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Expert Opinion on Therapeutic Targets Volume 25, 2021 - Issue 5
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Review

The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’s

Mani Iyer Prasantha Natural Products for Neuroprotection and Anti-ageing Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand;b Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, ThailandORCID Iconhttps://orcid.org/0000-0003-0956-0410View further author information
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Dicson Sheeja Malara Natural Products for Neuroprotection and Anti-ageing Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand;b Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, ThailandORCID Iconhttps://orcid.org/0000-0003-4253-9496View further author information
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Tewin Tencomnaoa Natural Products for Neuroprotection and Anti-ageing Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand;b Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, ThailandCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-4177-2165View further author information
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James Michael Brimsona Natural Products for Neuroprotection and Anti-ageing Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand;b Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, ThailandCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-2074-8262View further author information
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Pages 401-414 | Received 01 Apr 2021, Accepted 03 Jun 2021, Published online: 17 Jun 2021

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Chanichon Chomchoei, James Michael Brimson & Sirikalaya Brimson. (2022) Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction. Expert Opinion on Therapeutic Targets 26:12, pages 1087-1097.
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Mani Iyer Prasanth, Tewin Tencomnao & James Michael Brimson. (2021) The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke. Expert Opinion on Therapeutic Targets 25:7, pages 613-614.
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James Michael Brimson, Mani Iyer Prasanth, Dicson Sheeja Malar, Sirikalaya Brimson, Premrutai Thitilertdecha & Tewin Tencomnao. (2021) Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy. Expert Opinion on Therapeutic Targets 25:6, pages 435-449.
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Articles from other publishers (10)

Peng Ren, Jing-Ya Wang, Hong-Lei Chen, Hai-Xia Chang, Zhi-Rui Zeng, Guang-Xiang Li, Hui Ma, Yong-Qi Zhao & Yun-Feng Li. (2023) Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919). European Journal of Pharmacology 946, pages 175647.
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Joseph Pergolizzi, Giustino Varrassi, Mark Coleman, Frank Breve, Dana K Christo, Paul J Christo & Charbel Moussa. (2023) The Sigma Enigma: A Narrative Review of Sigma Receptors. Cureus.
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Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova & Sergei B. Seredenin. (2023) Chaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection. International Journal of Molecular Sciences 24:1, pages 823.
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James Michael Brimson, Mani Iyer Prasanth, Discon Sheeja Malar, Kanika Verma, Waluga Plaingam & Tewin Tencomnao. (2022) Bacopa monnieri protects neuronal cell line and Caenorhabditis elegans models of Alzheimer’s disease through sigma-1 receptor antagonist sensitive and antioxidant pathways. Nutrition and Healthy Aging 7:3-4, pages 173-196.
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Atul Kabra, Ruchika Garg, James Brimson, Jelena Živković, Saud Almawash, Muhammad Ayaz, Asif Nawaz, Syed Shams Ul Hassan & Simona Bungau. (2022) Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression. Frontiers in Pharmacology 13.
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Nassima Oumata, Kui Lu, Yuou Teng, Christian Cavé, Yu Peng, Hervé Galons & Bernard P. Roques. (2022) Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules. European Journal of Medicinal Chemistry 240, pages 114578.
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Takahiro Higuchi & Rudolf A. Werner. (2022) Unfolding the cardioprotective potential of sigma-1 receptor-directed molecular imaging. Journal of Nuclear Cardiology.
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Nada Elkholy, Ahmad Abdelwaly, Karim Mohamed, Emanuele Amata, Jessica Lombino, Giuseppe Cosentino, Sebastiano Intagliata & Mohamed A. Helal. (2022) Discovery of 3‐(2‐aminoethyl)‐thiazolidine‐2,4‐diones as a novel chemotype of sigma‐1 receptor ligands. Chemical Biology & Drug Design 100:1, pages 25-40.
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James Michael Brimson, Mani Iyer Prasanth, Dicson Sheeja Malar, Premrutai Thitilertdecha, Atul Kabra, Tewin Tencomnao & Anchalee Prasansuklab. (2021) Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases. Pharmaceuticals 14:10, pages 982.
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James Michael Brimson, Mani Iyer Prasanth, Dicson Sheeja Malar, Rajasekharan Sharika, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Chaiyavat Chaiyasut, Tewin Tencomnao & Anchalee Prasansuklab. (2021) Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health. Nutrients 13:7, pages 2162.
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