Search in:

Expert Opinion on Therapeutic Targets Volume 25, 2021 - Issue 1

Submit an article Journal homepage

Open access

5,592

Views

CrossRef citations to date

Altmetric

Review

Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability

Sumeet NayakDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MAUSA

https://orcid.org/0000-0002-3326-6484 View further author information

Jennifer A. CalvoDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MAUSA

https://orcid.org/0000-0002-4815-3546 View further author information

Sharon B. CantorDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MAUSACorrespondence[email protected]

https://orcid.org/0000-0003-2944-6156 View further author information

Pages 27-36 | Received 20 Oct 2020, Accepted 11 Dec 2020, Published online: 08 Jan 2021

Cite this article
https://doi.org/10.1080/14728222.2021.1864321
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF View EPUB EPUB

Citations (15)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (15)

C.F.M. Menck, R.S. Galhardo & A. Quinet. (2024) The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 828, pages 111840.
Crossref

Mehdi Sanati, Amir R. Afshari, Seyed Sajad Ahmadi, Prashant Kesharwani & Amirhossein Sahebkar. (2023) Aptamers against cancer drug resistance: Small fighters switching tactics in the face of defeat. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1869:6, pages 166720.
Crossref

Tom Egger, Antoine Aze & Domenico Maiorano. (2023) Detection of endogenous translesion DNA synthesis in single mammalian cells. Cell Reports Methods 3:6, pages 100501.
Crossref

Jay Anand, Lilly Chiou, Carly Sciandra, Xingyuan Zhang, Jiyong Hong, Di Wu, Pei Zhou & Cyrus Vaziri. (2023) Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy. NAR Cancer 5:1.
Crossref

Alexandre André B. A. da Costa, Dipanjan Chowdhury, Geoffrey I. Shapiro, Alan D. D’Andrea & Panagiotis A. Konstantinopoulos. (2022) Targeting replication stress in cancer therapy. Nature Reviews Drug Discovery 22:1, pages 38-58.
Crossref

Zhiquan Li, Sharath Anugula & Lene Juel Rasmussen. 2023. Aging. Aging 275 295 .

Akram Tayanloo-Beik, Shayesteh Kokabi Hamidpour, Amirabbas Nikkhah, Rasta Arjmand, Ahmad Rezazadeh Mafi, Mostafa Rezaei-Tavirani, Bagher Larijani, Kambiz Gilany & Babak Arjmand. 2023.

Jac A. Nickoloff. (2022) Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy. Molecules 27:15, pages 4736.
Crossref

Bruno César Feltes & Carlos Frederico Martins Menck. (2022) Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations. Mutation Research/Reviews in Mutation Research 790, pages 108436.
Crossref

Marcello Stanzione, Jun ZhongEdmond Wong, Thomas J. LaSalle, Jillian F. Wise, Antoine Simoneau, David T. Myers, Sarah Phat, Moshe Sade-Feldman, Michael S. Lawrence, M. Kyle Hadden, Lee Zou, Anna F. FaragoNicholas J. Dyson & Benjamin J. Drapkin. (2022) Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer. Science Advances 8:19.
Crossref

Katie A. Wilson, Ye Eun Rebecca Jeong & Stacey D. Wetmore. (2022) Multiscale computational investigations of the translesion synthesis bypass of tobacco-derived DNA adducts: critical insights that complement experimental biochemical studies. Physical Chemistry Chemical Physics 24:18, pages 10667-10683.
Crossref

Yunshang Chen, Xiaohua Jie, Biyuan Xing, Zilong Wu, Xijie Yang, Xinrui Rao, Yingzhuo Xu, Dong Zhou, Xiaorong Dong, Tao Zhang, Kunyu Yang, Zhenyu Li & Gang Wu. (2022) REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis. Cell Death & Disease 13:2.
Crossref

Sharon B. Cantor. (2021) Revisiting the BRCA-pathway through the lens of replication gap suppression. DNA Repair 107, pages 103209.
Crossref

Yitian Guo, Melanie Rall-Scharpf, Jean-Christophe Bourdon, Lisa Wiesmüller & Stephanie Biber. (2021) p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway. Cell Death & Disease 12:10.
Crossref

Thomas A. Guilliam. (2021) Mechanisms for Maintaining Eukaryotic Replisome Progression in the Presence of DNA Damage. Frontiers in Molecular Biosciences 8.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability

Articles from other publishers (15)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability

Citations (15)

Articles from other publishers (15)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date