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Drug Evaluation

Sirukumab: a promising therapy for rheumatoid arthritis

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Pages 755-763 | Received 09 Dec 2016, Accepted 30 Mar 2017, Published online: 10 Apr 2017

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Eleftherios Pelechas, Paraskevi V Voulgari & Alexandros A Drosos. (2019) Clinical evaluation of the safety, efficacy and tolerability of sarilumab in the treatment of moderate to severe rheumatoid arthritis. Therapeutics and Clinical Risk Management 15, pages 1073-1079.
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Eleftherios Pelechas, Paraskevi V. Voulgari & Alexandros A. Drosos. (2018) ABP 501 for the treatment of rheumatoid arthritis. Expert Opinion on Biological Therapy 18:3, pages 317-322.
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E. L. Nasonov & Eugen Feist. (2022) The prospects of interleukin-6 inhibition in rheumatoid arthritis: Olokizumab (novel monoclonal antibodies to IL-6). Rheumatology Science and Practice 60:5, pages 505-518.
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Tsutomu Takeuchi, Hisashi Yamanaka, Masayoshi Harigai, Ryo Tamamura, Yuichi Kato, Yoshifumi Ukyo, Toshikazu Nakano, Benjamin Hsu & Yoshiya Tanaka. (2018) Sirukumab in rheumatoid arthritis refractory to sulfasalazine or methotrexate: a randomized phase 3 safety and efficacy study in Japanese patients. Arthritis Research & Therapy 20:1.
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Yan Xu, Chuanpu Hu, Yanli Zhuang, Benjamin Hsu, Zhenhua Xu, Amarnath Sharma & Honghui Zhou. (2018) Exposure-Response Modeling Analyses for Sirukumab, a Human Monoclonal Antibody Targeting Interleukin 6, in Patients With Moderately to Severely Active Rheumatoid Arthritis. The Journal of Clinical Pharmacology 58:11, pages 1501-1515.
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Yan Xu, Chuanpu Hu, Yanli Zhuang, Benjamin Hsu, Zhenhua Xu & Honghui Zhou. (2018) Confirmatory Population Pharmacokinetic Analysis for Sirukumab, a Human Monoclonal Antibody Targeting Interleukin-6, in Patients With Moderately to Severely Active Rheumatoid Arthritis. The Journal of Clinical Pharmacology 58:7, pages 939-951.
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Raimon Sanmartí, Virginia Ruiz-Esquide, Carla Bastida & Dolor Soy. (2018) Tocilizumab in the treatment of adult rheumatoid arthritis. Immunotherapy 10:6, pages 447-464.
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