282
Views
31
CrossRef citations to date
0
Altmetric
Review

Targeting hypoxia to overcome radiation resistance in head & neck cancers: real challenge or clinical fairytale?

, , &
Pages 751-758 | Received 21 Dec 2015, Accepted 18 May 2016, Published online: 08 Jun 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Arpit Dheeraj, Chapla Agarwal, Isabel R Schlaepfer, David Raben, Rana Singh, Rajesh Agarwal & Gagan Deep. (2018) A novel approach to target hypoxic cancer cells via combining β-oxidation inhibitor etomoxir with radiation. Hypoxia 6, pages 23-33.
Read now
Hongmei Zhu, Shu Ruan, Feng Jia, Jiusheng Chu, Yong Zhu, Yongjiu Huang & Guan Liu. (2018) In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma. OncoTargets and Therapy 11, pages 8117-8125.
Read now

Articles from other publishers (29)

Ela DELİKGÖZ SOYKUT, Yasemin KEMAL, Serkan KAPLAN, Cengiz KARAÇİN, Eylem ODABAŞI, Asude UNAL, Zehra ER, Suheyla AYTAÇ ARSLAN & Yıldız GUNEY. (2023) The association of anemia and high neutrophil-lymphocyte ratio with decreased survival in patients with laryngeal cancer treated with radiotherapy. Anatolian Current Medical Journal 5:3, pages 227-236.
Crossref
Limei Li, Jun Zhao, Haishan Zhang, Danping Li, Shu Wu, Wenqing Xu, Xinli Pan, Wenjin Hu, Jiemei Chu, Wenqi Luo, Ping Li & Xiaoying Zhou. (2023) HIGD1A inactivated by DNA hypermethylation promotes invasion of kidney renal clear cell carcinoma. Pathology - Research and Practice 245, pages 154463.
Crossref
Pavel Burko, Giuseppa D’Amico, Ilia Miltykh, Federica Scalia, Everly Conway de Macario, Alberto J. L. Macario, Giuseppe Giglia, Francesco Cappello & Celeste Caruso Bavisotto. (2023) Molecular Pathways Implicated in Radioresistance of Glioblastoma Multiforme: What Is the Role of Extracellular Vesicles?. International Journal of Molecular Sciences 24:5, pages 4883.
Crossref
Zhongwen Yang, Changsong Shi, Dongliang Cheng, Yu Wang, Yan Xing, Fanfan Du, Fangfang Wu, Yao Jin, Yueli Dong & Mengli Li. (2022) Biomimetic nanomaterial-facilitated oxygen generation strategies for enhancing tumour treatment outcomes. Frontiers in Bioengineering and Biotechnology 10.
Crossref
Mattia Zaffaroni, Maria Giulia Vincini, Giulia Corrao, Giulia Marvaso, Matteo Pepa, Giuseppe Viglietto, Nicola Amodio & Barbara Alicja Jereczek-Fossa. (2022) Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy. International Journal of Molecular Sciences 23:19, pages 11343.
Crossref
Magdalena Zdrowowicz, Paulina Spisz, Aleksandra Hać, Anna Herman-Antosiewicz & Janusz Rak. (2022) Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine. International Journal of Molecular Sciences 23:3, pages 1429.
Crossref
Jinghui Lin, Yang Wang & Zhiqing Lin. (2021) HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission. Journal of Cellular and Molecular Medicine 25:24, pages 11170-11184.
Crossref
Moritz von Fallois, Friederike Katharina Kosyna, Markus Mandl, Yosef Landesman, Jürgen Dunst & Reinhard Depping. (2021) Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity. Journal of Cancer Research and Clinical Oncology 147:7, pages 2025-2033.
Crossref
Valentina Bravatà, Walter Tinganelli, Francesco P. Cammarata, Luigi Minafra, Marco Calvaruso, Olga Sokol, Giada Petringa, Giuseppe A.P. Cirrone, Emanuele Scifoni, Giusi I. Forte & Giorgio Russo. (2021) Hypoxia Transcriptomic Modifications Induced by Proton Irradiation in U87 Glioblastoma Multiforme Cell Line. Journal of Personalized Medicine 11:4, pages 308.
Crossref
Nils H. Nicolay, Alexander Rühle, Nicole Wiedenmann, Gabriele Niedermann, Michael Mix, Wolfgang A. Weber, Dimos Baltas, Martin Werner, Gian Kayser & Anca-L. Grosu. (2021) Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial. Journal of Nuclear Medicine 62:4, pages 471-478.
Crossref
Laurie J. Rich, Jossana A. Damasco, Julia C. Bulmahn, Hilliard L. Kutscher, Paras N. Prasad & Mukund Seshadri. (2020) Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer. Cancers 12:11, pages 3294.
Crossref
Chrysa Filippopoulou, George Simos & Georgia Chachami. (2020) The Role of Sumoylation in the Response to Hypoxia: An Overview. Cells 9:11, pages 2359.
Crossref
Faiqa Mudassar, Han Shen, Geraldine O’Neill & Eric Hau. (2020) Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas. Journal of Experimental & Clinical Cancer Research 39:1.
Crossref
