831
Views
49
CrossRef citations to date
0
Altmetric
Review

Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome

, &
Pages 333-348 | Received 23 Sep 2016, Accepted 06 Jan 2017, Published online: 25 Jan 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Aurélie Hurtevent, Morgan Le Naour, Veronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel-Henri Caignard, Catherine Dacquet & Nicolas Lebegue. (2020) Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 524-538.
Read now

Articles from other publishers (48)

Celene Titus, Md Tozammel Hoque & Reina Bendayan. (2023) PPAR agonists for the treatment of neuroinflammatory diseases. Trends in Pharmacological Sciences.
Crossref
Qi Huang, Xiantong Zou, Yingli Chen, Leili Gao, Xiaoling Cai, Lingli Zhou, Fei Gao, Jian Zhou, Weiping Jia & Linong Ji. (2023) Personalized glucose-lowering effect of chiglitazar in type 2 diabetes. iScience 26:11, pages 108195.
Crossref
Natalia Grigorova, Zhenya Ivanova, Ekaterina Vachkova, Valeria Petrova & Toncho Penev. (2023) DHA-Provoked Reduction in Adipogenesis and Glucose Uptake Could Be Mediated by Gps2 Upregulation in Immature 3T3-L1 Cells. International Journal of Molecular Sciences 24:17, pages 13325.
Crossref
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu & Hui Zeng. (2023) Osteoarthritis: Role of Peroxisome Proliferator-Activated Receptors. International Journal of Molecular Sciences 24:17, pages 13137.
Crossref
Haoyang Zou, Yiyao Gong, Haiqing Ye, Cuiping Yuan, Tiezhu Li, Jie Zhang & Li Ren. (2023) Dietary regulation of peroxisome proliferator-activated receptors in metabolic syndrome. Phytomedicine 116, pages 154904.
Crossref
N. A. Petunina, E. V. Goncharova, I. A. Kuzina, L. V. Nedosugova, N. S. Martirosyan & M. Е. Теlnova. (2022) The role of pioglitazone in the fight against insulin resistance, atherosclerosis, cardiovascular disease, and non-alcoholic fatty liver disease. Diabetes mellitus 25:5, pages 504-513.
Crossref
Amanda de Assis Carneiro, Simone Batista Pires Sinoti, Marcela Medeiros de Freitas, Luiz Alberto Simeoni, Christopher William Fagg, Pérola de Oliveira Magalhães, Dâmaris Silveira & Yris Maria Fonseca-Bazzo. (2022) Hydroethanolic Extract of Morus nigra L. Leaves: A Dual PPAR-α/γ Agonist with Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7. Plants 11:22, pages 3147.
Crossref
Vinesh Sharma & Vikram Patial. (2022) Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases. Frontiers in Pharmacology 13.
Crossref
Yongyan Song, Tariq Muhammad Raheel, Aimei Jia, Guowei Dai, Liang Liu, Xiaobin Long & Chuan He. (2022) rs10865710 polymorphism in PPARG promoter is associated with the severity of type 2 diabetes mellitus and coronary artery disease in a Chinese population . Postgraduate Medical Journal 98:1164, pages 778-787.
Crossref
Triana Espinosa-Jiménez, Oriol Busquets, Amanda Cano, Elena Sánchez-López, Ester Verdaguer, Antoni Parcerisas, Jordi Olloquequi, Carme Auladell, Jaume Folch, Walter Wahli, Manuel Vázquez-Carrera, Antoni Camins & Miren Ettcheto. (2022) Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations. Frontiers in Pharmacology 13.
Crossref
Manuel Vázquez-Carrera & Walter Wahli. (2022) PPARs as Key Mediators in the Regulation of Metabolism and Inflammation. International Journal of Molecular Sciences 23:9, pages 5025.
Crossref
Cheng Su, Rongzhi Huang, Zhenyuan Yu, Jie Zheng, Fengling Liu, Haiqi Liang & Zengnan Mo. (2022) Myelin and lymphocyte protein serves as a prognostic biomarker and is closely associated with the tumor microenvironment in the nephroblastoma. Cancer Medicine 11:5, pages 1427-1438.
Crossref
Carlos Villarroel-Vicente, Sergio Gutiérrez-Palomo, Jordi Ferri, Diego Cortes & Nuria Cabedo. (2021) Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview. European Journal of Medicinal Chemistry 221, pages 113535.
Crossref
Lin Han, Hao-yu Yang, Yu-jiao Zheng, Xiu-xiu Wei, Wen-chao Dan, Li-li Zhang, Qi-you Ding, Xu Ma, Xin-miao Wang, Lin-hua Zhao & Xiao-lin Tong. (2021) Mechanism exploration of Gouqi-wentang formula against type 2 diabetes mellitus by phytochemistry and network pharmacology-based analysis and biological validation. Chinese Medicine 16:1.
