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Expert Opinion on Emerging Drugs Volume 23, 2018 - Issue 4
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Review

Emerging drugs for the treatment of Dravet syndrome

Francesco BrigoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy;Division of Neurology, “Franz Tappeiner” Hospital, Merano, ItalyORCID Iconhttp://orcid.org/0000-0003-0928-1577View further author information
ORCID Icon,
Pasquale StrianoPediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, “G. Gaslini” Institute, Genova, ItalyORCID Iconhttp://orcid.org/0000-0002-6065-1476View further author information
ORCID Icon,
Ganna BalaguraPediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, “G. Gaslini” Institute, Genova, ItalyView further author information
&
Vincenzo BelcastroNeurology Unit, S. Anna Hospital, Como, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-3416-2900View further author information
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Pages 261-269 | Received 22 Aug 2018, Accepted 23 Nov 2018, Published online: 04 Dec 2018

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Antonella Riva, Gianluca D’Onofrio, Elisabetta Amadori, Domenico Tripodi, Ganna Balagura, Valentina Iurilli, Maria Stella Vari, Alberto Verrotti & Pasquale Striano. (2022) Current and promising therapeutic options for Dravet syndrome. Expert Opinion on Pharmacotherapy 23:15, pages 1727-1736.
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Alberto Verrotti & Pasquale Striano. (2021) Novel therapeutic options for Dravet and Lennox-Gastaut syndrome. Expert Review of Neurotherapeutics 21:11, pages 1191-1194.
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Barbara Miziak & Stanisław Czuczwar. (2021) Advances in the design and discovery of novel small molecule drugs for the treatment of Dravet Syndrome. Expert Opinion on Drug Discovery 16:5, pages 579-593.
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Adam Strzelczyk & Susanne Schubert-Bast. (2020) Therapeutic advances in Dravet syndrome: a targeted literature review. Expert Review of Neurotherapeutics 20:10, pages 1065-1079.
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Francesco Brigo, Pasquale Striano & Vicenzo Belcastro. (2019) A reappraisal of atypical absence seizures in children and adults: therapeutic implications. Expert Opinion on Pharmacotherapy 20:17, pages 2115-2120.
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Catherine Chiron. (2019) Stiripentol for the treatment of seizures associated with Dravet syndrome. Expert Review of Neurotherapeutics 19:4, pages 301-310.
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Robert Lersch, Rawan Jannadi, Leonie Grosse, Matias Wagner, Marius Frederik Schneider, Celina von Stülpnagel, Florian Heinen, Heidrun Potschka & Ingo Borggraefe. (2022) Targeted Molecular Strategies for Genetic Neurodevelopmental Disorders: Emerging Lessons from Dravet Syndrome. The Neuroscientist 29:6, pages 732-750.
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Gianluca Dini, Eleonora Tulli, Giovanni Battista Dell’Isola, Elisabetta Mencaroni, Giuseppe Di Cara, Pasquale Striano & Alberto Verrotti. (2022) Improving Therapy of Pharmacoresistant Epilepsies: The Role of Fenfluramine. Frontiers in Pharmacology 13.
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Francesca MarcheseMaria Stella VariGanna BalaguraAntonella RivaVincenzo SalpietroAlberto VerrottiRita CitraroSimona LattanziCarlo MinettiEmilio RussoPasquale Striano. (2022) An Open Retrospective Study of a Standardized Cannabidiol Based-Oil in Treatment-Resistant Epilepsy. Cannabis and Cannabinoid Research 7:2, pages 199-206.
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Adam Strzelczyk & Susanne Schubert-Bast. (2022) A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication. CNS Drugs 36:3, pages 217-237.
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Elena Cardenal‐Muñoz, Stéphane Auvin, Vicente Villanueva, J. Helen Cross, Sameer M. Zuberi, Lieven Lagae & José Ángel Aibar. (2021) Guidance on Dravet syndrome from infant to adult care: Road map for treatment planning in Europe. Epilepsia Open 7:1, pages 11-26.
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Scott C. Baraban. (2021) A zebrafish-centric approach to antiepileptic drug development. Disease Models & Mechanisms 14:7.
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Antonella Fattorusso, Sara Matricardi, Elisabetta Mencaroni, Giovanni Battista Dell'Isola, Giuseppe Di Cara, Pasquale Striano & Alberto Verrotti. (2021) The Pharmacoresistant Epilepsy: An Overview on Existant and New Emerging Therapies. Frontiers in Neurology 12.
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Kumar Sannagowdara & Nadir Khan. (2021) Medical Management in Focal versus Generalized Epilepsy. Journal of Pediatric Epilepsy 10:02, pages 081-087.
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Valentina Satta, Cristina Alonso, Paula Díez, Soraya Martín-Suárez, Marta Rubio, Juan M. Encinas, Javier Fernández-Ruiz & Onintza Sagredo. (2021) Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments. Frontiers in Molecular Neuroscience 13.
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Ganna Balagura, Marta Cacciatore, Eleonora A. Grasso, Pasquale Striano & Alberto Verrotti. (2020) Fenfluramine for the Treatment of Dravet Syndrome and Lennox–Gastaut Syndrome. CNS Drugs 34:10, pages 1001-1007.
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Zhou Han, Chunling ChenAnne ChristiansenSophina JiQian Lin, Charles AnumonwoChante Liu, Steven C. Leiser MeenaIsabel AznarezGene LiauLori L. Isom. (2020) Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome . Science Translational Medicine 12:558.
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Wolfgang Löscher, Heidrun Potschka, Sanjay M. Sisodiya & Annamaria Vezzani. (2020) Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options. Pharmacological Reviews 72:3, pages 606-638.
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James W. Wheless, Stephen P. Fulton & Basanagoud D. Mudigoudar. (2020) Dravet Syndrome: A Review of Current Management. Pediatric Neurology 107, pages 28-40.
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Alberto Verrotti, Simona Lattanzi, Francesco Brigo & Gaetano Zaccara. (2020) Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice. Epilepsy & Behavior 104, pages 106939.
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Stephen F. Traynelis, Dennis Dlugos, David Henshall, Heather C. Mefford, Michael A. Rogawski, Kevin J. Staley, Penny A. Dacks, Vicky Whittemore & Annapurna Poduri. (2020) Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects. Epilepsy Currents 20:1_suppl, pages 23S-30S.
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Guy A. Higgins, Paul J. Fletcher & William R. Shanahan. (2020) Lorcaserin: A review of its preclinical and clinical pharmacology and therapeutic potential. Pharmacology & Therapeutics 205, pages 107417.
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Leonardo B. Silenieks, Nicole K. Carroll, Annalise Van Niekerk, Emily Van Niekerk, Colleen Taylor, Neil Upton & Guy A. Higgins. (2019) Evaluation of Selective 5-HT 2C Agonists in Acute Seizure Models . ACS Chemical Neuroscience 10:7, pages 3284-3295.
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E. D. Belousova & A. A. Sharkov. (2019) Difficulties in the diagnosis, prognosis and treatment of genetic epileptic encephalopathies: the view of a neurologist. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 119:11, pages 34.
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