Yangle Huang, Qingting Huang, Jingfang Zhao, Yuanli Dong, Lijia Zhang, Xumeng Fang, Pian Sun, Lin Kong & Jiade Jay Lu. (2020) The Impacts of Different Types of Radiation on the CRT and PDL1 Expression in Tumor Cells Under Normoxia and Hypoxia. Frontiers in Oncology 10.
Crossref
María Auxiliadora Olivares-Urbano, Carmen Griñán-Lisón, Juan Antonio Marchal & María Isabel Núñez. (2020) CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer. Cells 9:7, pages 1651.
Crossref
Nils H. Nicolay, Nicole Wiedenmann, Michael Mix, Wolfgang A. Weber, Martin Werner, Anca L. Grosu & Gian Kayser. (2019) Correlative analyses between tissue-based hypoxia biomarkers and hypoxia PET imaging in head and neck cancer patients during radiochemotherapy—results from a prospective trial. European Journal of Nuclear Medicine and Molecular Imaging 47:5, pages 1046-1055.
Crossref
Huimin Liu, Ran Cheng, Xinghua Dong, Shuang Zhu, Ruyi Zhou, Liang Yan, Chenyang Zhang, Qing Wang, Zhanjun Gu & Yuliang Zhao. (2020) BiO 2– x Nanosheets as Radiosensitizers with Catalase-Like Activity for Hypoxia Alleviation and Enhancement of the Radiotherapy of Tumors . Inorganic Chemistry 59:6, pages 3482-3493.
Crossref
Christoph Reinhold Arnold, Julian Mangesius, Ira-Ida Skvortsova & Ute Ganswindt. (2020) The Role of Cancer Stem Cells in Radiation Resistance. Frontiers in Oncology 10.
Crossref
Xingguo Zhou, Hanghang Liu, Yanhui Zheng, Yaobao Han, Tingting Wang, Hao Zhang, Qiao Sun & Zhen Li. (2020) Overcoming Radioresistance in Tumor Therapy by Alleviating Hypoxia and Using the HIF-1 Inhibitor. ACS Applied Materials & Interfaces 12:4, pages 4231-4240.
Crossref
Xin Wang, Chenyang Zhang, Jiangfeng Du, Xinghua Dong, Shan Jian, Liang Yan, Zhanjun Gu & Yuliang Zhao. (2019) Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-type Heterostructures of Au–Bi 2 S 3 Nanoparticles via X-ray-Induced Catalytic Reaction for Radiosensitization . ACS Nano 13:5, pages 5947-5958.
Crossref
Zheng Zhang, Jingrong Yang, Qingqing Min, Chenjie Ling, Debabrata Maiti, Jiaying Xu, Liqiang Qin & Kai Yang. (2019) Holo-Lactoferrin Modified Liposome for Relieving Tumor Hypoxia and Enhancing Radiochemotherapy of Cancer. Small 15:6, pages 1803703.
Crossref
Yueh-Chun Lee, Wen-Ling Wang, Wei-Chao Chang, Yu-Hao Huang, Guan-Ci Hong, Hui-Lin Wang, Ying-Hsiang Chou, Hsien-Chun Tseng, Hsueh-Te Lee, Shao-Ti Li, Hsin-Lin Chen, Chun-Chieh Wu, Huei-Fan Yang, Bing-Yen Wang & Wen-Wei Chang. (2019) Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation. Cancers 11:2, pages 127.
Crossref
Michael J. McKay, Kim L. Taubman, Farshad Foroudi, Sze Ting Lee & Andrew M. Scott. (2018) Molecular Imaging Using PET/CT for Radiation Therapy Planning for Adult Cancers: Current Status and Expanding Applications. International Journal of Radiation Oncology*Biology*Physics 102:4, pages 783-791.
Crossref
Ian M. Cartwright, Cathy Su, Jeremy S. Haskins, Victoria A. Salinas, Shigeaki Sunada, Hao Yu, Mitsuru Uesaka, Hirokazu Hirakawa, David J. Chen, Akira Fujimori & Takamitsu A. Kato. (2018) DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions. International Journal of Molecular Sciences 19:8, pages 2228.
Crossref
Philippe Gorphe, Younès Chekkoury Idrissi, Yungan Tao, Antoine Schernberg, Dan Ou, Stéphane Temam, Odile Casiraghi, Pierre Blanchard & Haïtham Mirghani. (2018) Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation. Papillomavirus Research 5, pages 32-37.
Crossref
Haneen A. Basheer, Edvinas Pakanavicius, Patricia A. Cooper, Steven D. Shnyder, Lisette Martin, Keith D. Hunter, Victoria Vinader & Kamyar Afarinkia. (2018) Hypoxia modulates CCR7 expression in head and neck cancers. Oral Oncology 80, pages 64-73.
Crossref
Da Huo, Sen Liu, Chao Zhang, Jian He, Zhengyang Zhou, Hao Zhang & Yong Hu. (2017) Hypoxia-Targeting, Tumor Microenvironment Responsive Nanocluster Bomb for Radical-Enhanced Radiotherapy. ACS Nano 11:10, pages 10159-10174.
Crossref
Gabriella Lupo, Nunzia Caporarello, Melania Olivieri, Martina Cristaldi, Carla Motta, Vincenzo Bramanti, Roberto Avola, Mario Salmeri, Ferdinando Nicoletti & Carmelina D. Anfuso. (2017) Anti-angiogenic Therapy in Cancer: Downsides and New Pivots for Precision Medicine. Frontiers in Pharmacology 07.
Crossref
Jagadeesha Poyya, Chandrashekhar G Joshi, D Jagadeesha Kumar & HG Nagendra. (2017) Sequence Analysis and Phylogenetic Studies of Hypoxia-Inducible Factor-1α. Cancer Informatics 16, pages 117693511771224.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.