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Expert Opinion on Therapeutic Targets Volume 21, 2017 - Issue 3
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Review

Reactive nitrogen species as therapeutic targets for autophagy: implication for ischemic stroke

Jinghan FengSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China;The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, ChinaView further author information
,
Xingmiao ChenSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China;The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, ChinaView further author information
&
Jiangang ShenSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China;The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, ChinaCorrespondence[email protected]
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Pages 305-317 | Received 09 Aug 2016, Accepted 09 Jan 2017, Published online: 19 Jan 2017

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Seyed Fazel Nabavi, Antoni Sureda, Ana Sanches-Silva, Kasi Pandima Devi, Touqeer Ahmed, Momina Shahid, Eduardo Sobarzo-Sánchez, Marco Dacrema, Maria Daglia, Nady Braidy, Rosa Anna Vacca, Ioana Berindan-Neagoe, Diana Gulei, Davide Barreca, Maciej Banach, Seyed Mohammad Nabavi, Ahmad Reza Dehpour & Samira Shirooie. (2019) Novel therapeutic strategies for stroke: The role of autophagy. Critical Reviews in Clinical Laboratory Sciences 56:3, pages 182-199.
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Hansen Chen, Xi Chen, Yunhao Luo & Jiangang Shen. (2018) Potential molecular targets of peroxynitrite in mediating blood–brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment. Free Radical Research 52:11-12, pages 1220-1239.
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Articles from other publishers (27)

