683
Views
49
CrossRef citations to date
0
Altmetric
Review

Recent advances in the development and use of molecular tests to predict antimicrobial resistance in Neisseria gonorrhoeae

, , &
Pages 845-859 | Received 14 May 2017, Accepted 24 Jul 2017, Published online: 03 Aug 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Ivva Philipova, Victoriya Levterova, Ivan Simeonovski & Todor Kantardjiev. (2022) High rate of fluoroquinolone resistant Neisseria gonorrhoeae detected by molecular surveillance of antimicrobial resistance determinants in Bulgaria. Biotechnology & Biotechnological Equipment 36:1, pages 942-948.
Read now
Daniel Golparian & Magnus Unemo. (2022) Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects. Expert Review of Molecular Diagnostics 22:1, pages 29-48.
Read now
Charlotte A. Gaydos & Johan H. Melendez. (2020) Point-by-Point Progress: Gonorrhea Point of Care Tests. Expert Review of Molecular Diagnostics 20:8, pages 803-813.
Read now

Articles from other publishers (46)

Paul O. Verhoeven, Sylvie Gonzalo, Meriam Memmi, Bruno Pozzetto & Florence Grattard. 2024. Diagnostic Molecular Pathology. Diagnostic Molecular Pathology 147 158 .
Angela Ma, Christina Ferrato, Irene Martin, Petra Smyczek, Jennifer Gratrix & Tanis C. Dingle. (2023) Use of genome sequencing to resolve differences in gradient diffusion and agar dilution antimicrobial susceptibility testing performance of Neisseria gonorrhoeae isolates in Alberta, Canada . Journal of Clinical Microbiology 61:11.
Crossref
Laura T Phillips, Adam A Witney, Martina Furegato, Ken G Laing, Liqing Zhou & S Tariq Sadiq. (2023) Time Required for Nanopore Whole-Genome Sequencing of Neisseria gonorrhoeae for Identification of Phylogenetic Relationships . The Journal of Infectious Diseases 228:9, pages 1179-1188.
Crossref
Rafaela Rodrigues, Pedro Vieira-Baptista, Carlos Catalão, Maria José Borrego, Carlos Sousa & Nuno Vale. (2023) Chlamydial and Gonococcal Genital Infections: A Narrative Review. Journal of Personalized Medicine 13:7, pages 1170.
Crossref
Evan C. Ewers, John M. Curtin & Anuradha Ganesan. (2023) Challenges in Managing Gonorrhea and New Advances in Prevention. Infectious Disease Clinics of North America 37:2, pages 223-243.
Crossref
Francis Kakooza, Reuben Kiggundu, Gerald Mboowa, Patrick David Kateete, Olga Tendo Nsangi, Jupiter Marina Kabahita, Bernard Ssentalo Bagaya, Daniel Golparian & Magnus Unemo. (2023) Antimicrobial susceptibility surveillance and antimicrobial resistance in Neisseria gonorrhoeae in Africa from 2001 to 2020: A mini-review. Frontiers in Microbiology 14.
Crossref
Skylar L. Martin, Tatum D. Mortimer & Yonatan H. Grad. (2022) Machine learning models for Neisseria gonorrhoeae antimicrobial susceptibility tests . Annals of the New York Academy of Sciences 1520:1, pages 74-88.
Crossref
Nireshni Mitchev, Ravesh Singh, Veron Ramsuran, Arshad Ismail, Mushal Allam, Stanford Kwenda, Florah Mnyameni, Nigel Garrett, Khine Swe Swe-Han, Abraham J. Niehaus & Koleka P. Mlisana. (2022) Assessment of Antibiotic Resistance and Efflux Pump Gene Expression in Neisseria Gonorrhoeae Isolates from South Africa by Quantitative Real-Time PCR and Regression Analysis. International Journal of Microbiology 2022, pages 1-10.
