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Review

An update on extracellular vesicles in multiple myeloma: a focus on their role in cell-to-cell cross-talk and as potential liquid biopsy biomarkers

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Pages 249-258 | Received 28 Dec 2018, Accepted 12 Feb 2019, Published online: 26 Feb 2019

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Ilaria Laurenzana, Stefania Trino, Daniela Lamorte, Marco Girasole, Simone Dinarelli, Angelo De Stradis, Vitina Grieco, Maddalena Maietti, Antonio Traficante, Teodora Statuto, Oreste Villani, Pellegrino Musto, Alessandro Sgambato, Luciana De Luca & Antonella Caivano. (2021) Analysis of Amount, Size, Protein Phenotype and Molecular Content of Circulating Extracellular Vesicles Identifies New Biomarkers in Multiple Myeloma. International Journal of Nanomedicine 16, pages 3141-3160.
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S. Rajeev Krishnan & M. Bebawy. (2023) Circulating biosignatures in multiple myeloma and their role in multidrug resistance. Molecular Cancer 22:1.
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Rui Bergantim, Sara Peixoto da Silva, Bárbara Polónia, Mélanie A. G. Barbosa, André Albergaria, Jorge Lima, Hugo R. Caires, José E. Guimarães & M. Helena Vasconcelos. (2022) Detection of Measurable Residual Disease Biomarkers in Extracellular Vesicles from Liquid Biopsies of Multiple Myeloma Patients—A Proof of Concept. International Journal of Molecular Sciences 23:22, pages 13686.
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Kieran Brennan, Katrine F. Iversen, Alfonso Blanco-Fernández, Thomas Lund, Torben Plesner & Margaret M. Mc Gee. (2022) Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59. Cells 11:21, pages 3365.
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Ilaria Saltarella, Aurelia Lamanuzzi, Vanessa Desantis, Lucia Di Marzo, Assunta Melaccio, Paola Curci, Tiziana Annese, Beatrice Nico, Antonio Giovanni Solimando, Giulia Bartoli, Doron Tolomeo, Clelia Tiziana Storlazzi, Maria Addolorata Mariggiò, Roberto Ria, Pellegrino Musto, Angelo Vacca & Maria Antonia Frassanito. (2022) Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs . The Journal of Pathology 256:4, pages 402-413.
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Alireza Goodarzi, Mohsen Valikhani, Fatemeh Amiri & Armita Safari. (2022) The mechanisms of mutual relationship between malignant hematologic cells and mesenchymal stem cells: Does it contradict the nursing role of mesenchymal stem cells?. Cell Communication and Signaling 20:1.
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Paraskevi Karousi, Aristea-Maria Papanota, Pinelopi I. Artemaki, Christine-Ivy Liacos, Dimitrios Patseas, Nefeli Mavrianou-Koutsoukou, Aikaterini-Anna Liosi, Maria-Anna Kalioraki, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Efstathios Kastritis, Meletios-Athanasios Dimopoulos, Andreas Scorilas, Evangelos Terpos & Christos K. Kontos. (2021) tRNA Derivatives in Multiple Myeloma: Investigation of the Potential Value of a tRNA-Derived Molecular Signature. Biomedicines 9:12, pages 1811.
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Antonia Reale, Tiffany Khong, Sridurga Mithraprabhu & Andrew Spencer. (2021) Translational Potential of RNA Derived From Extracellular Vesicles in Multiple Myeloma. Frontiers in Oncology 11.
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Ping L. Zhang & Ming‐Lin Liu. (2021) Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney. Journal of Cellular Physiology 236:8, pages 5482-5494.
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Antonia Reale, Irena Carmichael, Rong Xu, Sridurga Mithraprabhu, Tiffany Khong, Maoshan Chen, Haoyun Fang, Ioanna Savvidou, Malarmathy Ramachandran, Nicholas Bingham, Richard J. Simpson, David W. Greening & Andrew Spencer. (2021) Human myeloma cell‐ and plasma‐derived extracellular vesicles contribute to functional regulation of stromal cells. PROTEOMICS 21:13-14, pages 2000119.
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Jihane Khalife, James F. Sanchez & Flavia Pichiorri. (2021) The Emerging Role of Extracellular Vesicle-Associated RNAs in the Multiple Myeloma Microenvironment. Frontiers in Oncology 11.
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Stefania Trino, Daniela Lamorte, Antonella Caivano, Luciana De Luca, Alessandro Sgambato & Ilaria Laurenzana. (2020) Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy. Leukemia 35:3, pages 661-678.
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Tianjiao Geng, Patrick Pan, Euphemia Leung, Qi Chen, Larry Chamley & Zimei Wu. (2021) Recent Advancement and Technical Challenges in Developing Small Extracellular Vesicles for Cancer Drug Delivery. Pharmaceutical Research 38:2, pages 179-197.
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Antonia Reale, Tiffany Khong, Rong Xu, Maoshan Chen, Sridurga Mithraprabhu, Nicholas Bingham, Andrew Spencer & David W. Greening. 2021. Proteomic Profiling. Proteomic Profiling 151 191 .
Elham Gholipour, Parisa Sarvarian, Parisa Samadi, Mehdi Talebi, Aliakbar Movassaghpour, Roza Motavalli, Mohammad Hojjat‐Farsangi & Mehdi Yousefi. (2020) Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment. BioFactors 46:5, pages 698-715.
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Stefania Raimondo, Ornella Urzì, Alice Conigliaro, Lavinia Raimondi, Nicola Amodio & Riccardo Alessandro. (2020) Emerging Insights on the Biological Impact of Extracellular Vesicle-Associated ncRNAs in Multiple Myeloma. Non-Coding RNA 6:3, pages 30.
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Vanessa Pinto, Rui Bergantim, Hugo R. Caires, Hugo Seca, José E. Guimarães & M. Helena Vasconcelos. (2020) Multiple Myeloma: Available Therapies and Causes of Drug Resistance. Cancers 12:2, pages 407.
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Sylvia Faict, Inge Oudaert, Ludovic D’Auria, Jonas Dehairs, Ken Maes, Philip Vlummens, Kim De Veirman, Elke De Bruyne, Karel Fostier, Isabelle Vande Broek, Rik Schots, Karin Vanderkerken, Johannes V. Swinnen & Eline Menu. (2019) The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma. Cancers 11:12, pages 1823.
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Matias Valenzuela Alvarez, Luciana M. Gutierrez, Alejandro Correa, Alberto Lazarowski & Marcela F. Bolontrade. (2019) Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes. International Journal of Molecular Sciences 20:8, pages 1946.
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