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Review

A comprehensive review of hormonal and biological therapies for endometriosis: latest developments

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Pages 343-360 | Received 01 Oct 2018, Accepted 08 Feb 2019, Published online: 27 Feb 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Barbara Gardella, Edoardo Rispoli, Marianna Francesca Pasquali, Matteo Mauri, Valentina Musacchi & Mattia Dominoni. (2023) Aromatase inhibitors in the pharmacotherapy of endometriosis. Expert Opinion on Pharmacotherapy 24:9, pages 1067-1073.
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Gabriel Hartner, Heinrich Husslein, Lorenz Kuessel, Manuela Gstoettner, Denise Tiringer, René Wenzl & Alexandra Perricos. (2023) The latest advances in the pharmacological management of endometriosis. Expert Opinion on Pharmacotherapy 24:1, pages 121-133.
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Giulio Evangelisti, Fabio Barra, Umberto Perrone, Nadine Di Donato, Stefano Bogliolo, Marcello Ceccaroni & Simone Ferrero. (2022) Comparing the pharmacokinetic and pharmacodynamic qualities of current and future therapies for uterine fibroids. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 441-457.
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Yasemin Kizilkaya, Mujde Can Ibanoglu, Sadiman Kıykac Altinbas & Yaprak Engin-Ustun. (2022) A prospective study examining the effect of dienogest treatment on endometrioma size and symptoms. Gynecological Endocrinology 38:5, pages 403-406.
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Silvia Vannuccini, Chiara Biagiotti, Maria Celeste Esposto, Francesco La Torre, Sara Clemenza, Gretha Orlandi, Tommaso Capezzuoli & Felice Petraglia. (2022) Long-term treatment of endometriosis-related pain among women seeking hormonal contraception. Gynecological Endocrinology 38:5, pages 398-402.
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Mohamed Ali, Sara A.R.Ayman Al Hendy. (2021) Elagolix in the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women. Expert Review of Clinical Pharmacology 14:4, pages 427-437.
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Eric S Surrey, Ahmed M Soliman, Beverly Johns, Jamie B Vora, Hugh S Taylor & Sanjay K Agarwal. (2020) Real-World Characterization of Women with Diagnosed Endometriosis Initiating Therapy with Elagolix Using a US Claims Database. ClinicoEconomics and Outcomes Research 12, pages 473-479.
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Luigi Della Corte, Fabio Barra, Antonio Mercorio, Giulio Evangelisti, Agnese Maria Chiara Rapisarda, Simone Ferrero, Giuseppe Bifulco & Pierluigi Giampaolino. (2020) Tolerability considerations for gonadotropin-releasing hormone analogues for endometriosis. Expert Opinion on Drug Metabolism & Toxicology 16:9, pages 759-768.
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Fabio Barra, Andrea Romano, Giovanni Grandi, Fabio Facchinetti & Simone Ferrero. (2019) Future directions in endometriosis treatment: discovery and development of novel inhibitors of estrogen biosynthesis. Expert Opinion on Investigational Drugs 28:6, pages 501-504.
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Articles from other publishers (35)

Alexandra Perricos-Hess & René Wenzl. (2023) Gibt es neue Hoffnungsträger abseits der chirurgischen Endometriosetherapie?Are there any emerging prospects beyond surgical endometriosis treatment?. Die Gynäkologie 56:11, pages 803-808.
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Shih-Chieh Lin, Wan-Ning Li, Shin-Chih Lin, Haun-Tzu Hou, Ya-Chuan Tsai, Tin-Chien Lin, Meng-Hsing Wu & Shaw-Jenq Tsai. (2023) Targeting YAP1 ameliorates progesterone resistance in endometriosis. Human Reproduction 38:6, pages 1124-1134.
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Simon Lindgren & Lorna Richardson. (2023) Endometriosis pain and epistemic community: Mapping discourses in online discussions among sufferers. Social Science & Medicine 326, pages 115889.
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K. E. Hansen, B. Brandsborg, U. S. Kesmodel, A. Forman, M. Kold, R. Pristed, O. Donchulyesko, D. Hartwell & L. Vase. (2023) Psychological interventions improve quality of life despite persistent pain in endometriosis: results of a 3-armed randomized controlled trial. Quality of Life Research 32:6, pages 1727-1744.
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Amy L Shafrir, Fan Mu, A Heather Eliassen, Madhavi Thombre Kulkarni, Kathryn L Terry, Susan E Hankinson & Stacey A Missmer. (2023) Endogenous Steroid Hormone Concentrations and Risk of Endometriosis in Nurses’ Health Study II. American Journal of Epidemiology 192:4, pages 573-586.