Crossref
Olivia Van Gerwen, Stacey Griner, Alissa Davis, Alison Footman, Casey N. Pinto, Johan H. Melendez, Susan Tuddenham, Cara Exten, Olusegun O. Soge, Payal Chakraborty, Ashley Nenninger, Elizabeth M. Marlowe, Ajith M. Joseph, Chris L. McGowin, Arlene C. Seña, J. Dennis Fortenberry, Khalil G. Ghanem & Barbara Van Der Pol. (2022) Summary of the Fourth Annual American Sexually Transmitted Diseases Association Workshop on Improving Sexually Transmitted Infection Control Efforts Through Cross-Sector Collaboration. Sexually Transmitted Diseases 49:8, pages 588-593.
Crossref
Yamei Li, Lulu Zhang, Leshan Xiu, Di Wang, Yaling Zeng, Feng Wang, Yueping Yin & Junping Peng. (2022) A Multiplex Molecular Assay for Detection of Six penA Codons To Predict Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae . Antimicrobial Agents and Chemotherapy 66:3.
Crossref
Hao Luo, Wentao Chen, Zhida Mai, Jianjiang Yang, Xiaomian Lin, Lihong Zeng, Yuying Pan, Qinghui Xie, Qingqing Xu, Xiaoxiao Li, Yiwen Liao, Zhanqin Feng, Jiangli Ou, Xiaolin Qin & Heping Zheng. (2021) Development and application of Cas13a-based diagnostic assay for Neisseria gonorrhoeae detection and azithromycin resistance identification . Journal of Antimicrobial Chemotherapy 77:3, pages 656-664.
Crossref
Kuangwen Hsieh, Johan H. Melendez, Charlotte A. Gaydos & Tza-Huei Wang. (2022) Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections. Lab on a Chip 22:3, pages 476-511.
Crossref
Johan H. Melendez, Fan-En Chen & Tza-Huei Wang. (2022) Antimicrobial susceptibility testing of Neisseria gonorrhoeae using a phenotypic-molecular assay and lyophilized antimicrobials. Diagnostic Microbiology and Infectious Disease 102:2, pages 115590.
Crossref
Liqing Zhou, Andrea Lopez Rodas, Luz Marina Llangarí, Natalia Romero Sandoval, Philip Cooper & Syed Tariq Sadiq. (2022) Single gene targeted nanopore sequencing enables simultaneous identification and antimicrobial resistance detection of sexually transmitted infections. PLOS ONE 17:1, pages e0262242.
Crossref
Nireshni Mitchev, Ravesh Singh, Veron Ramsuran, Arshad Ismail, Mushal Allam, Stanford Kwenda, Florah Mnyameni, Nigel Garrett, Khine Swe Swe-Han, Abraham J. Niehaus & Koleka P. Mlisana. (2022) High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens. International Journal of Microbiology 2022, pages 1-9.
Crossref
Ronza Hadad, Daniel Golparian, Inga Velicko, Anna-Karin Ohlsson, Ylva Lindroth, Eva-Lena Ericson, Hans Fredlund, Lars Engstrand & Magnus Unemo. (2022) First National Genomic Epidemiological Study of Neisseria gonorrhoeae Strains Spreading Across Sweden in 2016. Frontiers in Microbiology 12.
Crossref
Raphael Cavalcante de Medeiros, Sergio Eduardo Longo Fracalanzza & Raquel Regina Bonelli. 2022. Molecular Typing in Bacterial Infections, Volume I. Molecular Typing in Bacterial Infections, Volume I 155 165 .
Boris Shaskolskiy, Ilya Kandinov, Dmitry Kravtsov, Marina Filippova, Alexander Chestkov, Victoria Solomka, Alexey Kubanov, Dmitry Deryabin, Ekaterina Dementieva & Dmitry Gryadunov. (2021) Prediction of ceftriaxone MIC in Neisseria gonorrhoeae using DNA microarray technology and regression analysis . Journal of Antimicrobial Chemotherapy 76:12, pages 3151-3158.
