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Review

Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening

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Pages 47-62 | Received 11 Aug 2019, Accepted 04 Jan 2020, Published online: 09 Jan 2020

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Zhihao Gu, Yong Yan, Hequan Yao, Kejiang Lin & Xuanyi Li. (2022) Targeting the LPA1 signaling pathway for fibrosis therapy: a patent review (2010-present). Expert Opinion on Therapeutic Patents 32:10, pages 1097-1122.
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Yun Huang, Chu-Ru Mao, Yijie Lou, Shuai Zhan, Zhe Chen, Wanjing Ding & Zhongjun Ma. (2023) Design, Synthesis, and Biological Evaluation of an Orally Bioavailable, Potent, and Selective ROCK2 Inhibitor for Psoriasis Treatment. Journal of Medicinal Chemistry 66:22, pages 15205-15229.
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Mengqi Qin & Cynthia Yu-Wai-Man. (2023) Glaucoma: Novel antifibrotic therapeutics for the trabecular meshwork. European Journal of Pharmacology 954, pages 175882.
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Giuseppina Nicolini, Silvana Balzan & Francesca Forini. (2023) Activated fibroblasts in cardiac and cancer fibrosis: An overview of analogies and new potential therapeutic options. Life Sciences 321, pages 121575.
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Yang Chen & Daoquan Peng. (2023) New insights into the molecular mechanisms of SGLT2 inhibitors on ventricular remodeling. International Immunopharmacology 118, pages 110072.
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Yuting Xie, Lin Yue, Yaojie Shi, Xingping Su, Cailing Gan, Hongyao Liu, Taixiong Xue & Tinghong Ye. (2023) Application and Study of ROCK Inhibitors in Pulmonary Fibrosis: Recent Developments and Future Perspectives. Journal of Medicinal Chemistry 66:7, pages 4342-4360.
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Ning Xie, Cailan Xiao, Qiuai Shu, Bo Cheng, Ziwei Wang, Runxin Xue, Zhang Wen, Jinhai Wang, Haitao Shi, Daiming Fan, Na Liu & Feng Xu. (2023) Cell response to mechanical microenvironment cues via Rho signaling: From mechanobiology to mechanomedicine. Acta Biomaterialia 159, pages 1-20.
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Tadeu L. Montagnoli, Daniela R. de Oliveira & Carlos A. Manssour Fraga. (2023) Therapeutic Perspectives on ROCK Inhibition for Cerebral Cavernous Malformations. Kinases and Phosphatases 1:1, pages 72-96.
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Jianjian Shi & Lei Wei. (2022) Rho Kinases in Embryonic Development and Stem Cell Research. Archivum Immunologiae et Therapiae Experimentalis 70:1.
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Yiming Wang, Yuqing Zhang & Dingguo Zhang. 2022. Frontiers in Cardiovascular Drug Discovery: Volume 6. Frontiers in Cardiovascular Drug Discovery: Volume 6 54 101 .
Brian Yu, Afaf E.G. Osman, Nikola Sladojevic, Nicole Prabhu, Haw-Chih Tai, Daiqing Chen, Gerardo Perla, Linus Park, Richard A. Larson & James K. Liao. (2022) Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity. JACC: CardioOncology 4:3, pages 371-383.
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Yuxuan Xiao, Roberto I Vazquez-Padron, Laisel Martinez, Harold A Singer, Daniel Woltmann & Loay H Salman. (2022) Role of platelet factor 4 in arteriovenous fistula maturation failure: What do we know so far?. The Journal of Vascular Access, pages 112972982210854.
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Deniz Billur, Yusuf Olgar & Belma Turan. (2022) Intracellular Redistribution of Left Ventricular Connexin 43 Contributes to the Remodeling of Electrical Properties of the Heart in Insulin-resistant Elderly Rats. Journal of Histochemistry & Cytochemistry 70:6, pages 447-462.
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Julian C. Bachmann, Simon J. Baumgart, Anna K. Uryga, Markus H. Bosteen, Giulia Borghetti, Michael Nyberg & Kate M. Herum. (2022) Fibrotic Signaling in Cardiac Fibroblasts and Vascular Smooth Muscle Cells: The Dual Roles of Fibrosis in HFpEF and CAD. Cells 11:10, pages 1657.
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Fabian A Mendoza & Sergio A Jimenez. (2022) Serine/threonine kinase inhibition as antifibrotic therapy: transforming growth factor-β and Rho kinase inhibitors. Rheumatology 61:4, pages 1354-1365.
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Hao Qian & Lijuan Chen. (2021) TRIM proteins in fibrosis. Biomedicine & Pharmacotherapy 144, pages 112340.
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Yuxin Li, Haw‐Chih Tai, Nikola Sladojevic, Hyung‐Hwan Kim & James K. Liao. (2021) Vascular Stiffening Mediated by Rho‐Associated Coiled‐Coil Containing Kinase Isoforms. Journal of the American Heart Association 10:20.
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Kevin W. Huang, Ian H. Wang, Ping Fu, Henry Krum, Leon A. Bach & Bing H. Wang. (2021) Insulin-like growth factor-1 directly affects cardiac cellular remodelling via distinct pathways. IJC Heart & Vasculature 36, pages 100852.
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Dan Cristian Gheorghe, Andrei Ilie, Adelina-Gabriela Niculescu & Alexandru Mihai Grumezescu. (2021) Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices. Biomedicines 9:8, pages 1025.
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Weijun Ou, Weimin Xu, Fangyuan Liu, Yuegui Guo, Zhenyu Huang, Tienan Feng, Chen-Ying Liu & Peng Du. (2021) Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease. eBioMedicine 69, pages 103452.
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Tadeu L. Montagnoli, Jaqueline S. da Silva, Susumu Z. Sudo, Aimeé D. Santos, Gabriel F. Gomide, Mauro P. L. de Sá & Gisele Zapata-Sudo. (2021) ROCK Inhibition as Potential Target for Treatment of Pulmonary Hypertension. Cells 10:7, pages 1648.
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Corey Cutler. (2021) Treating Inflammation and Fibrosis in Chronic GVHD: Two Birds, One ROCK. Journal of Clinical Oncology 39:17, pages 1942-1945.
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Maria Paz Ocaranza, Jorge E. Jalil, Rodrigo Altamirano, Ana de León, Jackeline Moya, Alejandra Lonis, Luigi Gabrielli, Paul Mac Nab, Samuel Córdova, Alejandro Paredes, Ismael Vergara, Alex Bittner, Karime Sabat & Karla Pastorini. (2021) Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation. Frontiers in Pharmacology 12.
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