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O.A. Pustotina. (2023) Agonists of gonadotropin-releasing-hormone and add-back-therapy. Rossiiskii vestnik akushera-ginekologa 23:2, pages 63.
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Fabio Barra, Umberto Perrone, Angela Iasci, Simone Ferrero & Stefano Bogliolo. (2023) Exploring the Safety Profile of Ornidazole as Drug Candidate for Endometriosis Treatment. Gynecologic and Obstetric Investigation 88:3, pages 185-186.
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Denise Beck, Insa Winzenborg, Wei Gao, Nael M. Mostafa, Stephanie E. Chiuve, Charlotte Owens & Mohamad Shebley. (2022) Interdisciplinary model‐informed drug development for extending duration of elagolix treatment in patients with uterine fibroids. British Journal of Clinical Pharmacology 88:12, pages 5257-5268.
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Li‐ping Li, Yong Luo, Cheng Huang, Xin‐rong Wang, Ting‐ting Huang, Yong‐yi Zou, Shu‐hui Huang, Yan‐qiu Liu & Bi‐cheng Yang. (2022) In Vitro Inhibitory Effects of Maqian Essential Oil against Ectopic Endometrial Stromal Cells and LPS‐Induced Endometrial Epithelial Cells . Chemistry & Biodiversity 19:12.
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Henrik Marschall, Axel Forman, Sigrid Juhl Lunde, Ulrik Schiøler Kesmodel, Karina Ejgaard Hansen & Lene Vase. (2022) Is laparoscopic excision for superficial peritoneal endometriosis helpful or harmful? Protocol for a double-blinded, randomised, placebo-controlled, three-armed surgical trial. BMJ Open 12:11, pages e062808.
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Keisuke Tanaka, Deborah Gilroy, Sugarniya Subramaniam, Preethi Lakshmi, Madhura Bhadravathi Lokeshappa, Leanne M Wallace, Sharat Atluri, Bart Schmidt, Peter Ganter, David Baartz, Matthew Smith, Sally Mortlock, Anjali Henders, Akram Khalil, Grant Montgomery, Brett McKinnon & Akwasi Amoako. (2022) Protocol for the Endometriosis Research Queensland Study (ERQS): an integrated cohort study approach to improve diagnosis and stratify treatment. BMJ Open 12:10, pages e064073.
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Charlotte Thieffry, Marie Van Wynendaele, Lucie Samain, Donatienne Tyteca, Christophe Pierreux, Etienne Marbaix & Patrick Henriet. (2022) Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis. The Journal of Steroid Biochemistry and Molecular Biology 223, pages 106153.
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Abdelrahman Mohamed, Mohamed Salah, Mariam Tahoun, Manuel Hawner, Ahmed S. Abdelsamie & Martin Frotscher. (2022) Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. Journal of Medicinal Chemistry 65:17, pages 11726-11744.
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Jeevitha Poorasamy, Jayasree Sengupta, Asmita Patil & Debabrata Ghosh. (2022) Progesterone Resistance in Endometriosis. EMJ Reproductive Health.
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Daniel Ernesto Carvallo Ruiz, Elizabeth Natalia Martínez-Núñez & José Núñez-Troconis. (2022) Gynecological uses of GnRH antagonists: review article. Obstetrics & Gynecology International Journal 13:4, pages 226-238.
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Qingqing Feng, Yingjun Zhu, Xiaodong Fan, Jixiao Liu & Zhen Chen. (2022) Potential mechanism of four agents decoction in the treatment of endometriosis based on network pharmacology and molecular docking. South African Journal of Botany 148, pages 162-169.
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Manuela Cristina Russu. 2022. Endometriosis - Recent Advances, New Perspectives and Treatments. Endometriosis - Recent Advances, New Perspectives and Treatments.
Silvia Vannuccini, Sara Clemenza, Margherita Rossi & Felice Petraglia. (2021) Hormonal treatments for endometriosis: The endocrine background. Reviews in Endocrine and Metabolic Disorders 23:3, pages 333-355.
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James A. MacLeanIIII & Kanako Hayashi. (2022) Progesterone Actions and Resistance in Gynecological Disorders. Cells 11:4, pages 647.
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Fabio Barra, Giulio Evangelisti, Carolina Scala & Simone Ferrero. 2022. Immunology of Endometriosis. Immunology of Endometriosis 155 168 .