Crossref
Giani M. Garcia, Jérôme Roy, Ivan R. Pitta, Dulcinéia S. P. Abdalla, Andrea Grabe-Guimarães, Vanessa C. F. Mosqueira & Sylvain Richard. (2021) Polylactide Nanocapsules Attenuate Adverse Cardiac Cellular Effects of Lyso-7, a Pan-PPAR Agonist/Anti-Inflammatory New Thiazolidinedione. Pharmaceutics 13:9, pages 1521.
Crossref
Rana Ezzeddini, Mohammad Taghikhani, Amir Salek Farrokhi, Mohammad Hossein Somi, Nasser Samadi, Ali Esfahani & Mohammad Javad Rasaee. (2021) Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance. Journal of Physiology and Biochemistry 77:2, pages 249-260.
Crossref
Kalina Duszka & Walter Wahli. (2020) Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm. Nutrients 12:11, pages 3476.
Crossref
Young Sup Woo, Hyun Kook Lim, Sheng-Min Wang & Won-Myong Bahk. (2020) Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression—A Literature Review. International Journal of Molecular Sciences 21:18, pages 6969.
Crossref
Kalina Duszka, András Gregor, Hervé Guillou, Jürgen König & Walter Wahli. (2020) Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity. Cells 9:7, pages 1708.
Crossref
Tenzin D. Dagpo, Christopher J. Nolan & Viviane Delghingaro-Augusto. (2020) Exploring Therapeutic Targets to Reverse or Prevent the Transition from Metabolically Healthy to Unhealthy Obesity. Cells 9:7, pages 1596.
Crossref
Oana C Kulterer, Laura Niederstaetter, Carsten T Herz, Alexander R Haug, Andrea Bileck, Dietmar Pils, Alexandra Kautzky-Willer, Christopher Gerner & Florian W Kiefer. (2020) The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans. The Journal of Clinical Endocrinology & Metabolism 105:7, pages 2203-2216.
Crossref
Xue-Mei Tang, Wen Hu, Li Fan, Hang Wang, Min-Hui Tang & Da-Cheng Yang. (2020) Synthesis and evaluation of novel peptidomimetics bearing p -aminobenzoic acid moiety as potential antidiabetic agents . Future Medicinal Chemistry 12:11, pages 991-1013.
Crossref
Wendy Wen Ting Phua, Wei Ren Tan, Yun Sheng Yip, Ivan Dongzheng Hew, Jonathan Wei Kiat Wee, Hong Sheng Cheng, Melvin Khee Shing Leow, Walter Wahli & Nguan Soon Tan. (2020) PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle. International Journal of Molecular Sciences 21:5, pages 1747.
Crossref
K.J. Senthil Kumar, M. Gokila Vani, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-xi Lin, Fang-Hua Chu, Gow-Chin Yen & Sheng-Yang Wang. (2020) A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin. Journal of Food and Drug Analysis 28:1, pages 38-59.
Crossref
Belén Palomares, Francisco Ruiz-Pino, Martin Garrido-Rodriguez, M. Eugenia Prados, Miguel A. Sánchez-Garrido, Inmaculada Velasco, María J. Vazquez, Xavier Nadal, Carlos Ferreiro-Vera, Rosario Morrugares, Giovanni Appendino, Marco A Calzado, Manuel Tena-Sempere & Eduardo Muñoz. (2020) Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity. Biochemical Pharmacology 171, pages 113693.
Crossref
Wanwan Yuan, Cong Ma, Yumeng Zhou, Mengxi Wang, Guohua Zeng & Qiren Huang. (2019) Negative regulation of eNOS-NO signaling by over-SUMOylation of PPARγ contributes to insulin resistance and dysfunction of vascular endothelium in rats. Vascular Pharmacology 122-123, pages 106597.
Crossref
Narendra S. Choudhary, Naveen Kumar & Ajay Duseja. (2019) Peroxisome Proliferator-Activated Receptors and Their Agonists in Nonalcoholic Fatty Liver Disease. Journal of Clinical and Experimental Hepatology 9:6, pages 731-739.
Crossref
Dongyi Lan, Xiaodan Shen, Wanwan Yuan, Yumeng Zhou & Qiren Huang. (2019) Sumoylation of PPARγ contributes to vascular endothelium insulin resistance through stabilizing the PPARγ–NcoR complex. Journal of Cellular Physiology 234:11, pages 19663-19674.
Crossref
Cheng, Tan, Low, Marvalim, Lee & Tan. (2019) Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence. International Journal of Molecular Sciences 20:20, pages 5055.
Crossref
Hui Yun Penny Oh, Vivegan Visvalingam & Walter Wahli. (2019) The PPAR–microbiota–metabolic organ trilogy to fine‐tune physiology. The FASEB Journal 33:9, pages 9706-9730.