Crossref
Magnus Unemo, Monica M Lahra, Martina Escher, Sergey Eremin, Michelle J Cole, Patricia Galarza, Francis Ndowa, Irene Martin, Jo-Anne R Dillon, Marcelo Galas, Pilar Ramon-Pardo, Hillard Weinstock & Teodora Wi. (2021) WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017–18: a retrospective observational study. The Lancet Microbe.
Crossref
Magnus Unemo, Josefine Ahlstrand, Leonor Sánchez-Busó, Michaela Day, David Aanensen, Daniel Golparian, Susanne Jacobsson, Michelle J Cole, Raquel Abad Torreblanca, Lena Rós Ásmundsdóttir, Eszter Balla, Irith De Baetselier, Beatrice Bercot, Anna Carannante, Dominique Caugant, Maria José Borrego, Susanne Buder, Robert Cassar, Michelle Cole, Alje van Dam, Claudia Eder, Steen Hoffmann, Blazenka Hunjak, Samo Jeverica, Vesa Kirjavainen, Panayiota Maikanti-Charalambous, Vivi Miriagou, Beata Mlynarczyk-Bonikowska, Gatis Pakarna, Lynsey Patterson, Peter Pavlik, Monique Perrin, Jill Shepherd, Paola Stefanelli, Magnus Unemo, Jelena Viktorova & Hana Zákoucká. (2021) High susceptibility to zoliflodacin and conserved target (GyrB) for zoliflodacin among 1209 consecutive clinical Neisseria gonorrhoeae isolates from 25 European countries, 2018 . Journal of Antimicrobial Chemotherapy 76:5, pages 1221-1228.
Crossref
R. H. T. Nijhuis, R. G. Duinsbergen, A. Pol & P. C. R. Godschalk. (2020) Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis including relevant resistance-associated mutations in a single center in the Netherlands. European Journal of Clinical Microbiology & Infectious Diseases 40:3, pages 591-595.
Crossref
Gerald J. Kost. (2021) Geospatial Spread of Antimicrobial Resistance, Bacterial and Fungal Threats to Coronavirus Infectious Disease 2019 (COVID-19) Survival, and Point-of-Care Solutions. Archives of Pathology & Laboratory Medicine 145:2, pages 145-167.
Crossref
M Unemo, JDC Ross, AB Serwin, M Gomberg, M Cusini & JS Jensen. (2020) Background review for the ‘2020 European guideline for the diagnosis and treatment of gonorrhoea in adults’. International Journal of STD & AIDS 32:2, pages 108-126.
Crossref
Ronza Hadad, Michelle Jayne Cole, Samantha Ebeyan, Susanne Jacobsson, Lit Yeen Tan, Daniel Golparian, Simon Erskine, Michaela Day, David Whiley, Magnus Unemo, Raquel Abad Torreblanca, Lena Rós Ásmundsdóttir, Eszter Balla, Irith De Baetselier, Beatrice Bercot, Thea Bergheim, Maria José Borrego, Susanne Buder, Robert Cassar, Michelle Cole, Alje van Dam, Claudia Eder, Steen Hoffmann, Blazenka Hunjak, Samo Jeverica, Vesa Kirjavainen, Panayiota Maikanti-Charalambous, Vivi Miriagou, Beata Młynarczyk-Bonikowska, Gatis Pakarna, Peter Pavlik, Monique Perrin, Joseph Pett, Paola Stefanelli, Kate Templeton, Magnus Unemo, Jelena Viktorova & Hana Zákoucká. (2021) Evaluation of the SpeeDx ResistancePlus® GC and SpeeDx GC 23S 2611 (beta) molecular assays for prediction of antimicrobial resistance/susceptibility to ciprofloxacin and azithromycin in Neisseria gonorrhoeae . Journal of Antimicrobial Chemotherapy 76:1, pages 84-90.
