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Expert Opinion on Therapeutic Targets Volume 21, 2017 - Issue 5
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Review

Therapeutic effects of methionine sulfoximine in multiple diseases include and extend beyond inhibition of glutamine synthetase

William S. A. BrusilowDepartment of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USACorrespondence[email protected]
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Tyler J. PetersDepartment of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI, USAView further author information
Pages 461-469 | Received 26 Jan 2017, Accepted 03 Mar 2017, Published online: 15 Mar 2017

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Michael J. Tilby & Michael C. Willis. (2021) How do we address neglected sulfur pharmacophores in drug discovery?. Expert Opinion on Drug Discovery 16:11, pages 1227-1231.
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Jian-Jia Liang, Xiang-Feng Zhou, Hui Long, Chun-Yun Li, Jing Wei, Xiao-Qin Yu, Zhi-Yong Guo, Yi-Qing Zhou & Zhang-Shuang Deng. (2024) Recent advance of ATP citrate lyase inhibitors for the treatment of cancer and related diseases. Bioorganic Chemistry 142, pages 106933.
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Marek Pawlik, Anna Maria Czarnecka, Marcin Kołodziej, Katarzyna Skowrońska, Michał Węgrzynowicz, Martyna Podgajna, Stanisław Jerzy Czuczwar & Jan Albrecht. (2023) Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus. Epilepsia 64:5, pages 1390-1402.
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Amandine Rovini, Kareem A. Heslop & Eduardo N. Maldonado. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 493 510 .
Marek J. Pawlik, Blanca I. Aldana, Lautaro F. Belfiori-Carrasco, Marta Obara-Michlewska, Mariusz P. Popek, Anna Maria Czarnecka & Jan Albrecht. (2021) Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose. International Journal of Molecular Sciences 22:20, pages 11127.
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Yali Long, Jia Qiu, Bing Zhang, Peng He, Xinchong Shi, Qiao He, Zhifeng Chen, Wanqing Shen, Zhoulei Li & Xiangsong Zhang. (2021) Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase. Frontiers in Pharmacology 12.
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Go Woon Kim, Dong Hoon Lee, Yu Hyun Jeon, Jung Yoo, So Yeon Kim, Sang Wu Lee, Ha Young Cho & So Hee Kwon. (2021) Glutamine Synthetase as a Therapeutic Target for Cancer Treatment. International Journal of Molecular Sciences 22:4, pages 1701.
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Marek J. Pawlik, Marta Obara-Michlewska, Mariusz P. Popek, Anna Maria Czarnecka, Stanisław J. Czuczwar, Jarogniew Łuszczki, Marcin Kołodziej, Albert Acewicz, Teresa Wierzba-Bobrowicz & Jan Albrecht. (2021) Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats. Brain Research 1753, pages 147253.
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Hélène Gingras, Kévin Patron, Philippe Leprohon & Marc Ouellette. (2020) Azithromycin resistance mutations in Streptococcus pneumoniae as revealed by a chemogenomic screen. Microbial Genomics 6:11.
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Cátia Daniela dos Santos Moreira, Maria João Ribeiro Nunes Ramos & Pedro Manuel Azevedo Alexandrino Fernandes. (2018) Glutamine synthetase structure‐catalysis relationship—Recent advances and applications. WIREs Computational Molecular Science 9:4.
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Sameer H. Issaq, Arnulfo Mendoza, Stephen D. Fox & Lee J. Helman. (2019) Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth. Oncogenesis 8:3.
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Tyler J. Peters, Amruta A. Jambekar & William S. A. Brusilow. (2018) In vitro suppression of inflammatory cytokine response by methionine sulfoximine. Journal of Inflammation 15:1.
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Carlotta Granchi. (2018) ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism. European Journal of Medicinal Chemistry 157, pages 1276-1291.
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Jessica Y. El Khoury, Nancy Boucher, Michel G. Bergeron, Philippe Leprohon & Marc Ouellette. (2017) Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae. Scientific Reports 7:1.
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William S.A. Brusilow. (2017) Identification of the isomer of methionine sulfoximine that extends the lifespan of the SOD1 G93A mouse. Neuroscience Letters 647, pages 165-167.
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Surabhi Gupta, Priyanka Chaudhary, Nalluchamy Muniyappan, Shahulhameed Sabiah & Jeyakumar Kandasamy. (2017) Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions. Org. Biomol. Chem. 15:40, pages 8493-8498.
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