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Expert Opinion on Therapeutic Targets Volume 20, 2016 - Issue 10
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Original Research

HMGA1 silencing reduces stemness and temozolomide resistance in glioblastoma stem cells

Marianna ColamaioIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Nadia TostiIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, Italy;Molecular Pathology Unit, Institute of Pathology, University Hospital Basel, Basel, SwitzerlandView further author information
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Francesca PucaIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Alessia MariIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Rosaria GattordoIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Yalçın KuzayIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Antonella FedericoIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Anna PepeDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Daniela SarnataroCEINGE-Biotecnologie Avanzate, Naples, ItalyView further author information
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Elvira RagozzinoIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyView further author information
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Maddalena RaiaCEINGE-Biotecnologie Avanzate, Naples, ItalyView further author information
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Hidenari HirataDepartment of Surgery, Kyushu University Beppu Hospital, Beppu, JapanView further author information
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Marica GemeiCEINGE-Biotecnologie Avanzate, Naples, ItalyView further author information
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Koshi MimoriDepartment of Surgery, Kyushu University Beppu Hospital, Beppu, JapanView further author information
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Luigi del VecchioCEINGE-Biotecnologie Avanzate, Naples, ItalyView further author information
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Sabrina BattistaIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, ItalyCorrespondence[email protected] [email protected]
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Alfredo FuscoIstituto di Endocrinologia ed Oncologia Sperimentale – CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli ‘Federico II,’Naples, Italy;Programa de Carcinogênese Molecular, Instituto Nacional de Câncer – INCA, Rio de Janeiro, BrazilView further author information
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Pages 1169-1179 | Received 04 Sep 2015, Accepted 01 Aug 2016, Published online: 08 Sep 2016