Crossref
Magnus Unemo. (2020) Optimizations to keep gonorrhoea treatable and reduce antimicrobial resistance selection. Nature Reviews Urology 17:11, pages 609-610.
Crossref
Leshan Xiu, Yamei Li, Feng Wang, Chi Zhang, Yizhun Li, Yaling Zeng, Yueping Yin & Junping Peng. (2020) Multiplex High-Resolution Melting Assay for Simultaneous Identification of Molecular Markers Associated with Extended-Spectrum Cephalosporins and Azithromycin Resistance in Neisseria gonorrhoeae. The Journal of Molecular Diagnostics 22:11, pages 1344-1355.
Crossref
M Unemo, JDC Ross, AB Serwin, M Gomberg, M Cusini & JS Jensen. (2020) 2020 European guideline for the diagnosis and treatment of gonorrhoea in adults. International Journal of STD & AIDS, pages 095646242094912.
Crossref
Thomas Meyer, Josef Eberle, R. Stefan Roß, Christian G. Schüttler, Michael Baier, Susanne Buder, Peter K. Kohl, Dieter Münstermann, Hans-Jochen Hagedorn, Sigrid Nick, Klaus Jansen, Viviane Bremer, Marcus Mau & Norbert H. Brockmeyer. (2020) Schnelltestdiagnostik sexuell übertragbarer InfektionenRapid diagnosis of sexually transmitted infections. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 63:10, pages 1271-1286.
Crossref
Cecilia Ferreyra, Jennifer Osborn, Francis Moussy, Emilie Alirol, Monica Lahra, David Whiley, William Shafer, Magnus Unemo, Jeffrey Klausner, Cassandra Kelly Cirino & Teodora Wi. (2020) Developing target product profiles for Neisseria gonorrhoeae diagnostics in the context of antimicrobial resistance: An expert consensus. PLOS ONE 15:9, pages e0237424.
Crossref
Igor Toskin, Veloshnee Govender, Karel Blondeel, Maurine Murtagh, Magnus Unemo, Charifa Zemouri, Rosanna W Peeling & James Kiarie. (2020) Call to action for health systems integration of point-of-care testing to mitigate the transmission and burden of sexually transmitted infections. Sexually Transmitted Infections 96:5, pages 342-347.
Crossref
Arlene C Seña, Laura Bachmann, Christine Johnston, Teodora Wi, Kimberly Workowski, Edward W HookIIIIII, Jane S Hocking, George Drusano & Magnus Unemo. (2020) Optimising treatments for sexually transmitted infections: surveillance, pharmacokinetics and pharmacodynamics, therapeutic strategies, and molecular resistance prediction. The Lancet Infectious Diseases 20:8, pages e181-e191.
Crossref
F. Rob & M. Unemo. (2020) 'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' – Author’s reply. Clinical Microbiology and Infection 26:6, pages 799-800.
Crossref
Allison L Hicks, Stephen M Kissler, Tatum D Mortimer, Kevin C Ma, George Taiaroa, Melinda Ashcroft, Deborah A Williamson, Marc Lipsitch & Yonatan H Grad. (2020) Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants. eLife 9.
Crossref
Thomas Meyer & Susanne Buder. (2020) The Laboratory Diagnosis of Neisseria gonorrhoeae: Current Testing and Future Demands. Pathogens 9:2, pages 91.
Crossref
Leshan Xiu, Chi Zhang, Yamei Li, Feng Wang & Junping Peng. (2020) High-resolution melting analysis for rapid detection of the internationally spreading ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone. Journal of Antimicrobial Chemotherapy 75:1, pages 106-109.
Crossref
Michelle J. Cole, Chantal Quinten, Susanne Jacobsson, Michaela Day, Andrew J. Amato-Gauci, Neil Woodford, Gianfranco Spiteri & Magnus Unemo. (2019) The European gonococcal antimicrobial surveillance programme (Euro-GASP) appropriately reflects the antimicrobial resistance situation for Neisseria gonorrhoeae in the European Union/European Economic Area. BMC Infectious Diseases 19:1.