Jia-Xin Li, Hui-Li Zhang, Hui-Xiong Xu & Song-Yuan Yu. (2021) Contrast-enhanced ultrasound evaluation of a refractory ovarian endometrial cyst and ultrasound-guided aspiration sclerotherapy using urokinase and lauromacrogol. Clinical Hemorheology and Microcirculation 78:4, pages 391-400.
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Ana Corachán, Nuria Pellicer, Antonio Pellicer & Hortensia Ferrero. (2021) Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects. Human Reproduction Update 27:5, pages 923-972.
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Y. JACQUEMYN, C. DE BRUYN, A. VAN HOYWEGHEN, S. VAN DEN BROECK, A. DIERICK, A. VERMANDEL, H. NEELS, A. VEREST, D. DE NEUBOURG, J. ILLEGEMS, N. KOMEN, N. JACQUEMYN & O. ZEMTSOVA. (2021) Endometriose en pijn: een overzicht met argumentatie voor een individuele en multidisciplinaire aanpak. Tijdschrift voor Geneeskunde.
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Michele VIGNALI, Eugenio SOLIMA, Valeria BARBERA, Chiara BECHERINI & Gaia M. BELLONI. (2021) Approaching ovarian endometrioma with medical therapy. Minerva Obstetrics and Gynecology 73:2.
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Henrik Marschall, Karina Ejgaard Hansen, Axel Forman & Dorthe Kirkegaard Thomsen. (2021) Storying endometriosis: Examining relationships between narrative identity, mental health, and pain. Journal of Research in Personality 91, pages 104062.
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Jacques Donnez & Marie-Madeleine Dolmans. (2021) Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review. Journal of Clinical Medicine 10:5, pages 1085.
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Andrew C. Flick, Carolyn A. Leverett, Hong X. Ding, Emma McInturff, Sarah J. Fink, Christopher J. Helal, Jacob C. DeForest, Peter D. Morse, Subham Mahapatra & Christopher J. O’Donnell. (2020) Synthetic Approaches to New Drugs Approved during 2018. Journal of Medicinal Chemistry 63:19, pages 10652-10704.
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Luigi Della Corte, Marco Noventa, Michal Ciebiera, Maria Magliarditi, Zaki Sleiman, Erbil Karaman, Ursula Catena, Calogero Salvaggio, Giovanni Falzone & Simone Garzon. (2020) Phytotherapy in endometriosis: an up-to-date review. Journal of Complementary and Integrative Medicine 17:3.
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Lidia Filip, Florentina Duică, Alina Prădatu, Dragoș Crețoiu, Nicolae Suciu, Sanda Maria Crețoiu, Dragoș-Valentin Predescu, Valentin Nicolae Varlas & Silviu-Cristian Voinea. (2020) Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina 56:9, pages 460.
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Giulio Evangelisti, Fabio Barra, Michele Fichera & Simone Ferrero. (2020) Vitamin D and endometriosis: Is there a correlation with disease severity?. Clinical and Experimental Reproductive Medicine 47:3, pages 233-234.
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Fernando M Reis, Larissa M Coutinho, Silvia Vannuccini, Frédéric Batteux, Charles Chapron & Felice Petraglia. (2020) Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure. Human Reproduction Update 26:4, pages 565-585.
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Irene Scavello, Elisa Maseroli & Linda Vignozzi. (2020) L’endometriosi nell’ambulatorio di endocrinologia. L'Endocrinologo 21:3, pages 210-212.
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Michal Ciebiera, Salvatore G. Vitale, Simone Ferrero, George A. Vilos, Fabio Barra, Salvatore Caruso, Antonio S. Laganà, Antoni Sierant, Antonio Cianci & Grzegorz Jakiel. (2020) Vilaprisan, a New Selective Progesterone Receptor Modulator in Uterine Fibroid Pharmacotherapy-Will it Really be a Breakthrough?. Current Pharmaceutical Design 26:3, pages 300-309.
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Qinsheng Lu, Yanqing Huang, Jiabao Wu, Yutao Guan, Miaomiao Du, Fenghua Wang, Zhihong Liu, Yali Zhu, Guifang Gong, Huomei Hou, Min Zhang, Joy Yue Zhang, Fen Ning, Lixin Chen, Liwei Wang & Gendie E Lash. (2020) T-cadherin inhibits invasion and migration of endometrial stromal cells in endometriosis. Human Reproduction 35:1, pages 145-156.
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George Anderson. (2019) Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation. Biomolecular Concepts 10:1, pages 133-149.
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