaldo Amaral. (2020) Bioactive Fibrin Scaffolds for Use in Musculoskeletal Regenerative Medicine. Brazilian Archives of Biology and Technology 63.
Crossref
Dandan Song, Yan Huang, Jeroen Van Dessel, Sohaib Shujaat, Kaan Orhan, Tim Vangansewinkel, Kathleen Van den Eynde, Ivo Lambrichts, Tania Roskams, Constantinus Politis & Reinhilde Jacobs. (2019) Effect of platelet-rich and platelet-poor plasma on peri-implant innervation in dog mandibles. International Journal of Implant Dentistry 5:1.
Crossref
Changxu Han, Yuyan Na, Yong Zhu, Lingyue Kong, Tu Eerdun, Xuejun Yang & Yizhong Ren. (2019) Is platelet-rich plasma an ideal biomaterial for arthroscopic rotator cuff repair? A systematic review and meta-analysis of randomized controlled trials. Journal of Orthopaedic Surgery and Research 14:1.
Crossref
Thierry Burnouf, Lassina Barro, Ouada Nebie, Yu-Wen Wu, Hadi Goubran, Folke Knutson & Jerard Seghatchian. (2019) Viral safety of human platelet lysate for cell therapy and regenerative medicine: Moving forward, yes, but without forgetting the past. Transfusion and Apheresis Science 58:6, pages 102674.
Crossref
Eduardo Anitua & Mohammad H. Alkhraisat. (2019) The adjuvant use of plasma rich in growth factors in the inferior alveolar nerve repositioning technique. Heliyon 5:12, pages e02965.
Crossref
Şükran Şeker, Ayşe Eser Elçin & Yaşar Murat Elçin. (2019) Autologous protein-based scaffold composed of platelet lysate and aminated hyaluronic acid. Journal of Materials Science: Materials in Medicine 30:12.
Crossref
Elena Stocco, Silvia Barbon, Veronica Macchi, Cesare Tiengo, Lucia Petrelli, Anna Rambaldo, Alessio Borean, Stefano Capelli, Andrea Filippi, Filippo Romanato, Pier Paolo Parnigotto, Claudio Grandi, Raffaele De Caro & Andrea Porzionato. (2019) New bioresorbable wraps based on oxidized polyvinyl alcohol and leukocyte-fibrin-platelet membrane to support peripheral nerve neurorrhaphy: preclinical comparison versus NeuraWrap. Scientific Reports 9:1.
Crossref
Akira Takahashi, Tetsuhiro Tsujino, Sadahiro Yamaguchi, Kazushige Isobe, Taisuke Watanabe, Yutaka Kitamura, Kazuhiro Okuda, Koh Nakata & Tomoyuki Kawase. (2019) Distribution of platelets, transforming growth factor‐β1, platelet‐derived growth factor‐BB, vascular endothelial growth factor and matrix metalloprotease‐9 in advanced platelet‐rich fibrin and concentrated growth factor matrices. Journal of Investigative and Clinical Dentistry 10:4.
Crossref
Hon-Kan Yip, Kuan-Hung Chen, Navneet Kumar Dubey, Cheuk-Kwan Sun, Yue-Hua Deng, Chun-Wei Su, Wen-Cheng Lo, Hsin-Chung Cheng & Win-Ping Deng. (2019) Cerebro- and renoprotective activities through platelet-derived biomaterials against cerebrorenal syndrome in rat model. Biomaterials 214, pages 119227.
Crossref
Maryam Borhani-Haghighi & Yousef Mohamadi. (2019) The therapeutic effect of platelet-rich plasma on the experimental autoimmune encephalomyelitis mice. Journal of Neuroimmunology 333, pages 476958.
Crossref
Ellen Y. Lee & Aymeric Y.T. Lim. (2019) Nerve Compression in the Upper Limb. Clinics in Plastic Surgery 46:3, pages 285-293.
Crossref
V. P. Baklaushev, V. G. Bogush, V. A. Kalsin, N. N. Sovetnikov, E. M. Samoilova, V. A. Revkova, K. V. Sidoruk, M. A. Konoplyannikov, P. S. Timashev, S. L. Kotova, K. B. Yushkov, A. V. Averyanov, A. V. Troitskiy & J.-E. Ahlfors. (2019) Tissue Engineered Neural Constructs Composed of Neural Precursor Cells, Recombinant Spidroin and PRP for Neural Tissue Regeneration. Scientific Reports 9:1.
Crossref
Eduardo Anitua, Paquita Nurden, Roberto Prado, Alan T. Nurden & Sabino Padilla. (2019) Autologous fibrin scaffolds: When platelet- and plasma-derived biomolecules meet fibrin. Biomaterials 192, pages 440-460.
Crossref
Jesús Alcaraz Rubio & Juana María Sánchez López. 2018. Cerebral Palsy - Clinical and Therapeutic Aspects. Cerebral Palsy - Clinical and Therapeutic Aspects.
Akira Ikumi, Yuki Hara, Eriko Okano, Sho Kohyama, Norihito Arai, Yu Taniguchi, Hisashi Sugaya, Tomokazu Yoshioka, Akihiro Kanamori & Masashi Yamazaki. (2018) Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury. Case Reports in Orthopedics 2018, pages 1-6.
Crossref
Damla Torul, Mehmet Cihan Bereket, Mehmet Emin Onger & Gamze Altun. (2018) Comparison of the Regenerative Effects of Platelet-Rich Fibrin and Plasma Rich in Growth Factors on Injured Peripheral Nerve: An Experimental Study. Journal of Oral and Maxillofacial Surgery 76:8, pages 1823.e1-1823.e12.
Crossref
Akira Ikumi, Yuki Hara, Tomokazu Yoshioka, Akihiro Kanamori & Masashi Yamazaki. (2018) Effect of local administration of platelet-rich plasma (PRP) on peripheral nerve regeneration: An experimental study in the rabbit model. Microsurgery 38:3, pages 300-309.
Crossref
Unai García de Cortázar, Sabino Padilla, Enrique Lobato, Diego Delgado & Mikel Sánchez. (2018) Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report. Journal of Clinical Medicine 7:2, pages 13.
Crossref
Eduardo Anitua & Sabino Padilla. (2018) Biologic therapies to enhance intervertebral disc repair. Regenerative Medicine 13:1, pages 55-72.
Crossref
Joon Yeong Park, Seung Hun Park, Mal Geum Kim, Sang-Hyug Park, Tae Hyeon Yoo & Moon Suk Kim. 2018. Biomimetic Medical Materials. Biomimetic Medical Materials 109 121 .
R. López-Cebral, J. Silva-Correia, R. L. Reis, T. H. Silva & J. M. Oliveira. (2017) Peripheral Nerve Injury: Current Challenges, Conventional Treatment Approaches, and New Trends in Biomaterials-Based Regenerative Strategies. ACS Biomaterials Science & Engineering 3:12, pages 3098-3122.
Crossref
Tomoyuki Kawase, Taisuke Watanabe & Kazuhiro Okuda. (2017) Platelet-rich plasma and its derived platelet concentrates: what dentists involved in cell-based regenerative therapy should know. Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 59:2, pages 68-76.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.