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Jianghui Wang, Xiaoxue Zhang, Xiaojuan Wang, Fadi Li, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Qizhi Song, Liming Zhao, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin & Weimin Wang. (2023) Polymorphism and expression of the HMGA1 gene and association with tail fat deposition in Hu sheep. Animal Biotechnology 34:4, pages 1626-1634.
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Silvia Pegoraro, Gloria Ros, Michela Sgubin, Sara Petrosino, Alberto Zambelli, Riccardo Sgarra & Guidalberto Manfioletti. (2020) Targeting the intrinsically disordered architectural High Mobility Group A (HMGA) oncoproteins in breast cancer: learning from the past to design future strategies. Expert Opinion on Therapeutic Targets 24:10, pages 953-969.
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Francesca Puca, Nadia Tosti, Antonella Federico, Yalçın Kuzay, Anna Pepe, Sonia Morlando, Teresa Savarese, Federica D’Alessio, Marianna Colamaio, Daniela Sarnataro, Sihana Ziberi, Marco De Martino, Alfredo Fusco & Sabrina Battista. (2019) HMGA1 negatively regulates NUMB expression at transcriptional and post transcriptional level in glioblastoma stem cells. Cell Cycle 18:13, pages 1446-1457.
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Hailong Zheng, Jiajing Xie, Kai Song, Jing Yang, Huiting Xiao, Jiashuai Zhang, Keru Li, Rongqiang Yuan, Yuting Zhao, Yunyan Gu & Wenyuan Zhao. (2022) StemSC: a cross-dataset human stemness index for single-cell samples. Stem Cell Research & Therapy 13:1.
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Lias Saed, Agnieszka Jeleń, Marek Mirowski & Aleksandra Sałagacka-Kubiak. (2022) Prognostic Significance of HMGA1 Expression in Lung Cancer Based on Bioinformatics Analysis. International Journal of Molecular Sciences 23:13, pages 6933.
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Juliana B. Vilar, Markus Christmann & Maja T. Tomicic. (2022) Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?. Cancers 14:10, pages 2416.
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Camila M. Lopes-Ramos, Tatiana Belova, Tess H. Brunner, Marouen Ben Guebila, Daniel Osorio, John Quackenbush & Marieke L. Kuijjer. (2021) Regulatory Network of PD1 Signaling Is Associated with Prognosis in Glioblastoma Multiforme. Cancer Research 81:21, pages 5401-5412.
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Wensheng Zhang, Yigang Lu, Huibo Shi, Xungang Li, Zhuo Zhang, Xinxi Deng, Yang Yang & Bin Wan. (2021) LncRNA ITGB2-AS1 promotes the progression of clear cell renal cell carcinoma by modulating miR-328-5p/HMGA1 axis. Human Cell 34:5, pages 1545-1557.
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Ebru Güçlü, Canan Eroğlu Güneş, Ercan Kurar & Hasibe Vural. (2021) Knockdown of lncRNA HIF1A-AS2 increases drug sensitivity of SCLC cells in association with autophagy. Medical Oncology 38:9.
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Antonietta Rosella Farina, Lucia Annamaria Cappabianca, Veronica Zelli, Michela Sebastiano & Andrew Reay Mackay. (2021) Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting. World Journal of Stem Cells 13:7, pages 685-736.
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Guohui Yan, Shuidi Yan, Jiajia Wang, Shen Lei, Weimin Tian, Xin Yue & Yang Zhang. (2021) MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer. Experimental and Therapeutic Medicine 22:2.
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Yu Zeng, Tianshi Que, Jie Lin, Zhengming Zhan, Anqi Xu, Zhiyong Wu, Cheng Xie, Jie Luo, Shengfeng Ding, Hao Long, Xian Zhang & Ye Song. (2021) Oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin promotes the malignant phenotype of glioma. Molecular Therapy - Nucleic Acids 23, pages 769-782.
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Yanfei Jia, Wenzhen Yang, Bo Tang, Qian Feng & Zhiqiang Dong. (2021) Hub gene identification and prognostic model construction for isocitrate dehydrogenase mutation in glioma. Translational Oncology 14:1, pages 100979.
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Sabrina Battista, Laura Cerchia & Monica Fedele. 2021. Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies. Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies 365 400 .
Linjia Su, Nadezda Bryan, Sabrina Battista, Juliano Freitas, Alyssa Garabedian, Federica D’Alessio, Miriam Romano, Fabiana Falanga, Alfredo Fusco, Lidia Kos, Jeremy Chambers, Francisco Fernandez-Lima, Prem P. Chapagain, Stefan Vasile, Layton Smith & Fenfei Leng. (2020) Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Scientific Reports 10:1.
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Maria Wiese, Feda H. Hamdan, Klaudia Kubiak, Christopher Diederichs, Gerrit H. Gielen, Gunther Nussbaumer, Angel M. Carcaboso, Esther Hulleman, Steven A. Johnsen & Christof M. Kramm. (2020) Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells. Cell Death & Disease 11:8.
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Robert Vignali & Silvia Marracci. (2020) HMGA Genes and Proteins in Development and Evolution. International Journal of Molecular Sciences 21:2, pages 654.
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Silvia Parisi, Silvia Piscitelli, Fabiana Passaro & Tommaso Russo. (2020) HMGA Proteins in Stemness and Differentiation of Embryonic and Adult Stem Cells. International Journal of Molecular Sciences 21:1, pages 362.
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Jian Wang, Jialin Liu, Guochen Sun, Hengxing Meng, Jiayin Wang, Yunqian Guan, Yiheng Yin, Zhenyu Zhao, Xiying Dong, Shangjiong Yin, Hongwei Li, Yuefei Cheng, Hao Wu, Anhua Wu, Xinguang Yu & Ling Chen. (2019) Glioblastoma extracellular vesicles induce the tumour-promoting transformation of neural stem cells. Cancer Letters 466, pages 1-12.
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Yuhong Wang, Lin Hu, Yushuang Zheng & Lingchuan Guo. (2019) HMGA1 in cancer: Cancer classification by location. Journal of Cellular and Molecular Medicine 23:4, pages 2293-2302.
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Sevinci Pop, Ana‐Maria Enciu, Laura G. Necula & Cristiana Tanase. (2018) Long non‐coding RNA s in brain tumours: Focus on recent epigenetic findings in glioma . Journal of Cellular and Molecular Medicine 22:10, pages 4597-4610.
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Lei Shi & Guan Sun. (2018) DMC is not better than TMZ on intracranial anti‐glioma effects. Journal of Cellular Biochemistry 119:7, pages 6057-6064.
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Haijun Zhang, Jing Yang, Matthew S. Walters, Michelle R. Staudt, Yael Strulovici-Barel, Jacqueline Salit, Jason G. Mezey, Philip L. Leopold & Ronald G. Crystal. (2018) Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration. Oncotarget 9:18, pages 14324-14337.
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Reza Ahmadi-Beni & Alireza Khoshnevisan. (2017) An overview of crucial genes involved in stemness of glioblastoma multiforme. Neurochemical Journal 11:4, pages 259-265.
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Daniela D’Angelo, Paula Mussnich, Claudio Arra, Sabrina Battista & Alfredo Fusco. (2017) Critical role of HMGA proteins in cancer cell chemoresistance. Journal of Molecular Medicine 95:4, pages 353-360.
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Laura Garros-Regulez, Idoia Garcia, Estefania Carrasco-Garcia, Aquilino Lantero, Paula Aldaz, Leire Moreno-Cugnon, Olatz Arrizabalaga, Jose Undabeitia, Sergio Torres-Bayona, Jorge Villanua, Irune Ruiz, Larraitz Egaña, Nicolas Sampron & Ander Matheu. (2016) Targeting SOX2 as a Therapeutic Strategy in Glioblastoma. Frontiers in Oncology 6.
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