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Expert Opinion on Emerging Drugs Volume 26, 2021 - Issue 1
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Systematic Review

Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials

Amna Majeeda Temerty Faculty of Medicine, University of Toronto, CanadaView further author information
,
Jiaqi Xiongb Department of Pharmacology, University of Toronto, Toronto, CanadaView further author information
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Kayla M. Teopizc Institute of Medical Science, University of Toronto, Toronto, CanadaView further author information
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Jason Ngd Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, CanadaView further author information
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Roger Hoe Institute for Health Innovation and Technology (Ihealthtech), National University of Singapore, Singapore, Singapore;f Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeView further author information
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Joshua D. Rosenblatb Department of Pharmacology, University of Toronto, Toronto, Canada;d Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, CanadaView further author information
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Lee Phand Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, CanadaView further author information
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Bing Caog Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University (SWU), P. R. ChinaORCID Iconhttps://orcid.org/0000-0001-5963-2676View further author information
ORCID Icon &
Roger S. McIntyreb Department of Pharmacology, University of Toronto, Toronto, Canada;c Institute of Medical Science, University of Toronto, Toronto, Canada;d Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada;h Brain and Cognition Discovery Foundation, Toronto, CanadaCorrespondence[email protected]
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Pages 63-74 | Received 22 Dec 2020, Accepted 01 Mar 2021, Published online: 12 Mar 2021

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Read on this site (3)

Nicole Ledwos, Aurelia I. Andreiev, Tianna Costa, Nitin Chopra & Tony P. George. (2023) Successful treatment of dextromethorphan use disorder with combined naltrexone and gabapentin: a case report. The American Journal of Drug and Alcohol Abuse 49:2, pages 266-267.
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Bartłomiej Pochwat, Anna Julia Krupa, Marcin Siwek & Bernadeta Szewczyk. (2022) New investigational agents for the treatment of major depressive disorder. Expert Opinion on Investigational Drugs 31:10, pages 1053-1066.
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Roger S. McIntyre. (2022) Rapid-acting antidepressants in psychiatry: psychedelics, episodic treatments, innovation, and clarion call for methodologic rigor in drug development. Expert Opinion on Drug Safety 21:6, pages 715-716.
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Articles from other publishers (18)

Mu-Hong Chen & Shih-Jen Tsai. (2023) Maintenance of antidepressant effect by dextromethorphan in patients with treatment-resistant depression who respond to ketamine intervention. Medical Hypotheses, pages 111242.
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Mauro Scala, Giuseppe Fanelli, Diana De Ronchi, Alessandro Serretti & Chiara Fabbri. (2023) Clinical specificity profile for novel rapid acting antidepressant drugs. International Clinical Psychopharmacology 38:5, pages 297-328.
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Alessandro Serretti. (2023) Anhedonia and Depressive Disorders. Clinical Psychopharmacology and Neuroscience 21:3, pages 401-409.
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Aileen M. Bailey, Allison Barrett, Lane Havens, Erica Leyder, Taylor Merchant, Hannah Starnes & Scott M. Thompson. (2023) Changes in social, sexual, and hedonic behaviors in rats in response to stress and restoration by a negative allosteric modulator of α5-subunit containing GABA receptor. Behavioural Brain Research 452, pages 114554.
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Itamar Shapira, Bradley G. Burk, Harrison Hill & Brandon S. Pruett. (2023) Playing with a full dex of cards: Treatment resistant depression with suicidality responds to inpatient dextromethorphan therapy. Psychiatry Research Case Reports 2:1, pages 100105.
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Mujeeb U. Shad. (2023) Recent Developments in Pharmacotherapy of Depression: Bench to Bedside. Journal of Personalized Medicine 13:5, pages 773.
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Jenessa N. Johnston, Bashkim Kadriu, Josh Allen, Jessica R. Gilbert, Ioline D. Henter & Carlos A. ZarateJr.Jr.. (2023) Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment. Neuropharmacology 226, pages 109422.
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Shiyun Lv, Kejie Yao, Youyi Zhang & Shujia Zhu. (2023) NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research. Neuropharmacology 225, pages 109378.
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Bruno Pedraz‐Petrozzi, Michael Deuschle & Maria Gilles. (2023) Improvement of depressive symptoms, after a suicide attempt, with dextromethorphan/bupropion combination treatment in a patient with treatment‐resistant depression and psychiatric comorbidities. Clinical Case Reports 11:3.
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Yian Chen, Eric Wang, Brian D Sites & Steven P Cohen. (2023) Integrating mechanistic-based and classification-based concepts into perioperative pain management: an educational guide for acute pain physicians. Regional Anesthesia & Pain Medicine, pages rapm-2022-104203.
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Golnoush Banaei-Boroujeni, Ameneh Rezayof, Sakineh Alijanpour & Farzaneh Nazari-Serenjeh. (2023) Targeting mediodorsal thalamic CB1 receptors to inhibit dextromethorphan-induced anxiety/exploratory-related behaviors in rats: The post-weaning effect of exercise and enriched environment on adulthood anxiety. Journal of Psychiatric Research 157, pages 212-222.
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Steven Marwaha, Edward Palmer, Trisha Suppes, Emily Cons, Allan H Young & Rachel Upthegrove. (2023) Novel and emerging treatments for major depression. The Lancet 401:10371, pages 141-153.
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Karan Kverno. (2022) Dextromethorphan: From Cough Suppressant to Antidepressant. Journal of Psychosocial Nursing and Mental Health Services 60:11, pages 9-11.
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R. Guglielmo & G. Hasler. (2022) The neuroprotective and neuroplastic potential of glutamatergic therapeutic drugs in bipolar disorder. Neuroscience & Biobehavioral Reviews 142, pages 104906.
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Yu-Ming Wang, Cong-Yuan Xia, Hong-Mei Jia, Jun He, Wen-Wen Lian, Yu Yan, Wen-Ping Wang, Wei-Ku Zhang & Jie-Kun Xu. (2022) Sigma-1 receptor: A potential target for the development of antidepressants. Neurochemistry International 159, pages 105390.
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Octavian Vasiliu. (2022) Investigational Drugs for the Treatment of Depression (Part 2): Glutamatergic, Cholinergic, Sestrin Modulators, and Other Agents. Frontiers in Pharmacology 13.
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M. A. Novitsky, A. De Sousa, A. R. Asadullin, O. A. Gavrilyuk, A. V. Petrov & R. F. Nasyrova. (2021) Possibilities and limitations of antidepressant use to correct depressive and negative symptoms in schizophrenia. Personalized Psychiatry and Neurology 1:2, pages 21-45.
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Joshua D. Di Vincenzo, Orly Lipsitz, Nelson B. Rodrigues, Yena Lee, Hartej Gill, Kevin Kratiuk, Mehala Subramaniapillai, Rodrigo Mansur, Roger S. McIntyre & Joshua D. Rosenblat. (2021) Ketamine monotherapy versus adjunctive ketamine in adults with treatment-resistant depression: Results from the Canadian Rapid Treatment Centre of Excellence. Journal of Psychiatric Research 143, pages 209-214.
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