Crossref
Jiayu Yin, Jin Wang, Fahui Li, Zixun Yang, Xiaoqian Yang, Wanli Sun, Bin Xia, Ting Li, Weiguo Song & Shoudong Guo. (2019) The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice . Food & Function 10:8, pages 5124-5139.
Crossref
Genovefa D. Kolovou, Gerald F. Watts, Dimitri P. Mikhailidis, Pablo Pérez-Martínez, Samia Mora, Helen Bilianou, George Panotopoulos, Niki Katsiki, Teik C. Ooi, José Lopez-Miranda, Anne Tybjærg-Hansen, Nicholas Tentolouris & Børge G. Nordestgaard. (2019) Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Narrative Review. Current Vascular Pharmacology 17:5, pages 515-537.
Crossref
Chang-Ik Choi. (2019) Astaxanthin as a Peroxisome Proliferator-Activated Receptor (PPAR) Modulator: Its Therapeutic Implications. Marine Drugs 17:4, pages 242.
Crossref
Jules A. A. C. Heuberger & Adam F. Cohen. (2018) Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects. Sports Medicine 49:4, pages 525-539.
Crossref
Yi Liu, Jennifer Colby, Xiangsheng Zuo, Jonathan Jaoude, Daoyan Wei & Imad Shureiqi. (2018) The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. International Journal of Molecular Sciences 19:11, pages 3339.
Crossref
Antonella Giancristofaro, Arménio J. M. Barbosa, Alessandra Ammazzalorso, Pasquale Amoia, Barbara De Filippis, Marialuigia Fantacuzzi, Letizia Giampietro, Cristina Maccallini & Rosa Amoroso. (2018) Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking. MedChemComm 9:10, pages 1630-1638.
Crossref
José Roberto Santin, Isabel Daufenback Machado, Carine C. Drewes, Léonard de Vinci Kanda Kupa, Rodrigo Marcondes Soares, Danielle Maia Cavalcanti, Ivan da Rocha Pitta & Sandra H.P. Farsky. (2018) Role of an indole-thiazolidiene PPAR pan ligand on actions elicited by G-protein coupled receptor activated neutrophils. Biomedicine & Pharmacotherapy 105, pages 947-955.
Crossref
You-Lin Tain & Chien-Ning Hsu. (2018) Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?. International Journal of Molecular Sciences 19:9, pages 2584.
Crossref
Fan Hong, Pengfei Xu & Yonggong Zhai. (2018) The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development. International Journal of Molecular Sciences 19:8, pages 2189.
Crossref
Thomas Sæther, Steinar M. Paulsen, Jørn E. Tungen, Anders Vik, Marius Aursnes, Torgeir Holen, Trond Vidar Hansen & Hilde I. Nebb. (2018) Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. European Journal of Medicinal Chemistry 155, pages 736-753.
Crossref
Jiapeng Chen, Alexandra Montagner, Nguan Tan & Walter Wahli. (2018) Insights into the Role of PPARβ/δ in NAFLD. International Journal of Molecular Sciences 19:7, pages 1893.
Crossref
Reinhard Brunmeir & Feng Xu. (2018) Functional Regulation of PPARs through Post-Translational Modifications. International Journal of Molecular Sciences 19:6, pages 1738.
Crossref
Wendy Phua, Melissa Wong, Zehuan Liao & Nguan Tan. (2018) An aPPARent Functional Consequence in Skeletal Muscle Physiology via Peroxisome Proliferator-Activated Receptors. International Journal of Molecular Sciences 19:5, pages 1425.
Crossref
M.J. Nanjan, Manal Mohammed, B.R. Prashantha Kumar & M.J.N. Chandrasekar. (2018) Thiazolidinediones as antidiabetic agents: A critical review. Bioorganic Chemistry 77, pages 548-567.
Crossref
A.J. Scheen. (2018) Perspectives dans le traitement pharmacologique du diabète de type 2 pour les 10 prochaines années. Médecine des Maladies Métaboliques 12:2, pages 174-181.
Crossref
Sabbu Satish, Ankita Srivastava, Pragya Yadav, Salil Varshney, Rakhi Choudhary, Vishal M. Balaramnavar, Tadigoppula Narender & Anil Nilkanth Gaikwad. (2018) Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells. European Journal of Medicinal Chemistry 143, pages 780-791.
Crossref
Tiziana Caputo, Federica Gilardi & Béatrice Desvergne. (2017) From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. FEBS Letters 591:19, pages 3061-3088.
Crossref
Angel Moldes-Anaya, Thomas Sæther, Silvio Uhlig, Hilde Nebb, Terje Larsen, Hans Eilertsen & Steinar Paulsen. (2017) Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ. Marine Drugs 15:6, pages 148.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.