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Expert Opinion on Therapeutic Targets Volume 20, 2016 - Issue 10
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Review

Antitumorigenic targets of cannabinoids – current status and implications

Robert RamerInstitute of Toxicology and Pharmacology, Rostock University Medical Center, Rostock, Germany
&
Burkhard HinzInstitute of Toxicology and Pharmacology, Rostock University Medical Center, Rostock, GermanyCorrespondence[email protected]
Pages 1219-1235 | Received 20 Jul 2015, Accepted 08 Apr 2016, Published online: 11 May 2016

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Rico Schwarz, Robert Ramer & Burkhard Hinz. (2018) Targeting the endocannabinoid system as a potential anticancer approach. Drug Metabolism Reviews 50:1, pages 26-53.
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Nakea M. Pennant & Cimona V. Hinton. (2023) The evolution of cannabinoid receptors in cancer. WIREs Mechanisms of Disease 15:4.
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Qiang Song, Wenjin Zhang, Dan Shi, Zhiliang Zhang, Qiurong Zhao, Mengyuan Wang, Man Huang, Juanjuan Meng, Wei Cui & Xiaohe Luo. (2023) Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway. Cancer Medicine 12:12, pages 13538-13550.
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Franjo Grotenhermen. (2023) Der Nutzen von Cannabis in der Krebstherapie. Onkologische Welt 14:03, pages 146-153.
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Jennifer Ana Iden, Bitya Raphael-Mizrahi, Zamzam Awida, Aaron Naim, Dan Zyc, Tamar Liron, Melody Kasher, Gregory Livshits, Marilena Vered & Yankel Gabet. (2023) The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans. International Journal of Molecular Sciences 24:4, pages 4060.
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Ivan A. RossIvan A. Ross. 2023. Plant-Based Therapeutics, Volume 1. Plant-Based Therapeutics, Volume 1 427 511 .
Franjo Grotenhermen. (2022) Der Nutzen von Cannabis in der Krebstherapie. Deutsche Zeitschrift für Onkologie 54:04, pages 159-165.
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Viktoriia Cherkasova, Bo Wang, Marta Gerasymchuk, Anna Fiselier, Olga Kovalchuk & Igor Kovalchuk. (2022) Use of Cannabis and Cannabinoids for Treatment of Cancer. Cancers 14:20, pages 5142.
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Shiqi Li, Jianfang Chen, Xin Chen, Jin Yu, Yanzhi Guo, Menglong Li & Xuemei Pu. (2022) Therapeutic and prognostic potential of GPCRs in prostate cancer from multi-omics landscape. Frontiers in Pharmacology 13.
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Kyriaki Hatziagapiou, Kostas Bethanis, Eleni Koniari, Elias Christoforides, Olti Nikola, Athena Andreou, Aimilia Mantzou, George P. Chrousos, Christina Kanaka-Gantenbein & George I. Lambrou. (2022) Biophysical Studies and In Vitro Effects of Tumor Cell Lines of Cannabidiol and Its Cyclodextrin Inclusion Complexes. Pharmaceutics 14:4, pages 706.
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Amal M. Shoeib, Lance N. Benson, Shengyu Mu, Lee Ann MacMillan-Crow & Paul L. Prather. (2022) Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death. International Journal of Molecular Sciences 23:6, pages 3049.
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Vidyasagar Naik Bukke, Moola Archana, Rosanna Villani, Gaetano Serviddio & Tommaso Cassano. (2021) Pharmacological and Toxicological Effects of Phytocannabinoids and Recreational Synthetic Cannabinoids: Increasing Risk of Public Health. Pharmaceuticals 14:10, pages 965.
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Mariantonia Braile, Simone Marcella, Gianni Marone, Maria Rosaria Galdiero, Gilda Varricchi & Stefania Loffredo. (2021) The Interplay between the Immune and the Endocannabinoid Systems in Cancer. Cells 10:6, pages 1282.
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Andrea M. Tomko, Erin G. Whynot, Lee D. Ellis & Denis J. Dupré. (2020) Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis. Cancers 12:7, pages 1985.