Crossref
Magnus Unemo, H Steven Seifert, Edward W. HookIIIIII, Sarah Hawkes, Francis Ndowa & Jo-Anne R. Dillon. (2019) Gonorrhoea. Nature Reviews Disease Primers 5:1.
Crossref
Teodora EC Wi, Francis J Ndowa, Cecilia Ferreyra, Cassandra Kelly‐Cirino, Melanie M Taylor, Igor Toskin, James Kiarie, Nancy Santesso & Magnus Unemo. (2019) Diagnosing sexually transmitted infections in resource‐constrained settings: challenges and ways forward. Journal of the International AIDS Society 22:S6.
Crossref
Hyukmin Lee, Young Hee Suh, Sunhwa Lee, Yong-Kyun Kim, Mi-Soon Han, Hye Gyung Bae, Magnus Unemo & Kyungwon Lee. (2019) Emergence and Spread of Cephalosporin-Resistant Neisseria gonorrhoeae with Mosaic penA Alleles, South Korea, 2012–2017 . Emerging Infectious Diseases 25:3, pages 416-424.
Crossref
Shunji Suzuki, Shin-ichi Hoshi, Akihiko Sekizawa, Yoko Sagara, Masanobu Tanaka, Katsuyuki Kinoshita & Tadaichi Kitamura. (2019) Current status of Neisseria gonorrhoeae cervicitis in pregnant women in Japan. PLOS ONE 14:2, pages e0211595.
Crossref
Caroline J. Ngetsa, Marc W. Heymann, Alex Thiong'o, Elizabeth Wahome, John Mwambi, Clara Karani, Nelson C. Menza, Grace Mwashigadi, Margaret W. Muturi, Susan M. Graham, Peter M. Mugo & Eduard J. Sanders. (2020) Rectal gonorrhoea and chlamydia among men who have sex with men in coastal Kenya. Wellcome Open Research 4, pages 79.
Crossref
Magnus Unemo, Monica M. Lahra, Michelle Cole, Patricia Galarza, Francis Ndowa, Irene Martin, Jo-Anne R. Dillon, Pilar Ramon-Pardo, Gail Bolan & Teodora Wi. (2019) World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts. Sexual Health 16:5, pages 412.
Crossref
Magnus Unemo, Daniel Golparian & David W. Eyre. 2019. Neisseria gonorrhoeae. Neisseria gonorrhoeae 37 58 .
Daniel Golparian, Valentina Donà, Leonor Sánchez-Busó, Sunniva Foerster, Simon Harris, Andrea Endimiani, Nicola Low & Magnus Unemo. (2018) Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer. Scientific Reports 8:1.
Crossref
Justin Hardick, Trevor A Crowell, Kara Lombardi, Akindiran Akintunde, Sunday Odeyemi, Andrew Ivo, George Eluwa, Jean Njab, Stefan D Baral, Rebecca G Nowak, Thomas C Quinn, Kent Barbian, Sarah Anzick, Sylvia Adebajo, Manhattan E Charurat, Julie Ake & Charlotte A Gaydos. (2018) Molecular screening for Neisseria gonorrhoeae antimicrobial resistance markers in Nigerian men who have sex with men and transgender women . International Journal of STD & AIDS 29:13, pages 1273-1281.
Crossref
Valentina Donà, Joost H. Smid, Sara Kasraian, Dianne Egli-Gany, Ferah Dost, Fatime Imeri, Magnus Unemo, Nicola Low & Andrea Endimiani. (2018) Mismatch Amplification Mutation Assay-Based Real-Time PCR for Rapid Detection of Neisseria gonorrhoeae and Antimicrobial Resistance Determinants in Clinical Specimens. Journal of Clinical Microbiology 56:9.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.