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Expert Opinion on Biological Therapy Volume 20, 2020 - Issue 9
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Review

Engineering vaccinia virus as an immunotherapeutic battleship to overcome tumor heterogeneity

Adrian Pelina Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;b Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, CanadaView further author information
,
Stephen Boultona Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;b Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, CanadaView further author information
,
Levi A. Tamminga Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;b Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, CanadaView further author information
,
John C. Bella Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;b Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, CanadaCorrespondence[email protected] [email protected]
View further author information
&
Ragunath Singaravelua Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;b Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, CanadaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-2692-3650View further author information
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Pages 1083-1097 | Received 06 Jan 2020, Accepted 14 Apr 2020, Published online: 06 May 2020

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Andrew T. Russo, Douglas W. Grosenbach, Jarasvech Chinsangaram, Kady M. Honeychurch, Paul G Long, Candace Lovejoy, Biswajit Maiti, Ingrid Meara & Dennis E. Hruby. (2021) An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications. Expert Review of Anti-infective Therapy 19:3, pages 331-344.
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Articles from other publishers (12)

A-Rum Yoon, JinWoo Hong, Bo-Kyeong Jung, Hyo Min Ahn, Songnam Zhang & Chae-Ok Yun. (2023) Oncolytic adenovirus as pancreatic cancer-targeted therapy: Where do we go from here?. Cancer Letters 579, pages 216456.
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Palaniyandi Muthukutty & So Young Yoo. (2023) Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective. Viruses 15:8, pages 1645.
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Stephanie Riederer, Ana del Canizo, Javier Navas, Marlowe G. Peter, Ellen K. Link, Gerd Sutter & Juan J. Rojas. (2023) Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease. Cancer Gene Therapy 30:7, pages 1029-1039.
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Nikolas T. Martin, Mathieu J. F. Crupi, Zaid Taha, Joanna Poutou, Jack T. Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C. Dickinson, Jean-Simon Diallo, Carolina S. Ilkow & John C. Bell. (2023) Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy. Pharmaceuticals 16:5, pages 709.
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Jack T. Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A. Tamming, Giuseppe Pugliese, Nikolas T. Martin, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E. F. Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S. Huh, Matt Y. Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D. Lichty, Carolina S. Ilkow & John C. Bell. (2023) CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX. Frontiers in Immunology 13.
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Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett & Zong-Sheng Guo. (2022) Ferroptosis Inducer Improves the Efficacy of Oncolytic Virus-Mediated Cancer Immunotherapy. Biomedicines 10:6, pages 1425.
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Wen Lei, Qian Ye, Yuanyuan Hao, Jie Chen, Yu Huang, Liu Yang, Shibing Wang & Wenbin Qian. (2022) CD19-targeted BiTE expression by an oncolytic vaccinia virus significantly augments therapeutic efficacy against B-cell lymphoma. Blood Cancer Journal 12:2.
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Zongmin Zhao, Aaron C. Anselmo & Samir Mitragotri. (2021) Viral vector‐based gene therapies in the clinic . Bioengineering & Translational Medicine 7:1.
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Alberto Reale, Arianna Calistri & Jennifer Altomonte. (2021) Giving Oncolytic Viruses a Free Ride: Carrier Cells for Oncolytic Virotherapy. Pharmaceutics 13:12, pages 2192.
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Johannes P. W. Heidbuechel & Christine E. Engeland. (2021) Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies. Journal of Hematology & Oncology 14:1.
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Masmudur M. Rahman & Grant McFadden. (2021) Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy. Cancers 13:21, pages 5452.
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Cole W. D. Peters & Fares Nigim. (2021) Immunomodulatory Arming Factors—The Current Paradigm for Oncolytic Vectors Relies on Immune Stimulating Molecules. International Journal of Molecular Sciences 22:16, pages 9051.
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