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Chao Liu, Sayed H. Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat A. Panuganti, Shuling Ren, Yusuke Goto, Sunny Haft, Takahito Fukusumi, Mizuo Ando, Yuki Saito, Theresa Guo, Pablo Tamayo, Huwate Yeerna, William Kim, Jacqueline Hubbard, Andrew B. Sharabi, J. Silvio Gutkind & Joseph A. Califano. (2020) Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation. Clinical Cancer Research 26:11, pages 2693-2703.
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Pietrovito, Iozzo, Bacci, Giannoni & Chiarugi. (2020) Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression. International Journal of Molecular Sciences 21:3, pages 787.
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Roy Upton. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 470 483.e5 .
Marco Barchi, Elisa Innocenzi, Teresa Giannattasio, Susanna Dolci, Pellegrino Rossi & Paola Grimaldi. (2019) Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells. International Journal of Molecular Sciences 21:1, pages 25.
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Oscar Prospéro-García, Alejandra E. Ruiz Contreras, Alette Ortega Gómez, Andrea Herrera-Solís & Mónica Méndez-Díaz. (2019) Endocannabinoids as Therapeutic Targets. Archives of Medical Research 50:8, pages 518-526.
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Robert Ramer, Rico Schwarz & Burkhard Hinz. (2019) Modulation of the Endocannabinoid System as a Potential Anticancer Strategy. Frontiers in Pharmacology 10.
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Burkhard Hinz & Robert Ramer. (2019) Anti-tumour actions of cannabinoids. British Journal of Pharmacology 176:10, pages 1384-1394.
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Sandra Blasco-BenitoEstefanía MorenoMarta Seijo-VilaIsabel TundidorClara AndradasMaría M. Caffarel, Miriam Caro-VillalobosLeyre UrigüenRebeca Diez-AlarciaGema Moreno-BuenoLucía HernándezLuis MansoPatricia Homar-RuanoPeter J. McCormickLucka BibicCristina Bernadó-MoralesJoaquín ArribasMeritxell CanalsVicent CasadóEnric I. CanelaManuel Guzmán, Eduardo Pérez-GómezCristina Sánchez. (2019) Therapeutic targeting of HER2–CB 2 R heteromers in HER2-positive breast cancer . Proceedings of the National Academy of Sciences 116:9, pages 3863-3872.
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Ana Isabel Fraguas-Sánchez & Ana Isabel Torres-Suárez. (2018) Medical Use of Cannabinoids. Drugs 78:16, pages 1665-1703.
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Maria Antonietta De Luca & Liana Fattore. (2018) Therapeutic Use of Synthetic Cannabinoids: Still an Open Issue?. Clinical Therapeutics 40:9, pages 1457-1466.
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Nancy Maurya & Bharath Kumar Velmurugan. (2018) Therapeutic applications of cannabinoids. Chemico-Biological Interactions 293, pages 77-88.
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Ana Isabel Fraguas‐Sánchez, Cristina Martín‐Sabroso & Ana Isabel Torres‐Suárez. (2018) Insights into the effects of the endocannabinoid system in cancer: a review. British Journal of Pharmacology 175:13, pages 2566-2580.
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Attila Oláh, Zoltán Szekanecz & Tamás Bíró. (2017) Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges. Frontiers in Immunology 8.
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Francesca Punzo, Chiara Tortora, Daniela Di Pinto, Iolanda Manzo, Giulia Bellini, Fiorina Casale & Francesca Rossi. (2017) Anti-proliferative, pro-apoptotic and anti-invasive effect of EC/EV system in human osteosarcoma. Oncotarget 8:33, pages 54459-54471.
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Sanda Vladimir‐Knežević, Biljana Blažeković, Maja Bival Štefan & Marija Kindl. 2017. Natural Products and Cancer Drug Discovery. Natural Products and Cancer Drug Discovery.
Robert Ramer & Burkhard Hinz. 2017. Cannabinoid Pharmacology. Cannabinoid Pharmacology 397 436 .

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