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Review

Emerging role of SETDB1 as a therapeutic target

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Pages 319-331 | Received 14 Jul 2016, Accepted 21 Dec 2016, Published online: 20 Jan 2017

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Xiaoli Qian, Yang Yang, Yingfen Deng, Yali Liu, Yuwen Zhou, Fang Han, Yue Xu & Hongjian Yuan. (2023) SETDB1 induces lenalidomide resistance in multiple myeloma cells via epithelial‑mesenchymal transition and PI3K/AKT pathway activation. Experimental and Therapeutic Medicine 25:6.
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Lijun Zhang, Liqun Xu, Yixuan Wang, Xiaoyan Zhang, Tong Xue, Quan Sun, Hao Tang, Meng Li, Xinsheng Cao, Fei Shi, Ge Zhang, Shu Zhang & Zebing Hu. (2023) Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading. Cellular Signalling 102, pages 110554.
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Yuanling Zhang, Junhao Chen, Hang Liu, Rui Mi, Rui Huang, Xian Li, Fei Fan, Xueqing Xie & Jie Ding. (2023) The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy. Frontiers in Immunology 13.
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Jaemin Eom, Kyuheum Jeon, Jung Sun Park & Yong-Kook Kang. (2022) Functional dissection of N-terminal nuclear trafficking signals of SETDB1. Frontiers in Cell and Developmental Biology 10.
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Rosari Hernandez‐Vicens, Jagreeti Singh, Nomi Pernicone, Tamar Listovsky & Gabi Gerlitz. (2022) SETDB1 regulates microtubule dynamics. Cell Proliferation 55:12.
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Yiyang Li, Wei Zhou, Xiangbing Meng, Sarina D. Murray, Long Li, Abby Fronk, Vanessa J. Lazaro-Camp, Kuo-kuang Wen, Meng Wu, Adam Dupuy, Kimberly K. Leslie & Shujie Yang. (2022) Utilizing an Endogenous Progesterone Receptor Reporter Gene for Drug Screening and Mechanistic Study in Endometrial Cancer. Cancers 14:19, pages 4883.
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Seamus Balinth, Matthew L. Fisher, Yon Hwangbo, Caizhi Wu, Carlos Ballon, Xueqin Sun & Alea A. Mills. (2022) EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma. Oncogene 41:35, pages 4130-4144.
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Lijun Zhang, Liqun Xu, Xiaoyan Zhang, Ke Wang, Yingjun Tan, Gaozhi Li, Yixuan Wang, Tong Xue, Quan Sun, Xinsheng Cao, Ge Zhang, Zebing Hu, Shu Zhang & Fei Shi. (2022) Methyltransferase Setdb1 Promotes Osteoblast Proliferation by Epigenetically Silencing Macrod2 with the Assistance of Atf7ip. Cells 11:16, pages 2580.
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Tushar Warrier, Chadi El Farran, Yingying Zeng, Benedict Shao Quan Ho, Qiuye Bao, Zi Hao Zheng, Xuezhi Bi, Huck Hui Ng, Derrick Sek Tong Ong, Justin Jang Hann Chu, Amartya Sanyal, Melissa Jane Fullwood, James J Collins, Hu Li, Jian Xu & Yuin-Han Loh. (2022) SETDB1 acts as a topological accessory to Cohesin via an H3K9me3-independent, genomic shunt for regulating cell fates. Nucleic Acids Research 50:13, pages 7326-7349.
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Xin Lin, Min Xiao, Zhitao Chen, Chenchen Ding, Ting Zhang & Qiyong Li. (2022) Pancancer Analyses Reveal Genomics and Clinical Characteristics of the SETDB1 in Human Tumors. Journal of Oncology 2022, pages 1-40.
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Yaguan Fan, Libo Yang, Yi Ren, Yunhua Wu, Linhai Li & Lihua Li. (2022) Sp1-Induced SETDB1 Overexpression Transcriptionally Inhibits HPGD in a β-Catenin-Dependent Manner and Promotes the Proliferation and Metastasis of Gastric Cancer. Journal of Gastric Cancer 22:4, pages 319.
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Qiuyu Cai, Can Gan, Chengwei Tang, Hao Wu & Jinhang Gao. (2021) Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease. Frontiers in Pharmacology 12.
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Phyo Thiha, Norihisa Higashihori, Sakurako Kano & Keiji Moriyama. (2021) Histone methyltransferase SET domain bifurcated 1 negatively regulates parathyroid hormone/parathyroid hormone-related peptide receptor to control chondrocyte proliferation in Meckel’s cartilage. Archives of Oral Biology 131, pages 105251.
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Hsing-Ju Wu & Pei-Yi Chu. (2021) Epigenetic Regulation of Breast Cancer Stem Cells Contributing to Carcinogenesis and Therapeutic Implications. International Journal of Molecular Sciences 22:15, pages 8113.
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Li Yuan, Boshu Sun, Liangliang Xu, Limin Chen & Wenbin Ou. (2021) The Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma. International Journal of Molecular Sciences 22:14, pages 7416.
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Mariam Markouli, Dimitrios Strepkos, Sarantis Chlamydas & Christina Piperi. (2021) Histone lysine methyltransferase SETDB1 as a novel target for central nervous system diseases. Progress in Neurobiology 200, pages 101968.