Yuankai Sun, Xinchi Jiang & Jianqing Gao. (2023) Stem cell-based ischemic stroke therapy: Novel modifications and clinical challenges. Asian Journal of Pharmaceutical Sciences, pages 100867.
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Qian Zhang, Meng Jia, YunFu Wang, Qun Wang & Jianping Wu. (2022) Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury. Neurochemical Research 47:12, pages 3525-3542.
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Yijie Wang, Fenfang Hong & Shulong Yang. (2022) Roles of Nitric Oxide in Brain Ischemia and Reperfusion. International Journal of Molecular Sciences 23:8, pages 4243.
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Toushen Hong, Yang Zhou, Li Peng, Xiaoying Wu, Yixin Li, Yumei Li & Yong Zhao. (2022) Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia–Reperfusion Injury by Enhancing Mitophagy. Neuroscience 482, pages 30-42.
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Junjie Wang, Shiqi Gao, Cameron Lenahan, Yichen Gu, Xiaoyu Wang, Yuanjian Fang, Weilin Xu, Haijian Wu, Yuanbo Pan, Anwen Shao & Jianmin Zhang. (2022) Melatonin as an Antioxidant Agent in Stroke: An Updated Review. Aging and disease 13:6, pages 1823.
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Mimi Wu, Xiaoping Gu & Zhengliang Ma. (2021) Mitochondrial Quality Control in Cerebral Ischemia–Reperfusion Injury. Molecular Neurobiology 58:10, pages 5253-5271.
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Fulin Wang, Qiuhuan Yuan, Fengying Chen, Jiaojiao Pang, Chang Pan, Feng Xu & Yuguo Chen. (2021) Fundamental Mechanisms of the Cell Death Caused by Nitrosative Stress. Frontiers in Cell and Developmental Biology 9.
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Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen & Jingjing Zhang. (2021) Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia. Frontiers in Physiology 12.
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Ryszard Pluta, Stanisław J. Czuczwar, Sławomir Januszewski & Mirosław Jabłoński. (2021) The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type. Cells 10:9, pages 2213.
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Luoan Shen, Qinyi Gan, Youcheng Yang, Cesar Reis, Zheng Zhang, Shanshan Xu, Tongyu Zhang & Chengmei Sun. (2021) Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury. Frontiers in Aging Neuroscience 13.
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Hui Xu, Emily Wang, Feng Chen, Jianbo Xiao & Mingfu Wang. (2021) Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications. Oxidative Medicine and Cellular Longevity 2021, pages 1-45.
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Jialin He, Jianyang Liu, Yan Huang, Xiangqi Tang, Han Xiao & Zhiping Hu. (2021) Oxidative Stress, Inflammation, and Autophagy: Potential Targets of Mesenchymal Stem Cells-Based Therapies in Ischemic Stroke. Frontiers in Neuroscience 15.
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Ying Cai, Eryan Yang, Xiuhua Yao, Xuebin Zhang, Qixue Wang, Yunfei Wang, Ji Liu, Weijia Fan, Kaikai Yi, Chunsheng Kang & Jialing Wu. (2021) FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury. Redox Biology 38, pages 101792.
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Jia-Li Chen, Xin-Xin Wang, Lei Chen, Jie Tang, Yun-Fei Xia, Ke Qian, Zheng-Hong Qin, Christian Waeber & Rui Sheng. (2020) A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy. Neuropharmacology 181, pages 108326.
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Yifan Zhang, Yacong He, Meiling Wu, Hansen Chen, Lu Zhang, Dan Yang, Qi Wang & Jiangang Shen. (2020) Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation. Free Radical Biology and Medicine 160, pages 526-539.
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Olga Corti, Klas Blomgren, Angelo Poletti & Philip M. Beart. (2020) Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases. Journal of Neurochemistry 154:4, pages 354-371.
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Hui Xu, Ruixia Deng, Edmund T.S. Li, Jiangang Shen & Mingfu Wang. (2020) Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway. Journal of Functional Foods 71, pages 104019.
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Yibo Yang, Tianyi Li, Zhibo Li, Ning Liu, Youyou Yan & Bin Liu. (2020) Role of Mitophagy in Cardiovascular Disease. Aging and disease 11:2, pages 419.
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Simone Lieschke, Bozena Zechmeister, Matteo Haupt, Xuan Zheng, Fengyan Jin, Katharina Hein, Martin S. Weber, Dirk M. Hermann, Mathias Bähr, Ertugrul Kilic & Thorsten R. Doeppner. (2019) CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age. Cells 9:1, pages 66.
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Xin Chen & Hua Jiang. (2019) Tau as a potential therapeutic target for ischemic stroke. Aging 11:24, pages 12827-12843.
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Dai-Qiang Liu, Shu-Ping Chen, Jia Sun, Xiao-Mei Wang, Nan Chen, Ya-Qun Zhou, Yu-Ke Tian & Da-Wei Ye. (2019) Berberine protects against ischemia-reperfusion injury: A review of evidence from animal models and clinical studies. Pharmacological Research 148, pages 104385.
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Yu-huan Cui, Xiao-qing Zhang, Nai-dong Wang, Mao-dong Zheng & Juan Yan. (2019) Vitexin protects against ischemia/reperfusion-induced brain endothelial permeability. European Journal of Pharmacology 853, pages 210-219.
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Alejandro I. Lorenzo-Pouso, Pablo Castelo-Baz, Mario Pérez-Sayáns, Jason Lim & Yago Leira. (2019) Autophagy in periodontal disease: Evidence from a literature review. Archives of Oral Biology 102, pages 55-64.
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Jinghan Feng, Xingmiao Chen, Shengwen Lu, Wenting Li, Dan Yang, Weiwei Su, Xijun Wang & Jiangang Shen. (2018) Naringin Attenuates Cerebral Ischemia-Reperfusion Injury Through Inhibiting Peroxynitrite-Mediated Mitophagy Activation. Molecular Neurobiology 55:12, pages 9029-9042.
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Zhenhua Zhou, Jianfei Lu, Wen-Wu Liu, Anatol Manaenko, Xianhua Hou, Qiyong Mei, Jun-Long Huang, Jiping Tang, John H. Zhang, Honghong Yao & Qin Hu. (2018) Advances in stroke pharmacology. Pharmacology & Therapeutics 191, pages 23-42.
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Jinghan Feng, Xingmiao Chen, Binghe Guan, Caiming Li, Jinhua Qiu & Jiangang Shen. (2018) Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury. Molecular Neurobiology 55:8, pages 6369-6386.
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Han-sen Chen, Xi Chen, Wen-ting Li & Jian-gang Shen. (2018) Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery. Acta Pharmacologica Sinica 39:5, pages 669-682.
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