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Dimitrios Strepkos, Mariam Markouli, Alexia Klonou, Athanasios G. Papavassiliou & Christina Piperi. (2021) Histone Methyltransferase SETDB1: A Common Denominator of Tumorigenesis with Therapeutic Potential. Cancer Research 81:3, pages 525-534.
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Elisabetta Sauta, Andrea Demartini, Francesca Vitali, Alberto Riva & Riccardo Bellazzi. (2020) A Bayesian data fusion based approach for learning genome-wide transcriptional regulatory networks. BMC Bioinformatics 21:1.
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Pradeep Kumar Rajan, Utibe-Abasi Udoh, Juan D. Sanabria, Moumita Banerjee, Gary Smith, Mathew Steven Schade, Jacqueline Sanabria, Komal Sodhi, Sandrine Pierre, Zijian Xie, Joseph I. Shapiro & Juan Sanabria. (2020) The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma. International Journal of Molecular Sciences 21:23, pages 8894.
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Benjamin Wadowski, David T. Severson, Raphael Bueno & Assunta De Rienzo. 2020. Mesothelioma. Mesothelioma.
Shuai Han, Wei Zhen, Tongqi Guo, Jianjun Zou & Fuyong Li. (2020) RETRACTED ARTICLE: SETDB1 promotes glioblastoma growth via CSF-1-dependent macrophage recruitment by activating the AKT/mTOR signaling pathway. Journal of Experimental & Clinical Cancer Research 39:1.
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Aniello Federico, Tamara Steinfass, Lionel Larribère, Daniel Novak, Francisco Morís, Luz-Elena Núñez, Viktor Umansky & Jochen Utikal. (2020) Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma. Molecular Therapy - Oncolytics 18, pages 83-99.
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Lu Yu, Feng Ye, Yi-Yi Li, Yi-Zhi Zhan, Yang Liu, Hong-Mei Yan, Yuan Fang, Yu-Wen Xie, Feng-Jiao Zhang, Long-Hua Chen, Yi Ding & Ke-Li Chen. (2020) Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis. Carcinogenesis 41:5, pages 678-688.
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Shian-Ren Lin, Ntlotlang Mokgautsi & Yen-Nien Liu. (2020) Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis. Molecules 25:10, pages 2380.
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Nan Cao, Yali Yu, Hua Zhu, Meng Chen, Ping Chen, Mingxing Zhuo, Yujuan Mao, Lianyun Li, Qiu Zhao, Min Wu & Mei Ye. (2020) SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression. Cell Death & Disease 11:5.
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Shilong Liu, Bin Li, Jianyu Xu, Songliu Hu, Ning Zhan, Hong Wang, Chunzi Gao, Jian Li & Xiangying Xu. (2020) SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop. Frontiers in Cell and Developmental Biology 8.
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Yueyan Zhu, Daijing Sun, Mira Jakovcevski & Yan Jiang. (2020) Epigenetic mechanism of SETDB1 in brain: implications for neuropsychiatric disorders. Translational Psychiatry 10:1.
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Joachim Torrano, Abdullah Al Emran, Heinz Hammerlindl & Helmut Schaider. (2019) Emerging roles of H3K9me3, SETDB1 and SETDB2 in therapy-induced cellular reprogramming. Clinical Epigenetics 11:1.
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James P. Wells, Justin White & Peter C. Stirling. (2019) R Loops and Their Composite Cancer Connections. Trends in Cancer 5:10, pages 619-631.
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Batham, Lim & Rao. (2019) SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis. Cancers 11:8, pages 1143.
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Laura Monaghan, Matthew E. Massett, Roderick P. Bunschoten, Alex Hoose, Petrisor-Alin Pirvan, Robert M. J. Liskamp, Heather G. Jørgensen & Xu Huang. (2019) The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia. Frontiers in Oncology 9.
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Amelia K. Luciano & David A. Guertin. (2019) Oncogenic AKTivation by methylation. Nature Cell Biology 21:2, pages 114-115.
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Giulia Stazi, Clemens Zwergel & Sergio Valente. 2020. Chemical Epigenetics. Chemical Epigenetics 123 157 .
Tae-Su Han, Hyun Seung Ban, Keun Hur & Hyun-Soo Cho. (2018) The Epigenetic Regulation of HCC Metastasis. International Journal of Molecular Sciences 19:12, pages 3978.
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Han-Heom Na & Keun-Cheol Kim. (2018) SETDB1-mediated FosB regulation via ERK2 is associated with an increase in cell invasiveness during anticancer drug treatment of A549 human lung cancer cells. Biochemical and Biophysical Research Communications 495:1, pages 512-518.
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Xiaoyan Li, Yining Liu, Jiachun Lu & Min Zhao. (2017) Integrative analysis to identify oncogenic gene expression changes associated with copy number variations of enhancer in ovarian cancer. Oncotarget 8:53, pages 91558-91567.
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